KEGG   ENZYME: 3.1.4.3Help
Entry
EC 3.1.4.3                  Enzyme                                 

Name
phospholipase C;
lipophosphodiesterase I;
lecithinase C;
Clostridium welchii alpha-toxin;
Clostridium oedematiens beta- and gamma-toxins;
lipophosphodiesterase C;
phosphatidase C;
heat-labile hemolysin;
alpha-toxin
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
BRITE hierarchy
Sysname
phosphatidylcholine cholinephosphohydrolase
Reaction(IUBMB)
a phosphatidylcholine + H2O = 1,2-diacyl-sn-glycerol + phosphocholine [RN:R01312]
Reaction(KEGG)
Substrate
phosphatidylcholine [CPD:C00157];
H2O [CPD:C00001]
Product
1,2-diacyl-sn-glycerol [CPD:C00641];
phosphocholine [CPD:C00588]
Comment
The bacterial enzyme, which is a zinc protein, also acts on sphingomyelin and phosphatidylinositol; that from seminal plasma does not act on phosphatidylinositol.
History
EC 3.1.4.3 created 1961
Pathway
ec00562  Inositol phosphate metabolism
ec00564  Glycerophospholipid metabolism
ec00565  Ether lipid metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K01114  phospholipase C
K16619  phospholipase C / alpha-toxin
Genes
RSS: 109440734 109440754 109442762
NAI: NECAME_18973
ATH: AT1G07230(NPC1) AT2G26870(NPC2) AT3G03520(NPC3) AT3G03530(NPC4) AT3G03540(NPC5) AT3G48610(NPC6)
ALY: ARALYDRAFT_317234 ARALYDRAFT_477599 ARALYDRAFT_481562 ARALYDRAFT_665643 ARALYDRAFT_887934 ARALYDRAFT_896356
CRB: 17884902 17888378 17891215 17893062 17893396 17899115
CSAT: 104703502 104711356 104739289 104744444 104744445 104752587 104754889 104761389 104763975 104763976 104763977 104765258 104780675 104787501 104787579 104791079
EUS: EUTSA_v10001963mg EUTSA_v10007332mg EUTSA_v10010294mg EUTSA_v10020472mg EUTSA_v10020514mg
BRP: 103843966 103844249 103855165 103864845 103873127 103874784
BNA: 106365514 106376581 106382672 106387555 106391128 106400982 106430809 106431248 106432877 106445438 106446778 111198054 111212171
BOE: 106293041 106295442 106308215 106315255 106337025 106343659
LJA: Lj0g3v0152469.1(Lj0g3v0152469.1) Lj0g3v0158969.1(Lj0g3v0158969.1) Lj0g3v0198969.1(Lj0g3v0198969.1) Lj0g3v0241399.1(Lj0g3v0241399.1) Lj1g3v1500500.1(Lj1g3v1500500.1) Lj6g3v0964670.1(Lj6g3v0964670.1)
DOSA: Os01t0102000-01(Os01g0102000) Os01t0955000-02(Os01g0955000) Os03t0826600-01(Os03g0826600) Os03t0852800-00(Os03g0852800) Os11t0593000-01(Os11g0593000)
