KEGG   ENZYME: 3.1.1.13Help
Entry
EC 3.1.1.13                 Enzyme                                 

Name
sterol esterase;
cholesterol esterase;
cholesteryl ester synthase;
triterpenol esterase;
cholesteryl esterase;
cholesteryl ester hydrolase;
sterol ester hydrolase;
cholesterol ester hydrolase;
cholesterase;
acylcholesterol lipase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
steryl-ester acylhydrolase
Reaction(IUBMB)
a steryl ester + H2O = a sterol + a fatty acid [RN:R02115]
Reaction(KEGG)
Substrate
steryl ester [CPD:C01958];
H2O [CPD:C00001]
Product
sterol [CPD:C00370];
fatty acid [CPD:C00162]
Comment
A group of enzymes of broad specificity, acting on esters of sterols and long-chain fatty acids, that may also bring about the esterification of sterols. Activated by bile salts.
History
EC 3.1.1.13 created 1961, modified 1990
Pathway
ec00100  Steroid biosynthesis
Orthology
K01052  lysosomal acid lipase/cholesteryl ester hydrolase
K12298  bile salt-stimulated lipase
K14674  TAG lipase / steryl ester hydrolase / phospholipase A2 / LPA acyltransferase
Genes
HSA: 1056(CEL) 3988(LIPA)
PTR: 466150(LIPA) 473081(CEL)
PPS: 100969434(CEL) 100974714(LIPA)
GGO: 101125608 101125617(LIPA) 101144373(CEL)
PON: 100453604(LIPA) 100457585(CEL)
NLE: 100583764(LIPA) 100607639(CEL)
MCC: 695240(LIPA) 722291(CEL)
MCF: 101926160(LIPA) 102122348(CEL)
CSAB: 103216227(LIPA) 103239707(CEL)
RRO: 104669739(CEL) 104675144(LIPA)
RBB: 108513558(CEL) 108526597(LIPA)
CJC: 100398767(LIPA) 100412304(CEL)
SBQ: 101029494(CEL) 101032685(LIPA)
MMU: 12613(Cel) 16889(Lipa)
RNO: 24254(Cel) 25055(Lipa)
CGE: 100759060(Lipa) 100771549(Cel)
NGI: 103738034(Lipa) 103742832(Cel)
HGL: 101696378(Cel) 101713991(Lipa)
CCAN: 109691002(Cel) 109694733(Lipa)
OCU: 100009339(CEL) 100338588(LIPA)
TUP: 102477415(LIPA) 102500820(CEL)
CFA: 100856363(LIPA) 491280(CEL)
AML: 100472032(CEL) 100474016(LIPA)
UMR: 103661937(LIPA) 103670398(CEL)
ORO: 101362375(CEL) 101386245(LIPA)
FCA: 101080585(CEL) 101094134(LIPA)
PTG: 102951064(LIPA) 102965473(CEL)
AJU: 106980973(LIPA) 106985323(CEL)
BTA: 100125267(LIPA) 280748(CEL)
BOM: 102271904(LIPA) 102281926(CEL)
BIU: 109566574(CEL) 109579141(LIPA)
PHD: 102317188(CEL) 102338072(LIPA)
CHX: 102169934(LIPA) 102179573(CEL)
OAS: 100145859(LIPA) 101112299(CEL)
SSC: 100142668(LIPA) 100625953(CEL)
CFR: 102505197(CEL) 102517055(LIPA)
CDK: 105085185(CEL) 105102834(LIPA)
BACU: 103007835(CEL) 103018305(LIPA)
LVE: 103077341(LIPA) 103087076(CEL)
OOR: 101271382(LIPA) 101274747(CEL)
ECB: 100066592(CEL) 100071626(LIPA)
EPZ: 103553673(CEL) 103566588(LIPA)
EAI: 106831920(LIPA) 106845365(CEL)
HAI: 109377125 109382351(CEL)
RSS: 109446017(CEL) 109451064(LIPA)
PALE: 102879308(LIPA) 102879935(CEL)
LAV: 100658667(LIPA) 100666155(CEL)
MDO: 100017734(CEL) 100026924
SHR: 100918682(CEL) 100930405
OAA: 100080788(CEL)
GGA: 417165(CEL) 423789(LIPA)
MGP: 100539880(CEL) 100551061(LIPA)
CJO: 107315868(LIPA) 107315905 107321688(CEL)
APLA: 101795108(LIPA) 101799287(CEL) 101804243
TGU: 100219865(LIPA) 100227302(CEL)
CMY: 102938843(CEL) 102938945 102940789(LIPA)
XLA: 379474(cel.L) 380547(cel) 447025(cel) 495520 734759(lipa.L)
XTR: 100144991(cel) 100492444 548564(lipa)
