KEGG   ENZYME: 3.1.1.13Help
Entry
EC 3.1.1.13                 Enzyme                                 
Name
sterol esterase;
cholesterol esterase;
cholesteryl ester synthase;
triterpenol esterase;
cholesteryl esterase;
cholesteryl ester hydrolase;
sterol ester hydrolase;
cholesterol ester hydrolase;
cholesterase;
acylcholesterol lipase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
steryl-ester acylhydrolase
Reaction(IUBMB)
a steryl ester + H2O = a sterol + a fatty acid [RN:R02115]
Reaction(KEGG)
Substrate
steryl ester [CPD:C01958];
H2O [CPD:C00001]
Product
sterol [CPD:C00370];
fatty acid [CPD:C00162]
Comment
A group of enzymes of broad specificity, acting on esters of sterols and long-chain fatty acids, that may also bring about the esterification of sterols. Activated by bile salts.
Pathway
Steroid biosynthesis
Orthology
K01052  
lysosomal acid lipase/cholesteryl ester hydrolase
K12298  
bile salt-stimulated lipase
K14674  
TAG lipase / steryl ester hydrolase / phospholipase A2 / LPA acyltransferase
Genes
HSA: 
1056(CEL) 3988(LIPA)
PTR: 
466150(LIPA) 473081(CEL)
PPS: 
100969434(CEL) 100974714(LIPA)
GGO: 
PON: 
MCC: 
695240(LIPA) 722291(CEL)
MMU: 
12613(Cel) 16889(Lipa)
RNO: 
24254(Cel) 25055(Lipa)
CFA: 
AML: 
FCA: 
101080585(CEL) 101094134(LIPA)
BTA: 
100125267(LIPA) 280748(CEL)
SSC: 
100142668(LIPA) 100625953(CEL)
ECB: 
100066592(CEL) 100071626(LIPA)
MDO: 
100017734(CEL) 100026924
SHR: 
100918682(CEL)
GGA: 
417165(CEL) 423789(LIPA)
MGP: 
100539880 100551061
TGU: 
100219865(LIPA) 100227302(CEL)
ACS: 
100553883 100566622(cel)
XLA: 
379474(cel) 380547(cel) 447025(cel) 495520 734759(lipa)
XTR: 
100144991(cel) 100492444 548564(lipa)
DRE: 
322481(cel.1) 406713(lipf) 573994(cell)
TRU: 
101070169 101074906
OLA: 
101172670 101172916
BFO: 
BRAFLDRAFT_72470
SPU: 
586550
BMY: 
Bm1_21635
SMM: 
Smp_011000(yeh1)
NVE: 
NEMVE_v1g171796 NEMVE_v1g188332
HMG: 
100211176
TAD: 
TRIADDRAFT_54597
AQU: 
100641835
ATH: 
AT3G57140(SDP1-LIKE) AT5G04040(SDP1)
ALY: 
ARALYDRAFT_487184(SDP1) ARALYDRAFT_907172
GMX: 
100791261 100807526 100816093
MTR: 
MTR_1g087300
CSV: 
101220288 101229483
RCU: 
RCOM_0254330
POP: 
POPTR_560432 POPTR_903983
VVI: 
100258980
OSA: 
4327023 4334536
DOSA: 
Os01t0762000-01(Os01g0762000) Os03t0810900-01(Os03g0810900)
BDI: 
100825185 100830722
SBI: 
SORBI_01g003870(SORBIDRAFT_01g003870) SORBI_03g035280(SORBIDRAFT_03g035280)
ZMA: 
100382466(AY110479)
SMO: 
SELMODRAFT_116556 SELMODRAFT_236717
