KEGG   ENZYME: 2.7.11.24Help
Entry
EC 2.7.11.24                Enzyme                                 
Name
mitogen-activated protein kinase;
c-Jun N-terminal kinase;
Dp38;
ERK;
ERK1;
ERK2;
extracellular signal-regulated kinase;
JNK;
JNK3alpha1;
LeMPK3;
MAP kinase;
MAP-2 kinase;
MAPK;
MBP kinase I;
MBP kinase II;
microtubule-associated protein 2 kinase;
microtubule-associated protein kinase;
myelin basic protein kinase;
p38delta;
p38-2;
p42 mitogen-activated protein kinase;
p42mapk;
PMK-1;
PMK-2;
PMK-3;
pp42;
pp44mapk;
p44mpk;
SAPK;
STK26;
stress-activated protein kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:protein phosphotransferase (MAPKK-activated)
Reaction(IUBMB)
ATP + a protein = ADP + a phosphoprotein [RN:R00162]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
protein [CPD:C00017]
Product
ADP [CPD:C00008];
phosphoprotein [CPD:C00562]
Comment
Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC 2.7.12.2, mitogen-activated protein kinase kinase (MAPKK) is necessary for enzyme activation. Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline [6]. A distinguishing feature of all MAPKs is the conserved sequence Thr-Xaa-Tyr (TXY). Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
Orthology
K04371  
extracellular signal-regulated kinase 1/2
K04440  
c-Jun N-terminal kinase
K04441  
p38 MAP kinase
K04464  
mitogen-activated protein kinase 7
K04468  
nemo like kinase
K06855  
mitogen-activated protein kinase 4/6
K08293  
mitogen-activated protein kinase
K14512  
mitogen-activated protein kinase 6
Genes
HSA: 
1432(MAPK14) 225689(MAPK15) 51701(NLK) 5594(MAPK1) 5595(MAPK3) 5596(MAPK4) 5597(MAPK6) 5598(MAPK7) 5599(MAPK8) 5600(MAPK11) 5601(MAPK9) 5602(MAPK10) 5603(MAPK13) 6300(MAPK12)
PTR: 
450161(MAPK14) 450445(MAPK8) 453439(MAPK6) 454037(MAPK3) 454499(MAPK7) 458680(MAPK1) 461358(MAPK10) 462336(MAPK9) 462644(MAPK13) 468536(MAPK4) 739132(NLK) 746712(MAPK15) 747077(MAPK12)
PPS: 
100967254(MAPK7) 100972270(MAPK15) 100979222(NLK) 100979542(MAPK3) 100980937(MAPK11) 100981268(MAPK12) 100982480(MAPK8) 100982544(MAPK13) 100983649(MAPK14) 100984173(MAPK10) 100988980(MAPK6) 100989422(MAPK4) 100990080(MAPK9) 100995567(MAPK1)
GGO: 
101124033(MAPK8) 101129084(MAPK15) 101134492(MAPK12) 101134843(MAPK11) 101135988(MAPK3) 101137450(MAPK7) 101138810(NLK) 101140164 101143697(MAPK6) 101148438(MAPK13) 101151665(MAPK4) 101152026(MAPK9) 101152640(MAPK14)
PON: 
