KEGG   ENZYME: 3.1.3.36Help
Entry
EC 3.1.3.36                 Enzyme                                 

Name
phosphoinositide 5-phosphatase;
type II inositol polyphosphate 5-phosphatase;
triphosphoinositide phosphatase;
IP3 phosphatase;
PtdIns(4,5)P2 phosphatase;
triphosphoinositide phosphomonoesterase;
diphosphoinositide phosphatase;
inositol 1,4,5-triphosphate 5-phosphomonoesterase;
inositol triphosphate 5-phosphomonoesterase;
phosphatidylinositol-bisphosphatase;
phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase;
phosphatidylinositol 4,5-bisphosphate phosphatase;
polyphosphoinositol lipid 5-phosphatase;
phosphatidyl-inositol-bisphosphate phosphatase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
phosphatidyl-myo-inositol-4,5-bisphosphate 4-phosphohydrolase
Reaction(IUBMB)
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate [RN:R04404]
Reaction(KEGG)
Substrate
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [CPD:C04637];
H2O [CPD:C00001]
Product
1-phosphatidyl-1D-myo-inositol 4-phosphate [CPD:C01277];
phosphate [CPD:C00009]
Comment
These enzymes can also remove the 5-phosphate from Ins(1,4,5)P3 and/or Ins(1,3,4,5)P4. They are a diverse family of enzymes, with differing abilities to catalyse two or more of the four reactions listed. They are thought to use inositol lipids rather than inositol phosphates as substrates in vivo. All of them can use either or both of PtdIns(4,5)P2 and PtdIns(3,4,5)P3 as substrates; this is the main property that distinguishes them from EC 3.1.3.56, inositol-polyphosphate 5-phosphatase.
History
EC 3.1.3.36 created 1972, modified 2002
Pathway
Inositol phosphate metabolism
Metabolic pathways
Orthology
K01099  
phosphatidylinositol-bisphosphatase
Genes
HSA: 
3633(INPP5B) 4952(OCRL) 56623(INPP5E) 8867(SYNJ1) 8871(SYNJ2)
PTR: 
456767(INPP5B) 463094(SYNJ2) 465851(OCRL) 473959(SYNJ1) 748603(INPP5E)
PPS: 
100969564(SYNJ1) 100972826(INPP5B) 100973295(INPP5E) 100988033(OCRL)
GGO: 
101131117(SYNJ2) 101133552(SYNJ1) 101138003(INPP5B) 101141428(OCRL) 101150746(INPP5E)
PON: 
100172875(OCRL) 100437498(SYNJ1) 100445730(INPP5E) 100454307(SYNJ2) 100462526
MCC: 
702345(OCRL) 705639 707829(SYNJ1) 710121(INPP5E) 716851(INPP5B)
MCF: 
MMU: 
104015(Synj1) 16330(Inpp5b) 20975(Synj2) 320634(Ocrl) 64436(Inpp5e)
RNO: 
114089(Inpp5e) 317576(Ocrl) 362590(Inpp5b) 84018(Synj2) 85238(Synj1)
CGE: 
100751850(Inpp5b) 100757174(Synj1) 100759837(Inpp5e) 100774472(Synj2) 100774848(Ocrl)
HGL: 
101700219(Synj2) 101701719(Inpp5e) 101704216(Inpp5b) 101718278(Synj1) 101722262(Ocrl)
TUP: 
102475253(SYNJ1) 102476402(INPP5B) 102481520(INPP5E) 102497673(OCRL) 102502408(SYNJ2)
CFA: 
100686373(INPP5B) 478403(SYNJ1) 484052(SYNJ2) 492123(OCRL) 607443(INPP5E)
AML: 
FCA: 
101087233(SYNJ2) 101090793(SYNJ1) 101092699(INPP5B) 101093901(INPP5E) 101101038(OCRL)
PTG: 
102953623(SYNJ1) 102958336(SYNJ2) 102958429(INPP5E) 102964378(INPP5B) 102965696(OCRL)
BTA: 
282087(SYNJ1) 506349(INPP5E) 518435(SYNJ2) 535844(OCRL) 538291(INPP5B)
BOM: 
102273891(SYNJ1) 102274367(INPP5B) 102275943(INPP5E) 102278951(OCRL) 102280878(SYNJ2)
PHD: 
102324828(SYNJ2) 102328702(INPP5B) 102329841(SYNJ1) 102331514(INPP5E) 102338669(OCRL)
CHX: 
102169184(SYNJ2) 102172073(INPP5E) 102173254(INPP5B) 102173924(OCRL) 102176266(SYNJ1)
OAS: 
101101853(SYNJ1) 101109366(SYNJ2) 101115530(INPP5E) 101119358(INPP5B) 101119794(OCRL)
SSC: 
100512110(INPP5B) 100516167(SYNJ2) 100524726(OCRL) 100525664(SYNJ1)
CFR: 
102506558(INPP5B) 102512179(SYNJ2) 102513772 102518942(SYNJ1) 102519568(INPP5E) 102521852(OCRL)
BACU: 
103005365(INPP5B) 103005574(SYNJ2) 103015114(OCRL) 103017804(INPP5E) 103018952(SYNJ1)
LVE: 
103071058(SYNJ1) 103081690(INPP5E) 103084395(SYNJ2) 103085051 103086884(OCRL) 103091471(INPP5B)
ECB: 
100052605(SYNJ1) 100054559(INPP5B) 100059144(OCRL) 100059716(SYNJ2) 100068731(INPP5E)
MYB: 
102239005(SYNJ2) 102242464(OCRL) 102244484(SYNJ1) 102247367(INPP5B) 102247617(INPP5E)
