KEGG   ENZYME: 2.7.1.151Help
Entry
EC 2.7.1.151                Enzyme                                 

Name
inositol-polyphosphate multikinase;
IpK2;
IP3/IP4 6-/3-kinase;
IP3/IP4 dual-specificity 6-/3-kinase;
IpmK;
ArgRIII;
AtIpk2alpha;
AtIpk2beta;
inositol polyphosphate 6-/3-/5-kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase
Reaction(IUBMB)
2 ATP + 1D-myo-inositol 1,4,5-trisphosphate = 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (overall reaction) [RN:R10065];
(1a) ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate [RN:R05800];
(1b) ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate [RN:R05801]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
1D-myo-inositol 1,4,5-trisphosphate [CPD:C01245];
1D-myo-inositol 1,4,5,6-tetrakisphosphate [CPD:C11555]
Product
ADP [CPD:C00008];
1D-myo-inositol 1,3,4,5,6-pentakisphosphate [CPD:C01284];
1D-myo-inositol 1,4,5,6-tetrakisphosphate [CPD:C11555]
Comment
This enzyme also phosphorylates Ins(1,4,5)P3 to Ins(1,3,4,5)P4, Ins(1,3,4,5)P4 to Ins(1,3,4,5,6)P5, and Ins(1,3,4,5,6)P4 to Ins(PP)P4, isomer unknown. The enzyme from the plant Arabidopsis thaliana can also phosphorylate Ins(1,3,4,6)P4 and Ins(1,2,3,4,6)P5 at the D-5-position to produce 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate (InsP6), respectively [3]. Yeast produce InsP6 from Ins(1,4,5)P3 by the actions of this enzyme and EC 2.7.1.158, inositol-pentakisphosphate 2-kinase [4].
History
EC 2.7.1.151 created 2002, modified 2006
Pathway
Inositol phosphate metabolism
Orthology
K00328  
inositol-polyphosphate multikinase
K00915  
1D-myo-Inositol-tetrakisphosphate 5-kinase / inositol-polyphosphate multikinase
Genes
HSA: 
253430(IPMK)
PTR: 
450471(IPMK)
PPS: 
100973083(IPMK)
GGO: 
101154364(IPMK)
PON: 
100462505(IPMK)
NLE: 
100592716(IPMK)
MCC: 
703630(IPMK)
MCF: 
102143477(IPMK)
CJC: 
100415637(IPMK)
MMU: 
69718(Ipmk)
RNO: 
171458(Ipmk)
CGE: 
100772629(Ipmk)
NGI: 
103730748(Ipmk)
HGL: 
101700113(Ipmk)
OCU: 
100355723(IPMK)
TUP: 
102483332(IPMK)
AML: 
100478367(IPMK)
UMR: 
103667727(IPMK)
FCA: 
PTG: 
102959812(IPMK)
BTA: 
615135(IPMK)
BOM: 
102287037(IPMK)
PHD: 
102317812(IPMK)
CHX: 
102177585(IPMK)
OAS: 
101120714(IPMK)
SSC: 
CFR: 
102520396(IPMK)
BACU: 
103013713(IPMK)
LVE: 
103080830(IPMK)
ECB: 
100072153(IPMK)
MYB: 
102254091(IPMK)
MYD: 
102755711(IPMK)
PALE: 
102888012(IPMK)
MDO: 
100024450(IPMK)
SHR: 
100931610(IPMK)
OAA: 
100076322(IPMK)
GGA: 
101751177(IPMK)
MGP: 
APLA: 
101804228(IPMK)
TGU: 
100225175(IPMK)
FAB: 
101808343(IPMK)
PHI: 
102102225(IPMK)
FPG: 
101922653(IPMK)
FCH: 
102053151(IPMK)
CLV: 
102098297(IPMK)
ASN: 
102379224(IPMK)
AMJ: 
102574742(IPMK)
PSS: 
102448749(IPMK)
CMY: 
102934554(IPMK)
ACS: 
100560539(ipmk)
PBI: 
XLA: 
447535(ipmk)
XTR: 
100485175(ipmk)
DRE: 
790916(ipmkb)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102351435(IPMK)
CMK: 
103180913(ipmk)
BFO: 
CIN: 
SPU: 
DAN: 
DER: 
DSE: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AAG: 
CQU: 
AME: 
724909(Ipk2)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
LOA: 
TSP: 
HRO: 
LGI: 
SMM: 
NVE: 
TAD: 
AQU: 
ATH: 
AT5G07370(IPK2a) AT5G61760(IPK2BETA)
ALY: 
CRB: 
EUS: 
BRP: 
CIT: 
CIC: 
TCC: 
GMX: 
100127407(IPK2)
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
CSV: 
CMO: 
RCU: 
POP: 
POPTR_0012s11320g(POPTRDRAFT_423081) POPTR_0015s12100g(POPTRDRAFT_253088)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os02t0523800-01(Os02g0523800)
OBR: 
BDI: 
SBI: 
SORBI_04g021290(SORBIDRAFT_04g021290)
ZMA: 
SITA: 
PDA: 
MUS: 
ATR: 
s00016p00249320(AMTR_s00016p00249320)
SMO: 
PPP: 
CRE: 
VCN: 
BPG: 
CSL: 
SCE: 
YDR173C(ARG82)
AGO: 
ERC: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0B03200(NCAS0B03200)
NDI: 
NDAI_0A01200(NDAI0A01200)
TPF: 
TPHA_0C02470(TPHA0C02470)
TBL: 
TBLA_0H01030(TBLA0H01030)
TDL: 
TDEL_0F04950(TDEL0F04950)
KAF: 
KAFR_0B06020(KAFR0B06020)
PPA: 
DHA: 
PGU: 
SPAA: 
LEL: 
CAL: 
CaO19.1377(ARG82) CaO19.8957(ARG82)
CTP: 
COT: 
CDU: 
CTEN: 
CLU: 
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
TMN: 
NHE: 
TRE: 
CMT: 
VAL: 
ELA: 
MBE: 
ANI: 
PBL: 
ABE: 
TVE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
TML: 
CNE: 
CNB: 
CGI: 
TMS: 
DSQ: 
PCO: 
SHS: 
ADL: 
FME: 
GTR: 
LBC: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT121474(AGABI1DRAFT_121474)
ABV: 
AGABI2DRAFT209575(AGABI2DRAFT_209575)
CPUT: 
SLA: 
UMA: 
PFP: 
PGR: 
MLR: 
WSE: 
DDI: 
DPP: 
TPS: 
PIF: 
TVA: 
 » show all
Taxonomy
Reference
1  [PMID:10574768]
  Authors
Saiardi A, Erdjument-Bromage H, Snowman AM, Tempst P, Snyder SH.
  Title
Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases.
  Journal
Curr. Biol. 9 (1999) 1323-6.
  Sequence
[sce:YDR173C]
Reference
2  [PMID:10720331]
  Authors
Odom AR, Stahlberg A, Wente SR, York JD.
  Title
A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control.
  Journal
Science. 287 (2000) 2026-9.
Reference
3  [PMID:12226109]
  Authors
Stevenson-Paulik J, Odom AR, York JD.
  Title
Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases.
  Journal
J. Biol. Chem. 277 (2002) 42711-8.
  Sequence
Reference
4  [PMID:15531582]
  Authors
Verbsky JW, Chang SC, Wilson MP, Mochizuki Y, Majerus PW.
  Title
The pathway for the production of inositol hexakisphosphate in human cells.
  Journal
J. Biol. Chem. 280 (2005) 1911-20.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9077-69-4

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