DRE: 322481(cel.1) 406713(lipf) 565117(cel.2) 573994(cell)
IPU: 108273662(LIPA) 108279340(cel)
SFM: 108922669(cel) 108939690
LCM: 102348301(LIPA) 102351701 102353515(CEL)
SPU: 586550
SKO: 100371642
DME: Dmel_CG11406(CG11406) Dmel_CG18301(CG18301) Dmel_CG6113(Lip4) Dmel_CG8823(Lip3)
DSI: Dsimw501_GD18849(Dsim_GD18849) Dsimw501_GD20506(Dsim_GD20506) Dsimw501_GD23714(Dsim_GD23714) Dsimw501_GD24968(Dsim_GD24968) Dsimw501_GD28358(Dsim_GD28358)
AME: 409999(GB19317)
BIM: 100740326
BTER: 100652319
CEL: CELE_F54F3.3(lipl-1) CELE_ZK6.7(lipl-5)
BMY: Bm1_21635
TSP: Tsp_03103
AQU: 100641835
ATH: AT3G57140(SDP1-LIKE) AT5G04040(SDP1)
LJA: Lj0g3v0247869.1(Lj0g3v0247869.1) Lj0g3v0247879.1(Lj0g3v0247879.1) Lj0g3v0349529.1(Lj0g3v0349529.1) Lj1g3v4202350.1(Lj1g3v4202350.1) Lj2g3v2876120.1(Lj2g3v2876120.1) Lj5g3v1806990.1(Lj5g3v1806990.1) Lj6g3v0204560.1(Lj6g3v0204560.1)
PAVI: 110770245
DOSA: Os01t0762000-01(Os01g0762000) Os03t0810900-01(Os03g0810900) Os09t0103100-01(Os09g0103100)
ATS: 109743981(LOC109743981) 109745312(LOC109745312) 109758862(LOC109758862) 109777748(LOC109777748) 109784727(LOC109784727) 109787652(LOC109787652)
SCE: YKL140W(TGL1) YKR089C(TGL4)
ERC: Ecym_4030
KMX: KLMA_10402(TGL4)
NCS: NCAS_0A03250(NCAS0A03250) NCAS_0A04210(NCAS0A04210) NCAS_0G00340(NCAS0G00340)
NDI: NDAI_0E01950(NDAI0E01950) NDAI_0E04990(NDAI0E04990) NDAI_0F00390(NDAI0F00390)
TPF: TPHA_0G00420(TPHA0G00420) TPHA_0G02260(TPHA0G02260) TPHA_0H01400(TPHA0H01400)
TBL: TBLA_0A09160(TBLA0A09160) TBLA_0B09130(TBLA0B09130) TBLA_0I01620(TBLA0I01620)
TDL: TDEL_0A02000(TDEL0A02000) TDEL_0B02320(TDEL0B02320)
KAF: KAFR_0D02330(KAFR0D02330) KAFR_0D02890(KAFR0D02890) KAFR_0H00280(KAFR0H00280)
CAL: CAALFM_C113510CA(TGL99) CAALFM_C200740CA(CaO19.2050) CAALFM_C300400CA(CaO19.5426)
SLB: AWJ20_1457(TGL1) AWJ20_3409(TGL4)
NTE: NEUTE1DRAFT131060(NEUTE1DRAFT_131060) NEUTE1DRAFT70443(NEUTE1DRAFT_70443)
ANG: ANI_1_1698064(An07g04200) ANI_1_1740184(An04g03220)
ABE: ARB_00738
TVE: TRV_03371
ABP: AGABI1DRAFT71247(AGABI1DRAFT_71247)
ABV: AGABI2DRAFT204141(AGABI2DRAFT_204141)
DFA: DFA_11463
SMIN: v1.2.016398.t1(symbB.v1.2.016398.t1) v1.2.037542.t1(symbB.v1.2.037542.t1)
SPAR: SPRG_10696
 » show all
Taxonomy
Reference
1  [PMID:5780846]
  Authors
Hyun J, Kothari H, Herm E, Mortenson J, Treadwell CR, Vahouny GV.
  Title
Purification and properties of pancreatic juice cholesterol esterase.
  Journal
J. Biol. Chem. 244 (1969) 1937-45.
Reference
2  [PMID:19426]
  Authors
Okawa Y, Yamaguchi T.
  Title
Studies on sterol-ester hydrolase from Fusarium oxysporum. I. Partial purification and properties.
  Journal
J. Biochem. (Tokyo). 81 (1977) 1209-15.
Reference
3  [PMID:4877146]
  Authors
Vahouny GV, Treadwell CR.
  Title
Enzymatic synthesis and hydrolysis of cholesterol esters.
  Journal
Methods. Biochem. Anal. 16 (1968) 219-72.
Reference
4
  Authors
Warnaar, F.
  Title
Triterpene ester synthesis in latex of Euphorbia species.
  Journal
Phytochemistry 26 (1987) 2715-2721.
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.13
IUBMB Enzyme Nomenclature: 3.1.1.13
ExPASy - ENZYME nomenclature database: 3.1.1.13
BRENDA, the Enzyme Database: 3.1.1.13
CAS: 9026-00-0

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