KEGG   ENZYME: 2.7.3.2Help
Entry
EC 2.7.3.2                  Enzyme                                 
Name
creatine kinase;
ATP:creatine phosphotransferase;
CK;
MM-CK;
MB-CK;
BB-CK;
creatine phosphokinase;
creatine phosphotransferase;
phosphocreatine kinase;
adenosine triphosphate-creatine transphosphorylase;
Mi-CK;
CK-BB;
CK-MM;
CK-MB;
CKMiMi;
MiMi-CK
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a nitrogenous group as acceptor
BRITE hierarchy
Sysname
ATP:creatine N-phosphotransferase
Reaction(IUBMB)
ATP + creatine = ADP + phosphocreatine [RN:R01881]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
creatine [CPD:C00300]
Product
ADP [CPD:C00008];
phosphocreatine [CPD:C02305]
Comment
N-Ethylglycocyamine can also act as acceptor.
Pathway
Arginine and proline metabolism
Metabolic pathways
Orthology
K00933  
creatine kinase
Genes
HSA: 
1152(CKB) 1158(CKM) 1159(CKMT1B) 1160(CKMT2) 548596(CKMT1A)
PTR: 
100608872 453185(CKB) 461770(CKMT2) 744935(CKM)
PPS: 
100971845(CKMT2) 100993597(CKM)
GGO: 
101125452(CKM) 101126518(CKMT2) 101152129(CKMT1B)
PON: 
MCC: 
711167(CKB) 711434(CKMT2) 712886
MMU: 
12709(Ckb) 12715(Ckm) 12716(Ckmt1) 76722(Ckmt2)
RNO: 
24264(Ckb) 24265(Ckm) 29593(Ckmt1b) 688698(Ckmt2)
CFA: 
100855552 476435(CKM) 478277(CKMT1B) 479163(CKMT2)
AML: 
FCA: 
101088213(CKMT2) 101095936(CKM) 101097983(CKMT1B) 101098237(CKB)
BTA: 
100851864 281692(CKMT1B) 286822(CKM) 516210(CKB) 538944(CKMT2)
SSC: 
100519994 100627332(CKB) 397264(CKM) 733602(CKMT2)
ECB: 
100055201 100056283(CKMT1B) 100065641 100073253
MDO: 
100011609(CKMT1B) 100012235 100015112 100017071
SHR: 
100919833(CKMT2) 100920419(CKMT1B) 100921738(CKB)
OAA: 
100076820 100081308 100082097 100085972(CKMT1B)
GGA: 
374002(CKMT1A) 396248(CKB) 396507(CKM) 396508(CKMT2)
MGP: 
100538538 100550185
TGU: 
100190470 100225089(CKMT2) 100228000
ACS: 
100554759 100559238
XLA: 
379216(ckmt1b-b) 379765(ckm) 380055(ckb) 380155(ckmt1b-a)
XTR: 
395000(ckmt1b) 395005(ckm) 733543(ckb)
DRE: 
140744(ckbb) 30095(ckma) 321892(ckmt1) 799492(ckmt2)
TRU: 
101069967 101074201 101077669 101079669
OLA: 
101156742 101164721 101166239 101174062
BFO: 
BRAFLDRAFT_216834 BRAFLDRAFT_88544
CIN: 
100176946 100178756 100181049
SPU: 
373287(TCK) 589605 762696
DPO: 
Dpse_GA16624
DAN: 
Dana_GF23510
DER: 
Dere_GG15040
DPE: 
Dper_GL15080
DSE: 
Dsec_GM24893
DSI: 
Dsim_GD14150
DWI: 
Dwil_GK23865
DYA: 
Dyak_GE21263
DGR: 
Dgri_GH15902
DMO: 
Dmoj_GI16555
DVI: 
Dvir_GJ12807
AGA: 
AgaP_AGAP005627
AAG: 
AaeL_AAEL009185
CQU: 
CpipJ_CPIJ007538
AME: 
550932(Argk)
NVI: 
100114388(NV12741)
TCA: 
660479
PHU: 
Phum_PHUM616180
ISC: 
IscW_ISCW021028
CBR: 
CBG04174 CBG11000
BMY: 
Bm1_23610
NVE: 
NEMVE_v1g234345 NEMVE_v1g88035
HMG: 
100212485
AQU: 
100632036 100635973
ZMA: 
100273160
MBR: 
MONBRDRAFT_21418 MONBRDRAFT_34875
PTI: 
PHATRDRAFT_11733
TPS: 
THAPSDRAFT_263946
PIF: 
PITG_11046
NSA: 
Nitsa_0767
DPS: 
DP1035
 » show all
Taxonomy
Reference
1  [PMID:13235819]
  Authors
ENNOR AH, ROSENBERG H, ARMSTRONG MD.
  Title
Specificity of creatine phosphokinase.
  Journal
Nature. 175 (1955) 120.
Reference
2  [PMID:5750168]
  Authors
Keutel HJ, Jacobs HK, Okabe K, Yue RH, Kuby SA.
  Title
Studies on adenosine triphosphate transphosphorylases. VII. Isolation of the crystalline adenosine triphosphate--creatine transphosphorylase from calf brain.
  Journal
Biochemistry. 7 (1968) 4283-90.
  Organism
Bos taurus [GN:bta]
Reference
3  [PMID:13192073]
  Authors
KUBY SA, NODA L, LARDY HA.
  Title
Adenosinetriphosphate-creatine transphosphorylase. I. Isolation of the crystalline enzyme from rabbit muscle.
  Journal
J. Biol. Chem. 209 (1954) 191-201.
  Organism
Oryctolagus cuniculus
Reference
4
  Authors
Kuby, S.A. and Noltmann, E.A.
  Title
ATP-creatine transphosphorylase.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 6, Academic Press, New York, 1962, p. 515-603.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9001-15-4
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