PPP: 
PHYPADRAFT_120017 PHYPADRAFT_122940 PHYPADRAFT_156678
CRE: 
CHLREDRAFT_183258
VCN: 
VOLCADRAFT_117294
OLU: 
OSTLU_4077 OSTLU_41292
OTA: 
Ot06g03440 Ot17g02310
CME: 
CMJ049C
SCE: 
YKR089C(TGL4)
AGO: 
AGOS_ADR231C
ERC: 
Ecym_4030
KLA: 
KLLA0A07557g
LTH: 
KLTH0F18172g
PPA: 
PAS_chr2-1_0466
VPO: 
Kpol_489p10
ZRO: 
ZYRO0G14520g
CGR: 
CAGL0G02365g
NCS: 
NCAS_0A03250(NCAS0A03250)
NDI: 
NDAI_0E04990(NDAI0E04990)
TPF: 
TPHA_0G00420(TPHA0G00420) TPHA_0H01400(TPHA0H01400)
TBL: 
TBLA_0A09160(TBLA0A09160) TBLA_0I01620(TBLA0I01620)
TDL: 
TDEL_0B02320(TDEL0B02320)
KAF: 
KAFR_0H00280(KAFR0H00280)
DHA: 
DEHA2E05390g
PIC: 
PICST_40606
PGU: 
PGUG_02614
LEL: 
LELG_02304
CAL: 
CaO19.12881 CaO19.5426
CTP: 
CTRG_06185
CDU: 
CD36_80370
COT: 
CORT_0D06530
YLI: 
YALI0F10010g
CLU: 
CLUG_00597
NCR: 
NCU09407
SMP: 
SMAC_05668
PAN: 
PODANSg2357
TTT: 
THITE_2116976
MTM: 
MYCTH_2308988
MGR: 
MGG_05933
FGR: 
FG07555.1
NHE: 
NECHADRAFT_48024
VAL: 
VDBG_07116
SSL: 
SS1G_04723
BFU: 
BC1G_00078
ANI: 
AN1713.2
NFI: 
NFIA_107730
AFM: 
AFUA_4G08440
AOR: 
AOR_1_1234144(AO090023000717)
ANG: 
ANI_1_1740184(An04g03220)
AFV: 
AFLA_111240
ACT: 
ACLA_047810
PCS: 
Pc16g07520
CIM: 
CIMG_08841
CPW: 
CPC735_063630
PBL: 
PAAG_03194
URE: 
UREG_02722
AJE: 
HCAG_06225
PNO: 
SNOG_00639
PTE: 
PTT_20213
ZTR: 
MYCGRDRAFT_86046
TML: 
GSTUM_00008945001
SPO: 
SPAC1A6.05c
MBR: 
MONBRDRAFT_31257
DDI: 
DDB_G0268740
PTI: 
PHATRDRAFT_1971
TPS: 
THAPSDRAFT_41637
PIF: 
PITG_09954
 » show all
Taxonomy
Reference
1  [PMID:5780846]
  Authors
Hyun J, Kothari H, Herm E, Mortenson J, Treadwell CR, Vahouny GV.
  Title
Purification and properties of pancreatic juice cholesterol esterase.
  Journal
J. Biol. Chem. 244 (1969) 1937-45.
  Organism
Rattus norvegicus [GN:rno]
Reference
2  [PMID:19426]
  Authors
Okawa Y, Yamaguchi T.
  Title
Studies on sterol-ester hydrolase from Fusarium oxysporum. I. Partial purification and properties.
  Journal
J. Biochem. (Tokyo). 81 (1977) 1209-15.
  Organism
Fusarium oxysporum
Reference
3  [PMID:4877146]
  Authors
Vahouny GV, Treadwell CR.
  Title
Enzymatic synthesis and hydrolysis of cholesterol esters.
  Journal
Methods. Biochem. Anal. 16 (1968) 219-72.
Reference
4
  Authors
Warnaar, F.
  Title
Triterpene ester synthesis in latex of Euphorbia species.
  Journal
Phytochemistry 26 (1987) 2715-2721.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9026-00-0
DBGET integrated database retrieval system