KEGG   ENZYME: 3.1.1.7Help
Entry
EC 3.1.1.7                  Enzyme                                 
Name
acetylcholinesterase;
true cholinesterase;
choline esterase I;
cholinesterase;
acetylthiocholinesterase;
acetylcholine hydrolase;
acetyl.beta-methylcholinesterase;
AcCholE
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
acetylcholine acetylhydrolase
Reaction(IUBMB)
acetylcholine + H2O = choline + acetate [RN:R01026]
Reaction(KEGG)
Substrate
acetylcholine [CPD:C01996];
H2O [CPD:C00001]
Product
choline [CPD:C00114];
acetate [CPD:C00033]
Comment
Acts on a variety of acetic esters; also catalyses transacetylations.
Pathway
Glycerophospholipid metabolism
Orthology
K01049  
acetylcholinesterase
Genes
HSA: 
43(ACHE)
PTR: 
100609296(ACHE)
PPS: 
100980268(ACHE)
GGO: 
101143749(ACHE)
PON: 
100432513(ACHE)
MCC: 
713370(ACHE)
MMU: 
11423(Ache)
RNO: 
83817(Ache)
CFA: 
489828(ACHE)
AML: 
FCA: 
493674(ACHE)
BTA: 
540446(ACHE)
SSC: 
100621099
ECB: 
100069149
MDO: 
100017989
SHR: 
100923959(ACHE)
OAA: 
100087817
GGA: 
396388(ACHE)
XLA: 
100158421(ache)
XTR: 
100490673
DRE: 
114549(ache)
TRU: 
101066574
OLA: 
101161586
BFO: 
BRAFLDRAFT_119542
CIN: 
100169895(ache)
SPU: 
762935
DME: 
Dmel_CG17907(Ace)
DPO: 
Dpse_GA14718
DAN: 
Dana_GF17399
DER: 
Dere_GG17071
DPE: 
Dper_GL23135
DSE: 
Dsec_GM25956
DSI: 
Dsim_GD20515(Dsim_Ace)
DWI: 
Dwil_GK22772(Dwil_Ace)
DYA: 
Dyak_GE24460
DGR: 
Dgri_GH19184
DMO: 
Dmoj_GI24219
DVI: 
Dvir_GJ10790
AGA: 
AgaP_AGAP000466 AgaP_AGAP001356(ACES_ANOGA)
AAG: 
AaeL_AAEL000511 AaeL_AAEL012141
CQU: 
CpipJ_CPIJ000662 CpipJ_CPIJ006034
AME: 
406104(AChE-2) 410270(AChE-1)
NVI: 
100115855(AChE-1) 100121967(AChE-2)
TCA: 
659368(AChE-2) 662258(AChE-1)
API: 
100168865 100169250
PHU: 
Phum_PHUM391440 Phum_PHUM490200
ISC: 
IscW_ISCW012339
CEL: 
CELE_W09B12.1(ace-1) CELE_Y44E3A.2(ace-2) CELE_Y48B6A.7(ace-4)
CBR: 
CBG02827(Cbr-ace-4) CBG14965(Cbr-ace-2) CBG16374(Cbr-ace-1)
BMY: 
Bm1_47660
TSP: 
Tsp_03785
NVE: 
NEMVE_v1g171912
TAD: 
TRIADDRAFT_1836 TRIADDRAFT_1914 TRIADDRAFT_31923 TRIADDRAFT_32085 TRIADDRAFT_61121
AFM: 
AFUA_7G01710
TGO: 
TGME49_117000
 » show all
Taxonomy
Reference
1
  Authors
Augustinsson, K.-B.
  Title
Cholinesterases. A study in comparative enzymology.
  Journal
Acta Physiol. Scand. 15, Suppl. 2 (1948)
Reference
2  [PMID:13522650]
  Authors
BERGMANN F, RIMON S, SEGAL R.
  Title
Effect of pH on the activity of eel esterase towards different substrates.
  Journal
Biochem. J. 68 (1958) 493-9.
  Organism
Rattus norvegicus [GN:rno], Bos taurus [GN:bta]
Reference
3  [PMID:5073758]
  Authors
Ciliv G, Ozand PT.
  Title
Human erythrocyte acetylcholinesterase purification, properties and kinetic behavior.
  Journal
Biochim. Biophys. Acta. 284 (1972) 136-56.
  Organism
Homo sapiens [GN:hsa]
Reference
4  [PMID:5238989]
  Authors
Leuzinger W, Baker AL, Cauvin E.
  Title
Acetylcholinesterase. II. Crystallization, absorption spectra, isoionic point.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 59 (1968) 620-3.
  Organism
Electrophorus electricus
Reference
5  [PMID:14885021]
  Authors
NACHMANSOHN D, WILSON IB.
  Title
The enzymic hydrolysis and synthesis of acetylcholine.
  Journal
Adv. Enzymol. Relat. Subj. Biochem. 12 (1951) 259-339.
Reference
6  [PMID:14377597]
  Authors
ZITTLE CA, DELLAMONICA ES, CUSTER JH, KRIKORIAN R.
  Title
Purification of human red cell acetylcholinesterase by electrophoresis, ultracentrifugation and gradient extraction.
  Journal
Arch. Biochem. 56 (1955) 469-75.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9000-81-1
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