KEGG   ENZYME: 3.1.4.12Help
Entry
EC 3.1.4.12                 Enzyme                                 

Name
sphingomyelin phosphodiesterase;
neutral sphingomyelinase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
BRITE hierarchy
Sysname
sphingomyelin cholinephosphohydrolase
Reaction(IUBMB)
a sphingomyelin + H2O = a ceramide + phosphocholine [RN:R02541]
Reaction(KEGG)
Substrate
sphingomyelin [CPD:C00550];
H2O [CPD:C00001]
Product
ceramide [CPD:C00195];
phosphocholine [CPD:C00588]
Comment
Has very little activity on phosphatidylcholine.
History
EC 3.1.4.12 created 1972
Pathway
Sphingolipid metabolism
Metabolic pathways
Orthology
K01117  
sphingomyelin phosphodiesterase
K12350  
sphingomyelin phosphodiesterase
K12351  
sphingomyelin phosphodiesterase 2
K12352  
sphingomyelin phosphodiesterase 3
K12353  
sphingomyelin phosphodiesterase 4
K12354  
ectonucleotide pyrophosphatase/phosphodiesterase family member 7
Genes
HSA: 
339221(ENPP7) 55512(SMPD3) 55627(SMPD4) 6609(SMPD1) 6610(SMPD2)
PTR: 
450990(SMPD1) 459619(SMPD4) 462928(SMPD2) 468008(SMPD3) 742055(ENPP7)
PPS: 
GGO: 
101128835(SMPD2) 101145060(ENPP7) 101145253(SMPD1)
PON: 
100172518(SMPD1) 100174043(SMPD4) 100435456(SMPD3) 100455395(SMPD2) 100455485(ENPP7)
MCC: 
698865(SMPD2) 703384(SMPD3) 711248(SMPD1) 717416(ENPP7) 718018(SMPD4)
MCF: 
102135618(ENPP7) 102136513(SMPD1) 102138241(SMPD3) 102138369(SMPD2)
MMU: 
20597(Smpd1) 20598(Smpd2) 238011(Enpp7) 58994(Smpd3) 77626(Smpd4)
RNO: 
303729(Enpp7) 303790(Smpd4) 308909(Smpd1) 83537(Smpd2) 94338(Smpd3)
CGE: 
100753418(Smpd4) 100755276(Smpd3) 100755684(Enpp7) 100760557(Smpd1) 100761434 100771550(Smpd2)
HGL: 
TUP: 
102468976(SMPD1) 102477662(ENPP7) 102486081(SMPD3) 102486082(SMPD2) 102491151(SMPD4) 102498536
CFA: 
100855615 100856377(SMPD2) 485334(SMPD1) 486434(SMPD4) 489743(SMPD3) 608627(ENPP7)
AML: 
FCA: 
101082570(SMPD2) 101085334(ENPP7) 101091244 101094390(SMPD3) 101099497(SMPD1) 101100196(SMPD4)
PTG: 
102954580(ENPP7) 102962512(SMPD2) 102964338(SMPD1) 102964655(SMPD4) 102969137 102972684(SMPD3)
BTA: 
505097(SMPD1) 505388(ENPP7) 507207(SMPD4) 509018(SMPD2) 514201(SMPD3) 521021
BOM: 
102272896(SMPD2) 102274618 102274996(ENPP7) 102279104(SMPD4) 102284273(SMPD1) 102285822(SMPD3)
PHD: 
102324093(SMPD3) 102330317(SMPD4) 102333165(ENPP7) 102337691(SMPD1) 102339127 102342685(SMPD2)
CHX: 
102169323(SMPD3) 102170015 102179963(SMPD1) 102186017(SMPD2) 102186630(ENPP7)
OAS: 
SSC: 
100152155(SMPD2) 100152725(SMPD4) 100514726(ENPP7) 100518128 100518980(SMPD1)
CFR: 
102504439 102509587(SMPD1) 102519299(SMPD3) 102519400(ENPP7) 102519891(SMPD2) 102520572(SMPD4)
BACU: 
102997214(SMPD3) 102998207(SMPD1) 103000888(SMPD2) 103015051(ENPP7) 103016787(SMPD4)
LVE: 
103074234(SMPD4) 103075134(SMPD3) 103079318(SMPD1) 103079614(ENPP7) 103087233(SMPD2)
ECB: 
100052086(SMPD4) 100057000(ENPP7) 100066652(SMPD2) 100066707(SMPD3) 100069949(SMPD1)
MYB: 
102240352(SMPD3) 102245332 102250208(ENPP7) 102251335(SMPD4) 102252179(SMPD2) 102255688(SMPD1)
MYD: 
102759036(SMPD4) 102759843(SMPD2) 102764850(SMPD3) 102768084(SMPD1) 102769553(ENPP7)
PALE: 
102884990(SMPD3) 102889583(SMPD1) 102891823(SMPD2) 102895085(ENPP7) 102895575(SMPD4)
MDO: 
100022732(SMPD3) 100025584(SMPD4) 100026609 100029088(SMPD2) 100030863(SMPD1) 100030901(ENPP7)
SHR: 
OAA: 
GGA: 
415619(SMPD3) 416942(SMPD4) 419077(SMPD1) 426249(ENPP7) 770663(SMPD2)
MGP: 
TGU: 