ATS: 109737151(LOC109737151) 109747180(LOC109747180) 109759365(LOC109759365) 109767204(LOC109767204) 109777514(LOC109777514)
ANG: ANI_1_2022014(An01g14940) ANI_1_3028014(An01g11130) ANI_1_448114(An13g03600)
DFA: DFA_00818
SMIN: v1.2.006411.t2(symbB.v1.2.006411.t2)
SPE: Spro_4198
SRL: SOD_c40420(plcN)
SPLY: Q5A_021980(plcN_2)
SMAF: D781_3962
SMAR: SM39_3662
SERF: L085_07240
XDO: XDD1_3773(plcN)
XCC: XCC0947 XCC3037(plcN)
XCV: XCV1054(phlN1) XCV3291(phlN2)
XAX: XACM_1007(phlN1) XACM_3079(phlN2)
XAC: XAC1024 XAC3160(plcN)
XCI: XCAW_03446(plcC) XCAW_03558(plcC)
XOO: XOO1651(plcN) XOO3682(PlcC)
XOM: XOO1535(XOO1535) XOO3479(XOO3479)
XPH: XppCFBP6546_03415(XppCFBP6546P_03415) XppCFBP6546_06345(XppCFBP6546P_06345)
SML: Smlt1755(plcN1)
SMT: Smal_1494
SMZ: SMD_1690(plcC)
PSD: DSC_12570
LEZ: GLE_1552(plcN) GLE_1923(plcN)
PAE: PA0844(plcH) PA3319(plcN)
PAU: PA14_21110(plcN) PA14_53360(plcH)
PAG: PLES_17461(plcN) PLES_44741(plcH)
PAF: PAM18_1646(plcN) PAM18_4196(plcH)
PNC: NCGM2_1618(plcH) NCGM2_4449(plcN)
PAEB: NCGM1900_1882(plcH) NCGM1900_2957(plcN)
PAEU: BN889_00870(plcH_1) BN889_00871(plcH_2) BN889_03687(plcN)
PFL: PFL_3126
PPRC: PFLCHA0_c31570(plcN)
PPRO: PPC_3154
PSEM: TO66_16060
ABM: ABSDF0054(plc) ABSDF2207(plc)
ABY: ABAYE1520(plc) ABAYE3825(plc)
ABAD: ABD1_00420(plcD) ABD1_20510(plc)
ACC: BDGL_001526(plcN) BDGL_002961(plcN)
SAZ: Sama_0115
ILO: IL2595(plcC)
FTU: FTT_0221(acpA)
FTQ: RO31_0255
FTF: FTF0221(acpA)
FTW: FTW_1838
FTT: FTV_0207(acpA)
FTY: CH70_38
FTG: FTU_0207(acpA)
FTL: FTL_0158
FTA: FTA_0172
FTS: F92_00885
FTC: DA46_564
FTZ: CH68_166
FTM: FTM_1599
FTN: FTN_0090
FTX: AW25_111
FTD: AS84_624
FPH: Fphi_0739
FPT: BZ13_1287
FPI: BF30_949
FPX: KU46_606
NTT: TAO_1633
CVI: CV_0909(plcN)
RSO: RSc0319(plcN)
RSL: RPSI07_3091(plcN)
RSN: RSPO_c03330(acpA)
RSE: F504_340
REH: H16_A2724(plcN1) H16_B0534(plcN2) H16_B1067(plcN3) H16_B1166(plcN4)
CNC: CNE_1c26200 CNE_2c04740(plcN1) CNE_2c10260(plcN2) CNE_2c11270(plcN3)
RME: Rmet_4192(plcN) Rmet_4624(plcN2)
CTI: RALTA_A2216(plcN1) RALTA_B0343(plcN2) RALTA_B1069(plcN3)
CGD: CR3_3843(plcC) CR3_3844(plcC) CR3_3880(plcC)
BPE: BP2337
BPC: BPTD_2296
BPER: BN118_2262
BPET: B1917_2250
BPEU: Q425_22910
BPA: BPP1702
BBR: BB3406
BAV: BAV1084(plcN1) BAV1803(plcN2)
BHZ: ACR54_02024(plcN_1) ACR54_03336(plcN_2)
AXY: AXYL_01269(plcN1) AXYL_01506(plcN2) AXYL_02003(plcN3) AXYL_02675(plcN4)
AXX: ERS451415_01415(plcN_1) ERS451415_01888(plcN_2) ERS451415_02376(plcN_3) ERS451415_05203(plcN_4)