100169740(MAPK1) 100173242(MAPK6) 100174482(MAPK10) 100431824(MAPK3) 100437263(MAPK12) 100437341(NLK) 100437424(MAPK8) 100438440 100440111(MAPK15) 100449269(MAPK14) 100449853(MAPK13) 100451029(MAPK7) 100459133(MAPK9)
MCC: 
677693(NLK) 694444(MAPK6) 694998(MAPK6) 698569(MAPK1) 699736(MAPK10) 700969(MAPK4) 702837(MAPK7) 708938(MAPK3) 711115(MAPK8) 715745(MAPK12) 715794(MAPK11) 718976 719085
MMU: 
18099(Nlk) 19094(Mapk11) 225724(Mapk4) 23939(Mapk7) 26413(Mapk1) 26414(Mapk10) 26415(Mapk13) 26416(Mapk14) 26417(Mapk3) 26419(Mapk8) 26420(Mapk9) 29857(Mapk12) 332110(Mapk15) 50772(Mapk6)
RNO: 
100912585 114509(Mapk7) 116554(Mapk8) 116590(Mapk1) 25272(Mapk10) 286997(Mapk15) 29513(Mapk13) 497961(Nlk) 50658(Mapk9) 50689(Mapk3) 54268(Mapk4) 58840(Mapk6) 60352(Mapk12) 689314(Mapk11) 81649(Mapk14)
CFA: 
403856(MAPK14) 474652(MAPK9) 477575(MAPK1) 477746(MAPK8) 478311(MAPK6) 478464(MAPK10) 479790(MAPK3) 482080(MAPK15) 489532(MAPK7) 491160(NLK) 491690(MAPK4) 607019(MAPK11) 607023(MAPK12) 612821(MAPK13)
AML: 
FCA: 
101080751(NLK) 101081149(MAPK12) 101081396(MAPK11) 101084765(MAPK9) 101087614(MAPK1) 101087958(MAPK3) 101091310(MAPK8) 101091508(MAPK15) 101092057(MAPK4) 101093275(MAPK6) 101097357(MAPK7) 101101135(MAPK14) 101101463(MAPK10)
BTA: 
327672(MAPK1) 507204(NLK) 512125(MAPK15) 512943(MAPK12) 529183(MAPK4) 531391(MAPK3) 534125(MAPK9) 534492(MAPK14) 535327(MAPK13) 537631(MAPK10) 537703(MAPK7) 538094(MAPK6) 539941(MAPK8) 618906(MAPK11)
SSC: 
100153927(MAPK1) 100156630(MAPK14) 100511657(NLK) 100521736(MAPK10) 100523414(MAPK4) 100620270 396609(MAPK9) 396610(MAPK8) 396833(MAPK6) 445013(MAPK3) 574062(MAPK12)
ECB: 
100051798(MAPK8) 100052608(MAPK10) 100053916(MAPK4) 100055006(MAPK6) 100056239 100056278 100057701 100057961(MAPK9) 100058876(NLK) 100063532(MAPK14) 100066173(MAPK3)
MDO: 
100010279 100010891 100012916(MAPK3) 100014343(MAPK8) 100015101(MAPK4) 100016316 100016623 100019356(NLK) 100026324(MAPK14) 100026361(MAPK6) 100028089(MAPK9) 100028096 100028821 100618895(MAPK10)
SHR: 
100913231(MAPK1) 100917749(MAPK7) 100919388(MAPK15) 100919999(MAPK4) 100924267(MAPK9) 100925013(MAPK14) 100925447(MAPK13) 100928480(MAPK10) 100928564(NLK) 100928729(MAPK12) 100928990(MAPK11) 100930815(MAPK8) 100931440(MAPK6) 100934330(MAPK3)
OAA: 
100073424(MAPK9) 100075452 100076033(MAPK8) 100077098 100078507 100080539 100082590 100085480 100087250 100088657 100091330 100093026
GGA: 
