KEGG   ENZYME: 2.7.12.2Help
Entry
EC 2.7.12.2                 Enzyme                                 

Name
mitogen-activated protein kinase kinase;
MAP kinase kinase;
MAP kinase kinase 4;
MAP kinase kinase 7;
MAP kinase or ERK kinase;
MAP2K;
MAPKK;
MAPKK1;
MEK;
MEK1;
MEK2;
MKK;
MKK2;
MKK4;
MKK6;
MKK7;
STK27
Class
Transferases;
Transferring phosphorus-containing groups;
Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
BRITE hierarchy
Sysname
ATP:protein phosphotransferase (MAPKKK-activated)
Reaction(IUBMB)
ATP + a protein = ADP + a phosphoprotein [RN:R00162]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
protein [CPD:C00017]
Product
ADP [CPD:C00008];
phosphoprotein [CPD:C00562]
Comment
This enzyme is a dual-specific protein kinase and requires mitogen-activated protein kinase kinase kinase (MAPKKK) for activation. It is required for activation of EC 2.7.11.24, mitogen-activated protein kinase. Phosphorylation of MEK1 by Raf involves phosphorylation of two serine residues [5]. Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
History
EC 2.7.12.2 created 2005
Orthology
K04368  mitogen-activated protein kinase kinase 1
K04369  mitogen-activated protein kinase kinase 2
K04430  mitogen-activated protein kinase kinase 4
K04431  mitogen-activated protein kinase kinase 7
K04432  mitogen-activated protein kinase kinase 3
K04433  mitogen-activated protein kinase kinase 6
K04463  mitogen-activated protein kinase kinase 5
K08294  mitogen-activated protein kinase kinase
K08865  PDZ-binding kinase
K11226  mitogen-activated protein kinase kinase
K11227  mitogen-activated protein kinase kinase
K13413  mitogen-activated protein kinase kinase 4/5
K19763  dual specificity mitogen-activated protein kinase kinase JKK-1
K20602  mitogen-activated protein kinase kinase 1
K20603  mitogen-activated protein kinase kinase 2
K20604  mitogen-activated protein kinase kinase 9
K20607  mitogen-activated protein kinase kinase 3
Genes
HSA: 55872(PBK) 5604(MAP2K1) 5605(MAP2K2) 5606(MAP2K3) 5607(MAP2K5) 5608(MAP2K6) 5609(MAP2K7) 6416(MAP2K4)
PTR: 450188(MAP2K1) 453532(MAP2K5) 455065(MAP2K4) 456390(MAP2K2) 464496(PBK) 468310(MAP2K6) 743199(MAP2K7)
PPS: 100972424(MAP2K6) 100975020(MAP2K3) 100977025(MAP2K2) 100988422(MAP2K1) 100989445(PBK) 100989537(MAP2K7) 100991495(MAP2K4) 100994910(MAP2K5)
GGO: 101124339(MAP2K7) 101126885(MAP2K2) 101132391(MAP2K1) 101137194(MAP2K5) 101140044(PBK) 101142374(MAP2K6) 101143954(MAP2K4) 101145420(MAP2K3) 101154090
