| Entry |
|
|---|
| Name |
1-phosphatidylinositol-4-phosphate 5-kinase;
diphosphoinositide kinase;
PIP kinase;
phosphatidylinositol 4-phosphate kinase;
phosphatidylinositol-4-phosphate 5-kinase;
type I PIP kinase |
|---|
| Class |
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
 |
|---|
| Sysname |
ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase |
|---|
| Reaction(IUBMB) |
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP +
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [RN:R03469] |
|---|
| Reaction(KEGG) |
R03469
 |
|---|
| Substrate |
ATP [CPD:C00002];
1-phosphatidyl-1D-myo-inositol 4-phosphate [CPD:C01277] |
|---|
| Product |
ADP [CPD:C00008];
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [CPD:C04637] |
|---|
| Comment |
This enzyme can also phosphorylate PtdIns3P in the 4-position, and
PtdIns, PtdIns3P and PtdIns(3,4)P2 in the 5-position in vitro, but
to a lesser extent. The last of these reactions occurs in vivo and
is physiologically relevant. Three different isoforms are known. |
|---|
| Pathway |
ec00562 Inositol phosphate metabolism
ec01100 Metabolic pathways |
|---|
| Orthology |
K00889 1-phosphatidylinositol-4-phosphate 5-kinase
K13712 phosphatidylinositol-4-phosphate 5-kinase-like protein 1 |
|---|
| Genes |
HSA: 138429(PIP5KL1) 23396(PIP5K1C) 8394(PIP5K1A) 8395(PIP5K1B)
PTR: 455590(PIP5K1C) 464513(PIP5K1B) 464758(PIP5KL1)
MCC: 700538(PIP5K1B) 705749(PIP5KL1) 710007(PIP5K1A)
MMU: 100046931 18717(Pip5k1c) 18719(Pip5k1b) 18720(Pip5k1a)
227733(Pip5kl1)
RNO: 309419(Pip5k1b) 314641(Pip5k1c) 365865(Pip5k1a) 687758
CFA: 475846(PIP5K1A) 476331(PIP5K1B) 485054(PIP5K1C) 609122(PIP5KL1)
BTA: 100125224(PIP5K1A) 504715 508819(PIP5K1C) 523736(PIP5KL1)
537654(PIP5K1B)
ECB: 100050520(PIP5K1B) 100059655(PIP5K1A) 100070364
MDO: 100010549 100012245 100017950(PIP5K1A) 100021835
OAA: 100074263 100080469
GGA: 420072(PIP5K1C) 427243(PIP5K1B) 429983(PIP5K1A)
TGU: 100218810 100221379 100229771 100232143
XLA: 398687(MGC130766) 399203(pip5k1a) 444238(pip5k1b)
XTR: 100145583(pip5k1c) 448746(pip5k1a)
DRE: 100149843 447840(fj29b05) 449831(pip5k1b) 492549(im:7140933)
553629(pip5k1a)
BFO: BRAFLDRAFT_118884 BRAFLDRAFT_216408
CIN: 100186167 100187365
SPU: 578946 579944 580595
DME: Dmel_CG17471 Dmel_CG3682(PIP5K59B) Dmel_CG9985(sktl)
DPO: Dpse_GA22167 Dpse_GA25087
AAG: AaeL_AAEL010238 AaeL_AAEL015255
AME: 409276(GB12553) 724991(GB13779)
TCA: 663424
API: 100161889(ACYPI003078)
CEL: F55A12.3(ppk-1) VF11C1L.1(ppk-3)
CBR: CBG12324(Cbr-ppk-1) CBG16921(Cbr-ppk-3)
BMY: Bm1_33360 Bm1_36090
NVE: NEMVE_v1g105451 NEMVE_v1g146305 NEMVE_v1g237340
HMG: 100197010