100858386 373953(MAPK1) 395983(MAPK9) 415419(MAPK6) 417669(NLK) 417739(MAPK11) 421183(MAPK14) 422592(MAPK10) 423778(MAPK8) 426292(MAPK15) 769763(MAPK12) 771145(MAPK13)
MGP: 
100540259 100540416 100541011 100542628 100543845 100546825 100546830 100546983(MAPK13) 100547553 100547737(MAPK8) 100548558
TGU: 
100217568(NLK) 100218485 100218726(MAPK6) 100220802(MAPK1) 100220867(MAPK8) 100223519(MAPK10) 100225101(MAPK11) 100225285(MAPK9) 100227852 100227993(MAPK12) 100229840(MAPK4)
ACS: 
100553469(mapk4) 100553854 100555877 100560802(nlk) 100561204 100561907 100562588 100563538 100563731(mapk11) 100565814(mapk9) 100566699 100567479 100567676(mapk14)
XLA: 
100329215(p38-beta) 379876(mapk8) 379992(mapk14) 397785(mapk1-b) 398295(nlk.2) 398592(mapk12) 398985(mapk1-a) 414522(nlk) 446599(mapk7) 494669(mapk11) 734485(mapk15) 735153
XTR: 
100101766(mapk11) 100144638(nlk) 100144684(nlk.2) 100144715(mapk13) 100145045(mapk12) 100145558(mapk15) 100170194(mapk8) 100494114 100498202 448296(mapk14) 549834(mapk12) 549881(mapk1) 779515(mapk10) 779785(mapk7)
DRE: 
100002318(mapk13) 100149273(mapk9) 266756(mapk14b) 30681(mapk12a) 360144(mapk1) 399480(mapk3) 405892(nlk1) 406782(mapk4) 415185(mapk11) 541323(mapk7) 553780(mapk15) 557810(mapk12b) 562552(fc89f08) 562720(mapk8a) 563460(nlk2) 565830(mapk6) 569698(mapk10) 65236(mapk8b) 65237(mapk14a)
TRU: 
101062695 101063087 101063351 101064045 101066563 101067839 101073575 101074026 101074428 101077419 101078393 101078496 101078548 101079574 445934(nlk)
OLA: 
101154993 101155337 101157651 101157952 101158978 101159668 101159747 101160731 101162042 101162387 101164415 101164997 101168711 101168789 101168799 101171243 101172944 101175696
BFO: 
BRAFLDRAFT_123996 BRAFLDRAFT_166018 BRAFLDRAFT_219176 BRAFLDRAFT_60037 BRAFLDRAFT_84433 BRAFLDRAFT_86371 BRAFLDRAFT_88155 BRAFLDRAFT_93656
CIN: 
100184138 778596(erk1/2) 778597(erk5) 778660(jnk) 778685(nemo-like) 778927(p38)
SPU: 
373525 574672 574783 577728 579122 580919 587330
DME: 
Dmel_CG12559(rl) Dmel_CG32703(Erk7) Dmel_CG33338(p38c) Dmel_CG5475(Mpk2) Dmel_CG5680(bsk) Dmel_CG7393(p38b) Dmel_CG7892(nmo)
DPO: 
Dpse_GA17089 Dpse_GA18909 Dpse_GA20320 Dpse_GA26003 Dpse_GA26518 Dpse_GA28383
DAN: 
Dana_GF13942 Dana_GF14126 Dana_GF18893 Dana_GF18894 Dana_GF19228 Dana_GF23057 Dana_GF23805
DER: 
Dere_GG12369 Dere_GG12370 Dere_GG14461 Dere_GG18986 Dere_GG23119 Dere_GG23876 Dere_GG23964
DPE: 
Dper_GL16513 Dper_GL18977 Dper_GL20446 Dper_GL21224 Dper_GL24141