PON: 100431600(MAP2K7) 100439299(MAP2K4) 100446021(MAP2K1) 100448382(MAP2K6) 100449213(MAP2K5) 100450988(MAP2K2) 100453095(PBK) 100457536(MAP2K3)
NLE: 100579506(MAP2K1) 100587140(MAP2K7) 100587718(MAP2K4) 100587879(PBK) 100588703(MAP2K3) 100589848(MAP2K5) 100591256(MAP2K6) 100591827(MAP2K2)
MCC: 693914(MAP2K6) 705195(MAP2K3) 710077(MAP2K7) 710415(MAP2K1) 711672(MAP2K5) 713242(PBK) 718155(MAP2K4) 721821(MAP2K2)
MCF: 101925060(MAP2K6) 102116823(MAP2K3) 102118759(MAP2K5) 102125035(MAP2K4) 102126975(MAP2K7) 102136923(PBK) 102140855(MAP2K2) 102141214(MAP2K1)
CSAB: 103215531(PBK) 103233717(MAP2K2) 103233823(MAP2K7) 103242403(MAP2K4) 103242535(MAP2K3) 103243132(MAP2K6) 103245427(MAP2K5) 103245451(MAP2K1)
RRO: 104654038(MAP2K6) 104662575(MAP2K1) 104662585(MAP2K5) 104665487(MAP2K2) 104672345(MAP2K4) 104673940(PBK) 104678467(MAP2K3) 104679497(MAP2K7)
RBB: 108512087(MAP2K2) 108514672(MAP2K1) 108514696(MAP2K5) 108514958 108517313(MAP2K4) 108521513(MAP2K3) 108523215(MAP2K6) 108534524(MAP2K7) 108537529(PBK)
CJC: 100386168(MAP2K4) 100387394(MAP2K1) 100393991(MAP2K2) 100395249(MAP2K5) 100397389(MAP2K6) 100398406(PBK) 100398593(MAP2K3) 100412930(MAP2K7)
SBQ: 101030219(MAP2K6) 101034633(MAP2K3) 101036151(MAP2K2) 101037589(MAP2K4) 101037814(MAP2K5) 101040361(MAP2K1) 101047840(MAP2K7)
MMU: 23938(Map2k5) 26395(Map2k1) 26396(Map2k2) 26397(Map2k3) 26398(Map2k4) 26399(Map2k6) 26400(Map2k7) 52033(Pbk)
RNO: 108348082 114495(Map2k6) 170851(Map2k1) 287398(Map2k4) 290326(Pbk) 29568(Map2k5) 303200(Map2k3) 363855(Map2k7) 58960(Map2k2)
CGE: 100689403(Map2k1) 100754421(Map2k7) 100755573(Pbk) 100756793(Map2k3) 100760095(Map2k5) 100770977(Map2k4) 100771767(Map2k6) 100774204(Map2k2)
NGI: 103724822(Map2k3) 103726522(Map2k7) 103730027(Pbk) 103736801(Map2k1) 103736811(Map2k5) 103737276(Map2k2) 103742218(Map2k6) 103752052(Map2k4)
HGL: 101703028(Map2k6) 101705822(Map2k4) 101707562(Map2k2) 101710666(Map2k7) 101711080(Map2k5) 101715628(Map2k1) 101718318(Map2k3) 101720410(Pbk)
CCAN: 109685304(Map2k5) 109687808(Map2k2) 109687824(Map2k1) 109692052(Map2k3) 109692543(Pbk) 109693003(Map2k4) 109698434(Map2k7) 109698990(Map2k6)
OCU: 100009316(MAP2K1) 100339953(MAP2K3) 100341076(PBK) 100344852(MAP2K4) 100355230(MAP2K6) 100358715(MAP2K5) 103345313(MAP2K7)
TUP: 102469877(MAP2K5) 102476496(MAP2K1) 102478180(PBK) 102482054(MAP2K6) 102483700(MAP2K2) 102493856(MAP2K4) 102499419(MAP2K3) 102500732(MAP2K7)
CFA: 477371(PBK) 478347(MAP2K1) 480454(MAP2K6) 485004(MAP2K7) 489508(MAP2K4) 489547(MAP2K3) 609559(MAP2K5) 611939(MAP2K2)