TAD: TRIADDRAFT_19797 TRIADDRAFT_54491
ATH: AT1G01460(PIPK11) AT1G10900 AT1G21980 AT1G60890 AT1G71010
AT1G77740 AT2G26420(PIP5K3) AT2G41210(PIP5K5) AT3G07960
AT3G14270 AT3G56960(PIP5K4) AT4G01190
POP: POPTR_555053 POPTR_582189
OSA: 4332323(Os03g0262000) 4333051(Os03g0399500)
4333833(Os03g0701800) 4333853(Os03g0705300)
4340685(Os06g0259000) 4344166(Os07g0658700)
4345628(Os08g0428900) 4351470(Os12g0141100)
PPP: PHYPADRAFT_121474 PHYPADRAFT_30361 PHYPADRAFT_40660
CRE: CHLREDRAFT_120269 CHLREDRAFT_195580
OLU: OSTLU_850
CME: CME153C CMN333C
SCE: YDR208W(MSS4)
AGO: AGOS_AGL096W
KLA: KLLA0A04301g
VPO: Kpol_1029p20 Kpol_1061p18
CGR: CAGL0F05335g
PIC: PICST_64487(MSS4)
CAL: CaO19.10663(MSS4) CaO19.3153(MSS4)
YLI: YALI0F23573g
NCR: NCU02295
PAN: PODANSg1803
MGR: MGG_06572(MG06572.4)
FGR: FG10792.1
BFU: BC1G_16298
ANI: AN2766.2
AFM: AFUA_3G06080
NFI: NFIA_071170
AOR: AO090020000081
ANG: An11g10410
SPO: SPAC19G12.14(its3)
CNE: CNA03760
CNB: CNBA3560
LBC: LACBIDRAFT_392686 LACBIDRAFT_397690 LACBIDRAFT_397906
UMA: UM03809.1
MGL: MGL_0138
MBR: MONBRDRAFT_25486
DDI: DDB_G0267588 DDB_G0275635(PIPkinA) DDB_G0292190
EHI: EHI_153770(13.t00009)
PFA: PFA_0515w(PfPIP5K)
PFD: PFDG_01096
PFH: PFHG_00385
PYO: PY02398
PKN: PKH_020300
PVX: PVX_081270
TAN: TA11845
TPV: TP02_0200
BBO: BBOV_II007470(18.m06619)
CPV: cgd8_3280
CHO: Chro.80381
TGO: TGME49_030490
TET: TTHERM_00047210 TTHERM_00471898 TTHERM_01125130 TTHERM_01457080
PTM: GSPATT00000655001 GSPATT00000714001 GSPATT00005572001
GSPATT00006938001 GSPATT00006945001 GSPATT00010565001
GSPATT00014456001 GSPATT00015691001 GSPATT00019649001
GSPATT00022539001 GSPATT00032331001 GSPATT00033281001
TBR: Tb927.4.1620
TCR: 504057.104 509715.120 510105.130 511001.70
LMA: LmjF34.3090
GLA: GL50803_11897
TVA: TVAG_462290
PTI: PHATRDRAFT_49524
TPS: THAPSDRAFT_18434
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4295336]
Kai M, Salway JG, Hawthorne JN.
The diphosphoinositide kinase of rat brain.
Biochem. J. 106 (1968) 791-801.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
|
2
Kai, M., Salway, J.G., Michell, R.H. and Hawthorne, J.N.
The biosynthesis of triphosphoinositide by rat brain in vitro.
Biochem. Biophys. Res. Commun. 22 (1966) 370-375. |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:9367159]
Rameh LE, Tolias KF, Duckworth BC, Cantley LC.
A new pathway for synthesis of
phosphatidylinositol-4,5-bisphosphate.
Nature. 390 (1997) 192-6.
mammalian |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.7.1.68
IUBMB Enzyme Nomenclature: 2.7.1.68
ExPASy - ENZYME nomenclature database: 2.7.1.68
BRENDA, the Enzyme Database: 2.7.1.68
CAS: 104645-76-3 |
|---|
