KEGG   ENZYME: 2.7.1.149Help
Entry
EC 2.7.1.149                Enzyme                                 
Name
1-phosphatidylinositol-5-phosphate 4-kinase;
type II PIP kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:1-phosphatidyl-1D-myo-inositol-5-phosphate 4-phosphotransferase
Reaction(IUBMB)
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [RN:R05803]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
1-phosphatidyl-1D-myo-inositol 5-phosphate [CPD:C11557]
Product
ADP [CPD:C00008];
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [CPD:C04637]
Pathway
Inositol phosphate metabolism
Orthology
K00920  
1-phosphatidylinositol-5-phosphate 4-kinase
Genes
HSA: 
5305(PIP4K2A) 79837(PIP4K2C) 8396(PIP4K2B)
PTR: 
467044(PIP4K2C) 742458(PIP4K2A) 746830(PIP4K2B)
PPS: 
100969342(PIP4K2B) 100978631(PIP4K2C) 100984240(PIP4K2A)
GGO: 
101129094(PIP4K2A) 101142708(PIP4K2C) 101148420(PIP4K2B)
PON: 
100174032(PIP4K2C) 100459105(PIP4K2B) 100461518(PIP4K2A)
MCC: 
695366(PIP4K2B) 710724(PIP4K2A) 715120(PIP4K2C)
MMU: 
108083(Pip4k2b) 117150(Pip4k2c) 18718(Pip4k2a)
RNO: 
116723(Pip4k2a) 140607(Pip4k2c) 89812(Pip4k2b)
CFA: 
474417(PIP4K2C) 491034(PIP4K2B) 608414(PIP4K2A)
AML: 
FCA: 
101095026(PIP4K2C) 101096576(PIP4K2A) 101100097(PIP4K2B)
BTA: 
533289(PIP4K2A) 539211(PIP4K2B) 540005(PIP4K2C)
SSC: 
100516802 100520446(PIP4K2A) 100623031(PIP4K2B)
ECB: 
100053518 100055236(PIP4K2B) 100066733(PIP4K2A)
MDO: 
100016918(PIP4K2B) 100019731(PIP4K2A)
SHR: 
100928218(PIP4K2A) 100930099(PIP4K2B) 100934897(PIP4K2C)
OAA: 
100079689
GGA: 
419999(PIP4K2B) 420504(PIP4K2A)
MGP: 
100543719 100551336(PIP4K2B)
TGU: 
100219125(PIP4K2A)
ACS: 
100552595 100557825(pip4k2b) 100567083
XLA: 
100036841(pip4k2a) 399394(pip4k2b) 496028(pip4k2c)
XTR: 
100170468(pip4k2b) 100380045(pip4k2a) 448167(pip4k2c)
DRE: 
373124(pip5k2) 560360(pip4k2aa)
TRU: 
101063876 101079176 101079533
OLA: 
101167656 101169535 101171380
BFO: 
BRAFLDRAFT_81009
CIN: 
100175764 100179676
SPU: 
580595
DAN: 
Dana_GF23407
DER: 
Dere_GG16415
DPE: 
Dper_GL18405
DSE: 
Dsec_GM13005
DSI: 
Dsim_GD24357
DWI: 
Dwil_GK13624
DYA: 
Dyak_GE14484
DGR: 
Dgri_GH23952
DMO: 
Dmoj_GI14032
DVI: 
Dvir_GJ19634
AME: 
409276
NVI: 
100116347(NV18094)
TCA: 
660048
API: 
100164484
PHU: 
Phum_PHUM576800
ISC: 
IscW_ISCW009432
CEL: 
CELE_Y48G9A.8(ppk-2)
CBR: 
CBG15109(Cbr-ppk-2)
BMY: 
Bm1_57205
TSP: 
Tsp_06353
SMM: 
Smp_142370.2
NVE: 
NEMVE_v1g237340
HMG: 
100204551
TAD: 
TRIADDRAFT_22804
AQU: 
100631729
MBR: 
MONBRDRAFT_25091
TPV: 
TP02_0200
 » show all
Taxonomy
Reference
1  [PMID:9367159]
  Authors
Rameh LE, Tolias KF, Duckworth BC, Cantley LC.
  Title
A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate.
  Journal
Nature. 390 (1997) 192-6.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
247907-17-1
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