AML: 100465700(MAP2K2) 100468286(MAP2K5) 100469111(MAP2K6) 100475919(MAP2K4) 100475975(MAP2K7) 100476678(MAP2K3) 100478039(MAP2K1) 100482572(PBK)
UMR: 103658475(MAP2K3) 103660510(MAP2K4) 103665687(MAP2K6) 103675960(PBK) 103679052(MAP2K5) 103679064(MAP2K1) 103681834(MAP2K2) 103681888(MAP2K7)
ORO: 101365373(MAP2K1) 101375318(PBK) 101376586(MAP2K2) 101378651(MAP2K3) 101382078(MAP2K7) 101382167(MAP2K6) 101383722(MAP2K5) 101386473(MAP2K4)
FCA: 101080784(PBK) 101081387(MAP2K1) 101082274(MAP2K3) 101086432(MAP2K4) 101089813(MAP2K6) 101095157(MAP2K7) 101100281(MAP2K2) 101100725(MAP2K5)
PTG: 102949008(MAP2K5) 102949140(MAP2K7) 102949954(MAP2K3) 102956808(MAP2K2) 102958611(PBK) 102966485(MAP2K6) 102966812(MAP2K4) 102969757(MAP2K1)
AJU: 106970785(MAP2K7) 106973128(PBK) 106975474(MAP2K2) 106980282(MAP2K1) 106980398(MAP2K5) 106981449(MAP2K3) 106986552(MAP2K4) 106988444(MAP2K6)
BTA: 100295732(MAP2K5) 286883(MAP2K6) 510434(MAP2K2) 516039(MAP2K3) 526469(MAP2K4) 533199(MAP2K1) 534781(PBK) 787278(MAP2K7)
BOM: 102267773(MAP2K3) 102271353(PBK) 102271710(MAP2K2) 102272638(MAP2K7) 102272962(MAP2K6) 102280670(MAP2K1) 102283668(MAP2K5) 102287278(MAP2K4)
BIU: 109560948(MAP2K7) 109561751(MAP2K2) 109562807(PBK) 109564697(MAP2K1) 109564709(MAP2K5) 109573853(MAP2K6) 109573969(MAP2K4) 109574182(MAP2K3)
PHD: 102315849(MAP2K3) 102317867(MAP2K6) 102325860(MAP2K2) 102327200(MAP2K7) 102331780(MAP2K5) 102332128(PBK) 102333652(MAP2K4) 102334696 102338050
CHX: 102169516(MAP2K6) 102170427(MAP2K5) 102173178(MAP2K7) 102173967(MAP2K3) 102175285(MAP2K2) 102175799(MAP2K4) 102181210(PBK) 102190520(MAP2K1)
OAS: 100302082(MAP2K7) 101104069(MAP2K5) 101113846(MAP2K2) 101114676(PBK) 101115045(MAP2K4) 101115047(MAP2K6) 101122959(MAP2K3) 101123635(MAP2K1)
SSC: 100141310(PBK) 100233191(MAP2K1) 100520100(MAP2K4) 100520418(MAP2K7) 100525505(MAP2K2) 100625946(MAP2K6) 106504229(MAP2K5) 110256149(MAP2K3)
CFR: 102506459(MAP2K7) 102511209(MAP2K2) 102513578(MAP2K4) 102515937(MAP2K1) 102517293(MAP2K5) 102518252(PBK) 102519784(MAP2K6) 102523780(MAP2K3)
CDK: 105085694(MAP2K6) 105087572(MAP2K7) 105093267(MAP2K1) 105093278(MAP2K5) 105095916(MAP2K4) 105100607(MAP2K3) 105102987(PBK) 105105302(MAP2K2)
BACU: 103011683(MAP2K7) 103012105(MAP2K4) 103012373(PBK) 103012537(MAP2K6) 103017381(MAP2K1) 103018627(MAP2K2) 103019100(MAP2K3) 103019868(MAP2K5)
LVE: 103073248 103080993(PBK) 103081641 103082805(MAP2K1) 103088140(MAP2K5) 103090769(MAP2K2) 103091203(MAP2K4) 103091499(MAP2K7) 103091611(MAP2K3)
