KEGG   ENZYME: 2.7.11.12Help
Entry
EC 2.7.11.12                Enzyme                                 

Name
cGMP-dependent protein kinase;
3':5'-cyclic GMP-dependent protein kinase;
cGMP-dependent protein kinase Ibeta;
guanosine 3':5'-cyclic monophosphate-dependent protein kinase;
PKG;
PKG 1alpha;
PKG 1beta;
PKG II;
STK23
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:protein phosphotransferase (cGMP-dependent)
Reaction(IUBMB)
ATP + a protein = ADP + a phosphoprotein [RN:R00162]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
protein [CPD:C00017]
Product
ADP [CPD:C00008];
phosphoprotein [CPD:C00562]
Comment
CGMP is required to activate this enzyme. The enzyme occurs as a dimer in higher eukaryotes. The C-terminal region of each polypeptide chain contains the catalytic domain that includes the ATP and protein substrate binding sites. This domain catalyses the phosphorylation by ATP to specific serine or threonine residues in protein substrates [3]. The enzyme also has two allosteric cGMP-binding sites (sites A and B). Binding of cGMP causes a conformational change that is associated with activation of the kinase [4].
History
EC 2.7.11.12 created 2005 (EC 2.7.1.37 part-incorporated 2005)
Orthology
K07376  
protein kinase, cGMP-dependent
Genes
HSA: 
5592(PRKG1) 5593(PRKG2)
PTR: 
461217(PRKG2) 744467(PRKG1)
PPS: 
100975252(PRKG1) 100978260(PRKG2)
GGO: 
101139285(PRKG2) 101148943(PRKG1)
PON: 
100437791(PRKG1) 100438589(PRKG2)
MCC: 
696308(PRKG2) 703356(PRKG1)
MCF: 
102122483(PRKG1) 102142098(PRKG2)
MMU: 
19091(Prkg1) 19092(Prkg2)
RNO: 
25523(Prkg2) 54286(Prkg1)
CGE: 
HGL: 
101697843(Prkg2) 101708361(Prkg1)
TUP: 
102489899(PRKG2) 102497341(PRKG1)
CFA: 
100855930(PRKG2) 609616(PRKG1)
AML: 
100467892(PRKG2)
FCA: 
101091618(PRKG2) 101097420(PRKG1)
PTG: 
102949245(PRKG2) 102969150(PRKG1)
BTA: 
282004(PRKG1) 533330(PRKG2)
BOM: 
102269763(PRKG2) 102279305(PRKG1)
PHD: 
102340254(PRKG2) 102344359(PRKG1)
CHX: 
102172135(PRKG2) 102182753(PRKG1)
SSC: 
100512796(PRKG2) 733640(PRKG1)
CFR: 
102509252(PRKG1) 102519263(PRKG2)
ECB: 
100060358(PRKG2) 100071872(PRKG1)
MYB: 
102255009(PRKG1) 102258852(PRKG2)
MYD: 
PALE: 
102884723(PRKG1) 102894554(PRKG2)
MDO: 
100014568(PRKG2) 100023016(PRKG1)
SHR: 
100927283(PRKG2) 100928746(PRKG1)
OAA: 
GGA: 
423682(PRKG1) 428753(PRKG2)
MGP: 
100541294(PRKG2)
TGU: 
FAB: 
101813345(PRKG2) 101816835(PRKG1)
PHI: 
102105641(PRKG1) 102108417(PRKG2)
APLA: 
101790644(PRKG2) 101802614(PRKG1)
FPG: 
101914750(PRKG1) 101918759(PRKG2)
FCH: 
102051167(PRKG1) 102055004(PRKG2)
CLV: 
102089346(PRKG2) 102098659(PRKG1)
ASN: 
102375122(PRKG2) 102385836(PRKG1)
PSS: 
CMY: 
102942713(PRKG1)
ACS: 
XLA: 
444025(prkg2)
XTR: 
DRE: 
100125912(prkg2) 394005(prkg1a) 556339
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
406092(For)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG08401(Cbr-egl-4)
BMY: 
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
100636239(Prkg1)
MTR: 
CRE: 
VCN: 
OLU: 
OTA: 
MIS: 
MPP: 
CSL: 
CVR: 
MBR: 
PFA: 
PFD: 
PFH: 
PYO: 
PCB: 
PBE: 
PKN: 
PVX: 
PCY: 
TAN: 
TPV: 
BBO: 
BBOV_I004690(19.m02237)
BEQ: 
CPV: 
CHO: 
TGO: 
TET: 
PTM: 
TPS: 
PIF: 
 » show all
Taxonomy
Reference
1  [PMID:186778]
  Authors
Gill GN, Holdy KE, Walton GM, Kanstein CB.
  Title
Purification and characterization of 3':5'-cyclic GMP-dependent protein kinase.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 73 (1976) 3918-22.
  Organism
Bos taurus
Reference
2  [PMID:15312978]
  Authors
Murthy KS.
  Title
Modulation of soluble guanylate cyclase activity by phosphorylation.
  Journal
Neurochem. Int. 45 (2004) 845-51.
Reference
3  [PMID:12933804]
  Authors
Richie-Jannetta R, Francis SH, Corbin JD.
  Title
Dimerization of cGMP-dependent protein kinase Ibeta is mediated by an extensive amino-terminal leucine zipper motif, and dimerization modulates enzyme function.
  Journal
J. Biol. Chem. 278 (2003) 50070-9.
  Organism
Homo sapiens
Reference
4  [PMID:9395542]
  Authors
Zhao J, Trewhella J, Corbin J, Francis S, Mitchell R, Brushia R, Walsh D.
  Title
Progressive cyclic nucleotide-induced conformational changes in the cGMP-dependent protein kinase studied by small angle X-ray scattering in solution.
  Journal
J. Biol. Chem. 272 (1997) 31929-36.
  Organism
Bos taurus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
141588-27-4

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