KEGG   ENZYME: 2.7.11.10Help
Entry
EC 2.7.11.10                Enzyme                                 
Name
IkappaB kinase;
CHUK;
IKBKA;
IKBKB;
IKK;
IKK-1;
IKK-2;
inhibitor of NFkappaB kinase;
inhibitor of NF-kappaB kinase;
STK12;
TANK-binding kinase 1;
TBK1
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:[IkappaB protein] phosphotransferase
Reaction(IUBMB)
ATP + [IkappaB protein] = ADP + [IkappaB phosphoprotein]
Reaction(KEGG)
(other) R00162
Show
Substrate
ATP [CPD:C00002];
[IkappaB protein]
Product
ADP [CPD:C00008];
[IkappaB phosphoprotein]
Comment
The enzyme phosphorylates IkappaB proteins at specific serine residues, which marks them for destruction via the ubiquitination pathway. Subsequent degradation of the IkB complex (IKK) activates NF-kappaB, a translation factor that plays an important role in inflammation, immunity, cell proliferation and apoptosis. If the serine residues are replaced by threonine residues, the activity of the enzyme is decreased considerably.
Orthology
K04467  
inhibitor of nuclear factor kappa-B kinase subunit alpha
K05410  
TANK-binding kinase 1
K07209  
inhibitor of nuclear factor kappa-B kinase subunit beta
K07211  
inhibitor of nuclear factor kappa-B kinase subunit epsilon
Genes
HSA: 
1147(CHUK) 29110(TBK1) 3551(IKBKB) 9641(IKBKE)
PTR: 
450673(CHUK) 452047(TBK1) 472749(IKBKB) 742813(IKBKE)
PPS: 
100989390(IKBKB) 100990211(TBK1) 100992569(IKBKE) 100995228(CHUK)
GGO: 
101125384(IKBKE) 101137405(CHUK) 101138038(TBK1) 101141659(IKBKB)
PON: 
100174735(CHUK) 100433568(TBK1) 100440586(IKBKB) 100448480(IKBKE)
MCC: 
695607(IKBKE) 704683(IKBKB) 709511(CHUK) 717427(TBK1)
MMU: 
12675(Chuk) 16150(Ikbkb) 56480(Tbk1) 56489(Ikbke)
RNO: 
299827(Tbk1) 309361(Chuk) 363984(Ikbke) 84351(Ikbkb)
CFA: 
477796(CHUK) 478950(IKBKE) 481145(TBK1) 482839(IKBKB)
AML: 
FCA: 
100142682(IKBKB) 101086282(IKBKE) 101091955(TBK1) 101095617(CHUK)
BTA: 
281073(CHUK) 281854(IKBKB) 533141(TBK1) 533216(IKBKE)
SSC: 
100101471(IKBKB) 100125828(TBK1) 100135662(CHUK) 100519508(IKBKE)
ECB: 
100051650(TBK1) 100055384(IKBKE) 100070393(CHUK)
MDO: 
100019578(IKBKE) 100027952(CHUK) 100033031(IKBKB)
SHR: 
100913624(CHUK) 100915362(TBK1) 100928932(IKBKB) 100934784(IKBKE)
OAA: 
100076520(TBK1) 100077063(IKBKE) 100078925(IKBKB) 100082351(CHUK)
GGA: 
417825(TBK1) 423669(CHUK) 426792(IKBKB) 430480(IKBKE)
MGP: 
100542478 100542558 100542773 100548215(IKBKE)
TGU: 
100221281(CHUK) 100224042 100225072(IKBKB) 100225715(TBK1) 100228860(IKBKE)
ACS: 
100551699(ikbkb) 100553575(tbk1) 100562496(ikbke) 100565922
XLA: 
432200(ikbkb) 444556(chuk) 446351(tbk1) 734896(ikbke)
XTR: 
100216212(tbk1) 100487744 448125(ikbkb) 549654(chuk)
DRE: 
393287(chuk) 437024(ikbke) 563560(ikbkb) 692289(tbk1)
TRU: 
101062431 101069880 101071013 101074146
OLA: 
101159621 101168192 101170684
BFO: 
BRAFLDRAFT_123253 BRAFLDRAFT_80298
CIN: 
778650(ikk-epsilon) 778921(ikk-alpha/beta)
SPU: 
579073
DME: 
Dmel_CG2615(ik2) Dmel_CG4201(ird5)
DPO: 
Dpse_GA15402 Dpse_GA18025
DAN: 
Dana_GF11313 Dana_GF15349
DER: 
Dere_GG20201 Dere_GG21246
DPE: 
Dper_GL12407 Dper_GL18514
DSE: 
Dsec_GM23363 Dsec_GM25737
DSI: 
Dsim_GD20310(Dsim_ird5) Dsim_GD24274
DWI: 
Dwil_GK14018 Dwil_GK15052
DYA: 
Dyak_GE12340 Dyak_GE26340(Dyak_ird5)
DGR: 
Dgri_GH10877 Dgri_GH18841
DMO: 
Dmoj_GI10102 Dmoj_GI18250
DVI: 
Dvir_GJ22988 Dvir_GJ23839
AGA: 
AgaP_AGAP009166(IKK1) AgaP_AGAP009565
AAG: 
AaeL_AAEL003245 AaeL_AAEL005359 AaeL_AAEL010548
CQU: 
CpipJ_CPIJ006852 CpipJ_CPIJ015672
AME: 
413493(ik2) 550741(ird5)
NVI: 
100116284(NV15869) 100122336(NV14464)
TCA: 
655324 658218(ik2) 658393
API: 
100168269
PHU: 
Phum_PHUM387680 Phum_PHUM605130
ISC: 
IscW_ISCW020049
BMY: 
Bm1_21030
NVE: 
NEMVE_v1g163386
HMG: 
100207607
TAD: 
TRIADDRAFT_62259
AQU: 
100636688
 » show all
Taxonomy
Reference
1  [PMID:9244310]
  Authors
Regnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M.
  Title
Identification and characterization of an IkappaB kinase.
  Journal
Cell. 90 (1997) 373-83.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:9346484]
  Authors
Mercurio F, Zhu H, Murray BW, Shevchenko A, Bennett BL, Li J, Young DB, Barbosa M, Mann M, Manning A, Rao A.
  Title
IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation.
  Journal
Science. 278 (1997) 860-6.
  Organism
Homo sapiens [GN:hsa]
Reference
3  [PMID:9346241]
  Authors
Zandi E, Rothwarf DM, Delhase M, Hayakawa M, Karin M.
  Title
The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation.
  Journal
Cell. 91 (1997) 243-52.
  Organism
Homo sapiens [GN:hsa]
Reference
4  [PMID:15653325]
  Authors
Viatour P, Merville MP, Bours V, Chariot A.
  Title
Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation.
  Journal
Trends. Biochem. Sci. 30 (2005) 43-52.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
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