KEGG   ENZYME: 2.7.1.145Help
Entry
EC 2.7.1.145                Enzyme                                 
Name
deoxynucleoside kinase;
multispecific deoxynucleoside kinase;
ms-dNK;
multisubstrate deoxyribonucleoside kinase;
multifunctional deoxynucleoside kinase;
D. melanogaster deoxynucleoside kinase;
Dm-dNK
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:deoxynucleoside 5'-phosphotransferase
Reaction(IUBMB)
ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate [RN:R05806]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
2'-deoxynucleoside [CPD:C02269]
Product
ADP [CPD:C00008];
2'-deoxynucleoside 5'-phosphate [CPD:C00676]
Comment
The enzyme from embryonic cells of Drosophila melanogaster differs from other deoxynucleoside kinases [EC 2.7.1.76 (deoxyadenosine kinase) and EC 2.7.1.113 (deoxyguanosine kinase)] in its broad specificity for all four common deoxynucleosides.
Orthology
K05961  
deoxynucleoside kinase
Genes
BFO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
Dgri_GH14441
DMO: 
Dmoj_GI10047
DVI: 
Dvir_GJ22572
AGA: 
AgaP_AGAP001585
AAG: 
AaeL_AAEL014055
CQU: 
CpipJ_CPIJ003276
AME: 
552840(dnk)
TCA: 
660567
API: 
100165639
 » show all
Taxonomy
Reference
1  [PMID:9461577]
  Authors
Munch-Petersen B, Piskur J, Sondergaard L.
  Title
Four deoxynucleoside kinase activities from Drosophila melanogaster are contained within a single monomeric enzyme, a new multifunctional deoxynucleoside kinase.
  Journal
J. Biol. Chem. 273 (1998) 3926-31.
  Organism
Drosophila melanogaster [GN:dme]
Reference
2  [PMID:10692477]
  Authors
Munch-Petersen B, Knecht W, Lenz C, Sondergaard L, Piskur J.
  Title
Functional expression of a multisubstrate deoxyribonucleoside kinase from Drosophila melanogaster and its C-terminal deletion mutants.
  Journal
J. Biol. Chem. 275 (2000) 6673-9.
  Organism
Drosophila melanogaster [GN:dme]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
52227-81-3
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