KEGG   ENZYME: 2.7.1.68Help
Entry
EC 2.7.1.68                 Enzyme                                 
Name
1-phosphatidylinositol-4-phosphate 5-kinase;
diphosphoinositide kinase;
PIP kinase;
phosphatidylinositol 4-phosphate kinase;
phosphatidylinositol-4-phosphate 5-kinase;
type I PIP kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase
Reaction(IUBMB)
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [RN:R03469]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
1-phosphatidyl-1D-myo-inositol 4-phosphate [CPD:C01277]
Product
ADP [CPD:C00008];
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [CPD:C04637]
Comment
This enzyme can also phosphorylate PtdIns3P in the 4-position, and PtdIns, PtdIns3P and PtdIns(3,4)P2 in the 5-position in vitro, but to a lesser extent. The last of these reactions occurs in vivo and is physiologically relevant. Three different isoforms are known.
Pathway
Inositol phosphate metabolism
Metabolic pathways
Orthology
K00889  
1-phosphatidylinositol-4-phosphate 5-kinase
K13712  
phosphatidylinositol-4-phosphate 5-kinase-like protein 1
Genes
HSA: 
138429(PIP5KL1) 23396(PIP5K1C) 8394(PIP5K1A) 8395(PIP5K1B)
PTR: 
455590(PIP5K1C) 457288(PIP5K1A) 464513(PIP5K1B) 464758(PIP5KL1)
PPS: 
100975341(PIP5K1C) 100982914(PIP5K1B) 100990998 100994510(PIP5K1A) 100996122(PIP5KL1)
GGO: 
101132245(PIP5K1A) 101132548(PIP5K1C) 101150370(PIP5K1B) 101152925(PIP5KL1)
PON: 
100432274(PIP5K1B) 100435603(PIP5K1C) 100439984(PIP5KL1) 100456775
MCC: 
700538(PIP5K1B) 705749(PIP5KL1) 710007(PIP5K1A) 721744
MMU: 
18717(Pip5k1c) 18719(Pip5k1b) 18720(Pip5k1a) 227733(Pip5kl1)
RNO: 
309419(Pip5k1b) 314641(Pip5k1c) 365865(Pip5k1a) 687758
CFA: 
475846(PIP5K1A) 476331(PIP5K1B) 485054(PIP5K1C) 609122(PIP5KL1)
AML: 
FCA: 
101081420(PIP5K1B) 101094710(PIP5KL1) 101097791(PIP5K1C) 101098154(PIP5K1A)
BTA: 
100125224(PIP5K1A) 504715 508819(PIP5K1C) 523736(PIP5KL1) 537654(PIP5K1B)
SSC: 
100521362(PIP5K1C) 100523714(PIP5KL1) 100624272(PIP5K1A)
ECB: 
100050520(PIP5K1B) 100059655(PIP5K1A) 100070364(PIP5KL1)
MDO: 
100010549(PIP5K1C) 100012245 100017950(PIP5K1A) 100021835(PIP5K1B)
SHR: 
100918263(PIP5K1C) 100921742(PIP5KL1) 100925674 100930714(PIP5K1A)
OAA: 
100074263 100080469(PIP5K1C) 100089287
GGA: 
100857846 420072(PIP5K1C) 427243(PIP5K1B) 429983(PIP5K1A)
MGP: 
100540819 100543434(PIP5K1C)
TGU: 
100221379(PIP5K1C) 100229771(PIP5K1A) 100232143(PIP5K1B)
ACS: 
100553211 100564566
XLA: 
100653493 398687(pip5k1c) 399203(pip5k1a) 444238(pip5k1b)
XTR: 
100145583(pip5k1c) 100380056(pip5k1b) 100490940 448746(pip5k1a)
DRE: 
100149843 447840(pip5k1bb) 449831(pip5k1ba) 492549(pip5k1ab) 553629(pip5k1aa) 798876(pip5k1ca)
TRU: 
101064094 101066872 101070929 101073318 101075087 101076264
OLA: 
101157953 101162441 101163663 101166403 101173168
BFO: 
BRAFLDRAFT_118884 BRAFLDRAFT_216408
CIN: 
100186167 100187365
SPU: 
