KEGG   ENZYME: 3.2.1.113Help
Entry
EC 3.2.1.113                Enzyme                                 

Name
mannosyl-oligosaccharide 1,2-alpha-mannosidase;
mannosidase 1A;
mannosidase 1B;
1,2-alpha-mannosidase;
exo-alpha-1,2-mannanase;
mannose-9 processing alpha-mannosidase;
glycoprotein processing mannosidase I;
mannosidase I;
Man9-mannosidase;
ManI;
1,2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase
Reaction(IUBMB)
Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2
Reaction(KEGG)
(other) R05982(G) R06722(G)
Show
Comment
Involved in the synthesis of glycoproteins.
History
EC 3.2.1.113 created 1986
Pathway
N-Glycan biosynthesis
Various types of N-glycan biosynthesis
Metabolic pathways
Orthology
K01230  
mannosyl-oligosaccharide alpha-1,2-mannosidase
Genes
HSA: 
10905(MAN1A2) 11253(MAN1B1) 4121(MAN1A1) 57134(MAN1C1)
PTR: 
457159(MAN1A2) 463148(MAN1A1) 473099(MAN1B1) 736491(MAN1C1)
PPS: 
100977047(MAN1A2) 100983605(MAN1A1) 100984948(MAN1C1) 100987343(MAN1B1)
GGO: 
101133209(MAN1A2) 101134859(MAN1B1) 101142550(MAN1C1) 101144345(MAN1A1)
PON: 
100432279(MAN1B1) 100434522(MAN1A1) 100459953(MAN1A2)
MCC: 
706918(MAN1B1) 711548(MAN1A2) 714609(MAN1A1) 719686(MAN1C1)
MCF: 
101867098 102116178(MAN1A2) 102133475(MAN1C1) 102134558(MAN1A1)
MMU: 
17155(Man1a) 17156(Man1a2) 227619(Man1b1) 230815(Man1c1)
RNO: 
294410(Man1a1) 295319(Man1a2) 362625(Man1c1) 499751(Man1b1)
CGE: 
HGL: 
101699709(Man1c1) 101700934(Man1a2) 101714110(Man1a1) 101724891(Man1b1)
TUP: 
102470543(MAN1B1) 102475708(MAN1A1) 102490275(MAN1A2) 102498287(MAN1C1)
CFA: 
476275(MAN1A1) 478178(MAN1C1) 480667(MAN1B1) 483141(MAN1A2)
AML: 
100467154 100478118(MAN1B1) 100478751(MAN1A2) 100480907(MAN1C1)
FCA: 
101086830(MAN1A2) 101099737(MAN1C1) 101100723(MAN1A1)
PTG: 
102948947 102953645(MAN1A2) 102953958(MAN1A1) 102956478(MAN1C1)
BTA: 
100336900(MAN1B1) 530027(MAN1A1) 532645(MAN1A2) 615012(MAN1C1)
BOM: 
PHD: 
102321857(MAN1A1) 102323160(MAN1B1) 102323859 102338104(MAN1A2) 102344405(MAN1C1)
CHX: 
102172355(MAN1A1) 102178963(MAN1A2) 102182048 102182552(MAN1C1) 102182604(MAN1B1) 102184807
OAS: 
101103326(MAN1A1) 101108177(MAN1A2) 101118089(MAN1C1)
SSC: 
100154147(MAN1A2) 100524150(MAN1C1) 100627465(MAN1B1) 396919(MAN1A1)
CFR: 
BACU: 
103003282 103005884(MAN1A1) 103007272(MAN1C1) 103008754(MAN1B1) 103018894(MAN1A2)
LVE: 
103070296(MAN1C1) 103086557(MAN1B1) 103087206(MAN1A2) 103087551(MAN1A1)
ECB: 
100057488(MAN1C1) 100066466 100072869(MAN1A1) 100147103(MAN1A2) 100147680(MAN1B1)
MYB: 
102238828(MAN1A2) 102240083(MAN1B1) 102246069(MAN1A1) 102247391(MAN1C1)