DSE: 
Dsec_GM11912 Dsec_GM15179 Dsec_GM16932 Dsec_GM22284 Dsec_GM23508 Dsec_GM23509 Dsec_GM25010
DSI: 
Dsim_GD14046 Dsim_GD18318 Dsim_GD18319 Dsim_GD22289 Dsim_GD23919
DWI: 
Dwil_GK11930 Dwil_GK12444 Dwil_GK18192 Dwil_GK20588 Dwil_GK23361 Dwil_GK25827
DYA: 
Dyak_GE10824 Dyak_GE10825 Dyak_GE11327 Dyak_GE15459 Dyak_GE18678 Dyak_GE21651 Dyak_GE26274
DGR: 
Dgri_GH11110 Dgri_GH11922 Dgri_GH13352 Dgri_GH13559 Dgri_GH14986 Dgri_GH19092
DMO: 
Dmoj_GI10639 Dmoj_GI13148 Dmoj_GI15342 Dmoj_GI18232 Dmoj_GI18259 Dmoj_GI23428
DVI: 
Dvir_GJ13897 Dvir_GJ14531 Dvir_GJ17518 Dvir_GJ18140 Dvir_GJ19315 Dvir_GJ21884
AGA: 
AgaP_AGAP005898 AgaP_AGAP009207 AgaP_AGAP009460 AgaP_AGAP009461
AAG: 
AaeL_AAEL004797 AaeL_AAEL007958 AaeL_AAEL008379 AaeL_AAEL008622 AaeL_AAEL008634 AaeL_AAEL012269 AaeL_AAEL013939
CQU: 
CpipJ_CPIJ001156 CpipJ_CPIJ001157 CpipJ_CPIJ001158 CpipJ_CPIJ002174 CpipJ_CPIJ004910 CpipJ_CPIJ005303
AME: 
408917(erk7) 409286(bsk) 409523(rl) 410956(nmo) 411915(p38b)
NVI: 
100114440(P38mapk) 100121458(NV12980) 100121916(NV11643) 100122312(NV50046)
TCA: 
655225 659674 662230 663836(bsk)
API: 
100161230 100162414 100163276 100169493
PHU: 
Phum_PHUM128040 Phum_PHUM204070 Phum_PHUM233790 Phum_PHUM390460
ISC: 
IscW_ISCW003529 IscW_ISCW020577 IscW_ISCW021966 IscW_ISCW023655
CEL: 
CELE_B0218.3(pmk-1) CELE_B0478.1(jnk-1) CELE_C05D10.2(C05D10.2) CELE_F42G8.3(pmk-2) CELE_F42G8.4(pmk-3) CELE_F43C1.2(mpk-1) CELE_W06F12.1(lit-1)
CBR: 
CBG01554(Cbr-pmk-2) CBG01555(Cbr-pmk-1) CBG05733(Cbr-jnk-1) CBG18286(Cbr-lit-1) CBG21144 CBG21247(Cbr-mpk-1)
BMY: 
Bm1_00130 Bm1_25835 Bm1_31785 Bm1_40555 Bm1_46485
TSP: 
Tsp_00300 Tsp_01235 Tsp_01601 Tsp_03128 Tsp_05770
SMM: 
Smp_134260 Smp_140700 Smp_142050 Smp_172240
NVE: 
NEMVE_v1g106787 NEMVE_v1g116697 NEMVE_v1g180219 NEMVE_v1g233772 NEMVE_v1g243879 NEMVE_v1g91543 NEMVE_v1g92175
HMG: 
100197403 100201400 100204895 100205569 100209537 100212598 100212645 100213301 101235521
TAD: 
TRIADDRAFT_30150 TRIADDRAFT_38054 TRIADDRAFT_50163 TRIADDRAFT_50520 TRIADDRAFT_50661 TRIADDRAFT_814
AQU: 
100632128 100635536 100636234 100637545 100638502 100641640
ATH: 
AT1G01560(MPK11) AT1G07880(ATMPK13) AT1G10210(MPK1) AT1G59580(MPK2) AT2G18170(MPK7) AT2G43790(MPK6) AT2G46070(MPK12) AT3G45640(MPK3) AT3G59790(MPK10) AT4G01370(MPK4) AT4G11330(MPK5) AT4G36450(MPK14)
ALY: 