OOR: 101270607(MAP2K4) 101275000(PBK) 101275666(MAP2K3) 101280413(MAP2K6) 101286388(MAP2K1) 101287162(MAP2K2) 101288079(MAP2K7) 101289255(MAP2K5)
ECB: 100052849(MAP2K5) 100053056(MAP2K6) 100053481(MAP2K3) 100060789(PBK) 100063190(MAP2K2) 100065996(MAP2K1) 100073094(MAP2K4) 100147230(MAP2K7)
EPZ: 103543290 103543808(MAP2K7) 103549630(MAP2K1) 103550417(PBK) 103561410(MAP2K5) 103563092(MAP2K3) 103564566(MAP2K6) 103567795
EAI: 106825518(MAP2K3) 106830236(MAP2K6) 106832322(MAP2K2) 106832520(PBK) 106840602(MAP2K1) 106840611(MAP2K5) 106844503(MAP2K7) 106845730(MAP2K4)
MYB: 102240696(MAP2K1) 102244251(MAP2K4) 102245571(MAP2K2) 102246913(MAP2K6) 102247950(MAP2K7) 102253993(PBK) 102259712(MAP2K3) 102260280(MAP2K5)
MYD: 102753877(PBK) 102756005(MAP2K5) 102757282(MAP2K2) 102759247(MAP2K6) 102760954(MAP2K7) 102763997(MAP2K1) 102765923(MAP2K3) 102769098(MAP2K4)
HAI: 109371344(MAP2K6) 109379503(PBK) 109385248(MAP2K5) 109385252(MAP2K1) 109388626(MAP2K2) 109389137(MAP2K4) 109390353(MAP2K3) 109396087(MAP2K7)
RSS: 109434721(MAP2K7) 109437043(MAP2K3) 109441932 109442494 109442748 109444309(MAP2K1) 109444318(MAP2K5) 109448056(MAP2K6) 109448121(PBK) 109453977(MAP2K2) 109460161(MAP2K4)
PALE: 102879034(MAP2K2) 102886389(MAP2K3) 102888822(MAP2K6) 102891748(PBK) 102892533(MAP2K7) 102894177(MAP2K5) 102894945(MAP2K4) 102897122(MAP2K1)
LAV: 100655007(MAP2K4) 100656874(PBK) 100657587(MAP2K2) 100662511(MAP2K6) 100667623(MAP2K1) 100669040(MAP2K5) 100673238(MAP2K7) 100675607(MAP2K3)
MDO: 100014462 100016872(MAP2K3) 100018044(MAP2K2) 100018410(MAP2K1) 100019828(MAP2K4) 100025486(MAP2K5) 100026752(MAP2K7) 100029049(MAP2K6) 100030502(PBK)
SHR: 100917396(MAP2K2) 100921899(MAP2K1) 100922086(PBK) 100924259(MAP2K5) 100925586(MAP2K3) 100926110(MAP2K7) 100931587(MAP2K4) 100934929
OAA: 100077802(PBK) 100078394(MAP2K6) 100080362(MAP2K1) 100080734(MAP2K3) 100085895(MAP2K5) 100087942 100089737(MAP2K7) 100091407
GGA: 107050551 396349(MAP2K2) 415549(MAP2K1) 415557(MAP2K5) 416496(MAP2K3) 417312(MAP2K4) 417445(MAP2K6) 422003(PBK)
MGP: 100542290(MAP2K3) 100543421(MAP2K1) 100544509(MAP2K5) 100544828(MAP2K4) 100545287(MAP2K6) 100550535(PBK) 100551337(MAP2K2)
CJO: 107307804 107312368(PBK) 107318914(MAP2K5) 107318921(MAP2K1) 107320760(MAP2K3) 107322198(MAP2K6) 107322213(MAP2K4) 107325595(MAP2K2)
APLA: 101791037(MAP2K1) 101793398(MAP2K2) 101794019(MAP2K7) 101798109(PBK) 101799389(MAP2K6) 101801808(MAP2K5) 101803371(MAP2K3) 101805315(MAP2K4)
