KEGG   ENZYME: 2.7.12.2Help
Entry
EC 2.7.12.2                 Enzyme                                 

Name
mitogen-activated protein kinase kinase;
MAP kinase kinase;
MAP kinase kinase 4;
MAP kinase kinase 7;
MAP kinase or ERK kinase;
MAP2K;
MAPKK;
MAPKK1;
MEK;
MEK1;
MEK2;
MKK;
MKK2;
MKK4;
MKK6;
MKK7;
STK27
Class
Transferases;
Transferring phosphorus-containing groups;
Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
BRITE hierarchy
Sysname
ATP:protein phosphotransferase (MAPKKK-activated)
Reaction(IUBMB)
ATP + a protein = ADP + a phosphoprotein [RN:R00162]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
protein [CPD:C00017]
Product
ADP [CPD:C00008];
phosphoprotein [CPD:C00562]
Comment
This enzyme is a dual-specific protein kinase and requires mitogen-activated protein kinase kinase kinase (MAPKKK) for activation. It is required for activation of EC 2.7.11.24, mitogen-activated protein kinase. Phosphorylation of MEK1 by Raf involves phosphorylation of two serine residues [5]. Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
History
EC 2.7.12.2 created 2005
Orthology
K04368  
mitogen-activated protein kinase kinase 1
K04369  
mitogen-activated protein kinase kinase 2
K04430  
mitogen-activated protein kinase kinase 4
K04431  
mitogen-activated protein kinase kinase 7
K04432  
mitogen-activated protein kinase kinase 3
K04433  
mitogen-activated protein kinase kinase 6
K04463  
mitogen-activated protein kinase kinase 5
K08294  
mitogen-activated protein kinase kinase
K08865  
PDZ-binding kinase
K11226  
mitogen-activated protein kinase kinase
K11227  
mitogen-activated protein kinase kinase
K13413  
mitogen-activated protein kinase kinase 4/5, plant
K14511  
mitogen-activated protein kinase kinase SIMKK
Genes
HSA: 
55872(PBK) 5604(MAP2K1) 5605(MAP2K2) 5606(MAP2K3) 5607(MAP2K5) 5608(MAP2K6) 5609(MAP2K7) 6416(MAP2K4)
PTR: 
100611792 450188(MAP2K1) 453532(MAP2K5) 454515(MAP2K3) 455065(MAP2K4) 456390(MAP2K2) 464496(PBK) 468310(MAP2K6) 743199(MAP2K7) 746715
PPS: 
100972424(MAP2K6) 100975020(MAP2K3) 100977025(MAP2K2) 100988422(MAP2K1) 100988437 100989445(PBK) 100989537(MAP2K7) 100991495(MAP2K4) 100994910(MAP2K5)
GGO: 
101124339(MAP2K7) 101126885(MAP2K2) 101132391(MAP2K1) 101137194(MAP2K5) 101140044(PBK) 101142374(MAP2K6) 101143954(MAP2K4) 101145420(MAP2K3) 101148200 101154090
PON: 
100431600(MAP2K7) 100439299 100446021(MAP2K1) 100448382(MAP2K6) 100449213(MAP2K5) 100450988 100453095(PBK) 100457536(MAP2K3)
MCC: 
693914(MAP2K6) 705195(MAP2K3) 710077 710415(MAP2K1) 711672(MAP2K5) 713242(PBK) 718155(MAP2K4) 721821(MAP2K2)
MCF: 
101925060 102116823(MAP2K3) 102118759(MAP2K5) 102125035(MAP2K4) 102126975(MAP2K7) 102136923(PBK) 102140855(MAP2K2) 102141214(MAP2K1)
MMU: 
23938(Map2k5) 26395(Map2k1) 26396(Map2k2) 26397(Map2k3) 26398(Map2k4) 26399(Map2k6) 26400(Map2k7) 52033(Pbk)
RNO: 
100911550 114495(Map2k6) 170851(Map2k1) 287398(Map2k4) 290326(Pbk) 29568(Map2k5) 303200(Map2k3) 363855(Map2k7) 58960(Map2k2)