ARALYDRAFT_322261 ARALYDRAFT_353194 ARALYDRAFT_471135(ATMPK1) ARALYDRAFT_484948(ATMPK3) ARALYDRAFT_675475 ARALYDRAFT_678414 ARALYDRAFT_887292 ARALYDRAFT_903782 ARALYDRAFT_911474 ARALYDRAFT_912096
GMX: 
100779469 100798863 100801339 100802929 100803024 100805830 100807109 100815697 547616(MAPK2)
MTR: 
MTR_4g061130 MTR_4g061320 MTR_4g087620 MTR_5g010030 MTR_7g038040 MTR_7g078690 MTR_8g086000
CSV: 
101202796(TIPK) 101204301 101213478 101214254 101215189 101229716 101231335 101231411
RCU: 
RCOM_0327510 RCOM_0723010 RCOM_1595540 RCOM_1616300 RCOM_1688090
POP: 
POPTR_414369 POPTR_643073 POPTR_718188 POPTR_735966 POPTR_791419 POPTR_797351 POPTR_801509 POPTR_816604 POPTR_833180
VVI: 
100242320 100251947 100254083 100260441 100263976 100852927
OSA: 
4328297 4332475 4340170 4341956 4344698 4349225
DOSA: 
Os02t0148100-01(Os02g0148100) Os03t0285800-01(Os03g0285800) Os06t0154500-01(Os06g0154500) Os06t0699400-01(Os06g0699400) Os08t0157000-00(Os08g0157000) Os10t0533600-01(Os10g0533600)
BDI: 
100834779(MPK6) 100837420(MPK3) 100839224(MPK11) 100839537(MPK14) 100841616(MPK7-1) 100846323
SBI: 
SORBI_01g030680(SORBIDRAFT_01g030680) SORBI_04g003480(SORBIDRAFT_04g003480) SORBI_07g003810(SORBIDRAFT_07g003810) SORBI_10g003810(SORBIDRAFT_10g003810) SORBI_10g028780(SORBIDRAFT_10g028780)
ZMA: 
100283121(pco133201) 100286386(MPK7) 100381337 542144(simk1) 542594(gpm355)
SMO: 
SELMODRAFT_449420(MPK4-1) SELMODRAFT_449423(MPK4-2) SELMODRAFT_449429(MPK1) SELMODRAFT_82767
PPP: 
PHYPADRAFT_105202 PHYPADRAFT_126277 PHYPADRAFT_132891 PHYPADRAFT_167171 PHYPADRAFT_185890 PHYPADRAFT_193902 PHYPADRAFT_217865
CRE: 
CHLREDRAFT_131998(MAPK5) CHLREDRAFT_183031(MAPK6) CHLREDRAFT_193901(MAPK8) CHLREDRAFT_78072(MAPK3)
VCN: 
VOLCADRAFT_80080(mapk3) VOLCADRAFT_81346(mapk5)
OLU: 
OSTLU_35051 OSTLU_94760
OTA: 
Ot09g04000 Ot15g00120
CME: 
CMQ039C CMS295C
SCE: 
YBL016W(FUS3) YGR040W(KSS1) YHR030C(SLT2) YKL161C(KDX1) YLR113W(HOG1) YPR054W(SMK1)
AGO: 
AGOS_ACL191C AGOS_ADL315C AGOS_AER232C AGOS_AFR019W AGOS_AGR048C
ERC: 
Ecym_3488 Ecym_4266 Ecym_6145 Ecym_6196 Ecym_7361
KLA: 
KLLA0A02497g KLLA0B11902g KLLA0B11946g KLLA0E10539g KLLA0F20053g
LTH: 
KLTH0E15004g KLTH0G06974g KLTH0G12738g KLTH0G17512g KLTH0H08316g
PPA: 
PAS_chr1-3_0232 PAS_chr2-1_0872 PAS_chr3_0041 PAS_chr3_0895 PAS_chr4_0530
VPO: 
Kpol_1002p111 Kpol_1033p1 Kpol_376p5 Kpol_499p3 Kpol_543p55
ZRO: 
ZYRO0A12826g ZYRO0C13156g ZYRO0C15862g ZYRO0D06182g ZYRO0G16082g
CGR: 
CAGL0D01694g CAGL0J00539g CAGL0J04290g CAGL0K04169g CAGL0M11748g