ACYG: 106032094(MAP2K3) 106034753(MAP2K6) 106043651(MAP2K1) 106043660(MAP2K5) 106044951(MAP2K2) 106047193(MAP2K4) 106049517(PBK)
TGU: 100219724(MAP2K5) 100219801(MAP2K4) 100225195(MAP2K2) 100226448(MAP2K1) 100229860(MAP2K3)
GFR: 102031727(MAP2K1) 102032727(MAP2K5) 102037348(MAP2K4) 102038813(MAP2K7) 102039295(MAP2K3) 102039445(MAP2K6) 102041148(MAP2K2) 102042100(PBK)
FAB: 101808780 101809415(MAP2K3) 101812216 101815546(MAP2K5) 101816905(MAP2K1) 101819388(MAP2K6) 101820507(MAP2K2) 101822010(MAP2K4) 101822092(PBK)
PHI: 102100701(MAP2K7) 102102285(MAP2K2) 102102585(MAP2K4) 102105268(MAP2K6) 102106364(MAP2K5) 102109535(MAP2K3) 102110075(MAP2K1) 102114327(PBK)
PMAJ: 107198843(MAP2K7) 107198946(PBK) 107209134(MAP2K5) 107209483(MAP2K1) 107211348(MAP2K3) 107212284(MAP2K6) 107212510(MAP2K4) 107215477(MAP2K2)
CCW: 104683873(MAP2K5) 104683880(MAP2K1) 104684789(MAP2K3) 104695676(MAP2K4) 104696025(MAP2K6) 104697410(MAP2K2)
FPG: 101913671(MAP2K6) 101918161(MAP2K4) 101919170(MAP2K3) 101922949(PBK) 101924219(MAP2K7) 101924296(MAP2K2) 101924559(MAP2K5) 101924998(MAP2K1)
FCH: 102047307(MAP2K4) 102048069(MAP2K7) 102048212(PBK) 102049695(MAP2K2) 102052703(MAP2K3) 102053088(MAP2K6) 102053397(MAP2K1) 102053857(MAP2K5)
CLV: 102084805(PBK) 102085143(MAP2K3) 102085780(MAP2K4) 102086996(MAP2K6) 102095101(MAP2K5) 102096091(MAP2K1) 102097053(MAP2K2)
EGZ: 104124397(MAP2K2) 104125237(MAP2K5) 104129979(MAP2K7) 104132033(PBK) 104132608(MAP2K3) 104132828(MAP2K6) 104133527(MAP2K1) 104133811(MAP2K4)
AAM: 106486395(PBK) 106486833 106487663(MAP2K1) 106490233(MAP2K6) 106492199(MAP2K2) 106494573(MAP2K5) 106496868(MAP2K4)
ASN: 102372350(MAP2K7) 102373782(MAP2K6) 102373880(MAP2K1) 102375508(MAP2K2) 102378558(PBK) 102379245(MAP2K4) 102380357(MAP2K5) 102383945(MAP2K3)
AMJ: 102560641(PBK) 102562496(MAP2K7) 102563228(MAP2K1) 102566638(MAP2K3) 102574038(MAP2K5) 102577347(MAP2K4) 106736984(MAP2K6) 106736997(MAP2K2)
PSS: 102443595(MAP2K1) 102451373(MAP2K5) 102452927(MAP2K4) 102453281(PBK) 102454019(MAP2K3) 102457075(MAP2K2) 102461243(MAP2K6) 102463924(MAP2K7)
CMY: 102929430 102931357(MAP2K2) 102932325(MAP2K7) 102934520(PBK) 102939584(MAP2K3) 102942953(MAP2K6) 102945547(MAP2K1) 102946856(MAP2K5)
CPIC: 101931768(MAP2K7) 101935028(MAP2K6) 101936976(MAP2K3) 101938330(MAP2K2) 101938416(PBK) 101939128(MAP2K4) 101948796(MAP2K5) 101949355(MAP2K1)
ACS: 100556629(map2k4) 100558982 100561588(map2k3) 100562970(map2k5) 100565867(pbk) 100566152(map2k7) 100567176(map2k2) 100567963(map2k6)
PVT: 110072466(MAP2K2) 110075065(MAP2K4) 110077815(MAP2K6) 110082669(MAP2K7) 110085468(MAP2K1) 110087206(MAP2K3) 110087994(MAP2K5) 110090553(PBK)
