KEGG   ENZYME: 2.7.11.30Help
Entry
EC 2.7.11.30                Enzyme                                 

Name
receptor protein serine/threonine kinase;
activin receptor kinase;
receptor type I serine/threonine protein kinase;
receptor type II serine/threonine protein kinase;
STK13;
TGF-beta kinase;
receptor serine/threonine protein kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:[receptor-protein] phosphotransferase
Reaction(IUBMB)
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Reaction(KEGG)
(other) R00162
Show
Substrate
ATP [CPD:C00002];
[receptor-protein]
Product
ADP [CPD:C00008];
[receptor-protein] phosphate
Comment
The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. Signalling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates [1,3].
History
EC 2.7.11.30 created 2005 (EC 2.7.1.37 part-incorporated 2005)
Orthology
K04388  
TGF-beta receptor type-2
K04670  
activin receptor type-2A
K04671  
bone morphogenetic protein receptor type-2
K04672  
anti-mullerian hormone receptor type-2
K04673  
bone morphogenetic protein receptor type-1A
K04674  
TGF-beta receptor type-1
K04675  
activin receptor type-1
K13567  
activin receptor type-1B
K13568  
activin receptor type-1C
K13578  
bone morphogenetic protein receptor type-1B
K13594  
activin receptor-like kinase 1
K13596  
activin receptor type-2B
Genes
HSA: 
130399(ACVR1C) 269(AMHR2) 657(BMPR1A) 658(BMPR1B) 659(BMPR2) 7046(TGFBR1) 7048(TGFBR2) 90(ACVR1) 91(ACVR1B) 92(ACVR2A) 93(ACVR2B) 94(ACVRL1)
PTR: 
450572(BMPR1A) 451910(ACVRL1) 451911(ACVR1B) 459646(ACVR2A) 459885(BMPR2) 460243(TGFBR2) 460271(ACVR2B) 461683(BMPR1B) 467005(AMHR2) 470564(ACVR1C) 470565(ACVR1) 472992(TGFBR1)
PPS: 
100967435(ACVR1) 100968350(ACVR1C) 100973488(BMPR1A) 100978253(ACVR1B) 100978576(ACVRL1) 100978909(ACVR2A) 100984463(TGFBR1) 100984661(AMHR2) 100985497(TGFBR2) 100987362(BMPR2) 100991587(BMPR1B) 100993873(ACVR2B)
GGO: 
101124161(ACVR1) 101126947(ACVR2A) 101127602(BMPR1B) 101128510(TGFBR1) 101135109(BMPR1A) 101146131(TGFBR2) 101147417(ACVRL1) 101147783(ACVR1B) 101149682(AMHR2) 101152104 101153315(ACVR2B) 101153902
PON: 
100172614(ACVRL1) 100173725(ACVR1B) 100435220(ACVR2A) 100441106(AMHR2) 100441517(BMPR2) 100444576(BMPR1B) 100450136(BMPR1A) 100450864(TGFBR1) 100455362(ACVR1C) 100455728(ACVR1) 100456564(ACVR2B) 100459236(TGFBR2)
MCC: 
696071(ACVR2B) 696471(ACVRL1) 696587(ACVR1B) 696898(BMPR1A) 697826(ACVR1C) 697935(ACVR1) 702822(AMHR2) 703088(TGFBR2) 704088(BMPR2) 705474(BMPR1B) 707017(ACVR2A) 714952(TGFBR1)
MCF: 
101865702 102115287(TGFBR1) 102117592(AMHR2) 102118668(ACVR2B) 102121129(ACVR2A) 102122481(BMPR1A) 102131774(ACVR1C) 102132657(BMPR2) 102134051(ACVR1) 102134273(TGFBR2) 102136230(BMPR1B) 102143641(ACVRL1)
MMU: 
