| Entry |
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| Name |
carboxylesterase;
ali-esterase;
B-esterase;
monobutyrase;
cocaine esterase;
procaine esterase;
methylbutyrase;
vitamin A esterase;
butyryl esterase;
carboxyesterase;
carboxylate esterase;
carboxylic esterase;
methylbutyrate esterase;
triacetin esterase;
carboxyl ester hydrolase;
butyrate esterase;
methylbutyrase;
alpha-carboxylesterase;
propionyl esterase;
nonspecific carboxylesterase;
esterase D;
esterase B;
esterase A;
serine esterase;
carboxylic acid esterase;
cocaine esterase
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| Class |
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
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| Sysname |
carboxylic-ester hydrolase
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| Reaction(IUBMB) |
a carboxylic ester + H2O = an alcohol + a carboxylate [RN: R00630]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Wide specificity. The enzymes from microsomes also catalyse the reactions of EC 3.1.1.2 (arylesterase), EC 3.1.1.5 (lysophospholipase), EC 3.1.1.6 (acetylesterase), EC 3.1.1.23 (acylglycerol lipase), EC 3.1.1.28 (acylcarnitine hydrolase), EC 3.1.2.2 (palmitoyl-CoA hydrolase), EC 3.5.1.4 (amidase) and EC 3.5.1.13 (aryl-acylamidase). Also hydrolyses vitamin A esters.
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| Pathway |
| Drug metabolism - other enzymes |
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| Orthology |
| carboxylesterase 1 | | carboxylesterase 2 | | carboxylesterase | | carboxylesterase 3/5 |
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | MCC: | | MMU: | | RNO: | | CFA: | | AML: | | FCA: | | BTA: | | SSC: | | ECB: | | MDO: | | SHR: | | OAA: | | GGA: | | TGU: | | ACS: | | XTR: | | DRE: | | BFO: | | CIN: | | DME: | | DPO: | | CEL: | | CBR: | | FGR: | | NHE: | | SSL: | | BFU: | | ANI: | | NFI: | | AFM: | | AOR: | | ANG: | | AFV: | | PCS: | | XAL: | | SML: | | SMT: | | BUJ: | | SMZ: | | RHD: | | PFL: | | PFS: | | PFC: | | PPZ: | | LPN: | | LPU: | | LPF: | | LPP: | | LPC: | | LPA: | | LPE: | | LLO: | | CVI: | | LHK: | | RPI: | | RPF: | | REU: | | RME: | | BPS: | | BPM: | | BPL: | | BPD: | | BPZ: | | BPQ: | | BTD: | | BUR: | | BCN: | | BCH: | | BCM: | | BCJ: | | BPH: | | BPY: | | BGL: | | BUG: | | BGF: | | BGD: | | BYI: | | BPX: | | PNU: | | AXY: | | AAV: | | AAA: | | DAC: | | DEL: | | VAP: | | VPE: | | CTT: | | HSE: | | CFU: | | RGE: | | DAR: | | DSU: | | MEH: | | MEI: | | MEP: | | SLT: | | GCA: | | PCA: | | DVU: | | DVL: | | DVM: | | DVG: | | DDE: | | DAF: | | DRT: | | BMX: | | ADE: | | ACP: | | AFW: | | ANK: | | MXA: | | MFU: | | MSD: | | CCX: | | SUR: | | HOH: | | ARA: | | AVI: | | AGR: | | RTR: | | RPA: | | RPB: | | RPT: | | RPX: | | XAU: | | AZC: | | HDN: | | HDT: | | HMC: | | AZL: | | BSU: | | BSR: | | BSL: | | BSH: | | BSY: | | BSS: | | BST: | | BSO: | | BSN: | | BSQ: | | BSUB: | | BSX: | | BLI: | | BLD: | | BAO: | | BAY: | | BAQ: | | BYA: | | BAMP: | | BAML: | | BAZ: | | BQL: | | BXH: | | BQY: | | BAMI: | | BAE: | | BHA: | | BAN: | | BAR: | | BAT: | | BAH: | | BAI: | | BAX: | | BAL: | | BCE: | | BCA: | | BCZ: | | BCR: | | BCB: | | BCU: | | BCG: | | BCQ: | | BCX: | | BNC: | | BCF: | | BCER: | | BCY: | | BTK: | | BTL: | | BTB: | | BTT: | | BTC: | | BTF: | | BTM: | | BTG: | | BTI: | | BTN: | | BTHT: | | BWE: | | BCL: | | BPU: | | BPF: | | BMQ: | | BMD: | | BMH: | | BSE: | | BCO: | | BCK: | | BAG: | | BJS: | | BACI: | | OIH: | | GKA: | | GTN: | | GTH: | | GTE: | | GWC: | | GYC: | | GYA: | | GCT: | | GMC: | | GGH: | | AFL: | | AXL: | | SAU: | | SAV: | | SAW: | | SAH: | | SAJ: | | SAM: | | SAS: | | SAR: | | SAC: | | SAX: | | SAA: | | SAO: | | SAE: | | SAD: | | SUU: | | SUV: | | SUH: | | SUE: | | SUJ: | | SUK: | | SUC: | | SUT: | | SUQ: | | SUZ: | | SUD: | | SUX: | | SUW: | | SUG: | | SUF: | | SAB: | | SUY: | | SAUB: | | SAUM: | | SEP: | | SER: | | SHA: | | SSP: | | SCA: | | SLG: | | SLN: | | SSD: | | SDT: | | SWA: | | LMO: | | LMF: | | LMH: | | LMC: | | LMN: | | LMY: | | LMT: | | LMG: | | LMS: | | LMJ: | | LMQ: | | LML: | | LMP: | | LMW: | | LMX: | | LMZ: | | LMON: | | LMOC: | | LMOS: | | LMOO: | | LMOY: | | LMOT: | | LMOA: | | LMOL: | | LMOG: | | LMOE: | | LMOB: | | LIN: | | LWE: | | LSG: | | LIV: | | LSP: | | HHD: | | ESI: | | EAT: | | EAN: | | MCL: | | BBE: | | PMS: | | PMQ: | | PMW: | | BTS: | | SIV: | | LPL: | | LPJ: | | LPT: | | LPS: | | LSA: | | LBR: | | LBK: | | LCA: | | LCB: | | LCZ: | | LCS: | | LCE: | | LCW: | | LRE: | | LRF: | | LRU: | | LRH: | | LRG: | | LRL: | | LRA: | | LBH: | | LBN: | | EFA: | | EFL: | | EFI: | | EFD: | | EFS: | | EFC: | | EFU: | | EFM: | | EHR: | | ECAS: | | MPS: | | MPX: | | THL: | | AUR: | | CRN: | | CML: | | CSR: | | STH: | | SWO: | | SLP: | | SGY: | | DOR: | | DAI: | | DMI: | | DED: | | DEC: | | CLE: | | CPO: | | TNR: | | NTH: | | HOR: | | HAS: | | HPK: | | HHL: | | SSG: | | SRI: | | MHG: | | AFN: | | AIN: | | SCO: | | SMA: | | SGR: | | SCB: | | SSX: | | SVL: | | SCT: | | SCY: | | SFA: | | SBH: | | SHY: | | SHO: | | SVE: | | SDV: | | SALB: | | STRP: | | SFI: | | KSK: | | ART: | | AAU: | | ACH: | | AAI: | | APN: | | ARR: | | RSA: | | KRH: | | MLU: | | RMU: | | RDN: | | BFA: | | KSE: | | MPH: | | NCA: | | KFL: | | NDA: | | NAL: | | SRO: | | FRA: | | FRE: | | FRI: | | FAL: | | FSY: | | NML: | | BSD: | | KRA: | | SVI: | | TBI: | | AMD: | | AMN: | | AMM: | | CAI: | | SNA: | | AYM: | | TPA: | | TPP: | | TPU: | | TPH: | | TPO: | | TPC: | | TPG: | | TPM: | | TPB: | | TDE: | | TPL: | | SSM: | | SCC: | | SCD: | | SFC: | | TPX: | | SBU: | | SGP: | | SLI: | | GAU: | | SYG: | | SYX: | | CYA: | | CYB: | | SYNE: | | TEL: | | CYN: | | AMR: | | GVI: | | CEP: | | ARP: | | CTE: | | CPC: | | CCH: | | CPH: | | CPB: | | CLI: | | PVI: | | PLT: | | PPH: | | PAA: | | RRS: | | RCA: | | CAU: | | CAG: | | CHL: | | HAU: | | TRO: | | STI: | | ATM: | | CAP: | | TRA: | | TTH: | | TTJ: | | TTS: | | TTL: | | TSC: | | THC: | | TOS: | | MRB: | | MRE: | | MSV: | | OPR: | | MHD: | | HYA: | | HHO: | | HYS: | | SUL: | | SAF: | | TMA: | | TPT: | | TLE: | | TRQ: | | TNA: | | TNP: | | TTA: | | TME: | | TAF: | | FNO: | | FPE: | | PMO: | | KOL: | | MPZ: | | DDF: | | DAP: | | CNI: | | FSI: | | CEX: | | MOX: | |
» show all
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| Reference |
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| Authors |
Augusteyn RC, de Jersey J, Webb EC, Zerner B. |
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| Title |
On the homology of the active-site peptides of liver carboxylesterases. |
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| Journal |
Biochim. Biophys. Acta. 171 (1969) 128-37. |
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| Organism |
Bos taurus [GN: bta], Sus scofa [GN: ssc], Gallus gallus [GN: gga], Ovis aries |
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| Reference |