100225712(SMPD4) 100226949(ENPP7) 100227648(SMPD3)
FAB: 
101806515(ENPP7) 101809366(SMPD1) 101812312(SMPD3) 101817484(SMPD4) 101819908(SMPD2)
PHI: 
102101799(ENPP7) 102101835(SMPD4) 102104472(SMPD3) 102113323(SMPD1) 102114253(SMPD2)
APLA: 
101796515(SMPD3) 101797457(ENPP7) 101798690(SMPD4)
FPG: 
101914970(SMPD4) 101918131(ENPP7) 101921655(SMPD1) 101923170(SMPD3) 101923831(SMPD2)
FCH: 
102050875(SMPD4) 102051582(ENPP7) 102052173(SMPD1) 102054815(SMPD3) 102060051(SMPD2)
CLV: 
102086716(SMPD4) 102088815 102091270(ENPP7) 102096161(SMPD2)
ASN: 
AMJ: 
PSS: 
102447344 102447556(SMPD2) 102453490(SMPD3) 102457945(SMPD4) 102462744(ENPP7)
CMY: 
102935543(SMPD2) 102941840(SMPD3) 102943179(ENPP7) 102943505(SMPD4) 102944026
ACS: 
100552784(smpd2) 100555572(smpd4) 100560692(smpd1) 100561467 100562803(enpp7) 100564529(smpd3)
PBI: 
103048042(SMPD4) 103050708(SMPD3) 103052650(SMPD1) 103054403(ENPP7) 103058368(SMPD2) 103065467
XLA: 
495009(smpd4) 734723(smpd3)
XTR: 
DRE: 
100334069(enpp7) 100334149 556700(smpd1) 557756 557817 567548(smpd2a) 567592(smpd5) 568381(smpd3) 569930(si:ch211-225l4.2) 793294(smpd4) 797914
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
412170(GB18267) 551484(GB10643) 727146
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CELE_B0252.2(asm-1) CELE_R05D11.9(R05D11.9) CELE_T27F6.6(T27F6.6) CELE_W03G1.7(asm-3) CELE_ZK455.4(asm-2)
CBR: 
CBG01606(Cbr-asm-3) CBG11183(Cbr-asm-1) CBG12510 CBG17365(Cbr-asm-2) CBG23668
BMY: 
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
BDI: 
SITA: 
ATR: 
s00111p00045560(AMTR_s00111p00045560)
VCN: 
CSL: 
CVR: 
CME: 
PIC: 
TTT: 
TMN: 
FGR: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
ELA: 
SSL: 
BFU: 
AFM: 
AOR: 
AOR_1_1620144(AO090023000919)
ANG: 
ANI_1_1578094(An11g00670)
AFV: 
NFI: 
PCS: 
PFJ: 
SHS: 
PCO: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MRR: 
CCI: 
ABP: 
AGABI1DRAFT115230(AGABI1DRAFT_115230)
ABV: 
AGABI2DRAFT194192(AGABI2DRAFT_194192)
PGR: 
MLR: 
DDI: 
DPP: 
DFA: 
DFA_05558(sgmA) DFA_09070(sgmB)
EHI: 
EHI_007460(427.t00005) EHI_040600(164.t00014) EHI_088080(539.t00001) EHI_118110(18.t00042) EHI_193190(43.t00036)
EDI: 
ACAN: 
TAN: 
TPV: 
BBO: 
BBOV_IV006490(23.m06085)
BEQ: 
TET: 
PTM: 
PIF: 
NGR: 
BAN: 
BA_0678(spH)
BAR: 
BAT: 
BAH: 
BAI: 
BAL: 
BCE: 
BCA: 
BCZ: 
BCR: 
BCB: 
BCU: 
BCG: 
BCQ: 
BCX: 
BCY: 
BTK: 
BTL: 
BTB: 
BWE: 
SGR: 
STP: 
SAQ: 
SNG: 
LIL: 
LIC: 
LBJ: 
LBL: 
SYP: 
 » show all
Taxonomy
Reference
1  [PMID:5916388]
  Authors
Barnholz Y, Roitman A, Gatt S.
  Title
Enzymatic hydrolysis of sphingolipids. II. Hydrolysis of sphingomyelin by an enzyme from rat brain.
  Journal
J. Biol. Chem. 241 (1966) 3731-7.
Reference
2  [PMID:2545711]
  Authors
Chatterjee S, Ghosh N.
  Title
Neutral sphingomyelinase from human urine. Purification and preparation of monospecific antibodies.
  Journal
J. Biol. Chem. 264 (1989) 12554-61.
Reference
3  [PMID:5911524]
  Authors
Heller M, Shapiro B.
  Title
Enzymic hydrolysis of sphingomyelin by rat liver.
  Journal
Biochem. J. 98 (1966) 763-9.
Reference
4  [PMID:5933867]
  Authors
Kanfer JN, Young OM, Shapiro D, Brady RO.
  Title
The metabolism of sphingomyelin. I. Purification and properties of a sphingomyelin-cleaving enzyme from rat liver tissue.
  Journal
J. Biol. Chem. 241 (1966) 1081-4.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9031-54-3

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