CGE: 
HGL: 
101703028(Map2k6) 101705822(Map2k4) 101707562(Map2k2) 101710666(Map2k7) 101711080(Map2k5) 101715628(Map2k1) 101718318(Map2k3) 101720410(Pbk)
TUP: 
102469877(MAP2K5) 102476496(MAP2K1) 102478180(PBK) 102482054(MAP2K6) 102483700(MAP2K2) 102493856(MAP2K4) 102499419(MAP2K3) 102500732(MAP2K7)
CFA: 
477371(PBK) 478347(MAP2K1) 480454(MAP2K6) 485004(MAP2K7) 489508(MAP2K4) 489547(MAP2K3) 609559(MAP2K5) 611939(MAP2K2)
AML: 
FCA: 
101080784(PBK) 101081387(MAP2K1) 101082274(MAP2K3) 101086432(MAP2K4) 101089813(MAP2K6) 101095157(MAP2K7) 101100281 101100725(MAP2K5)
PTG: 
102949008(MAP2K5) 102949140(MAP2K7) 102949954(MAP2K3) 102956808 102958611(PBK) 102966485(MAP2K6) 102966812(MAP2K4) 102969757(MAP2K1)
BTA: 
100295732(MAP2K5) 286883(MAP2K6) 510434(MAP2K2) 516039(MAP2K3) 526469(MAP2K4) 533199(MAP2K1) 534781(PBK) 787278(MAP2K7)
BOM: 
102267773(MAP2K3) 102271353(PBK) 102271710(MAP2K2) 102272638(MAP2K7) 102272962(MAP2K6) 102280670(MAP2K1) 102283668(MAP2K5) 102287278(MAP2K4)
PHD: 
102315849(MAP2K3) 102317867(MAP2K6) 102325860(MAP2K2) 102327200(MAP2K7) 102331780(MAP2K5) 102332128(PBK) 102333652(MAP2K4) 102334696 102338050
CHX: 
102169516(MAP2K6) 102170427(MAP2K5) 102173178(MAP2K7) 102173967(MAP2K3) 102175285(MAP2K2) 102175799(MAP2K4) 102181210(PBK) 102190520(MAP2K1)
SSC: 
100141310(PBK) 100233191(MAP2K1) 100520100(MAP2K4) 100520164(MAP2K5) 100520418(MAP2K7) 100525505(MAP2K2) 100625946(MAP2K6)
CFR: 
102506459(MAP2K7) 102511209(MAP2K2) 102513578(MAP2K4) 102515937(MAP2K1) 102517293(MAP2K5) 102518252(PBK) 102519784(MAP2K6) 102523780(MAP2K3)
ECB: 
100052849(MAP2K5) 100053056(MAP2K6) 100053481(MAP2K3) 100060789(PBK) 100063190(MAP2K2) 100065996(MAP2K1) 100073094(MAP2K4) 100147230(MAP2K7)
MYB: 
102240696(MAP2K1) 102244251(MAP2K4) 102245571(MAP2K2) 102246913(MAP2K6) 102247950(MAP2K7) 102253993(PBK) 102259712(MAP2K3) 102260280(MAP2K5)
MYD: 
102753877(PBK) 102756005(MAP2K5) 102757282(MAP2K2) 102759247(MAP2K6) 102760954(MAP2K7) 102763997(MAP2K1) 102765923(MAP2K3) 102769098(MAP2K4)
PALE: 
102879034(MAP2K2) 102886389(MAP2K3) 102888822(MAP2K6) 102891748(PBK) 102892533(MAP2K7) 102894177(MAP2K5) 102894945(MAP2K4) 102897122(MAP2K1)
MDO: 
100016872(MAP2K3) 100018044(MAP2K2) 100018410(MAP2K1) 100019828(MAP2K4) 100025486(MAP2K5) 100026752(MAP2K7) 100029049(MAP2K6)
SHR: 
OAA: 
100077802(PBK) 100078394(MAP2K6) 100080362(MAP2K1) 100080734(MAP2K3) 100085895(MAP2K5) 100087942 100091407
GGA: 
396349(MAP2K2) 415549(MAP2K1) 415557(MAP2K5) 416496(MAP2K3) 417312(MAP2K4) 417445(MAP2K6) 422003(PBK)
MGP: 
TGU: 
100219724(MAP2K5) 100219801 100226448(MAP2K1) 100229860(MAP2K3)
FAB: 
101808780 101809415(MAP2K3) 101812216 101815546(MAP2K5) 101816905(MAP2K1) 101819388(MAP2K6) 101820507(MAP2K2) 101822010(MAP2K4) 101822092(PBK)
PHI: 
102100701(MAP2K7) 102102285(MAP2K2) 102102585 102105268(MAP2K6) 102106364(MAP2K5) 102109535(MAP2K3) 102110075(MAP2K1) 102114327(PBK)
APLA: 
101791037(MAP2K1) 101793398(MAP2K2) 101794019 101798109(PBK) 101799389(MAP2K6) 101801808(MAP2K5) 101803371(MAP2K3) 101805315(MAP2K4)
