KEGG   ENZYME: 2.7.11.14Help
Entry
EC 2.7.11.14                Enzyme                                 

Name
rhodopsin kinase;
cone opsin kinase;
G-protein-coupled receptor kinase 1;
GPCR kinase 1;
GRK1;
GRK7;
opsin kinase;
opsin kinase (phosphorylating);
rhodopsin kinase (phosphorylating);
RK;
STK14
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:rhodopsin phosphotransferase
Reaction(IUBMB)
ATP + rhodopsin = ADP + phosphorhodopsin [RN:R02903]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
rhodopsin [CPD:C00778]
Product
ADP [CPD:C00008];
phosphorhodopsin [CPD:C02456]
Comment
Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). Acts on the bleached or activated form of rhodopsin; also phosphorylates the beta-adrenergic receptor, but more slowly. Does not act on casein, histones or phosphvitin. Inhibited by Zn2+ and digitonin (cf. EC 2.7.11.15, beta-adrenergic-receptor kinase and EC 2.7.11.16, G-protein-coupled receptor kinase).
History
EC 2.7.11.14 created 1989 as EC 2.7.1.125 (EC 2.7.1.97 created 1978, incorporated 1992), transferred 2005 to EC 2.7.11.14
Orthology
K00909  
rhodopsin kinase
Genes
HSA: 
131890(GRK7) 6011(GRK1)
PTR: 
467338(GRK1) 470950(GRK7)
PPS: 
100978320(GRK7) 100991375(GRK1)
GGO: 
PON: 
100446305(GRK7) 100460558(GRK1)
MCC: 
714916(GRK7) 715484(GRK1) 715589
MCF: 
102131074(GRK1) 102133613(GRK7)
MMU: 
24013(Grk1)
RNO: 
81760(Grk1)
CGE: 
100750718(Grk1)
HGL: 
101697548(Grk1) 101726058(Grk7)
TUP: 
102487091(GRK7)
CFA: 
485557(GRK1)
AML: 
FCA: 
101089290(GRK7) 101092327(GRK1)
PTG: 
102951583(GRK7) 102963599(GRK1)
BTA: 
281457(GRK1) 281802(GRK7)
BOM: 
102270913(GRK7) 102276250(GRK1)
PHD: 
102316540(GRK1) 102330051(GRK7)
CHX: 
102176894(GRK1) 102180541(GRK7)
SSC: 
100620646(GRK1) 397114(GRK7)
CFR: 
102513037(GRK7) 102520487(GRK1)
BACU: 
103002736(GRK1) 103013851(GRK7)
LVE: 
103075679(GRK1) 103084736(GRK7)
ECB: 
100062922(GRK7) 100069151(GRK1)
MYB: 
102242883(GRK7) 102257754(GRK1)
MYD: 
102761230(GRK1) 102772275(GRK7)
PALE: 
102881273(GRK1) 102897090(GRK7)
MDO: 
100013800(GRK7) 100016174(GRK1)
SHR: 
100914558(GRK1) 100931224(GRK7)
OAA: 
GGA: 
395431(GRK1) 429125(GRK7)
MGP: 
TGU: 
FAB: 
PHI: 
APLA: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
XLA: 
100192358(grk7-a) 100192359(grk7-b)
XTR: 
100145727(grk7) 100486335(grk1)
DRE: 
373871(grk7b) 550406(grk1b) 564152(grk1a) 566120(grk7a)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103177456(grk1) 103178747(grk7)
 » show all
Taxonomy
Reference
1  [PMID:3014340]
  Authors
Benovic JL, Mayor F Jr, Somers RL, Caron MG, Lefkowitz RJ.
  Title
Light-dependent phosphorylation of rhodopsin by beta-adrenergic receptor kinase.
  Journal
Nature. 321 (1986) 869-72.
Reference
2  [PMID:690139]
  Authors
Shichi H, Somers RL.
  Title
Light-dependent phosphorylation of rhodopsin. Purification and properties of rhodopsin kinase.
  Journal
J. Biol. Chem. 253 (1978) 7040-6.
  Organism
Bos taurus
Reference
3  [PMID:2844754]
  Authors
Palczewski K, McDowell JH, Hargrave PA.
  Title
Purification and characterization of rhodopsin kinase.
  Journal
J. Biol. Chem. 263 (1988) 14067-73.
  Organism
Bos taurus
Reference
4  [PMID:164024]
  Authors
Weller M, Virmaux N, Mandel P.
  Title
Light-stimulated phosphorylation of rhodopsin in the retina: the presence of a protein kinase that is specific for photobleached rhodopsin.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 72 (1975) 381-5.
  Organism
Bos taurus
Reference
5  [PMID:9380677]
  Authors
Cha K, Bruel C, Inglese J, Khorana HG.
  Title
Rhodopsin kinase: expression in baculovirus-infected insect cells, and characterization of post-translational modifications.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 10577-82.
  Organism
Bos taurus
Reference
6  [PMID:8812493]
  Authors
Khani SC, Abitbol M, Yamamoto S, Maravic-Magovcevic I, Dryja TP.
  Title
Characterization and chromosomal localization of the gene for human rhodopsin kinase.
  Journal
Genomics. 35 (1996) 571-6.
  Organism
Homo sapiens
  Sequence
[hsa:6011]
Reference
7  [PMID:11754336]
  Authors
Chen CK, Zhang K, Church-Kopish J, Huang W, Zhang H, Chen YJ, Frederick JM, Baehr W.
  Title
Characterization of human GRK7 as a potential cone opsin kinase.
  Journal
Mol. Vis. 7 (2001) 305-13.
  Organism
Homo sapiens
  Sequence
[hsa:131890]
Reference
8  [PMID:14654303]
  Authors
Willets JM, Challiss RA, Nahorski SR.
  Title
Non-visual GRKs: are we seeing the whole picture?
  Journal
Trends. Pharmacol. Sci. 24 (2003) 626-33.
  Organism
Homo sapiens
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
54004-64-7

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