KEGG   ENZYME: 3.1.2.18Help
Entry
EC 3.1.2.18                 Enzyme                                 

Name
ADP-dependent short-chain-acyl-CoA hydrolase;
short-chain acyl coenzyme A hydrolase;
propionyl coenzyme A hydrolase;
propionyl-CoA hydrolase;
propionyl-CoA thioesterase;
short-chain acyl-CoA hydrolase;
short-chain acyl-CoA thioesterase
Class
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
BRITE hierarchy
Sysname
ADP-dependent-short-chain-acyl-CoA hydrolase
Reaction(IUBMB)
acyl-CoA + H2O = CoA + a carboxylate [RN:R00383]
Reaction(KEGG)
Substrate
acyl-CoA [CPD:C00040];
H2O [CPD:C00001]
Product
CoA [CPD:C00010];
carboxylate [CPD:C00060]
Comment
Requires ADP; inhibited by NADH. Maximum activity is shown with propanoyl-CoA.
History
EC 3.1.2.18 created 1992
Reference
1  [PMID:2901416]
  Authors
Alexson SE, Nedergaard J.
  Title
A novel type of short- and medium-chain acyl-CoA hydrolases in brown adipose tissue mitochondria.
  Journal
J. Biol. Chem. 263 (1988) 13564-71.
Reference
2  [PMID:2570608]
  Authors
Alexson SE, Svensson LT, Nedergaard J.
  Title
NADH-sensitive propionyl-CoA hydrolase in brown-adipose-tissue mitochondria of the rat.
  Journal
Biochim. Biophys. Acta. 1005 (1989) 13-9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
117698-16-5

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