100890134 579944
DME: 
Dmel_CG17471 Dmel_CG3682(PIP5K59B) Dmel_CG9985(sktl)
DPO: 
Dpse_GA22167 Dpse_GA25087
DAN: 
Dana_GF12741 Dana_GF13551
DER: 
Dere_GG20828 Dere_GG22810
DPE: 
Dper_GL10132 Dper_GL17422
DSE: 
Dsec_GM15773 Dsec_GM15967
DSI: 
Dsim_GD11719 Dsim_GD25249
DWI: 
Dwil_GK20789 Dwil_GK22881
DYA: 
Dyak_GE13767 Dyak_GE14244
DGR: 
Dgri_GH19882 Dgri_GH21799
DMO: 
Dmoj_GI19831 Dmoj_GI20548
DVI: 
Dvir_GJ18651 Dvir_GJ22401
AAG: 
AaeL_AAEL010238 AaeL_AAEL015255
CQU: 
CpipJ_CPIJ006826
AME: 
724991
NVI: 
100123047(NV13055)
TCA: 
663424
API: 
100161889 100167842
PHU: 
Phum_PHUM064910
ISC: 
IscW_ISCW003331
CEL: 
CELE_F55A12.3(ppk-1) CELE_VF11C1L.1(ppk-3)
CBR: 
CBG12324(Cbr-ppk-1) CBG16921(Cbr-ppk-3)
BMY: 
Bm1_33360 Bm1_36090
TSP: 
Tsp_09431
SMM: 
Smp_124970
NVE: 
NEMVE_v1g105451 NEMVE_v1g146305
HMG: 
100197010
TAD: 
TRIADDRAFT_19797 TRIADDRAFT_54491
ATH: 
AT1G01460(PIPK11) AT1G10900 AT1G21980(PIP5K1) AT1G60890 AT1G77740(PIP5K2) AT2G26420(PIP5K3) AT2G41210(PIP5K5) AT3G07960 AT3G09920(PIP5K9) AT3G56960(PIP5K4) AT4G01190(PIPK10)
ALY: 
ARALYDRAFT_311290 ARALYDRAFT_320430 ARALYDRAFT_471229 ARALYDRAFT_472433 ARALYDRAFT_475243 ARALYDRAFT_476937 ARALYDRAFT_478317 ARALYDRAFT_663829 ARALYDRAFT_666568 ARALYDRAFT_896970 ARALYDRAFT_903427
GMX: 
100775866 100782430 100782728 100789427 100789775 100789949 100790049 100805371 100808235 100813118
MTR: 
MTR_1g050740 MTR_3g014650 MTR_3g073100 MTR_8g039100 MTR_8g088930 MTR_8g095170
CSV: 
101203066 101208080 101208830 101215596 101219958 101220755
RCU: 
RCOM_0502210 RCOM_1032640 RCOM_1320440 RCOM_1353360 RCOM_1452400 RCOM_1765120
POP: 
POPTR_1078405 POPTR_178459 POPTR_282262 POPTR_410440 POPTR_548747 POPTR_555053 POPTR_582189 POPTR_777034
VVI: 
100250604 100251489 100255527 100258261 100260604
OSA: 
4331188 4333833 4333853 4344166 4351470 9267438
DOSA: 
Os02t0822500-01(Os02g0822500) Os03t0356582-01(Os03g0356582) Os03t0705300-01(Os03g0705300) Os07t0658700-01(Os07g0658700) Os12t0141100-01(Os12g0141100)
BDI: 
100822182 100828766 100830370 100837336 100846412
SBI: 
SORBI_01g010710(SORBIDRAFT_01g010710) SORBI_01g035000(SORBIDRAFT_01g035000) SORBI_02g041770(SORBIDRAFT_02g041770) SORBI_05g002690(SORBIDRAFT_05g002690) SORBI_08g001115(SORBIDRAFT_08g001115)
ZMA: 
100216938 100281652(cl27615_1) 100381628
SMO: 
SELMODRAFT_230263 SELMODRAFT_88573
PPP: 
PHYPADRAFT_30361 PHYPADRAFT_40660
CRE: 
CHLREDRAFT_120269 CHLREDRAFT_195580
VCN: 
VOLCADRAFT_106487
OLU: 
OSTLU_850
OTA: 
Ot07g03990
CME: 
CME153C CMN333C
SCE: 
YDR208W(MSS4)
AGO: 
AGOS_AGL096W
ERC: 
Ecym_4149
KLA: 
KLLA0A04301g
LTH: 
KLTH0F08008g
PPA: 
PAS_chr1-1_0457
VPO: 
Kpol_1029p20 Kpol_1061p18
ZRO: 
ZYRO0C04730g
CGR: 
CAGL0F05335g
NCS: 
NCAS_0B02920(NCAS0B02920)
NDI: 
NDAI_0C04800(NDAI0C04800)
TPF: 
TPHA_0L01040(TPHA0L01040)
TBL: 
TBLA_0H03310(TBLA0H03310)
TDL: 
TDEL_0F05420(TDEL0F05420)
KAF: 
KAFR_0B06280(KAFR0B06280)