110542(Amhr2) 11477(Acvr1) 11479(Acvr1b) 11480(Acvr2a) 11481(Acvr2b) 11482(Acvrl1) 12166(Bmpr1a) 12167(Bmpr1b) 12168(Bmpr2) 21812(Tgfbr1) 21813(Tgfbr2) 269275(Acvr1c)
RNO: 
140590(Bmpr2) 245921(Acvr1c) 25237(Acvrl1) 25366(Acvr2b) 29263(Acvr2a) 29381(Acvr1b) 29530(Amhr2) 29591(Tgfbr1) 310914(Bmpr1b) 79558(Acvr1) 81507(Bmpr1a) 81810(Tgfbr2)
CGE: 
100750332(Bmpr1a) 100755103 100756930(Acvr1c) 100758565(Acvr1) 100764519(Bmpr2) 100764896(Acvrl1) 100772657 100772727 100773953(Tgfbr2) 100774605(Acvr2a) 100774629(Bmpr1b)
HGL: 
101698756(Amhr2) 101700899(Bmpr1a) 101701138(Bmpr2) 101704397(Tgfbr2) 101707586(Acvr2a) 101709452(Acvr1b) 101709807(Acvrl1) 101710196(Bmpr1b) 101711343(Acvr1) 101711703(Acvr2b) 101712645(Acvr1c) 101718090(Tgfbr1)
TUP: 
102468744(ACVR2B) 102471973(ACVR1) 102472860(BMPR2) 102473834(AMHR2) 102476700(TGFBR1) 102483055(BMPR1A) 102486518(TGFBR2) 102489862(ACVRL1) 102490297(ACVR1B) 102496847(BMPR1B) 102497450(ACVR1C) 102499226(ACVR2A)
CFA: 
476140(ACVR2A) 477039(TGFBR2) 477603(ACVRL1) 478484(BMPR1B) 478757(ACVR1) 478875(BMPR2) 481628(TGFBR1) 485590(ACVR2B) 486506(AMHR2) 486537(ACVR1B) 488361(ACVR1C) 489077(BMPR1A)
AML: 
100467049(BMPR1B) 100472026 100472999(BMPR1A) 100475241(AMHR2) 100475698 100476073(ACVR1C) 100476325(ACVR1) 100477787 100482103(ACVR1B) 100482358(ACVRL1) 100482939(TGFBR2) 100483427(BMPR2)
FCA: 
101082489(BMPR1B) 101085902(AMHR2) 101086087(ACVR2B) 101089548(BMPR1A) 101091037(ACVR1C) 101091298(ACVR1) 101091725(TGFBR2) 101094057(TGFBR1) 101096338(BMPR2) 101097406(ACVRL1) 101097654(ACVR1B) 101097750(ACVR2A)
PTG: 
102948807(ACVR2A) 102950020(TGFBR1) 102950575(ACVR2B) 102955517(AMHR2) 102955784(ACVR1) 102956256(ACVR1C) 102958413(TGFBR2) 102968798(BMPR1B) 102971045(ACVRL1) 102971536(ACVR1B) 102972795(BMPR1A) 102972964(BMPR2)
BTA: 
281598(ACVR2A) 282131(ACVR2B) 282382(TGFBR1) 338068(ACVR1) 404101(BMPR1A) 407127(BMPR2) 407128(BMPR1B) 514963(AMHR2) 534536(ACVRL1) 535376(TGFBR2) 536380(ACVR1C) 539315(ACVR1B)
BOM: 
102267018(TGFBR2) 102269707(BMPR1A) 102269861(ACVR2A) 102275369(ACVR1) 102275656(ACVR1C) 102276585(BMPR2) 102281557(ACVR2B) 102282014(AMHR2) 102283685(TGFBR1) 102284193(BMPR1B) 102287367(ACVRL1) 102287655(ACVR1B)
PHD: 
102318690(AMHR2) 102319226(BMPR1A) 102323863(ACVR2B) 102324779(TGFBR1) 102324899(ACVR1C) 102325720(ACVR1) 102330019(TGFBR2) 102331981(BMPR2) 102333540(BMPR1B) 102336283(ACVRL1) 102336645(ACVR1B) 102338238(ACVR2A)
CHX: 
100860918(ACTR2) 100860926(ACTR1A) 100861211(BMPR-IB) 100861241(BMPR1A) 100861300(TGF-BETARII) 102173240(BMPR2) 102174882(ACVR1C) 102175649(AMHR2) 102186186(ACVR1B) 102186663(ACVRL1)
SSC: 
100038019 100127483(BMPR2) 100152307(ACVR1) 100152462(ACVR1B) 100153279(ACVRL1) 100154297(AMHR2) 100156756(ACVR1C) 100169652(BMPR1A) 100738857 396665(TGFBR1) 396691(BMPR1B) 397282(ACVR2A) 448845(ACVR2B)