FPG: 
101913671(MAP2K6) 101918161 101919170(MAP2K3) 101922949(PBK) 101924219 101924296(MAP2K2) 101924559(MAP2K5) 101924998(MAP2K1)
FCH: 
102047307 102048069 102048212(PBK) 102049695(MAP2K2) 102052703(MAP2K3) 102053088(MAP2K6) 102053397(MAP2K1) 102053857(MAP2K5)
CLV: 
102084805(PBK) 102085143(MAP2K3) 102085780 102086996(MAP2K6) 102088655 102095101(MAP2K5) 102096091(MAP2K1) 102097053(MAP2K2)
ASN: 
102372350 102373782(MAP2K6) 102373880(MAP2K1) 102375508(MAP2K2) 102378558(PBK) 102379245 102380357(MAP2K5) 102383945(MAP2K3)
PSS: 
102443595(MAP2K1) 102451373(MAP2K5) 102452927 102453281(PBK) 102454019(MAP2K3) 102457075(MAP2K2) 102461243(MAP2K6) 102463924(MAP2K7)
CMY: 
102929430 102931357(MAP2K2) 102932325(MAP2K7) 102934520(PBK) 102939584(MAP2K3) 102942953(MAP2K6) 102945547(MAP2K1) 102946856(MAP2K5)
ACS: 
XLA: 
379638(map2k6) 379991(map2k1) 394391(map2k7) 414694(map2k5) 496340(pbk)
XTR: 
100135013(map2k4) 448132(map2k6) 493420(map2k1) 496810(pbk) 549042(map2k5) 613115(map2k7)
DRE: 
100002225(map2k2b) 100007679(map2k5) 360218(pbk) 403052(map2k4a) 406728(map2k1) 560913(map2k7) 563181(map2k2a) 568951(map2k4b) 65239(map2k6)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102350370(MAP2K2) 102351267(MAP2K3) 102352547(MAP2K4) 102353461(PBK) 102357895(MAP2K5) 102358560(MAP2K1) 102362389(MAP2K6) 102365163
BFO: 
CIN: 
100179846 778672(mapkk4) 778673(mapkk5) 778674(mapkk7) 778902(mapkk3/6) 778923(mapkk1/2)
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
409925(Dsor1) 410575(Mkk4) 413389(hem) 551365(GB13701)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG01940(Cbr-mkk-4) CBG04190(Cbr-mek-2) CBG16698(Cbr-mek-1) CBG16802(Cbr-sek-1)
BMY: 
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
ATH: 
AT1G51660(MKK4) AT3G21220(MKK5) AT4G26070(MEK1) AT4G29810(MKK2) AT5G56580(MKK6)
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
MTR: 
CAM: 
FVE: 
CSV: 
RCU: 
POP: 
POPTR_0001s02130g POPTR_0006s14850g(POPTRDRAFT_831948) POPTR_0008s01030g(POPTRDRAFT_563479) POPTR_0010s25570g(POPTRDRAFT_228518) POPTR_0012s04010g(POPTRDRAFT_421814) POPTR_0014s04645g POPTR_0015s05400g POPTR_0018s05420g(POPTRDRAFT_577971) POPTR_0018s06810g
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os01t0510100-01(Os01g0510100) Os02t0787300-01(Os02g0787300) Os06t0147800-01(Os06g0147800) Os06t0191300-01(Os06g0191300) Os11t0226100-00(Os11g0226100)
OBR: 
BDI: 
SBI: 
SORBI_01g010180(SORBIDRAFT_01g010180) SORBI_01g010200(SORBIDRAFT_01g010200) SORBI_02g022450(SORBIDRAFT_02g022450) SORBI_03g033190(SORBIDRAFT_03g033190) SORBI_04g035370(SORBIDRAFT_04g035370) SORBI_10g006080(SORBIDRAFT_10g006080)
ZMA: 
SITA: 
ATR: 
s00011p00235890(AMTR_s00011p00235890) s00011p00236650(AMTR_s00011p00236650) s00056p00155580(AMTR_s00056p00155580) s00083p00130670(AMTR_s00083p00130670) s00146p00077810(AMTR_s00146p00077810)
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
OTA: 
MIS: 
MPP: 
CCP: 
SCE: 
