KEGG   ENZYME: 3.1.2.22Help
Entry
EC 3.1.2.22                 Enzyme                                 

Name
palmitoyl[protein] hydrolase;
palmitoyl-protein thioesterase;
palmitoyl-(protein) hydrolase
Class
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
BRITE hierarchy
Sysname
palmitoyl[protein] hydrolase
Reaction(IUBMB)
palmitoyl[protein] + H2O = palmitate + protein [RN:R01705]
Reaction(KEGG)
R01705 > R08602;
(other) R01274
Show
Substrate
palmitoyl[protein];
H2O [CPD:C00001]
Product
palmitate [CPD:C00249];
protein [CPD:C00017]
Comment
Specific for long-chain thioesters of fatty acids. Hydrolyses fatty acids from S-acylated cysteine residues in proteins, palmitoyl cysteine and palmitoyl-CoA.
History
EC 3.1.2.22 created 1999
Pathway
ec00062  Fatty acid elongation
ec01100  Metabolic pathways
Orthology
K01074  palmitoyl-protein thioesterase
Genes
HSA: 5538(PPT1) 9374(PPT2)
PTR: 456789(PPT1) 462580(PPT2)
PPS: 100969155(PPT1) 100989791(PPT2)
GGO: 101127127(PPT2) 101154001(PPT1)
PON: 100174770(PPT1) 100434271(PPT2)
NLE: 100599270(PPT2) 100604487(PPT1)
MCC: 693377(PPT1) 717212(PPT2)
MCF: 102124313(PPT2) 102126191(PPT1)
CSAB: 103221712(PPT2) 103225040(PPT1)
RRO: 104654886(PPT1) 104674001(PPT2)
RBB: 108519890(PPT2) 108530410(PPT1)
CJC: 100403808(PPT1) 100413646(PPT2)
SBQ: 101038156(PPT1) 101043430(PPT2)
MMU: 19063(Ppt1) 54397(Ppt2)
RNO: 29411(Ppt1) 54398(Ppt2)
CGE: 100750408(Ppt1) 100758494(Ppt2)
NGI: 103724411(Ppt2) 103735139(Ppt1)
HGL: 101713926(Ppt2) 101718692(Ppt1)
CCAN: 109690406(Ppt2) 109691574(Ppt1)
OCU: 100339827(PPT1) 100358167(PPT2)
TUP: 102484501(PPT2) 102490310(PPT1)
CFA: 474856(PPT2) 475316(PPT1)
AML: 100475095(PPT1) 100476267(PPT2)
UMR: 103682279(PPT2) 103682394(PPT1)
ORO: 101362292(PPT2) 101368745 101386758(PPT1)
FCA: 101095578(PPT2) 101097408(PPT1)
PTG: 102963070(PPT1) 102971153(PPT2)
AJU: 106983473(PPT2) 106988413(PPT1)
BTA: 281421(PPT1) 516797(PPT2)
BOM: 102264883(PPT2) 102280715(PPT1)
BIU: 109556456(PPT1) 109576851(PPT2)
PHD: 102334148(PPT2) 102338079(PPT1)
CHX: 102173897(PPT2) 102188105(PPT1)
OAS: 101112855(PPT2) 101121049(PPT1)
SSC: 100144537(PPT2) 100517533(PPT1)
CFR: 102512385(PPT1) 102522115(PPT2)
CDK: 105090849(PPT2) 105103370(PPT1)
BACU: 103006799(PPT1) 103014067(PPT2)
LVE: 103084593(PPT1) 103091119(PPT2)
OOR: 101277496(PPT2) 101283893(PPT1)
ECB: 100051483 100068301(PPT1)
EPZ: 103553563(PPT1) 103566642(PPT2)
EAI: 106823113(PPT1) 106831016(PPT2)
MYB: 102242959(PPT1) 102253546(PPT2)
MYD: 102768095(PPT2) 102770643(PPT1)
HAI: 109373111(PPT2) 109383389(PPT1)
PALE: 102897388(PPT2) 102898049(PPT1)
LAV: 100665656 100671106(PPT1)
MDO: 100024015(PPT2) 100032080(PPT1)
SHR: 100917850(PPT1) 100933490(PPT2)
OAA: 100077897(PPT1) 100078347(PPT2)
GGA: 419681(PPT1)
MGP: 100540149(PPT1) 104915837(PPT2)
CJO: 107307852(PPT2) 107323936(PPT1)
APLA: 101789761(PPT1)
ACYG: 106037878(PPT1)
TGU: 100190233(PPT1)
GFR: 102042422(PPT1)
FAB: 101810323(PPT1)
PHI: 102113700(PPT1) 102114091(PPT2)
PMAJ: 107214159(PPT1)
CCW: 104694666(PPT1)
FPG: 101924773(PPT1)
FCH: 102053964(PPT1)
CLV: 102085710(PPT1) 102094639(PPT2)
EGZ: 104134971(PPT1)
AAM: 106493355(PPT1)
ASN: 102377936(PPT2) 102384268(PPT1)