MYD: 
102763868(MAN1C1) 102764904(MAN1A1) 102766164(MAN1A2) 102775495(MAN1B1)
PALE: 
102887313(MAN1A1) 102889844(MAN1A2) 102890593(MAN1B1) 102897246(MAN1C1)
MDO: 
100010854(MAN1A2) 100022731(MAN1B1) 100023598(MAN1A1) 100617488(MAN1C1)
SHR: 
OAA: 
100079674(MAN1A1) 100080650(MAN1B1) 100081124(MAN1A2)
GGA: 
417296(MAN1B1) 418265(MAN1A2) 419588(MAN1C1) 421726(MAN1A1)
MGP: 
100543997(MAN1B1) 100546016(MAN1A2) 100549489(MAN1C1) 100549765
TGU: 
100220181 100221810(MAN1C1) 100223461(MAN1B1) 100232070(MAN1A1)
FAB: 
101814086(MAN1A1) 101816081(MAN1B1) 101817258(MAN1A2) 101820958(MAN1C1)
PHI: 
102101333(MAN1A2) 102103624(MAN1B1) 102108536(MAN1C1) 102109517(MAN1A1)
APLA: 
101789687(MAN1C1) 101795067(MAN1A1) 101803362(MAN1B1) 101803658(MAN1A2)
FPG: 
FCH: 
102045806(MAN1B1) 102048637(MAN1C1) 102052529(MAN1A2) 102054649(MAN1A1)
CLV: 
102083787(MAN1B1) 102087646(MAN1A2) 102093752(MAN1A1) 102094812(MAN1C1)
ASN: 
102369572(MAN1A1) 102378356(MAN1C1) 102387590(MAN1B1) 102388362(MAN1A2)
AMJ: 
102558211(MAN1C1) 102563847(MAN1A2) 102565105(MAN1A1) 102567138(MAN1B1)
PSS: 
102449928(MAN1A1) 102451974(MAN1C1) 102453471(MAN1A2) 102455673(MAN1B1)
CMY: 
ACS: 
100552898(man1a1) 100561704(man1a2) 100562395(man1b1)
PBI: 
103051064(MAN1C1) 103052908(MAN1B1) 103057418(MAN1A1) 103063461(MAN1A2)
XLA: 
446337(man1a2) 447291(man1b1) 734993
XTR: 
100145194(man1b1) 100216029(man1a2) 100485889(man1c1) 100491314(man1a1)
DRE: 
335538(fj20e02) 556237(man1b1) 562592 566078(man1a1)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102347754(MAN1B1) 102354592(MAN1C1) 102364126(MAN1A1) 102365619 102366726(MAN1A2)
CMK: 
103179580 103180170(man1a2) 103180403(man1b1) 103182593(man1a1)
BFO: 
CIN: 
SPU: 
DME: 
Dmel_CG11874(alpha-Man-Ib) Dmel_CG31202 Dmel_CG42275(alpha-Man-I)
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
409174(alpha-Man-I) 413579(GB18388)
NVI: 
100119267 100119928(Alpha-man-i)
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CELE_D2030.1(mans-1) CELE_T03G11.4(mans-3) CELE_ZC410.3(mans-4)
CBR: 
BMY: 
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
ATH: 
AT1G30000(MNS3) AT1G51590(MNS1) AT3G21160(MNS2)
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
PMUM: 
MDM: 
CSV: 
CMO: 
RCU: 
POP: 
POPTR_0004s13920g(POPTRDRAFT_831216) POPTR_0008s00800g(POPTRDRAFT_655661) POPTR_0018s13790g(POPTRDRAFT_1107454)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os04t0606400-01(Os04g0606400) Os05t0209100-01(Os05g0209100)
OBR: 
BDI: 
SBI: 
SORBI_06g027810(SORBIDRAFT_06g027810) SORBI_07g006915(SORBIDRAFT_07g006915) SORBI_09g006500(SORBIDRAFT_09g006500)