YDL159W(STE7) YJL128C(PBS2) YOR231W(MKK1) YPL140C(MKK2)
AGO: 
ERC: 
KLA: 
LTH: 
PPA: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0A09750(NCAS0A09750) NCAS_0B01450(NCAS0B01450) NCAS_0C01580(NCAS0C01580)
NDI: 
NDAI_0E01310(NDAI0E01310) NDAI_0G06150(NDAI0G06150)
TPF: 
TPHA_0B01150(TPHA0B01150) TPHA_0B03130(TPHA0B03130) TPHA_0G01730(TPHA0G01730)
TBL: 
TBLA_0B03990(TBLA0B03990) TBLA_0D05640(TBLA0D05640)
TDL: 
TDEL_0A05980(TDEL0A05980) TDEL_0H01070(TDEL0H01070)
KAF: 
KAFR_0A03710(KAFR0A03710) KAFR_0G01810(KAFR0G01810)
DHA: 
PIC: 
PGU: 
LEL: 
CAL: 
CaO19.469(HST7) CaO19.6889(MKK2) CaO19.7388(PBS2) CaO19.8100(HST7)
CTP: 
CDU: 
COT: 
YLI: 
CLU: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
MGR: 
FGR: 
NHE: 
TRE: 
VAL: 
SSL: 
BFU: 
ANI: 
AFM: 
AOR: 
AOR_1_106084(AO090020000060) AOR_1_1906174(AO090005001093) AOR_1_570184(AO090009000347)
ANG: 
ANI_1_1390094(An11g10690) ANI_1_3024014(An01g11080) ANI_1_476164(An18g03740)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
ZTR: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
PPL: 
LBC: 
MPR: 
CCI: 
SCM: 
UMA: 
MGL: 
PGR: 
MBR: 
DDI: 
DPP: 
DFA: 
DFA_10137(mekA)
ACAN: 
CHO: 
TET: 
PTM: 
PIF: 
NGD: 
NGA_2020600(MAP2K1)
EHX: 
GTT: 
TBR: 
Tb927.8.5950(Tb08.11J15.920)
TCR: 
LBZ: 
NGR: 
TVA: 
GLA: 
 » show all
Taxonomy
Reference
1  [PMID:8004006]
  Authors
Mordret G.
  Title
MAP kinase kinase: a node connecting multiple pathways.
  Journal
Biol. Cell. 79 (1993) 193-207.
  Organism
Homo sapiens, Rattus norvegicus, Schizosaccharomyces pombe, Mus musculus, Oryctolagus cuniculus, Xenopus laevis, Saccharomyces cerevisiae, Drosophila melanogaster
Reference
2  [PMID:8388392]
  Authors
Zheng CF, Guan KL.
  Title
Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2.
  Journal
J. Biol. Chem. 268 (1993) 11435-9.
  Organism
Homo sapiens
  Sequence
[hsa:5604 5605]
Reference
3  [PMID:8393135]
  Authors
Wu J, Harrison JK, Dent P, Lynch KR, Weber MJ, Sturgill TW.
  Title
Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2.
  Journal
Mol. Cell. Biol. 13 (1993) 4539-48.
  Organism
Rattus norvegicus
  Sequence
[rno:58960]
Reference
4  [PMID:8157000]
  Authors
Alessi DR, Saito Y, Campbell DG, Cohen P, Sithanandam G, Rapp U, Ashworth A, Marshall CJ, Cowley S.
  Title
Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.
  Journal
EMBO. J. 13 (1994) 1610-9.
  Organism
Oryctolagus cuniculus
  Sequence
[up:P29678]
Reference
5  [PMID:7731726]
  Authors
Pham CD, Arlinghaus RB, Zheng CF, Guan KL, Singh B.
  Title
Characterization of MEK1 phosphorylation by the v-Mos protein.
  Journal
Oncogene. 10 (1995) 1683-8.
Reference
6  [PMID:8621675]
  Authors
Han J, Lee JD, Jiang Y, Li Z, Feng L, Ulevitch RJ.
  Title
Characterization of the structure and function of a novel MAP kinase kinase (MKK6).
  Journal
J. Biol. Chem. 271 (1996) 2886-91.
  Organism
Homo sapiens
  Sequence
[hsa:5608]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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