ODI: ODI_R4164
AAA: Acav_0273
CTES: O987_25980
JAG: GJA_4137
HSE: Hsero_2607(plcN)
HRB: Hrubri_2689(plcN) Hrubri_3787(plcN)
CFU: CFU_0030 CFU_0341 CFU_0674(plcN) CFU_3159(plcN2)
TIN: Tint_2706
THI: THI_3248
RGE: RGE_22010(plc)
PBH: AAW51_0637(plcC)
GEB: GM18_2899
SCL: sce3773 sce6979(phlC2) sce7154(phlC1)
HOH: Hoch_4899
ARA: Arad_3908
BJA: bll6723
BRA: BRADO5754(plcN)
BBT: BBta_1163(plcN) BBta_6264(plcN)
BRO: BRAD285_5724(plcN) BRAD285_6387(plcN)
CCR: CC_3031
CSE: Cseg_3204
NAR: Saro_1552
SPHK: SKP52_18755(plcN)
SPHI: TS85_12050
SSAN: NX02_19790
SPMI: K663_03485
SPHR: BSY17_988
AAY: WYH_02185(plcN)
ACR: Acry_3054
GDI: GDI2475(plcA) GDI2477(plcN)
APK: APA386B_447(plcN)
ASZ: ASN_2503(plcN) ASN_643
BAN: BA_0677(plC)
BAR: GBAA_0677(plC)
BAT: BAS0643
BAH: BAMEG_3909(plC)
BAI: BAA_0760(plC)
BANT: A16_07400
BANR: A16R_07460
BANS: BAPAT_0654
BANV: DJ46_5135(plc)
BCE: BC0670
BCA: BCE_0744(plC)
BCZ: BCE33L0588(plc)
BCR: BCAH187_A0804(plC)
BCB: BCB4264_A0707(plC)
BCU: BCAH820_0732(plC)
BCG: BCG9842_B4629(plC)
BCQ: BCQ_0743(plC)
BCX: BCA_0713(plC)
BAL: BACI_c06850(plcB)
BNC: BCN_0652
BCF: bcf_03465
BCER: BCK_04770
BTK: BT9727_0587(plc)
BTL: BALH_0617(plC)
BTB: BMB171_C0589(plC)
BTT: HD73_0751
BTHI: BTK_03835
BTC: CT43_CH0600(plC)
BTM: MC28_1098 MC28_5401(cerA)
BTG: BTB_c06910(cerA)
BTI: BTG_17775
BTW: BF38_1922(plc)
BWW: bwei_4921(plc) bwei_5379(plc2)
BMYC: DJ92_3267(plc) DJ92_3544(plc) DJ92_5281(plc) DJ92_5342(plc)
SAU: SA1811(truncated(hlb))
SAV: SAV2003(truncated-hlb)
SAW: SAHV_1989
SAM: MW1940(truncated_hlb)
SAC: SACOL2003(hlb)
SAE: NWMN_1926
SAD: SAAV_2071(hlb)
SUE: SAOV_2040
SUC: ECTR2_1875(sph)
SUQ: HMPREF0772_11179(sph)
SUZ: MS7_2035(sph)
SUW: SATW20_19320(hlb)
SUG: SAPIG2059(sph)
SUF: SARLGA251_18220(hlb)
SAUA: SAAG_02520
SAUS: SA40_1779(hlb)
SAUU: SA957_1863(hlb)
SAUG: SA268_1935(hlb)
SAUF: X998_1994(sph)
SAB: SAB1874
SUY: SA2981_1965(hlb)
SAUB: C248_2026
SAUC: CA347_2096(sph)
SAUR: SABB_02524(hlb)
SAUI: AZ30_10655
SAUD: CH52_08880
SEP: SE0008
SER: SERP2544(hlb)
SEPP: SEB_00009
SEPS: DP17_1390(sph)
SLN: SLUG_00320(hlb)
SDT: SPSE_2228(hlb)
SCAP: AYP1020_1985(hlb)
SSCH: LH95_11415
SSCZ: RN70_12120
SAGQ: EP23_08555
LMO: lmo0205(plcB)
LMF: LMOf2365_0216(plcB)
LMC: Lm4b_00203(plcB)
LMN: LM5578_2813(plcB)
LMY: LM5923_2762(plcB)
LMS: LMLG_2380
LMQ: LMM7_0226(plcB)
LML: lmo4a_0221(plcB)
LMP: MUO_01170
LMW: LMOSLCC2755_0204(plcB)
LMX: LMOSLCC2372_0206(plcB)