AMJ: 102566224(PPT1) 102570797(PPT2)
PSS: 102450927(PPT1)
CMY: 102945976(PPT1)
CPIC: 101942757(PPT1) 101949778(PPT2)
ACS: 100556763(ppt2) 100563048(ppt1)
PBI: 103048105(PPT2) 103065485(PPT1)
GJA: 107112540(PPT1) 107118454(PPT2)
XLA: 100036952(ppt1.S) 100037210(ppt1.L) 379689(ppt2.L) 444228(ppt2l.L)
XTR: 100101696(ppt2) 448650(ppt1)
NPR: 108786546(PPT2) 108793538(PPT1)
DRE: 100126133(ppt2) 393135(zgc:55621) 393657(zgc:66024) 405845(zgc:77118) 406648(ppt1) 619258(zgc:113969)
IPU: 108257031(ppt1) 108274839(ppt2) 108277463
LCO: 104921533(ppt1) 104922538(ppt2) 104935034
MZE: 101472327 101475534(ppt2) 101479416(ppt1)
XMA: 102235654 102236538(ppt1) 102238371(ppt2)
PRET: 103472910(ppt2) 103473078(ppt1) 103477738
CSEM: 103394015(ppt1) 103394071(ppt2)
BPEC: 110155804 110159233(ppt1) 110173282(ppt2)
SASA: 100196302(ppt2a) 106570032(PPT1) 106570067 106588210 106588481(PPT1)
SFM: 108927395 108931813(ppt1) 108935599(ppt2)
LCM: 102353105(PPT1) 102355870(PPT2)
CMK: 103188689(ppt1)
DME: Dmel_CG12108(Ppt1) Dmel_CG4851(Ppt2)
DSI: Dsimw501_GD16099(Dsim_GD16099) Dsimw501_GD23774(Dsim_GD23774)
AME: 408426(Ppt2) 551664(Ppt1)
NVI: 100119223(Ppt2) 100119614
CEL: CELE_F44C4.5(ppt-1)
CBR: CBG18981(Cbr-ppt-1)
BMY: Bm1_51565
TSP: Tsp_00608
OBI: 106871646
VRA: 106778007
VAR: 108335114
LJA: Lj2g3v1989240.1(Lj2g3v1989240.1)
SOE: 110795412
DOSA: Os03t0101100-01(Os03g0101100) Os10t0563000-01(Os10g0563000)
ATS: 109758352(LOC109758352) 109772768(LOC109772768) 109786319(LOC109786319)
PDA: 103713625
EGU: 105043725
ATR: 18428257
MNG: MNEG_5752
APRO: F751_3938
CAL: CAALFM_CR04490CA(CaO19.540)
CAUR: QG37_05293
NCR: NCU06530
NTE: NEUTE1DRAFT145000(NEUTE1DRAFT_145000)
MGR: MGG_04920
MAW: MAC_00241
MAJ: MAA_08177
CMT: CCM_08776
MBE: MBM_01578
ANI: AN2497.2
ANG: ANI_1_1416084(An09g04580)
PBL: PAAG_12104(PAAG_05837)
ABE: ARB_05715
TVE: TRV_03000
PTE: PTT_08509
SPO: SPBC530.12c(pdf1)
CNE: CNA00890
CNB: CNBA0860
ABP: AGABI1DRAFT112549(AGABI1DRAFT_112549)
ABV: AGABI2DRAFT192516(AGABI2DRAFT_192516)
MGL: MGL_1417
DDI: DDB_G0285533(ppt1) DDB_G0288807(ppt2) DDB_G0292862(ppt3)
DFA: DFA_01175(ppt3) DFA_01247(ppt1) DFA_08205(ppt2)
SMIN: v1.2.004002.t1(symbB.v1.2.004002.t1)
 » show all
Taxonomy
Reference
1  [PMID:7651163]
  Authors
Camp LA, Hofmann SL.
  Title
Assay and isolation of palmitoyl-protein thioesterase from bovine brain using palmitoylated H-Ras as substrate.
  Journal
Methods. Enzymol. 250 (1995) 336-47.
Reference
2  [PMID:8786130]
  Authors
Schriner JE, Yi W, Hofmann SL.
  Title
cDNA and genomic cloning of human palmitoyl-protein thioesterase (PPT), the enzyme defective in infantile neuronal ceroid lipofuscinosis.
  Journal
Genomics. 34 (1996) 317-22.
  Sequence
[hsa:5538]
Reference
3  [PMID:8663305]
  Authors
Verkruyse LA, Hofmann SL.
  Title
Lysosomal targeting of palmitoyl-protein thioesterase.
  Journal
J. Biol. Chem. 271 (1996) 15831-6.
  Sequence
[bta:281421]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.2.22
IUBMB Enzyme Nomenclature: 3.1.2.22
ExPASy - ENZYME nomenclature database: 3.1.2.22
BRENDA, the Enzyme Database: 3.1.2.22
CAS: 150605-49-5

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