KEGG   ENZYME: 2.7.11.31Help
Entry
EC 2.7.11.31                Enzyme                                 

Name
[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase;
AMPK;
AMP-activated protein kinase;
HMG-CoA reductase kinase;
beta-hydroxy-beta-methylglutaryl-CoA reductase kinase;
[hydroxymethylglutaryl-CoA reductase (NADPH2)] kinase;
3-hydroxy-3-methylglutaryl coenzyme A reductase kinase;
3-hydroxy-3-methylglutaryl-CoA reductase kinase;
hydroxymethylglutaryl coenzyme A reductase kinase;
hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating);
hydroxymethylglutaryl-CoA reductase kinase;
reductase kinase;
STK29
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphotransferase
Reaction(IUBMB)
ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] = ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate [RN:R04555]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
[hydroxymethylglutaryl-CoA reductase (NADPH)] [CPD:C04632]
Product
ADP [CPD:C00008];
[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate [CPD:C04768]
Comment
The enzyme is activated by AMP. EC 1.1.1.34, hydroxymethylglutaryl-CoA reductase (NADPH) is inactivated by the phosphorylation of the enzyme protein. Histones can also act as acceptors. The enzyme can also phosphorylate hepatic acetyl-CoA carboxylase (EC 6.4.1.2) and adipose hormone-sensitive lipase (EC 3.1.1.79) [5]. Thr-172 within the catalytic subunit (alpha-subunit) is the major site phosphorylated by the AMP-activated protein kinase kinase [7]. GTP can act instead of ATP [4]
History
EC 2.7.11.31 created 1984 as EC 2.7.1.109, transferred 2005 to EC 2.7.11.31
Orthology
K05958  
[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase
Genes
CAL: 
Taxonomy
Reference
1  [PMID:278983]
  Authors
Beg ZH, Stonik JA, Brewer HB Jr.
  Title
3-Hydroxy-3-methylglutaryl coenzyme A reductase: regulation of enzymatic activity by phosphorylation and dephosphorylation.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 75 (1978) 3678-82.
  Organism
Homo sapiens, Rattus norvegicus
Reference
2  [PMID:216867]
  Authors
Gibson DM, Ingebritsen TS.
  Title
Reversible modulation of liver hydroxymethylglutaryl CoA reductase.
  Journal
Life. Sci. 23 (1978) 2649-64.
  Organism
Rattus norvegicus
Reference
3  [PMID:666819]
  Authors
Ingebritsen TS, Lee HS, Parker RA, Gibson DM.
  Title
Reversible modulation of the activities of both liver microsomal hydroxymethylglutaryl coenzyme A reductase and its inactivating enzyme. Evidence for regulation by phosphorylation-dephosphorylation.
  Journal
Biochem. Biophys. Res. Commun. 81 (1978) 1268-77.
  Organism
Rattus norvegicus
Reference
4  [PMID:3689494]
  Authors
Ferrer A, Caelles C, Massot N, Hegardt FG.
  Title
Allosteric activation of rat liver microsomal [hydroxymethylglutaryl-CoA reductase (NADPH)]kinase by nucleoside phosphates.
  Journal
Biol. Chem. Hoppe. Seyler. 368 (1987) 249-57.
  Organism
Rattus norvegicus
Reference
5  [PMID:7902296]
  Authors
Weekes J, Ball KL, Caudwell FB, Hardie DG.
  Title
Specificity determinants for the AMP-activated protein kinase and its plant homologue analysed using synthetic peptides.
  Journal
FEBS. Lett. 334 (1993) 335-9.
  Organism
Rattus norvegicus
Reference
6  [PMID:9857077]
  Authors
Crute BE, Seefeld K, Gamble J, Kemp BE, Witters LA.
  Title
Functional domains of the alpha1 catalytic subunit of the AMP-activated protein kinase.
  Journal
J. Biol. Chem. 273 (1998) 35347-54.
  Organism
Homo sapiens, Rattus norvegicus
  Sequence
[hsa:5562]
Reference
7  [PMID:10642499]
  Authors
Stein SC, Woods A, Jones NA, Davison MD, Carling D.
  Title
The regulation of AMP-activated protein kinase by phosphorylation.
  Journal
Biochem. J. 345 Pt 3 (2000) 437-43.
  Organism
Rattus norvegicus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
172522-01-9

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