KEGG   ENZYME: 2.7.7.86Help
Entry
EC 2.7.7.86                 Enzyme                                 

Name
cyclic GMP-AMP synthase;
cGAMP synthase;
cGAS
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
ATP:GTP adenylyltransferase (cyclizing)
Reaction(IUBMB)
ATP + GTP = 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5') (overall reaction) [RN:R10462];
(1a) ATP + GTP = pppGp(2'-5')A + diphosphate;
(1b) pppGp(2'-5')A = cyclic Gp(2'-5')Ap(3'-5') + diphosphate
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
GTP [CPD:C00044];
pppGp(2'-5')A
Product
diphosphate [CPD:C00013];
cyclic Gp(2'-5')Ap(3'-5') [CPD:C20640];
pppGp(2'-5')A
Comment
Cyclic Gp(2'-5')Ap(3'-5') is a signalling molecule in mammalian cells that triggers the production of type I interferons and other cytokines.
History
EC 2.7.7.86 created 2013, modified 2014
Orthology
K17834  cyclic GMP-AMP synthase
Genes
HSA: 115004(CGAS)
PTR: 462822(CGAS)
PPS: 100990327(MB21D1)
GGO: 101146170(MB21D1)
PON: 100456001(CGAS)
NLE: 100583298(MB21D1)
MCC: 717665(MB21D1)
MCF: 102133276(MB21D1)
CSAB: 103243898(MB21D1)
RRO: 104669277(MB21D1)
RBB: 108529201(MB21D1)
CJC: 100387233(MB21D1)
SBQ: 101052976(MB21D1)
MMU: 214763(Mb21d1)
RNO: 682147(Mb21d1)
NGI: 103744364(Mb21d1)
HGL: 101717623(Mb21d1)
OCU: 100349407(MB21D1)
TUP: 102474401(MB21D1)
CFA: 611033(MB21D1)
AML: 100471590(MB21D1)
UMR: 103657480(MB21D1)
ORO: 101374743(MB21D1)
FCA: 101098056(CGAS)
PTG: 102952381(MB21D1)
AJU: 106980198(MB21D1)
BTA: 782472(MB21D1)
BOM: 102285090(MB21D1)
BIU: 109563704(MB21D1)
PHD: 102315593(MB21D1)
CHX: 102187049(MB21D1)
OAS: 101117253(MB21D1)
SSC: 100516408(MB21D1)
CFR: 102523852(MB21D1)
CDK: 105099837(MB21D1)
LVE: 103082954(MB21D1)
OOR: 101289557(MB21D1)
ECB: 100067982(CGAS)
EPZ: 103562297(MB21D1)
EAI: 106827075(MB21D1)
MYB: 102243555
MYD: 102775467(MB21D1)
HAI: 109387546(MB21D1)
RSS: 109456819(MB21D1)
PALE: 102883365(MB21D1)
LAV: 100664322(CGAS)
TMU: 101344880
MDO: 100021282(MB21D1)
SHR: 100920386(CGAS)
OAA: 100087769(MB21D1)
GGA: 421864(MB21D1)
MGP: 100549716(MB21D1)
CJO: 107312047(MB21D1)
APLA: 101797757(MB21D1)
ACYG: 106030386(MB21D1)
TGU: 100224044(MB21D1)
GFR: 102042126(MB21D1)
FAB: 101809319(MB21D1)
PHI: 102108130(MB21D1)
PMAJ: 107201290(MB21D1)
CCW: 104694402(MB21D1)
FPG: 101922902(MB21D1)
FCH: 102047663(MB21D1)
CLV: 102091030(MB21D1)
EGZ: 104125162(MB21D1)
AAM: 106492488(MB21D1)
ASN: 102379168 102388310(MB21D1)
AMJ: 102565317(MB21D1) 102576030
PSS: 102447277(MB21D1)
CPIC: 101937365(MB21D1) 101951637
ACS: 100567354(mb21d1)
PVT: 110075025(MB21D1)
GJA: 107107013 107123189(MB21D1)
XLA: 108704160(mb21d1.L) 108717996
XTR: 100488048(mb21d1)
DRE: 557043(mb21d1)
SRX: 107706136 107718834(mb21d1)
IPU: 108256977 108263730(mb21d1)
AMEX: 103037406(mb21d1) 103045125
OLA: 101161502(cgas)
XMA: 102238245(cgas) 106699738
NFU: 107375894(mb21d1)
LCF: 108873443(mb21d1) 108898898
BPEC: 110156913(mb21d1)
LCM: 102346272(MB21D1) 102353888
CMK: 103172828
NVL: 108568334
EPA: 110240579
HMG: 105850432
 » show all
Taxonomy
Reference
1  [PMID:23258413]
  Authors
Sun L, Wu J, Du F, Chen X, Chen ZJ
  Title
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.
  Journal
Science. 339 (2013) 786-91.
  Sequence
[hsa:115004] [mmu:214763]
Reference
2  [PMID:23722158]
  Authors
Ablasser A, Goldeck M, Cavlar T, Deimling T, Witte G, Rohl I, Hopfner KP, Ludwig J, Hornung V.
  Title
cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates  STING.
  Journal
Nature. 498 (2013) 380-4.
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.86
IUBMB Enzyme Nomenclature: 2.7.7.86
ExPASy - ENZYME nomenclature database: 2.7.7.86
BRENDA, the Enzyme Database: 2.7.7.86

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