KEGG   ENZYME: 2.7.4.24Help
Entry
EC 2.7.4.24                 Enzyme                                 

Name
diphosphoinositol-pentakisphosphate kinase;
PP-IP5 kinase;
diphosphoinositol pentakisphosphate kinase;
ATP:5-diphospho-1D-myo-inositol-pentakisphosphate phosphotransferase;
PP-InsP5 kinase;
PPIP5K;
PPIP5K1;
PPIP5K2;
VIP1;
VIP2
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a phosphate group as acceptor
BRITE hierarchy
Sysname
ATP:1D-myo-inositol-5-diphosphate-pentakisphosphate phosphotransferase
Reaction(IUBMB)
(1) ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate [RN:R08964];
(2) ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate [RN:R05799]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate [CPD:C11526];
1D-myo-inositol hexakisphosphate [CPD:C01204]
Product
ADP [CPD:C00008];
1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate [CPD:C20690];
1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate [CPD:C11174]
Comment
This enzyme is activated by osmotic shock [4]. Ins(1,3,4,5,6)P5, 1D-myo-inositol diphosphate tetrakisphosphate and 1D-myo-inositol bisdiphosphate triphosphate are not substrates [4].
History
EC 2.7.4.24 created 2003 as EC 2.7.1.155, transferred 2007 to EC 2.7.4.24, modified 2014
Orthology
K13024  
inositol hexakisphosphate/diphosphoinositol-pentakisphosphate kinase
Genes
HSA: 
23262(PPIP5K2) 9677(PPIP5K1)
PTR: 
100608132 453381(PPIP5K1) 461976(PPIP5K2)
PPS: 
100969708(PPIP5K2)
GGO: 
101151797(PPIP5K2) 101153329(PPIP5K1)
PON: 
100171621(PPIP5K2)
MCC: 
703458(PPIP5K2) 710588
MCF: 
102130122(PPIP5K2)
MMU: 
227399(Ppip5k2) 327655(Ppip5k1)
RNO: 
311355(Ppip5k1)
CGE: 
100767441(Ppip5k1) 100769408(Ppip5k2)
HGL: 
101719804(Ppip5k2) 101722963(Ppip5k1)
TUP: 
102468274(PPIP5K1) 102475948(PPIP5K2)
CFA: 
478276(PPIP5K1) 488883(PPIP5K2)
AML: 
FCA: 
101091503(PPIP5K2) 101098233(PPIP5K1)
PTG: 
102960108(PPIP5K2) 102971201(PPIP5K1)
BTA: 
510684(PPIP5K1) 780855(PPIP5K2)
BOM: 
102273676(PPIP5K2) 102280665(PPIP5K1)
PHD: 
102335892(PPIP5K1) 102336419(PPIP5K2)
CHX: 
102181541(PPIP5K1) 102190688(PPIP5K2)
SSC: 
100520287(PPIP5K1) 100625306(PPIP5K2)
CFR: 
102510231(PPIP5K2) 102524244(PPIP5K1)
BACU: 
103002825(PPIP5K1) 103010253(PPIP5K2)
LVE: 
103080540(PPIP5K1) 103087706(PPIP5K2)
ECB: 
100064726(PPIP5K2) 100070782(PPIP5K1)
MYB: 
102260148(PPIP5K1) 102260503(PPIP5K2)
MYD: 
102758169(PPIP5K1) 102771195(PPIP5K2)
PALE: 
102880534(PPIP5K1) 102896791(PPIP5K2)
MDO: 
100011533(PPIP5K1) 100030703(PPIP5K2)
SHR: 
100925666(PPIP5K2) 100927893(PPIP5K1)
OAA: 
100074142(PPIP5K2)
GGA: 
415587(PPIP5K1) 427276(PPIP5K2)
TGU: 
100224061(PPIP5K2) 100225111(PPIP5K1)
FAB: 
101808161(PPIP5K1) 101820580(PPIP5K2)
PHI: 
102102428(PPIP5K1) 102114390(PPIP5K2)
APLA: 
101796180(PPIP5K2) 101804165(PPIP5K1)
FPG: 
101912634(PPIP5K1) 101918574(PPIP5K2)
FCH: 
102047825(PPIP5K1) 102058743(PPIP5K2)
CLV: 
102086840(PPIP5K2) 102090237(PPIP5K1)