PBI: 103051071(MAP2K1) 103051479(PBK) 103058491(MAP2K6) 103059198(MAP2K5) 103061657(MAP2K4) 103065723(MAP2K3) 103066234(MAP2K7) 103067786(MAP2K2)
GJA: 107113289(MAP2K5) 107113793(PBK) 107117671(MAP2K7) 107118240(MAP2K2) 107120519 107121194(MAP2K1) 107122462(MAP2K6) 107123125(MAP2K4)
XLA: 108706146 108712658 108712802(map2k1.S) 379638(map2k6.L) 379991(map2k1.L) 394391(map2k7.S) 399150(map2k3) 399471(map2k4.L) 414694(map2k5.L) 431908(map2k4.S) 496340(pbk.L)
XTR: 100135013(map2k4) 448132(map2k6) 493420(map2k1) 496810(pbk) 549042(map2k5) 613115(map2k7)
NPR: 108784075(MAP2K5) 108784101(MAP2K1) 108790540(MAP2K7) 108796918(PBK) 108801499(MAP2K4)
DRE: 100002225(map2k2b) 100007679(map2k5) 360218(pbk) 403052(map2k4a) 406728(map2k1) 560913(map2k7) 563181(map2k2a) 568951(map2k4b) 65239(map2k6)
IPU: 100528123(mp2k2) 100528146(pbk) 108258614(map2k7) 108259579(map2k5) 108264753(map2k1) 108271291 108272999(map2k4) 108274084(map2k6) 108274195
AMEX: 103024363(map2k7) 103025205(pbk) 103027486(map2k5) 103028644(map2k1) 103030512(map2k2) 103042940 103045018(map2k4) 111191499
TRU: 101063584(map2k1) 101064151 101064650(map2k7) 101064673 101070236(map2k2) 101072590(pbk) 101073869(map2k6) 101078396(map2k5) 101078980
NCC: 104944235(map2k6) 104946717(map2k4) 104947390 104948325 104948326 104949852(map2k5) 104951572(map2k7) 104953947(pbk) 104963431(map2k2) 104965132 104967860(map2k1)
OLA: 101161098 101162677(map2k1) 101163933 101164950(map2k7) 101169919(map2k5) 101170843 101171635(pbk) 101173453(map2k2) 101174917(map2k4)
XMA: 102217036(map2k1) 102219049 102221885 102225231 102225775(map2k2) 102232155(map2k4) 102234956(pbk) 102235643(map2k5) 102238025(map2k7)
PRET: 103457318(pbk) 103461263 103462105(map2k5) 103463649(map2k2) 103466546(map2k1) 103467648(map2k7) 103468828 103469437 103481589 103481917(map2k4)
NFU: 107377770(pbk) 107378273 107381740(map2k5) 107382265(map2k7) 107387425 107388720(map2k1) 107393294(map2k2) 107397308(map2k4) 107397353
CSEM: 103376625(map2k2) 103379107(map2k5) 103380238(map2k1) 103381131(pbk) 103382222 103382416(map2k4) 103383563(map2k7) 103392559 103392800
SFM: 108919814 108921692(map2k2) 108922496 108923933(map2k3) 108924851 108926724(map2k1) 108928494(pbk) 108934673(map2k5) 108939797(map2k7) 108940146(map2k4) 108941534
LCM: 102350370(MAP2K2) 102351267(MAP2K3) 102352547(MAP2K4) 102353461(PBK) 102357895(MAP2K5) 102358560(MAP2K1) 102362389(MAP2K6) 102365163(MAP2K7)