LMZ: LMOSLCC2482_0205(plcB)
LMON: LMOSLCC2376_0176(plcB)
LMOC: LMOSLCC5850_0199(plcB)
LMOS: LMOSLCC7179_0199(plcB)
LMOO: LMOSLCC2378_0218(plcB)
LMOY: LMOSLCC2479_0205(plcB)
LMOT: LMOSLCC2540_0208(plcB)
LMOA: LMOATCC19117_0213(plcB)
LMOL: LMOL312_0203(plcB)
LMOG: BN389_02190(plcB)
LMOE: BN418_0216
LMOB: BN419_0221
LMOD: LMON_0203(plcB)
LMOW: AX10_09480
LMOX: AX24_13635
LMOQ: LM6179_0495(plcB)
LMR: LMR479A_0214(plcB)
LMOK: CQ02_01100
LMOM: IJ09_09340
LSG: lse_0189(plcB)
LIV: LIV_1186(smcL)
AAC: Aaci_1827
AAD: TC41_1922(plcC)
BTS: Btus_0254
CAC: CA_C1019 CA_P0148(phlc)
CAE: SMB_G1037 SMB_P146(phlc)
CAY: CEA_G1031 CEA_P0147(phlc)
CPE: CPE0036
CPF: CPF_0042(plc)
CPR: CPR_0041(plc)
CTC: CTC_00990
CBO: CBO2632
CBA: CLB_2576
CBH: CLC_2507
CBY: CLM_2998
CBL: CLK_2020
CBK: CLL_A2118
CBB: CLD_1931
CBI: CLJ_B2864
CBF: CLI_2699
CBM: CBF_2691
CKL: CKL_1485
CKR: CKR_1379
CPAS: Clopa_3296
CSQ: CSCA_1331
CTYK: CTK_C17380
AMT: Amet_0549
ASF: SFBM_0315
CTH: Cthe_3193
PTH: PTH_1370
HMO: HM1_3138
SAY: TPY_0920(plcC)
PUF: UFO1_3703
PFT: JBW_01122
MTU: Rv2349c(plcC) Rv2350c(plcB) Rv2351c(plcA)
MRA: MRA_1766(plcD) MRA_1768A MRA_2369(plcC) MRA_2370(plcB) MRA_2371(plcA)
MTUR: CFBS_2487(plcC) CFBS_2488(plcB) CFBS_2489(plcA)
MTO: MTCTRI2_2392(plcC) MTCTRI2_2393(plcB)
MTD: UDA_2349c(plcC) UDA_2350c(plcB) UDA_2351c(plcA)
MTUT: HKBT1_2478(plcC) HKBT1_2479(plcB) HKBT1_2480(plcA)
MTUU: HKBT2_2480(plcC) HKBT2_2481(plcB) HKBT2_2482(plcA)
MTQ: HKBS1_2484(plcC) HKBS1_2485(plcB) HKBS1_2486(plcA)
MBO: BQ2027_MB1784C(plcD)
MBB: BCG_1794c(plcD)
MBT: JTY_1769(plcD)
MBM: BCGMEX_1766c(plcD)
MBX: BCGT_1572
MAF: MAF_17740(plcD) MAF_23620(plcC) MAF_23630(plcB) MAF_23640(plcA)
MCE: MCAN_17701(plcD) MCAN_23811(plcC) MCAN_23821(plcB) MCAN_23831(plcA)
MCQ: BN44_40004(plcD) BN44_50315(plcC) BN44_50316(plcB) BN44_50317(plcA)
MCV: BN43_30888(plcD) BN43_30889 BN43_31613(plcC) BN43_31614(plcB) BN43_31615(plcA)
MCX: BN42_30004(plcD) BN42_40281(plcC) BN42_40282(plcB) BN42_40283(plcA)
MCZ: BN45_50007(plcD) BN45_50712(plcC) BN45_50713(plcB) BN45_50714(plcA)
MUL: MUL_2799(plcB)
MMI: MMAR_1485(plcB_2) MMAR_3566(plcB) MMAR_3656(plcB_5) MMAR_3657(plcB_4) MMAR_3823(plcB_1) MMAR_4722(plcB_6)
MLI: MULP_03825(plcB) MULP_03907(plcB_5) MULP_04061(plcB_1) MULP_04944(plcB_6)
MAB: MAB_0555
MABB: MASS_0524
MABO: NF82_02805
ASD: AS9A_1033
CJK: jk0010(acpA)
COA: DR71_1073
NNO: NONO_c24950(plcD)
RER: RER_56920(plc)
REY: O5Y_27190