CFR: 
102503742(BMPR1A) 102509744(TGFBR2) 102510501(ACVR1B) 102511434(ACVR1C) 102511519(BMPR1B) 102512007(ACVR1) 102517419(ACVRL1) 102518044(ACVR2A) 102518140 102520441(AMHR2) 102522485(TGFBR1)
ECB: 
100033860(TGFBR2) 100034117(ALK5) 100049823(ACVR2A) 100050899(ACVR1) 100053554(BMPR1B) 100053588(ACVR2B) 100059573(ACVR1C) 100061313(ACVRL1) 100062619(ACVR1B) 100063905(AMHR2) 100064367(BMPR1A) 100067195(BMPR2)
MYB: 
102241353(TGFBR1) 102243009(ACVR1C) 102246021(ACVR1B) 102246548(ACVRL1) 102246825(ACVR2B) 102248472(TGFBR2) 102253638(ACVR2A) 102255023(BMPR2) 102255240(BMPR1B) 102256807(BMPR1A) 102257719(AMHR2) 102263759(ACVR1)
MYD: 
102759199(ACVR2B) 102764015(BMPR1B) 102765939(ACVR1B) 102766490(ACVRL1) 102767691(ACVR1C) 102767756(TGFBR2) 102767973(ACVR1) 102768276(ACVR2A) 102769364(BMPR2) 102769420(BMPR1A) 102774743(AMHR2)
PALE: 
102880288(ACVR1C) 102880759(TGFBR1) 102880880(ACVR1) 102882003(BMPR2) 102885131(ACVR1B) 102885386(ACVRL1) 102886920(BMPR1A) 102889618(TGFBR2) 102889861(AMHR2) 102891559(ACVR2A) 102894735(ACVR2B) 102896177(BMPR1B)
MDO: 
SHR: 
100913352(TGFBR2) 100913438(ACVRL1) 100913702(ACVR1B) 100913844(TGFBR1) 100918537(ACVR2A) 100920492(BMPR1B) 100925781(BMPR2) 100928279(ACVR1) 100928319(BMPR1A) 100929763(AMHR2) 100931037(ACVR1C) 100933894(ACVR2B)
OAA: 
GGA: 
100857446(ACVRL1) 374094(TGFBR1) 374147(BMPR2) 374213(ACVR2B) 395246(ACVR1) 396030(BMPR1B) 396308(BMPR1A) 396324(ACVR2A) 396399(TGFBR2) 424261 424325(ACVR1C) 768878(ACVR1B)
MGP: 
TGU: 
100218713(BMPR1B) 100220619(TGFBR2) 100220695(ACVR1B) 100223148(BMPR1A) 100224301(ACVR2A) 100224677 100227149(BMPR2) 100230545(ACVR1) 100230911 100230960(ACVR2B) 100232553(ACVR1C)
FAB: 
101806244(BMPR2) 101808986 101809222(ACVRL1) 101809241(TGFBR1) 101809573(ACVR1B) 101811048(TGFBR2) 101814029(BMPR1A) 101817282(ACVR1C) 101818057(ACVR1) 101818178(BMPR1B) 101819929(ACVR2B) 101821260(ACVR2A)
PHI: 
102099204 102102106(ACVRL1) 102103410(BMPR1B) 102105645(ACVR1B) 102107002(ACVR2B) 102107888(BMPR1A) 102109524(ACVR1) 102110191(BMPR2) 102110252(ACVR1C) 102112281(TGFBR2) 102113091(AMHR2) 102113171(ACVR2A) 102113190(TGFBR1)
APLA: 
101789784(ACVR2A) 101791121(ACVR2B) 101793707(BMPR2) 101793792(ACVR1) 101794439(BMPR1B) 101794795(TGFBR2) 101794826(ACVR1C) 101796697(ACVR1B) 101798636(BMPR1A) 101799198(ACVRL1) 101801641 101805328(TGFBR1)
FPG: 
101911268(TGFBR2) 101911977(ACVR1) 101912153(ACVR1C) 101913989(BMPR1B) 101915701(ACVR2A) 101918473(ACVR2B) 101918686(BMPR1A) 101919199(BMPR2) 101922518(TGFBR1) 101924328 101924360(ACVR1B) 101924528(ACVRL1)
FCH: 
102045945(BMPR1A) 102046018(ACVR1B) 102046188(ACVRL1) 102046415(BMPR2) 102048434(ACVR2B) 102048632 102052691(ACVR1C) 102053092(ACVR1) 102053325(ACVR2A) 102053489(TGFBR2) 102054291(BMPR1B) 102055038(TGFBR1)