CMK: 103173024(map2k7) 103175698(map2k4) 103175734(map2k6) 103178264(pbk) 103183530(map2k2) 103185143 103186399(map2k1) 103189582(map2k5)
CIN: 100179846 778672(mapkk4) 778673(mapkk5) 778674(mapkk7) 778902(mapkk3/6) 778923(mapkk1/2)
DSI: Dsimw501_GD15909(Dsim_GD15909) Dsimw501_GD16945(Dsim_Dsor1) Dsimw501_GD17342(Dsim_GD17342) Dsimw501_GD20857(Dsim_GD20857) Dsimw501_GD24803(Dsim_lic)
AME: 409925(Dsor1) 410575(MAPKK4) 413389(hem) 551365 725374(GB16739)
CEL: CELE_F35C8.3(jkk-1) CELE_F42G10.2(mkk-4) CELE_K08A8.1(mek-1) CELE_R03G5.2(sek-1) CELE_VZC374L.1(sek-6) CELE_Y54E10BL.6(mek-2)
CBR: CBG01940(Cbr-mkk-4) CBG04190(Cbr-mek-2) CBG14676(Cbr-jkk-1) CBG16698(Cbr-mek-1) CBG16802(Cbr-sek-1)
ATH: AT1G51660(MKK4) AT1G73500(MKK9) AT3G21220(MKK5) AT4G26070(MEK1) AT4G29810(MKK2) AT5G40440(MKK3) AT5G56580(MKK6)
LJA: Lj0g3v0328319.1(Lj0g3v0328319.1) Lj2g3v0648070.1(Lj2g3v0648070.1) Lj2g3v0890200.1(Lj2g3v0890200.1) Lj2g3v0934140.1(Lj2g3v0934140.1) Lj2g3v1496150.1(Lj2g3v1496150.1) Lj3g3v2040150.1(Lj3g3v2040150.1) Lj4g3v2172990.1(Lj4g3v2172990.1) Lj4g3v2172990.2(Lj4g3v2172990.2) Lj6g3v1211800.1(Lj6g3v1211800.1)
SLY: 101252056 543720(mek1) 543946(MKK2) 543947(MKK3) 543948(MKK4)
DOSA: Os01t0510100-01(Os01g0510100) Os02t0787300-01(Os02g0787300) Os06t0147800-01(Os06g0147800) Os06t0191300-01(Os06g0191300) Os06t0473200-01(Os06g0473200)
ATS: 109733284(LOC109733284) 109734638(LOC109734638) 109734813(LOC109734813) 109736155(LOC109736155) 109743739(LOC109743739) 109763919(LOC109763919) 109766288(LOC109766288) 109779339(LOC109779339) 109779340(LOC109779340) 109780008(LOC109780008) 109780014(LOC109780014) 109783679(LOC109783679) 109784980(LOC109784980)
CRE: CHLREDRAFT_155835(MAPKK1)
MNG: MNEG_0570
APRO: F751_3118
SCE: YDL159W(STE7) YJL128C(PBS2) YOR231W(MKK1) YPL140C(MKK2)
KMX: KLMA_20786(MKK1) KLMA_60035(PBS2) KLMA_70246(STE7)
NCS: NCAS_0A09750(NCAS0A09750) NCAS_0A14050(NCAS0A14050) NCAS_0B01450(NCAS0B01450) NCAS_0C01580(NCAS0C01580)
NDI: NDAI_0A01970(NDAI0A01970) NDAI_0E01310(NDAI0E01310) NDAI_0G06150(NDAI0G06150)
TPF: TPHA_0B01150(TPHA0B01150) TPHA_0B03130(TPHA0B03130) TPHA_0F02870(TPHA0F02870) TPHA_0G01730(TPHA0G01730)
TBL: TBLA_0B03990(TBLA0B03990) TBLA_0D05640(TBLA0D05640) TBLA_0F02350(TBLA0F02350)
TDL: TDEL_0A05980(TDEL0A05980) TDEL_0C02110(TDEL0C02110) TDEL_0H01070(TDEL0H01070)
KAF: KAFR_0A03710(KAFR0A03710) KAFR_0B00920(KAFR0B00920) KAFR_0G01810(KAFR0G01810)
SLB: AWJ20_2035(PBS2) AWJ20_2320(MKK2) AWJ20_312(STE7)
NCR: NCU00587(os-5) NCU04612(mek-2) NCU06419(mek-1)
