Entry
Name
deoxynucleoside kinase;
multispecific deoxynucleoside kinase;
ms-dNK;
multisubstrate deoxyribonucleoside kinase;
multifunctional deoxynucleoside kinase;
D. melanogaster deoxynucleoside kinase;
Dm-dNK;
ATP:deoxynucleoside 5'-phosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:deoxyribonucleoside 5'-phosphotransferase
Reaction(IUBMB)
ATP + a 2'-deoxyribonucleoside = ADP + a 2'-deoxyribonucleoside 5'-phosphate [RN:
R05806 ]
Reaction(KEGG)
Substrate
Product
ADP [CPD:
C00008 ];
2'-deoxyribonucleoside 5'-phosphate [CPD:
C00676 ]
Comment
The enzyme from embryonic cells of the fruit fly Drosophila melanogaster differs from other 2'-deoxyribonucleoside kinases [EC
2.7.1.76 (deoxyadenosine kinase) and EC
2.7.1.113 (deoxyguanosine kinase)] in its broad specificity for all four common 2'-deoxyribonucleosides.
History
EC 2.7.1.145 created 2001
Pathway
Orthology
Genes
DSI : Dsimw501_GD19261(Dsim_GD19261)
CLON : 129605891 129612847
ASTE : 118505597 118516567
AALB : 109405935 109417111 115266522
CNS : 116347604 116350021 116351806
BCOO : 119069920 119070619 119075577 119079253 119085227
MPHA : 105836053 105837551
ACEP : 105623946 105626028
PBAR : 105422323 105427465
TCA : 659303 659935 660567
SOY : 115876628 115880872 115880987 115883471
AGRG : 126746792 126747076 126747310
CSET : 123319946 123321861
AGB : 108907401 108911548 108915258
NVL : 108559729 108561321 108567605
APLN : 108736123 108740527
PPYR : 116171896 116172019 116178371 116181669 116182896
OTU : 111416219 111424509 111429051
BMAN : 114244024 114245792
MSEX : 115448679 115450116
DPL : KGM_201543 KGM_210835
BANY : 112044401 112051943
MCIX : 123655306 123657209
PMAC : 106707992 106716895
PPOT : 106109692 106111772
PRAP : 111000809 111002863
PNAP : 125049648 125059630
CCRC : 123694796 123695479
LSIN : 126976424 126979176
AAGE : 121730760 121732263
SLIU : 111353352 111359721
CFEL : 113376318 113377350
API : 100165338 100165639 100573648
ACOO : 126837273 126839223
BTAB : 109030166 109030645 109042887
PHU : Phum_PHUM399920 Phum_PHUM407830
TPAL : 117642345 117644223 117644227 117644838 117645549 117646362 117646570 117647020 117647901 117648133 117650702 117650881 117652427 117652670 117653641
CSEC : 111866426 111875651
DPX : DAPPUDRAFT_305834 DAPPUDRAFT_99663
MNZ : 135206122 135213635 135213638
EAF : 111699873 111704998 111706452 111718376
TCF : 131878958 131879683 131882528 131885170 131889936
PMEO : 129588944 129593989
» show all
Taxonomy
Reference
Authors
Munch-Petersen B, Piskur J, Sondergaard L.
Title
Four deoxynucleoside kinase activities from Drosophila melanogaster are contained within a single monomeric enzyme, a new multifunctional deoxynucleoside kinase.
Journal
Sequence
Reference
Authors
Munch-Petersen B, Knecht W, Lenz C, Sondergaard L, Piskur J
Title
Functional expression of a multisubstrate deoxyribonucleoside kinase from Drosophila melanogaster and its C-terminal deletion mutants.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.7.1.145