KEGG   ENZYME: 3.2.1.18Help
Entry
EC 3.2.1.18                 Enzyme                                 
Name
exo-alpha-sialidase;
neuraminidase;
sialidase;
alpha-neuraminidase;
acetylneuraminidase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
acetylneuraminyl hydrolase
Reaction(IUBMB)
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates
Reaction(KEGG)
Comment
The enzyme does not act on 4-O-acetylated sialic acids. endo-alpha-Sialidase activity is listed as EC 3.2.1.129, endo-alpha-sialidase. See also EC 4.2.2.15 anhydrosialidase.
Pathway
Other glycan degradation
Sphingolipid metabolism
Orthology
K01186  
sialidase-1
K12357  
sialidase-2/3/4
Genes
HSA: 
10825(NEU3) 129807(NEU4) 4758(NEU1) 4759(NEU2)
PTR: 
470682(NEU2) 471968(NEU1) 748654(NEU3)
PPS: 
100968718(NEU4) 100982628(NEU3) 100988881(NEU2) 100992636(NEU1)
GGO: 
101139428(NEU1) 101139512(NEU2) 101139514(NEU4) 101150288(NEU3)
PON: 
100171663(NEU3) 100172668(NEU1) 100434013(NEU4) 100444319(NEU2)
MCC: 
694310 702264(NEU4) 713979(NEU2) 716740(NEU1)
MMU: 
18010(Neu1) 23956(Neu2) 241159(Neu4) 50877(Neu3)
RNO: 
117185(Neu3) 24591(Neu1) 29204(Neu2) 316642(Neu4)
CFA: 
481717(NEU1) 485195(NEU3) 486166(NEU2) 609668(NEU4)
AML: 
FCA: 
101080656(NEU3) 101085144(NEU2) 101091282(NEU1) 101098566(NEU4)
BTA: 
281349(NEU3) 505554(NEU1) 528030(NEU4) 614542
SSC: 
100124381(NEU1) 100738467 100739223
ECB: 
100057378 100059083(NEU1) 100064871(NEU3)
MDO: 
100012303 100012630 100021389 100025319
SHR: 
100916396(NEU2) 100920198(NEU3) 100929484(NEU4) 100930623(NEU1)
OAA: 
100082341 100092279
GGA: 
429131(NEU4) 430542(NEU3) 768823(NEU2)
MGP: 
100542483 100546814
TGU: 
100220481(NEU3) 100224381(NEU4) 100224454(NEU2)
ACS: 
100553632(neu1) 100557782 100557978 100560635(neu4)
XLA: 
444511(neu1)
XTR: 
100145410(neu3) 100485853 100486976 100496715
DRE: 
100000684(neu3.5) 445250(neu3.2) 553569(neu4) 555206(neu3.3) 559850(neu1) 780844(neu3.1) 793046(neu3.4)
TRU: 
101065981 101075335 101078624(neu3)
OLA: 
101155611 101160183 101163509
BFO: 
BRAFLDRAFT_236233 BRAFLDRAFT_249134
SPU: 
100890472 583431 585449
NVE: 
NEMVE_v1g210903
PIC: 
PICST_3402(HYR6.2) PICST_3529(HYR6.3) PICST_61722(HYR6.4)
AFM: 
AFUA_4G13800
PCS: 
Pc22g00140
MBR: 
MONBRDRAFT_22854
TBR: 
Tb927.7.6850(Tb07.25D22.110) Tb927.7.7480(Tb07.30D13.290)
STM: 
STM0928(nanH)
ETR: 
ETAE_1245
HAP: 
HAPS_1616(nanH)
PMU: 
PM0663 PM1000
VCH: 
VC1784