MYD: 
102752783(SYNJ1) 102753741(SYNJ2) 102754754(OCRL) 102759168(INPP5B) 102762883(INPP5E)
PALE: 
102884156(OCRL) 102885509(SYNJ2) 102886022(INPP5E) 102890440(SYNJ1) 102894285(INPP5B)
MDO: 
100016332(SYNJ1) 100020283(INPP5E) 100021521(OCRL) 100031802(INPP5B) 100032343(SYNJ2)
SHR: 
100914199(INPP5B) 100917371(OCRL) 100920906(SYNJ2) 100927587(SYNJ1) 100930476(INPP5E) 100935335
OAA: 
100074182(SYNJ2) 100081303(INPP5B) 100083729(SYNJ1) 100087165(OCRL) 100092732(INPP5E)
GGA: 
417135(INPP5E) 418498(SYNJ1) 419609(INPP5B) 421656(SYNJ2) 422136(OCRL)
MGP: 
TGU: 
100218296(INPP5E) 100219842(OCRL) 100220826(INPP5B) 100224437 100227989(SYNJ2) 100228100(SYNJ1)
FAB: 
101806093(SYNJ1) 101807630(SYNJ2) 101807806 101809360(INPP5B) 101813228(OCRL) 101814688(INPP5E) 101817124
PHI: 
102100258(INPP5B) 102104956(OCRL) 102108331(SYNJ1) 102112471(SYNJ2) 102113826(INPP5E)
APLA: 
101800513(SYNJ2) 101802967(INPP5B) 101803505 101805183(SYNJ1) 101805278(INPP5E)
FPG: 
101911635(OCRL) 101913351(SYNJ2) 101916469 101917096(INPP5B) 101924984(INPP5E)
FCH: 
102047189(INPP5E) 102048578(SYNJ2) 102048833(INPP5B) 102051014(OCRL) 102055766 102055769(SYNJ1)
CLV: 
102084313(INPP5E) 102088002(OCRL) 102089265(INPP5B) 102097894(SYNJ1) 102098667(SYNJ2)
ASN: 
102369635(SYNJ2) 102380140(INPP5E) 102382497(INPP5B) 102385377(SYNJ1) 102386023(OCRL)
AMJ: 
102558549(INPP5B) 102566738(INPP5E) 102571633(OCRL) 102575458(SYNJ1) 102576053(SYNJ2)
PSS: 
102446991(INPP5E) 102449725(INPP5B) 102460113(OCRL) 102461279(SYNJ2) 102463325(SYNJ1)
CMY: 
102932373(INPP5E) 102936655(INPP5B) 102938143 102938192(SYNJ2) 102939662(OCRL) 102947907(SYNJ1)
ACS: 
100555178(inpp5e) 100555494(inpp5b) 100562404(synj2) 100563751(ocrl) 100567389(synj1)
PBI: 
103052147(SYNJ2) 103053023(INPP5E) 103056566(INPP5B) 103058036(OCRL) 103064194(SYNJ1)
XTR: 
100125214(ocrl) 100216051(synj2) 100486470(inpp5e) 100487517(synj1) 100497120
DRE: 
100329312 337236(synj1) 563543 606579(inpp5e) 777716(ocrl)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102349621(OCRL) 102357566(INPP5E) 102361906(SYNJ2) 102364570(INPP5B) 102367670(SYNJ1)
CMK: 
103177560(ocrl) 103179631(inpp5b) 103181657(synj2) 103184698(inpp5e) 103187290(synj1)
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
AGA: 
AAG: 
CQU: 
AME: 
409136(GB11376) 411705(synj) 412731(GB15872)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CELE_JC8.10(unc-26)
CBR: 
CBG01799(Cbr-unc-26) CBG03815(Cbr-ocrl-1)
BMY: 
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
PMUM: 
MDM: 
CSV: 
CMO: 
RCU: 
POP: 
VVI: 
SLY: 
SOT: 
SMO: 
PPP: 
CRE: 
VCN: 
OTA: 
BPG: 
MIS: 
MPP: 
CVR: 
CME: 
GSL: 
CCP: 
DSQ: 
SHS: 
PCO: 
PSQ: 
ADL: 
FME: 
GTR: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT101055(AGABI1DRAFT_101055) AGABI1DRAFT121436(AGABI1DRAFT_121436)
ABV: 
AGABI2DRAFT153211(AGABI2DRAFT_153211) AGABI2DRAFT187599(AGABI2DRAFT_187599)
CPUT: 
PGR: 
MLR: 
MBR: 
DDI: 
DPP: 
DFA: 
DFA_07655(Dd5P4)
EHI: 
EHI_153490(13.t00027) EHI_159880(256.t00004)
EDI: 
ACAN: 
PTI: 
TPS: 
PIF: 
NGD: 
EHX: 
GTT: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
NGR: 
 » show all
Taxonomy
Reference
1  [PMID:4284485]
  Authors
Dawson RM, Thompson W.
  Title
The triphosphoinositide phosphomonoesterase of brain tissue.
  Journal
Biochem. J. 91 (1964) 244-50.
Reference
2  [PMID:6271223]
  Authors
Roach PD, Palmer FB.
  Title
Human erythrocyte cytosol phosphatidyl-inositol-bisphosphate phosphatase.
  Journal
Biochim. Biophys. Acta. 661 (1981) 323-33.
Reference
3
  Authors
Woscholski, R. and Parker, P.J.
  Title
Inositol phosphatases: constructive destruction of phosphoinositides and inositol phosphates.
  Journal
In: Cockcroft, S. (Ed.), Biology of Phosphoinositides, Biology of Phosphoinositides, Oxford, 2000, p. 320-338.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9036-01-5

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