KEGG   ENZYME: 2.7.1.52Help
Entry
EC 2.7.1.52                 Enzyme                                 

Name
fucokinase;
fucokinase (phosphorylating);
fucose kinase;
L-fucose kinase;
L-fucokinase;
ATP:6-deoxy-L-galactose 1-phosphotransferase;
ATP:L-fucose 1-phosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:beta-L-fucose 1-phosphotransferase
Reaction(IUBMB)
ATP + L-fucose = ADP + beta-L-fucose 1-phosphate [RN:R03161]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
L-fucose [CPD:C01019]
Product
ADP [CPD:C00008];
beta-L-fucose 1-phosphate [CPD:C02985]
Comment
Requires a divalent cation for activity, with Mg2+ and Fe2+ giving rise to the highest enzyme activity. Forms part of a salvage pathway for reutilization of L-fucose. Can also phosphorylate D-arabinose, but more slowly.
History
EC 2.7.1.52 created 1972, modified 2004
Pathway
Fructose and mannose metabolism
Amino sugar and nucleotide sugar metabolism
Metabolic pathways
Orthology
K05305  
fucokinase
Genes
HSA: 
197258(FUK)
PTR: 
468015(FUK)
PPS: 
GGO: 
PON: 
MCC: 
709226(FUK)
MCF: 
MMU: 
234730(Fuk)
RNO: 
307848(Fuk)
CGE: 
HGL: 
TUP: 
CFA: 
489715(FUK)
AML: 
FCA: 
PTG: 
BTA: 
519181(FUK)
BOM: 
PHD: 
CHX: 
SSC: 
CFR: 
BACU: 
LVE: 
ECB: 
MYB: 
MYD: 
PALE: 
MDO: 
SHR: 
OAA: 
GGA: 
770049(FUK)
TGU: 
FAB: 
PHI: 
APLA: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
CMY: 
ACS: 
PBI: 
XLA: 
XTR: 
DRE: 
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
CIN: 
SPU: 
NVE: 
TAD: 
ATH: 
AT1G01220(FKGP)
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
CSV: 
RCU: 
POP: 
POPTR_0002s17540g(POPTRDRAFT_755427) POPTR_0014s09690g(POPTRDRAFT_664148)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os03t0115100-01(Os03g0115100)
OBR: 
BDI: 
SBI: 
SORBI_01g049620(SORBIDRAFT_01g049620)
ZMA: 
SITA: 
ATR: 
s00069p00036320(AMTR_s00069p00036320)
PPP: 
OTA: 
MIS: 
MPP: 
MBR: 
DDI: 
DPP: 
DFA: 
ACAN: 
PTI: 
TPS: 
EHX: 
GTT: 
TCR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
ROB: 
RTO: 
SGY: 
SUS: 
 » show all
Taxonomy
Reference
1  [PMID:5646161]
  Authors
Ishihara H, Massaro DJ, Heath EC.
  Title
The metabolism of L-fucose. 3. The enzymatic synthesis of beta-L-fucose 1-phosphate.
  Journal
J. Biol. Chem. 243 (1968) 1103-9.
  Organism
Sus scofa
Reference
2  [PMID:2986701]
  Authors
Butler W, Serif GS.
  Title
Fucokinase, its anomeric specificity and mechanism of phosphate group transfer.
  Journal
Biochim. Biophys. Acta. 829 (1985) 238-43.
Reference
3  [PMID:9488699]
  Authors
Park SH, Pastuszak I, Drake R, Elbein AD.
  Title
Purification to apparent homogeneity and properties of pig kidney L-fucose kinase.
  Journal
J. Biol. Chem. 273 (1998) 5685-91.
  Organism
Sus scofa
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37278-00-5

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