CLV: 
102083591(TGFBR2) 102083697(ACVR2B) 102086688(BMPR2) 102086761(ACVR1C) 102087076(ACVR1) 102087897(BMPR1A) 102089002(ACVR1B) 102089196(ACVRL1) 102091992 102092756(BMPR1B) 102095465(TGFBR1) 102098638(ACVR2A)
ASN: 
102368733(ACVR2A) 102369865 102370042(BMPR2) 102370172(AMHR2) 102370778(TGFBR1) 102376220(BMPR1A) 102378519(ACVR1) 102379420(ACVR1C) 102380434(TGFBR2) 102381128(ACVR2B) 102385749 102386283(ACVRL1) 102386528(ACVR1B)
PSS: 
102444710(TGFBR2) 102447606(ACVRL1) 102449724(BMPR1B) 102452383(ACVR2B) 102453202(BMPR1A) 102454243(ACVR1B) 102454507(ACVR2A) 102455070(ACVR1C) 102455326(ACVR1) 102456232(BMPR2) 102457599
CMY: 
102929309(ACVR1C) 102929585(BMPR2) 102930932(ACVR2B) 102936225(ACVR1B) 102939323(BMPR1A) 102940838(ACVRL1) 102942001(TGFBR1) 102943295(AMHR2) 102945112(BMPR1B) 102945188(ACVR2A) 102947040(TGFBR2) 102948189(ACVR1)
ACS: 
XLA: 
397711 397712(bmpr1a) 397859(xstk2) 397981(bmpr2) 399083(acvr1-a) 399103(acvr1-b) 399283(acvr2a) 399295(tgfbr1) 399454(acvr1b) 495087
XTR: 
100216172(acvr2a) 100487548(acvr1c) 100488582(tgfbr2) 100494339(bmpr2) 448641(acvr2b) 548715(tgfbr1) 550111(acvr1) 733849(acvr1b) 734017(bmpr1a) 780089(bmpr1b)
DRE: 
100149664(bmpr1bb) 30183(acvr1b) 30457(acvr2b) 30615(acvr1l) 30739(tgfbr2) 30742(bmpr1ba) 447846(bmpr1ab) 553359(acvr2aa) 555655(bmpr2b) 560446 560578(tgfbr1a) 562822(bmpr2a) 58145(bmpr1aa) 792928(tgfbr1b)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102345137(ACVR1) 102346621(TGFBR2) 102350402 102351086(ACVR2B) 102353534(BMPR2) 102354804(ACVR2A) 102356233 102357203(ACVR1B) 102364169(BMPR1B) 102367134(ACVR1C)
BFO: 
CIN: 
778776(tgfbr-ia) 778777(tgfbr-iia) 778778(tgfbr-iib)
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
408442(tkv) 413895(wit) 550930(babo) 725711(sax)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG02627(Cbr-sma-6)
BMY: 
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
 » show all
Taxonomy
Reference
1  [PMID:8047140]
  Authors
Wrana JL, Attisano L, Wieser R, Ventura F, Massague J.
  Title
Mechanism of activation of the TGF-beta receptor.
  Journal
Nature. 370 (1994) 341-7.
  Organism
Homo sapiens
Reference
2  [PMID:10733523]
  Authors
Massague J, Chen YG.
  Title
Controlling TGF-beta signaling.
  Journal
Genes. Dev. 14 (2000) 627-44.
  Organism
Caenorhabditis elegans, mammalian
Reference
3  [PMID:9153220]
  Authors
de Caestecker MP, Hemmati P, Larisch-Bloch S, Ajmera R, Roberts AB, Lechleider RJ.
  Title
Characterization of functional domains within Smad4/DPC4.
  Journal
J. Biol. Chem. 272 (1997) 13690-6.
  Organism
Caenorhabditis elegans
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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