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| Authors |
Barker DL, Jencks WP. |
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| Title |
Pig liver esterase. Physical properties. |
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| Journal |
Biochemistry. 8 (1969) 3879-89. |
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| Organism |
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| Reference |
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| Authors |
Bertram J, Krisch K. |
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| Title |
Hydrolysis of vitamin A acetate by unspecific carboxylesterases from liver and kidney. |
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| Journal |
Eur. J. Biochem. 11 (1969) 122-6. |
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| Organism |
Homo sapiens [GN: hsa], Bos taurus [GN: bta], Sus scofa [GN: ssc] |
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| Reference |
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| Authors |
BURCH J. |
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| Title |
The purification and properties of horse liver esterase. |
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| Journal |
Biochem. J. 58 (1954) 415-26. |
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| Organism |
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| Reference |
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| Authors |
Horgan DJ, Stoops JK, Webb EC, Zerner B. |
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| Title |
Carboxylesterases (EC 3.1.1). A large-scale purification of pig liver carboxylesterase. |
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| Journal |
Biochemistry. 8 (1969) 2000-6. |
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| Organism |
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| Reference |
6 |
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| Authors |
Malhotra, O.P. and Philip, G. |
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| Title |
Specificity of goat intestinal esterase. |
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| Journal |
Biochem. Z. 346 (1966) 386-402. |
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| Reference |
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| Authors |
Mentlein R, Schumann M, Heymann E. |
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| Title |
Comparative chemical and immunological characterization of five lipolytic enzymes (carboxylesterases) from rat liver microsomes. |
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| Journal |
Arch. Biochem. Biophys. 234 (1984) 612-21. |
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| Organism |
Rattus norvegicus [GN: rno] |
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| Reference |
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| Authors |
Runnegar MT, Scott K, Webb EC, Zerner B. |
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| Title |
Carboxylesterases (EC 3.1.1). Purification and titration of ox liver carboxylesterase. |
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| Journal |
Biochemistry. 8 (1969) 2013-8. |
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| Organism |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: UM-BBD (Biocatalysis/Biodegradation Database): BRENDA, the Enzyme Database: CAS: 9016-18-6 |
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