NCS: 
NCAS_0A02120(NCAS0A02120) NCAS_0A06680(NCAS0A06680) NCAS_0A11020(NCAS0A11020) NCAS_0B05560(NCAS0B05560) NCAS_0C03380(NCAS0C03380)
NDI: 
NDAI_0A05280(NDAI0A05280) NDAI_0B02900(NDAI0B02900) NDAI_0D01620(NDAI0D01620) NDAI_0D04050(NDAI0D04050) NDAI_0G02700(NDAI0G02700)
TPF: 
TPHA_0A01630(TPHA0A01630) TPHA_0B02440(TPHA0B02440) TPHA_0C02880(TPHA0C02880) TPHA_0J00630(TPHA0J00630) TPHA_0M01500(TPHA0M01500)
TBL: 
TBLA_0A06670(TBLA0A06670) TBLA_0A08430(TBLA0A08430) TBLA_0A08810(TBLA0A08810) TBLA_0A10420(TBLA0A10420) TBLA_0H01330(TBLA0H01330)
TDL: 
TDEL_0B04490(TDEL0B04490) TDEL_0C04800(TDEL0C04800) TDEL_0D02650(TDEL0D02650) TDEL_0E03520(TDEL0E03520) TDEL_0F04290(TDEL0F04290)
KAF: 
KAFR_0B02980(KAFR0B02980) KAFR_0C02840(KAFR0C02840) KAFR_0E01810(KAFR0E01810) KAFR_0F03900(KAFR0F03900) KAFR_0H01040(KAFR0H01040)
DHA: 
DEHA2E03586g DEHA2E18348g DEHA2E20086g DEHA2E20944g
PIC: 
PICST_18249 PICST_33003 PICST_38082(ERK1) PICST_54431 PICST_62189
PGU: 
PGUG_01253 PGUG_03489 PGUG_05033
LEL: 
LELG_00002 LELG_01317 LELG_03183 LELG_03656 LELG_05717
CAL: 
CaO19.10404(ERK1) CaO19.2886(ERK1) CaO19.460(CEK2) CaO19.7208(CSK1) CaO19.7523(MKC1) CaO19.8091(CEK2) CaO19.8514(HOG1) CaO19.895(HOG1)
CTP: 
CTRG_00659 CTRG_01071 CTRG_01181 CTRG_03677 CTRG_03810
CDU: 
CD36_12990 CD36_18080(HOG1) CD36_25140(MKC1) CD36_31320(CEK2) CD36_45970(CEK1)
COT: 
CORT_0A00210 CORT_0A11180 CORT_0B01250 CORT_0D05290 CORT_0G00400
YLI: 
YALI0B02816g YALI0E23496g YALI0E25135g
CLU: 
CLUG_01484 CLUG_01883 CLUG_03997 CLUG_04129 CLUG_05410
NCR: 
NCU02393 NCU07024 NCU11376
SMP: 
SMAC_03492(mak2) SMAC_05504(mak1) SMAC_09127(os2)
PAN: 
PODANSg3754 PODANSg9198 PODANSg9249
TTT: 
THITE_2049821 THITE_2082381 THITE_2149193
MTM: 
MYCTH_2095610 MYCTH_2302899 MYCTH_2309838
MGR: 
MGG_01822 MGG_04943 MGG_09565
FGR: 
FG06385.1 FG09612.1 FG10313.1
NHE: 
NECHADRAFT_103967(FUS3) NECHADRAFT_58353 NECHADRAFT_69616
VAL: 
VDBG_02117 VDBG_04396
SSL: 
SS1G_05445 SS1G_07590 SS1G_11866
BFU: 
BC1G_03001 BC1G_07144 BC1G_13966
ANI: 
AN1017.2 AN3719.2 AN4668.2 AN5666.2
NFI: 
NFIA_012610 NFIA_058770 NFIA_102670
AFM: 
AFUA_1G12940 AFUA_4G13720 AFUA_6G12820
AOR: 
AOR_1_1044194 AOR_1_332184(AO090009000199) AOR_1_692154(AO090003000402)
ANG: 
ANI_1_1286014(An01g09520) ANI_1_1432074(An08g10670) ANI_1_492064(An07g03980) ANI_1_826074(An08g05850)
AFV: 
AFLA_034170 AFLA_052570 AFLA_099500
ACT: 
ACLA_022520 ACLA_052670 ACLA_086060
PCS: 
