| Entry |
|
|---|
| Name |
phosphatidylinositol-4,5-bisphosphate 3-kinase;
type I phosphoinositide 3-kinase |
|---|
| Class |
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
 |
|---|
| Sysname |
ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate
3-phosphotransferase |
|---|
| Reaction(IUBMB) |
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP +
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate [RN:R04545] |
|---|
| Reaction(KEGG) |
R04545
 |
|---|
| Substrate |
ATP [CPD:C00002];
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [CPD:C04637] |
|---|
| Product |
ADP [CPD:C00008];
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate [CPD:C05981] |
|---|
| Comment |
This enzyme also catalyses the phosphorylation of PtdIns4P to
PtdIns(3,4)P2, and of PtdIns to PtdIns3P. Four mammalian isoforms
are known to exist. |
|---|
| Pathway |
ec00562 Inositol phosphate metabolism |
|---|
| Orthology |
K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase |
|---|
| Genes |
HSA: 5290(PIK3CA) 5291(PIK3CB) 5293(PIK3CD) 5294(PIK3CG)
PTR: 457922(PIK3CD) 460858(PIK3CA) 463649(PIK3CG)
MCC: 698857(PIK3CG) 709959(PIK3CA) 716098(PIK3CB)
MMU: 18706(Pik3ca) 18707(Pik3cd) 30955(Pik3cg) 74769(Pik3cb)
RNO: 170911(Pik3ca) 298947(Pik3cg) 366508(Pik3cd) 85243(Pik3cb)
CFA: 477085(PIK3CB) 483266(PIK3CG) 488084(PIK3CA) 489644(PIK3CD)
BTA: 282306(PIK3CA) 504531(PIK3CD) 517948(PIK3CB) 530001(PIK3CG)
SSC: 396979(PIK3CG)
ECB: 100050532 100051623(PIK3CD) 100051753 100058141
MDO: 100009879 100010412
OAA: 100073788 100086270
GGA: 417706(PIK3CG) 419444(PIK3CD) 424826(PIK3CB) 424971(PIK3CA)
TGU: 100229232
XTR: 100144924(pik3ca) 100158519(pik3cg) 780390(pik3cb)
DRE: 100002263(fb92a07) 100334588 394174(pik3cd) 406598(PIK3CG)
561737 564261
BFO: BRAFLDRAFT_228095 BRAFLDRAFT_94886
CIN: 100180112 100180924 100183611
SPU: 588097 754280 758343
DME: Dmel_CG4141(Pi3K92E)
DPO: Dpse_GA17984
DAN: Dana_GF18327
DER: Dere_GG15290
DPE: Dper_GL27142
DSE: Dsec_GM23175
DSI: Dsim_GD20048
DWI: Dwil_GK22711
DYA: Dyak_GE25053
DGR: Dgri_GH16124
DMO: Dmoj_GI22170
DVI: Dvir_GJ24290
AGA: AgaP_AGAP000018
AAG: AaeL_AAEL002903
CQU: CpipJ_CPIJ005543
AME: 551500(GB19635)
NVI: 100115810(Pik3cb)
TCA: 657286
API: 100160001(ACYPI001335)
PHU: Phum_PHUM169940
ISC: IscW_ISCW010469 IscW_ISCW014229
CEL: B0334.8(age-1)
CBR: CBG02868(Cbr-age-1)
BMY: Bm1_55680
SMM: Smp_164960
NVE: NEMVE_v1g242402
HMG: 100210375
TAD: TRIADDRAFT_26293
MBR: MONBRDRAFT_18656(PI3K-CA_alpha)
NGR: NAEGRDRAFT_270 NAEGRDRAFT_29590 NAEGRDRAFT_48457
DDI: DDB_G0275011(pikC) DDB_G0278727(pikA)
EHI: EHI_006130(83.t00026) EHI_095130(269.t00003)
EDI: EDI_013060 EDI_198920
PTM: GSPATT00039649001
TCR: 508859.90 510167.10
LIF: LinJ14.0020
TVA: TVAG_284350
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:11395417]
Vanhaesebroeck B, Leevers SJ, Ahmadi K, Timms J, Katso R, Driscoll
PC, Woscholski R, Parker PJ, Waterfield MD.
Synthesis and function of 3-phosphorylated inositol lipids.
Annu. Rev. Biochem. 70 (2001) 535-602.
Drosophila melanogaster [GN:dme], Caenorhabditis elegans [GN:cel],
Dictyostelium discoideum [GN:ddi], mammalian |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.7.1.153
IUBMB Enzyme Nomenclature: 2.7.1.153
ExPASy - ENZYME nomenclature database: 2.7.1.153
BRENDA, the Enzyme Database: 2.7.1.153
CAS: 103843-30-7 |
|---|
