KEGG   ENZYME: 2.7.4.24Help
Entry
EC 2.7.4.24                 Enzyme                                 
Name
diphosphoinositol-pentakisphosphate kinase;
PP-IP5 kinase;
diphosphoinositol pentakisphosphate kinase;
ATP:5-diphospho-1D-myo-inositol-pentakisphosphate phosphotransferase;
PP-InsP5 kinase;
PPIP5K;
PPIP5K1;
PPIP5K2;
VIP1;
VIP2
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a phosphate group as acceptor
BRITE hierarchy
Sysname
ATP:1D-myo-inositol-5-diphosphate-pentakisphosphate phosphotransferase
Reaction(IUBMB)
ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate = ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate (isomeric configuration unknown) [RN:R08964]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
1D-myo-inositol 5-diphosphate pentakisphosphate [CPD:C11526]
Product
ADP [CPD:C00008];
1D-myo-inositol bisdiphosphate tetrakisphosphate [CPD:C18058]
Comment
This enzyme is activated by osmotic shock [4]. The enzyme can also phosphorylate InsP6, but more slowly [4]. Ins(1,3,4,5,6)P5, POP-InsP4 and (POP)2-InsP3 are not substrates [4].
Orthology
K13024  
inositol hexakisphosphate/diphosphoinositol-pentakisphosphate kinase
Genes
HSA: 
23262(PPIP5K2) 9677(PPIP5K1)
PTR: 
100608132 453381(PPIP5K1) 461976(PPIP5K2)
PPS: 
100969708(PPIP5K2)
GGO: 
101151797(PPIP5K2) 101153329(PPIP5K1)
PON: 
100171621(PPIP5K2)
MCC: 
703458(PPIP5K2) 710588
MMU: 
227399(Ppip5k2) 327655(Ppip5k1)
RNO: 
311355(Ppip5k1)
CFA: 
478276(PPIP5K1) 488883(PPIP5K2)
AML: 
FCA: 
101091503(PPIP5K2) 101098233(PPIP5K1)
BTA: 
510684(PPIP5K1) 780855(PPIP5K2)
SSC: 
100520287 100625306(PPIP5K2)
ECB: 
100064726(PPIP5K2)
MDO: 
100011533(PPIP5K1) 100030703(PPIP5K2)
SHR: 
100925666(PPIP5K2) 100927893(PPIP5K1)
OAA: 
100074142(PPIP5K2)
GGA: 
415587(PPIP5K1) 427276(PPIP5K2)
TGU: 
100224061(PPIP5K2) 100225111(PPIP5K1)
ACS: 
100554395(ppip5k1) 100568184
XLA: 
495012(ppip5k2)
XTR: 
100135086(ppip5k2) 100493265(ppip5k1)
DRE: 
449862 556748(ppip5k1)
TRU: 
101078927
OLA: 
101165380
BFO: 
BRAFLDRAFT_118894
CIN: 
100182708(ppip5k1)
SPU: 
574572(PPIP5K2)
DME: 
Dmel_CG14616(l(1)G0196)
DPO: 
Dpse_GA13115
DER: 
Dere_GG19746
DPE: 
Dper_GL13299
DSE: 
Dsec_GM11733
DSI: 
Dsim_GD24413
DWI: 
Dwil_GK25772
DYA: 
Dyak_GE17941
DGR: 
Dgri_GH24076
DMO: 
Dmoj_GI14473
DVI: 
Dvir_GJ18811
AGA: 
AgaP_AGAP000926
AAG: 
AaeL_AAEL008950
CQU: 
CpipJ_CPIJ012460
AME: 
725179
NVI: 
100115546(NV15853)
TCA: 
663934
API: 
100158865
PHU: 
Phum_PHUM208020
CEL: 
CELE_F46F11.1(F46F11.1)
CBR: 
CBG14896
BMY: 
Bm1_57300
TSP: 
Tsp_10123
SMM: 
Smp_045860.1
NVE: 
NEMVE_v1g20017
HMG: 
100198226
TAD: 
TRIADDRAFT_19973
AQU: 
100635064
ALY: 
ARALYDRAFT_488348
GMX: 
100776866
MTR: 
MTR_7g009060
CSV: 
101210866
RCU: 
RCOM_0854040
POP: 
POPTR_831208
VVI: 
100262888
DOSA: 
Os03t0689100-01(Os03g0689100)
BDI: 
100830891
SBI: 
SORBI_01g011620(SORBIDRAFT_01g011620)
SMO: 
SELMODRAFT_429797 SELMODRAFT_444048
PPP: 
PHYPADRAFT_184130 PHYPADRAFT_187835
CRE: 
CHLREDRAFT_115639(FAP160)
VCN: 
VOLCADRAFT_56293
OTA: 
Ot03g03030
MBR: 
MONBRDRAFT_37460
PTM: 
GSPATT00006245001 GSPATT00009575001
PTI: 
PHATR_46684
TPS: 
THAPSDRAFT_12441
PIF: 
PITG_03590 PITG_17745
 » show all
Taxonomy
Reference
1  [PMID:7737983]
  Authors
Shears SB, Ali N, Craxton A, Bembenek ME.
  Title
Synthesis and metabolism of bis-diphosphoinositol tetrakisphosphate in vitro and in vivo.
  Journal
J. Biol. Chem. 270 (1995) 10489-97.
Reference
2  [PMID:9359429]
  Authors
Albert C, Safrany ST, Bembenek ME, Reddy KM, Reddy K, Falck J, Brocker M, Shears SB, Mayr GW.
  Title
Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cells.
  Journal
Biochem. J. 327 ( Pt 2) (1997) 553-60.
  Organism
Dictyostelium discoideum [GN:ddi]
Reference
3  [PMID:17690096]
  Authors
Fridy PC, Otto JC, Dollins DE, York JD.
  Title
Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinases.
  Journal
J. Biol. Chem. 282 (2007) 30754-62.
  Organism
Homo sapiens [GN:hsa], Mus musculus [GN:mmu]
  Sequence
HSA: 23262 9677
MMU: 227399
Reference
4  [PMID:17702752]
  Authors
Choi JH, Williams J, Cho J, Falck JR, Shears SB.
  Title
Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress.
  Journal
J. Biol. Chem. 282 (2007) 30763-75.
  Organism
Homo sapiens [GN:hsa], Rattus norvegicus [GN:rno]
  Sequence
HSA: 23262 9677
RNO: 311355
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
DBGET integrated database retrieval system