ROP: ROP_22030(plc)
TPR: Tpau_2452
SRT: Srot_1710
SCO: SCO6691(SC4C6.01)
SMA: SAVERM_1715(plcA)
SBH: SBI_08798
SDV: BN159_1732(plcN)
SALS: SLNWT_0477
SLV: SLIV_05055(plcN)
SGU: SGLAU_27995(plcN)
SAMB: SAM23877_6344(plcN)
SPRI: SPRI_2371
SRW: TUE45_07240(plcN)
SLE: sle_11360(sle_11360)
STRD: NI25_04950
SALF: SMD44_06112(plcC) SMD44_07208(plcC)
SALJ: SMD11_2069(plcC) SMD11_2773 SMD11_3735(plcC)
SLX: SLAV_09770(plcN1) SLAV_12120(plcN2) SLAV_33870(plcN3)
CMI: CMM_0504
CMS: CMS0264
ARR: ARUE_c31850(plcN)
AAU: AAur_3036
LMOI: VV02_03990
NCA: Noca_3201
KFL: Kfla_2643
NAL: B005_3638(sph)
SEN: SACE_5775(plcN)
AMD: AMED_3228(plcC) AMED_7590(plcC) AMED_8964(plcC)
AMM: AMES_3193(plcC) AMES_7478(plcC) AMES_8827(plcC)
AMZ: B737_3193(plcC) B737_7478(plcC) B737_8828(plcC)
AOI: AORI_1438(plcC) AORI_2698(plcC)
AMQ: AMETH_4401(plcC)
PDX: Psed_4307
ASE: ACPL_2371(plcN) ACPL_5685(plcN)
ACTN: L083_0276(plcN)
AFS: AFR_15205
AFO: Afer_0521
MIN: Minf_0120(plcC)
PBOR: BSF38_03162(plcN)
FLN: FLA_3819
SMIZ: 4412673_01610(plcN_1) 4412673_01915(plcN_2)
MGOT: MgSA37_01973(plcN_1) MgSA37_01976(plcN_2)
SLI: Slin_1378
LBY: Lbys_2889
FAE: FAES_4673(plcN)
ZPR: ZPR_3206
EAO: BD94_2498
ELB: VO54_00215(plcN)
MYR: MYRA21_0324(plcN)
MPW: MPR_2859
CHZ: CHSO_4611
NJA: NSJP_3236
SID: M164_0637
SIH: SiH_0446
MCN: Mcup_1169
TUZ: TUZN_1521
 » show all
Taxonomy
Reference
1  [PMID:13066482]
  Authors
DRUZHININA KV, KRITSMAN MG.
  Title
[Lecithinase C in animal tissue.]
  Journal
Biokhimiia. 17 (1952) 77-81.
Reference
2  [PMID:807246]
  Authors
Little C, Otnass AB.
  Title
The metal ion dependence of phospholipase C from Bacillus cereus.
  Journal
Biochim. Biophys. Acta. 391 (1975) 326-33.
Reference
3  [PMID:3086312]
  Authors
Sheikhnejad RG, Srivastava PN.
  Title
Isolation and properties of a phosphatidylcholine-specific phospholipase C from bull seminal plasma.
  Journal
J. Biol. Chem. 261 (1986) 7544-9.
Reference
4  [PMID:4365891]
  Authors
Takahashi T, Sugahara T, Ohsaka A.
  Title
Purification of Clostridium perfringens phospholipase C (alpha-toxin) by affinity chromatography on agarose-linked egg-yolk lipoprotein.
  Journal
Biochim. Biophys. Acta. 351 (1974) 155-71.
Other DBs
ExplorEnz - The Enzyme Database: 3.1.4.3
IUBMB Enzyme Nomenclature: 3.1.4.3
ExPASy - ENZYME nomenclature database: 3.1.4.3
BRENDA, the Enzyme Database: 3.1.4.3
CAS: 9001-86-9

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