ASN: 
102373631(PPIP5K2) 102386038(PPIP5K1)
AMJ: 
102560130(PPIP5K2) 102570807(PPIP5K1)
PSS: 
102459058(PPIP5K1) 102461289(PPIP5K2)
CMY: 
102934620(PPIP5K1) 102946417(PPIP5K2)
ACS: 
PBI: 
XLA: 
495012(ppip5k2)
XTR: 
100135086(ppip5k2) 100493265(ppip5k1)
DRE: 
449862(ppip5k2) 556748(ppip5k1)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102345122 102345812(PPIP5K1) 102349094(PPIP5K2)
CMK: 
103178403(ppip5k2) 103188433(ppip5k1)
BFO: 
CIN: 
100182708(ppip5k1)
SPU: 
574572(PPIP5K2)
DME: 
Dmel_CG14616(l(1)G0196)
DPO: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
725179(GB19480)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
CEL: 
CELE_F46F11.1(F46F11.1)
CBR: 
BMY: 
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
CSV: 
RCU: 
POP: 
POPTR_0004s135001 POPTR_0004s135002(POPTRDRAFT_831208) POPTR_0017s11280g(POPTRDRAFT_736216)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os01t0777700-00(Os01g0777700) Os03t0689100-01(Os03g0689100)
OBR: 
BDI: 
SBI: 
SORBI_01g011620(SORBIDRAFT_01g011620) SORBI_03g036270(SORBIDRAFT_03g036270)
SITA: 
ATR: 
s00054p00189880(AMTR_s00054p00189880)
SMO: 
PPP: 
CRE: 
VCN: 
OTA: 
MIS: 
MPP: 
BPG: 
CSL: 
CVR: 
CCP: 
MBR: 
DFA: 
TET: 
PTM: 
PTI: 
TPS: 
PIF: 
EHX: 
GTT: 
 » show all
Taxonomy
Reference
1  [PMID:7737983]
  Authors
Shears SB, Ali N, Craxton A, Bembenek ME.
  Title
Synthesis and metabolism of bis-diphosphoinositol tetrakisphosphate in vitro and in vivo.
  Journal
J. Biol. Chem. 270 (1995) 10489-97.
Reference
2  [PMID:9359429]
  Authors
Albert C, Safrany ST, Bembenek ME, Reddy KM, Reddy K, Falck J, Brocker M, Shears SB, Mayr GW.
  Title
Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cells.
  Journal
Biochem. J. 327 ( Pt 2) (1997) 553-60.
  Organism
Dictyostelium discoideum
Reference
3  [PMID:17690096]
  Authors
Fridy PC, Otto JC, Dollins DE, York JD.
  Title
Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinases.
  Journal
J. Biol. Chem. 282 (2007) 30754-62.
  Organism
Homo sapiens, Mus musculus
  Sequence
[hsa:23262 9677] [mmu:227399]
Reference
4  [PMID:17702752]
  Authors
Choi JH, Williams J, Cho J, Falck JR, Shears SB.
  Title
Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress.
  Journal
J. Biol. Chem. 282 (2007) 30763-75.
  Organism
Homo sapiens, Rattus norvegicus
  Sequence
[hsa:23262 9677] [rno:311355]
Reference
5  [PMID:18981179]
  Authors
Lin H, Fridy PC, Ribeiro AA, Choi JH, Barma DK, Vogel G, Falck JR, Shears SB, York JD, Mayr GW
  Title
Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases.
  Journal
J. Biol. Chem. 284 (2009) 1863-72.
Reference
6  [PMID:22119861]
  Authors
Wang H, Falck JR, Hall TM, Shears SB
  Title
Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding.
  Journal
Nat. Chem. Biol. 8 (2012) 111-6.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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