DHA: 
DEHA2F18062g
PIC: 
PICST_64487(MSS4)
PGU: 
PGUG_03452
LEL: 
LELG_02070
CAL: 
CaO19.10663(MSS4) CaO19.3153(MSS4)
CTP: 
CTRG_02191
CDU: 
CD36_81060
COT: 
CORT_0B03260
YLI: 
YALI0F23573g
CLU: 
CLUG_04229
NCR: 
NCU02295
SMP: 
SMAC_08733(mss4)
PAN: 
PODANSg1803
TTT: 
THITE_2117149
MTM: 
MYCTH_2308809
MGR: 
MGG_06572
FGR: 
FG10792.1
NHE: 
NECHADRAFT_69097
VAL: 
VDBG_03451 VDBG_03452
BFU: 
BC1G_16298
ANI: 
AN2766.2
NFI: 
NFIA_071170
AFM: 
AFUA_3G06080
AOR: 
AOR_1_140084(AO090020000081)
ANG: 
ANI_1_1356094(An11g10410)
AFV: 
AFLA_103280
ACT: 
ACLA_034040
PCS: 
Pc20g07880
CIM: 
CIMG_00514
CPW: 
CPC735_057190
PBL: 
PAAG_05999
URE: 
UREG_00542
ABE: 
ARB_07224
TVE: 
TRV_07668
AJE: 
HCAG_01271
PNO: 
SNOG_12229
PTE: 
PTT_12883
ZTR: 
MYCGRDRAFT_10540
TML: 
GSTUM_00000277001
SPO: 
SPAC19G12.14(its3)
CNE: 
CNA03760
CNB: 
CNBA3560
CGI: 
CGB_A3490C
LBC: 
LACBIDRAFT_392686 LACBIDRAFT_397690 LACBIDRAFT_397906
CCI: 
CC1G_10722
SCM: 
SCHCODRAFT_86051
UMA: 
UM03809.1
MGL: 
MGL_0138
EIN: 
Eint_030240
NCE: 
NCER_100850
MBR: 
MONBRDRAFT_25486
NGR: 
NAEGRDRAFT_77681 NAEGRDRAFT_81864
DDI: 
DDB_G0267588 DDB_G0275635(PIPkinA) DDB_G0292190
DPP: 
DICPUDRAFT_154611 DICPUDRAFT_37984 DICPUDRAFT_55653
EHI: 
EHI_153770(13.t00009)
EDI: 
EDI_093870
PFA: 
PFA_0515w(PfPIP5K)
PFD: 
PFDG_01096
PFH: 
PFHG_00385
PYO: 
PY02398
PCB: 
PC000509.02.0
PBE: 
PB000893.02.0
PKN: 
PKH_020300
PVX: 
PVX_081270
PCY: 
PCYB_021380
TAN: 
TA11845
TPV: 
TP02_0200
BBO: 
BBOV_II007470(18.m06619)
CPV: 
cgd8_3280
CHO: 
Chro.80381
TGO: 
TGME49_030490
TET: 
TTHERM_00047210 TTHERM_00471898 TTHERM_01125130 TTHERM_01457080
PTM: 
GSPATT00000655001 GSPATT00000714001 GSPATT00005572001 GSPATT00006938001 GSPATT00006945001 GSPATT00010565001 GSPATT00014456001 GSPATT00015691001 GSPATT00019649001 GSPATT00022539001 GSPATT00032331001 GSPATT00033281001
TBR: 
Tb927.4.1620(Tb04.2L9.1030)
TCR: 
504057.104 509715.120 510105.130 511001.70
LMA: 
LMJF_34_3090
LDO: 
LDBPK_044320
LMI: 
LMXM_33_3090
LBZ: 
LBRM_20_2670
GLA: 
GL50803_11897
TVA: 
TVAG_462290
PTI: 
PHATRDRAFT_49524
TPS: 
THAPSDRAFT_18434 THAPSDRAFT_264335
PIF: 
PITG_15552
 » show all
Taxonomy
Reference
1  [PMID:4295336]
  Authors
Kai M, Salway JG, Hawthorne JN.
  Title
The diphosphoinositide kinase of rat brain.
  Journal
Biochem. J. 106 (1968) 791-801.
  Organism
Rattus norvegicus [GN:rno]
Reference
2
  Authors
Kai, M., Salway, J.G., Michell, R.H. and Hawthorne, J.N.
  Title
The biosynthesis of triphosphoinositide by rat brain in vitro.
  Journal
Biochem. Biophys. Res. Commun. 22 (1966) 370-375.
Reference
3  [PMID:9367159]
  Authors
Rameh LE, Tolias KF, Duckworth BC, Cantley LC.
  Title
A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate.
  Journal
Nature. 390 (1997) 192-6.
  Organism
mammalian
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
104645-76-3
DBGET integrated database retrieval system