KEGG   ENZYME: 2.7.11.15Help
Entry
EC 2.7.11.15                Enzyme                                 
Name
beta-adrenergic-receptor kinase;
ATP:beta-adrenergic-receptor phosphotransferase;
[beta-adrenergic-receptor] kinase;
beta-adrenergic receptor-specific kinase;
beta-AR kinase;
beta-ARK;
beta-ARK 1;
beta-ARK 2;
beta-receptor kinase;
GRK2;
GRK3;
beta-adrenergic-receptor kinase (phosphorylating);
beta2ARK;
betaARK1;
beta-adrenoceptor kinase;
beta-adrenoceptor kinase 1;
beta-adrenoceptor kinase 2;
ADRBK1;
BARK1;
adrenergic receptor kinase;
STK15
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:[beta-adrenergic receptor] phosphotransferase
Reaction(IUBMB)
ATP + [beta-adrenergic receptor] = ADP + phospho-[beta-adrenergic receptor] [RN:R03274]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
[beta-adrenergic receptor] [CPD:C01141]
Product
ADP [CPD:C00008];
phospho-beta-adrenergic receptor [CPD:C04141]
Comment
Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). Acts on the agonist-occupied form of the receptor; also phosphorylates rhodopsin, but more slowly. Does not act on casein or histones. The enzyme is inhibited by Zn2+ and digitonin but is unaffected by cyclic-AMP (cf. EC 2.7.11.14, rhodopsin kinase and EC 2.7.11.16, G-protein-coupled receptor kinase).
Orthology
K00910  
beta-adrenergic-receptor kinase
Genes
HSA: 
156(ADRBK1) 157(ADRBK2)
PTR: 
100614029(ADRBK2) 451363(ADRBK1)
PPS: 
100984800(ADRBK2) 100991802(ADRBK1)
GGO: 
101140574(ADRBK1) 101148325(ADRBK2)
PON: 
100454669(ADRBK2) 100461893(ADRBK1)
MCC: 
714510(ADRBK2) 721754(ADRBK1)
MMU: 
110355(Adrbk1)
RNO: 
25238(Adrbk1) 25372(Adrbk2)
CFA: 
483701(ADRBK1) 486327(ADRBK2)
AML: 
FCA: 
101090393(ADRBK2) 101101082(ADRBK1)
BTA: 
282136(ADRBK2) 282682(ADRBK1)
SSC: 
100156449(ADRBK2) 100513842(ADRBK1)
ECB: 
100059001 100065495(ADRBK2)
MDO: 
100009844
SHR: 
100913578(ADRBK2)
OAA: 
100078284 100090102
GGA: 
416904(ADRBK2) 426000(ADRBK1)
MGP: 
100541374 100545380
TGU: 
100217970(ADRBK2) 100227701(ADRBK1)
ACS: 
100555775(adrbk1)
XTR: 
100379889(adrbk2)
DRE: 
569403(adrbk2)
TRU: 
101073064
OLA: 
101161494
BFO: 
BRAFLDRAFT_218343
CIN: 
100184862(adrbk2)
SPU: 
100888242(adrbk2)
DME: 
Dmel_CG40129(Gprk1)
DAN: 
Dana_GF14814
DER: 
Dere_GG16712
DSE: 
Dsec_GM19330
DSI: 
Dsim_GD17695
DWI: 
Dwil_GK21377
DYA: 
Dyak_GE25059
DGR: 
Dgri_GH21712
DMO: 
Dmoj_GI18854
DVI: 
Dvir_GJ19694
AGA: 
AgaP_AGAP012026
AAG: 
AaeL_AAEL006868
CQU: 
CpipJ_CPIJ004653 CpipJ_CPIJ004656
AME: 
413197(Gprk1)
NVI: 
100121113(NV12967)
TCA: 
654946
API: 
100166085(Gprk1)
PHU: 
Phum_PHUM014910
ISC: 
IscW_ISCW009785
CEL: 
CELE_W02B3.2(grk-2)
CBR: 
CBG15249(Cbr-grk-2)
TSP: 
Tsp_00495
SMM: 
Smp_159010.1
NVE: 
NEMVE_v1g246204
HMG: 
100214170
TAD: 
TRIADDRAFT_59012
AQU: 
100638292(Adrbk1)
MBR: 
MONBRDRAFT_38629
PTI: 
PHATRDRAFT_27639
TPS: 
THAPSDRAFT_15351
 » show all
Taxonomy
Reference
1  [PMID:3036840]
  Authors
Benovic JL, Mayor F Jr, Staniszewski C, Lefkowitz RJ, Caron MG
  Title
Purification and characterization of the beta-adrenergic receptor kinase.
  Journal
J. Biol. Chem. 262 (1987) 9026-32.
  Organism
Bos taurus [GN:bta]
Reference
2  [PMID:8394172]
  Authors
Kim CM, Dion SB, Onorato JJ, Benovic JL.
  Title
Expression and characterization of two beta-adrenergic receptor kinase isoforms using the baculovirus expression system.
  Journal
Receptor. 3 (1993) 39-55.
  Organism
Bos taurus [GN:bta]
Reference
3  [PMID:9349395]
  Authors
Laugwitz KL, Kronsbein K, Schmitt M, Hoffmann K, Seyfarth M, Schomig A, Ungerer M.
  Title
Characterization and inhibition of beta-adrenergic receptor kinase in intact myocytes.
  Journal
Cardiovasc. Res. 35 (1997) 324-33.
  Organism
Rattus norvegicus [GN:rno], hamster
Reference
4  [PMID:7559596]
  Authors
Ferguson SS, Menard L, Barak LS, Koch WJ, Colapietro AM, Caron MG.
  Title
Role of phosphorylation in agonist-promoted beta 2-adrenergic receptor sequestration. Rescue of a sequestration-defective mutant receptor by beta ARK1.
  Journal
J. Biol. Chem. 270 (1995) 24782-9.
  Organism
Bos taurus [GN:bta]
Reference
5  [PMID:14654303]
  Authors
Willets JM, Challiss RA, Nahorski SR.
  Title
Non-visual GRKs: are we seeing the whole picture?
  Journal
Trends. Pharmacol. Sci. 24 (2003) 626-33.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
102925-39-3
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