Pc13g11680 Pc22g01670 Pc22g03870
CIM: 
CIMG_01715 CIMG_01981 CIMG_05915
CPW: 
CPC735_025180 CPC735_045500 CPC735_047700
PBL: 
PAAG_00535 PAAG_05033 PAAG_06948
URE: 
UREG_04432 UREG_05430 UREG_06906
ABE: 
ARB_07504 ARB_07820
TVE: 
TRV_02393 TRV_05665 TRV_07105
AJE: 
HCAG_05250 HCAG_06189 HCAG_08451
PNO: 
SNOG_03299 SNOG_05764 SNOG_13296
PTE: 
PTT_10964 PTT_14847
ZTR: 
MYCGRDRAFT_102121(MgSlt2) MYCGRDRAFT_73071(MgFus3) MYCGRDRAFT_76502(MgHog1)
TML: 
GSTUM_00000551001 GSTUM_00001034001 GSTUM_00005852001
SPO: 
SPAC24B11.06c(sty1) SPAC31G5.09c(spk1) SPBC119.08(pmk1)
CNE: 
CNC06590 CNE00350 CNE00520 CNI00410
CNB: 
CNBC0610 CNBE0270 CNBE0440 CNBH0400
CGI: 
CGB_C0630C CGB_E0290W CGB_E0450W CGB_H1030C
PPL: 
POSPLDRAFT_109357 POSPLDRAFT_116648 POSPLDRAFT_125584 POSPLDRAFT_46675
LBC: 
LACBIDRAFT_174940 LACBIDRAFT_184962 LACBIDRAFT_187188 LACBIDRAFT_232153 LACBIDRAFT_250005
MPR: 
MPER_08593 MPER_13703 MPER_14395
CCI: 
CC1G_00577 CC1G_02007 CC1G_03633 CC1G_07620
SCM: 
SCHCODRAFT_17138 SCHCODRAFT_70675 SCHCODRAFT_72648 SCHCODRAFT_82727
UMA: 
UM00421.1 UM02331.1 UM02357.1 UM03305.1
MGL: 
MGL_0949 MGL_2190 MGL_2432 MGL_2731
PGR: 
PGTG_04715 PGTG_06617 PGTG_13814 PGTG_16812
MBR: 
MONBRDRAFT_13771 MONBRDRAFT_14615 MONBRDRAFT_19272 MONBRDRAFT_27550 MONBRDRAFT_2871 MONBRDRAFT_35273 MONBRDRAFT_39353
NGR: 
NAEGRDRAFT_83211
DDI: 
DDB_G0280557 DDB_G0280855 DDB_G0283903(erkB) DDB_G0286353(erkA)
DPP: 
DICPUDRAFT_53558 DICPUDRAFT_93783
EHI: 
EHI_073650(67.t00005) EHI_194420(46.t00053)
EDI: 
EDI_289590 EDI_350740
PFA: 
PF11_0147(map-2) PF14_0294(PfMAP1)
PFH: 
PFHG_00506 PFHG_01814
PYO: 
PY00731 PY02176
PCB: 
PC000139.04.0 PC001036.02.0
PBE: 
PB000659.00.0 PB000806.03.0
PKN: 
PKH_091110 PKH_131880
PVX: 
PVX_084965 PVX_091340
PCY: 
PCYB_092020 PCYB_132720
TAN: 
TA02810 TA21080
TPV: 
TP01_0359
BBO: 
BBOV_IV005520(23.m06268)
CPV: 
cgd2_4340 cgd3_3030
CHO: 
Chro.20213 Chro.20465 Chro.30343
TGO: 
TGME49_007820 TGME49_033010
TET: 
TTHERM_00085220 TTHERM_00195990 TTHERM_00469230 TTHERM_01083090
PTM: 
GSPATT00001183001 GSPATT00002839001 GSPATT00004874001 GSPATT00006379001 GSPATT00009693001 GSPATT00019885001 GSPATT00023631001
TBR: 
Tb10.389.1730 Tb10.61.0250 Tb10.70.2070 Tb927.6.1780(Tb06.28P18.710) Tb927.8.3550(Tb08.10J17.940)
TCR: 
506007.40 509553.60 510123.20 510295.50 511299.70 511491.80 511837.70
LMA: 
LMJF_19_1440(MPK4) LMJF_30_0370(MPK12) LMJF_33_1380(MPK11) LMJF_36_0720
LIF: 