ZMA: 
SITA: 
ATR: 
s00019p00253350(AMTR_s00019p00253350) s00141p00108250(AMTR_s00141p00108250)
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
OTA: 
BPG: 
MIS: 
MPP: 
CSL: 
CVR: 
CME: 
CCP: 
SCE: 
YJR131W(MNS1) YLR057W(MNL2)
AGO: 
ERC: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0J00430(NCAS0J00430) NCAS_0J02160(NCAS0J02160)
NDI: 
NDAI_0C06450(NDAI0C06450) NDAI_0J02870(NDAI0J02870)
TPF: 
TPHA_0D00420(TPHA0D00420) TPHA_0L00320(TPHA0L00320)
TBL: 
TBLA_0B06140(TBLA0B06140) TBLA_0D02500(TBLA0D02500)
TDL: 
TDEL_0C00640(TDEL0C00640) TDEL_0D00600(TDEL0D00600)
KAF: 
KAFR_0D01000(KAFR0D01000) KAFR_0E04290(KAFR0E04290)
PPA: 
DHA: 
PIC: 
PGU: 
SPAA: 
LEL: 
CAL: 
CTP: 
COT: 
CDU: 
CTEN: 
YLI: 
CLU: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
ELA: 
SSL: 
BFU: 
MBE: 
ANI: 
AFM: 
AOR: 
AOR_1_100154(AO090003000057) AOR_1_2162154(AO090003001225) AOR_1_2802154(AO090003000476)
ANG: 
ANI_1_1702014(An01g12550) ANI_1_180054(An06g01510) ANI_1_2010184(An04g06990)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
TMS: 
PPL: 
DSQ: 
SHS: 
PCO: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MPR: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT115219(AGABI1DRAFT_115219) AGABI1DRAFT117691(AGABI1DRAFT_117691) AGABI1DRAFT130713(AGABI1DRAFT_130713) AGABI1DRAFT54540(AGABI1DRAFT_54540) AGABI1DRAFT70315(AGABI1DRAFT_70315) AGABI1DRAFT86588(AGABI1DRAFT_86588)
ABV: 
AGABI2DRAFT176302(AGABI2DRAFT_176302) AGABI2DRAFT181939(AGABI2DRAFT_181939) AGABI2DRAFT194179(AGABI2DRAFT_194179) AGABI2DRAFT194180(AGABI2DRAFT_194180) AGABI2DRAFT206040(AGABI2DRAFT_206040) AGABI2DRAFT222683(AGABI2DRAFT_222683)
CPUT: 
SLA: 
UMA: 
PFP: 
MGL: 
PGR: 
MLR: 
WSE: 
MBR: 
DDI: 
DPP: 
DFA: 
ACAN: 
PTI: 
TPS: 
PIF: 
NGD: 
EHX: 
GTT: 
NGR: 
TVA: 
CAK: 
CSE: 
SCT: 
SCY: 
 » show all
Taxonomy
Reference
1  [PMID:500665]
  Authors
Tabas I, Kornfeld S.
  Title
Purification and characterization of a rat liver Golgi alpha-mannosidase capable of processing asparagine-linked oligosaccharides.
  Journal
J. Biol. Chem. 254 (1979) 11655-63.
Reference
2  [PMID:7061502]
  Authors
Tulsiani DR, Hubbard SC, Robbins PW, Touster O.
  Title
alpha-D-Mannosidases of rat liver Golgi membranes. Mannosidase II is the GlcNAcMAN5-cleaving enzyme in glycoprotein biosynthesis and mannosidases Ia and IB are the enzymes converting Man9 precursors to Man5 intermediates.
  Journal
J. Biol. Chem. 257 (1982) 3660-8.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9068-25-1

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