NTE: NEUTE1DRAFT34238(NEUTE1DRAFT_34238) NEUTE1DRAFT62379(NEUTE1DRAFT_62379) NEUTE1DRAFT92974(NEUTE1DRAFT_92974)
SMP: SMAC_01279(putative os5) SMAC_02183(putative mek1) SMAC_06526(putative mek2)
BFU: BCIN_04g05630(Bcste7)
ANG: ANI_1_1390094(An11g10690) ANI_1_3024014(An01g11080) ANI_1_476164(An18g03740)
ZTR: MYCGRDRAFT_52389(MgSte7) MYCGRDRAFT_71299(MgMkk1) MYCGRDRAFT_76249(MgPbs2)
SPO: SPAC1D4.13(byr1) SPBC409.07c(wis1) SPBC543.07(pek1)
ABP: AGABI1DRAFT114072(AGABI1DRAFT_114072) AGABI1DRAFT123361(AGABI1DRAFT_123361) AGABI1DRAFT38036(AGABI1DRAFT_38036) AGABI1DRAFT71099(AGABI1DRAFT_71099)
ABV: AGABI2DRAFT185122(AGABI2DRAFT_185122) AGABI2DRAFT186680(AGABI2DRAFT_186680) AGABI2DRAFT187496(AGABI2DRAFT_187496) AGABI2DRAFT70301(AGABI2DRAFT_70301)
DDI: DDB_G0269152(mekA)
SMIN: v1.2.017385.t1(symbB.v1.2.017385.t1) v1.2.018514.t1(symbB.v1.2.018514.t1) v1.2.031054.t1(symbB.v1.2.031054.t1) v1.2.031054.t3(symbB.v1.2.031054.t3)
TCR: 511075.60
 » show all
Taxonomy
Reference
1  [PMID:8004006]
  Authors
Mordret G.
  Title
MAP kinase kinase: a node connecting multiple pathways.
  Journal
Biol. Cell. 79 (1993) 193-207.
Reference
2  [PMID:8388392]
  Authors
Zheng CF, Guan KL.
  Title
Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2.
  Journal
J. Biol. Chem. 268 (1993) 11435-9.
  Sequence
[hsa:5604 5605]
Reference
3  [PMID:8393135]
  Authors
Wu J, Harrison JK, Dent P, Lynch KR, Weber MJ, Sturgill TW.
  Title
Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2.
  Journal
Mol. Cell. Biol. 13 (1993) 4539-48.
  Sequence
[rno:58960]
Reference
4  [PMID:8157000]
  Authors
Alessi DR, Saito Y, Campbell DG, Cohen P, Sithanandam G, Rapp U, Ashworth A, Marshall CJ, Cowley S.
  Title
Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.
  Journal
EMBO. J. 13 (1994) 1610-9.
  Sequence
[ocu:100009316]
Reference
5  [PMID:7731726]
  Authors
Pham CD, Arlinghaus RB, Zheng CF, Guan KL, Singh B.
  Title
Characterization of MEK1 phosphorylation by the v-Mos protein.
  Journal
Oncogene. 10 (1995) 1683-8.
Reference
6  [PMID:8621675]
  Authors
Han J, Lee JD, Jiang Y, Li Z, Feng L, Ulevitch RJ.
  Title
Characterization of the structure and function of a novel MAP kinase kinase (MKK6).
  Journal
J. Biol. Chem. 271 (1996) 2886-91.
  Sequence
[hsa:5608]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.12.2
IUBMB Enzyme Nomenclature: 2.7.12.2
ExPASy - ENZYME nomenclature database: 2.7.12.2
BRENDA, the Enzyme Database: 2.7.12.2

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