LINJ_19_1480(MPK4) LINJ_30_0370(MPK12) LINJ_33_1470(MPK11) LINJ_36_0780
LDO: 
LDBPK_100540 LDBPK_191480 LDBPK_300370 LDBPK_331470 LDBPK_360780
LMI: 
LMXM_10_0490 LMXM_19_1440 LMXM_29_0370 LMXM_32_1380 LMXM_36_0720
LBZ: 
LBRM_19_1710(MPK4) LBRM_30_0410 LBRM_33_1650(MPK11) LBRM_35_0840
GLA: 
GL50803_17563 GL50803_22850
TVA: 
TVAG_008800 TVAG_258130 TVAG_260190 TVAG_338030
PTI: 
PHATRDRAFT_14453(hCDK7) PHATRDRAFT_21410(hCDK1)
TPS: 
THAPSDRAFT_32230(MAPK) THAPSDRAFT_5018 THAPSDRAFT_9710(mapk)
PIF: 
PITG_00254 PITG_02212 PITG_12186
 » show all
Taxonomy
Reference
1  [PMID:2842341]
  Authors
Ray LB, Sturgill TW.
  Title
Characterization of insulin-stimulated microtubule-associated protein kinase. Rapid isolation and stabilization of a novel serine/threonine kinase from 3T3-L1 cells.
  Journal
J. Biol. Chem. 263 (1988) 12721-7.
  Organism
Bos taurus [GN:bta]
Reference
2  [PMID:1657919]
  Authors
Rossomando AJ, Sanghera JS, Marsden LA, Weber MJ, Pelech SL, Sturgill TW.
  Title
Biochemical characterization of a family of serine/threonine protein kinases regulated by tyrosine and serine/threonine phosphorylations.
  Journal
J. Biol. Chem. 266 (1991) 20270-5.
  Organism
Mus musculus [GN:mmu], Xenopus laevis [GN:xla]
Reference
3  [PMID:1321146]
  Authors
Seger R, Ahn NG, Posada J, Munar ES, Jensen AM, Cooper JA, Cobb MH, Krebs EG.
  Title
Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells.
  Journal
J. Biol. Chem. 267 (1992) 14373-81.
  Organism
Xenopus laevis [GN:xla]
Reference
4  [PMID:9235954]
  Authors
Stein B, Yang MX, Young DB, Janknecht R, Hunter T, Murray BW, Barbosa MS.
  Title
p38-2, a novel mitogen-activated protein kinase with distinct properties.
  Journal
J. Biol. Chem. 272 (1997) 19509-17.
  Organism
Homo sapiens [GN:hsa]
Reference
5  [PMID:10715136]
  Authors
Lisnock J, Griffin P, Calaycay J, Frantz B, Parsons J, O'Keefe SJ, LoGrasso P.
  Title
Activation of JNK3 alpha 1 requires both MKK4 and MKK7: kinetic characterization of in vitro phosphorylated JNK3 alpha 1.
  Journal
Biochemistry. 39 (2000) 3141-8.
  Organism
Homo sapiens [GN:hsa]
Reference
6  [PMID:15187187]
  Authors
Roux PP, Blenis J.
  Title
ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions.
  Journal
Microbiol. Mol. Biol. Rev. 68 (2004) 320-44.
  Organism
Saccharomyces cerevisiae [GN:sce], mammalian
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
DBGET integrated database retrieval system