KEGG   ENZYME: 2.7.1.159Help
Entry
EC 2.7.1.159                Enzyme                                 

Name
inositol-1,3,4-trisphosphate 5/6-kinase;
Ins(1,3,4)P3 5/6-kinase;
inositol trisphosphate 5/6-kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:1D-myo-inositol 1,3,4-trisphosphate 5-phosphotransferase
Reaction(IUBMB)
(1) ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate [RN:R03428];
(2) ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate [RN:R03429]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
1D-myo-inositol 1,3,4-trisphosphate [CPD:C01243]
Product
ADP [CPD:C00008];
1D-myo-inositol 1,3,4,5-tetrakisphosphate [CPD:C01272];
1D-myo-inositol 1,3,4,6-tetrakisphosphate [CPD:C04477]
Comment
In humans, this enzyme, along with EC 2.7.1.127 (inositol-trisphosphate 3-kinase), EC 2.7.1.140 (inositol-tetrakisphosphate 5-kinase) and EC 2.7.1.158 (inositol pentakisphosphate 2-kinase) is involved in the production of inositol hexakisphosphate (InsP6). InsP6 is involved in many cellular processes, including mRNA export from the nucleus [2]. Yeasts do not have this enzyme, so produce InsP6 from Ins(1,4,5)P3 by the actions of EC 2.7.1.151 (inositol-polyphosphate multikinase) and EC 2.7.1.158 (inositol-pentakisphosphate 2-kinase) [2].
Pathway
Inositol phosphate metabolism
Metabolic pathways
Orthology
K00913  
inositol-1,3,4-trisphosphate 5/6-kinase / inositol-tetrakisphosphate 1-kinase
Genes
HSA: 
3705(ITPK1)
PTR: 
453121(ITPK1)
PPS: 
100980755(ITPK1)
GGO: 
101134664(ITPK1)
PON: 
100448118(ITPK1)
MCC: 
698756(ITPK1)
MCF: 
102119398(ITPK1)
MMU: 
217837(Itpk1)
RNO: 
500709(Itpk1)
CGE: 
HGL: 
101700462(Itpk1)
TUP: 
102479480(ITPK1)
CFA: 
490591(ITPK1)
AML: 
FCA: 
101087672(ITPK1)
BTA: 
518488(ITPK1)
BOM: 
102279411(ITPK1)
PHD: 
102333268(ITPK1)
CHX: 
102183460(ITPK1)
SSC: 
100152339(ITPK1)
CFR: 
102508931(ITPK1)
ECB: 
100063828(ITPK1)
MYB: 
102246792(ITPK1)
MDO: 
SHR: 
100924957(ITPK1)
OAA: 
GGA: 
423421(ITPK1)
MGP: 
TGU: 
100222999(ITPK1)
FAB: 
101819235(ITPK1)
PHI: 
102106037(ITPK1)
APLA: 
101801656(ITPK1)
FPG: 
101920131(ITPK1)
FCH: 
102048369(ITPK1)
CLV: 
102088692(ITPK1)
ASN: 
102373418(ITPK1)
PSS: 
102452019(ITPK1)
ACS: 
XLA: 
379828(itpk1)
XTR: 
549890(itpk1)
DRE: 
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102351625(ITPK1)
BFO: 
CIN: 
SPU: 
AME: 
551726(GB12674)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
SMM: 
NVE: 
HMG: 
TAD: 
ATH: 
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
GMX: 
MTR: 
CAM: 
FVE: 
CSV: 
RCU: 
POP: 
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os02t0466400-01(Os02g0466400) Os03t0230500-01(Os03g0230500) Os03t0726200-01(Os03g0726200) Os10t0103800-01(Os10g0103800) Os10t0576100-01(Os10g0576100)
BDI: 
SBI: 
SORBI_01g009550(SORBIDRAFT_01g009550) SORBI_01g027420(SORBIDRAFT_01g027420) SORBI_01g028090(SORBIDRAFT_01g028090) SORBI_01g042010(SORBIDRAFT_01g042010) SORBI_04g017450(SORBIDRAFT_04g017450)
ZMA: 
SITA: 
SMO: 
PPP: 
CRE: 
VCN: 
MIS: 
CSL: 
GSL: 
CCP: 
MBR: 
DDI: 
DPP: 
DFA: 
DFA_02662(ITPK1)
EHI: 
EHI_042120(11.t00022) EHI_100310(151.t00008)
EDI: 
ACAN: 
TET: 
PTM: 
PTI: 
TPS: 
PIF: 
GTT: 
TVA: 
 » show all
Taxonomy
Reference
1  [PMID:8662638]
  Authors
Wilson MP, Majerus PW.
  Title
Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme.
  Journal
J. Biol. Chem. 271 (1996) 11904-10.
  Organism
Bos taurus [GN:bta]
  Sequence
[bta:518488]
Reference
2  [PMID:15531582]
  Authors
Verbsky JW, Chang SC, Wilson MP, Mochizuki Y, Majerus PW.
  Title
The pathway for the production of inositol hexakisphosphate in human cells.
  Journal
J. Biol. Chem. 280 (2005) 1911-20.
  Organism
Homo sapiens [GN:hsa]
Reference
3  [PMID:15837423]
  Authors
Miller GJ, Wilson MP, Majerus PW, Hurley JH.
  Title
Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase.
  Journal
Mol. Cell. 18 (2005) 201-12.
  Organism
Entamoeba histolytica [GN:ehi], Homo sapiens [GN:hsa]
  Sequence
[ehi:EHI_100310] [hsa:3705]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
288307-53-9

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