VCE: 
Vch1786_I1277(nanH)
VCJ: 
VCD_002587
VCO: 
VC0395_A1381(nanH)
VCR: 
VC395_1898(nanH)
VCM: 
VCM66_1722(nanH)
VCI: 
O3Y_08635
VCL: 
VCLMA_A1545
ABM: 
ABSDF1049
SPL: 
Spea_1515
PHA: 
PSHAb0159
SSD: 
SPSINT_0694
SPN: 
SP_1326 SP_1687
SPD: 
SPD_1499(nanB) SPD_1504(nanA)
SPR: 
spr1531(nanB) spr1536(nanA)
SPW: 
SPCG_0853(nanC) SPCG_1660(nanB) SPCG_1665(nanA)
SPX: 
SPG_1219(nanC) SPG_1595(nanB) SPG_1600(nanA)
SNE: 
SPN23F_12180 SPN23F_16870(nanB) SPN23F_16920(nanA)
SPV: 
SPH_1468 SPH_1797
SNM: 
SP70585_1726 SP70585_1731
SJJ: 
SPJ_1242 SPJ_1581 SPJ_1586
SPP: 
SPP_1704 SPP_1709
SNT: 
SPT_1625 SPT_1630
SNC: 
HMPREF0837_11930(nanB) HMPREF0837_11935
SNB: 
SP670_1773 SP670_1783
SNP: 
SPAP_1692 SPAP_1700
SAG: 
SAG1932
SAN: 
gbs1919
SAK: 
SAK_1891
SGC: 
A964_1791(neu1)
SEQ: 
SZO_05310
SEZ: 
Sez_1425(nanA)
SEU: 
SEQ_1612
SMB: 
smi_0601(nanA)
SOR: 
SOR_0548(nanA)
STD: 
SPPN_08220
CPE: 
CPE0553(nanJ) CPE0725(nanI)
CPF: 
CPF_0532 CPF_0721 CPF_0985
CPR: 
CPR_0877
CTC: 
CTC00453
ERH: 
ERH_0299(nanH.1)
CGL: 
NCgl1495(Cgl1556)
CGB: 
cg1756(nanH)
CGT: 
cgR_1608
CDI: 
DIP0330 DIP0543
CKP: 
ckrop_1872(nanI)
CPU: 
cpfrc_00386(nanH)
SCO: 
SCO6557(SC4B5.07c)
SMA: 
SAV_1842(nanH) SAV_5934
SGR: 
SGR_6429
ART: 
Arth_0189 Arth_0543
AAU: 
AAur_0636 AAur_3540
ACH: 
Achl_3384 Achl_3385
BCV: 
Bcav_1440
BFA: 
Bfae_08300
ICA: 
Intca_0420
PAC: 
PPA0684 PPA0685 PPA1560
PAK: 
HMPREF0675_3754 HMPREF0675_4627
KFL: 
Kfla_0127 Kfla_5280
SEN: 
SACE_1663 SACE_5159(nanH)
AMD: 
AMED_4157(neu)
MAU: 
Micau_2667
SNA: 
Snas_5835
AHE: 
Arch_1299
MCU: 
HMPREF0573_10118
BLN: 
Blon_0646 Blon_2348
BBI: 
BBIF_1733 BBIF_1734
BBP: 
BBPR_1793 BBPR_1794
TDE: 
TDE0471
BRM: 
Bmur_1914
BPO: 
BP951000_0923
SUS: 
Acid_0193
BTH: 
BT_0455
BFR: 
BF1729 BF3936 BF4242
BFS: 
BF1806(nanH) BF3709 BF4051(nanH2)
BVU: 
BVU_4143
BHL: 
Bache_2784
PGI: 
PG0352
PGN: 
PGN_1608
PDI: 
BDI_2946
PHE: 
Phep_1703 Phep_2214
SHG: 
Sph21_4587 Sph21_5174
HHY: 
Halhy_3291
CMR: 
Cycma_3733 Cycma_3805
DFE: 
Dfer_3020
SLI: 
Slin_2629
RSI: 
Runsl_0157
COC: 
Coch_0016
FBC: 
FB2170_03925 FB2170_04925
MRS: 
Murru_0548
SMF: 
Smon_0005
AMU: 
Amuc_0625 Amuc_1835
RBA: 
RB3353 RB8895(nanH)
PSL: 
Psta_4638
PLM: 
Plim_2856 Plim_3447
HMA: 
pNG5066
 » show all
Taxonomy
Reference
1  [PMID:6762816]
  Authors
Schauer R.
  Title
Chemistry, metabolism, and biological functions of sialic acids.
  Journal
Adv. Carbohydr. Chem. Biochem. 40 (1982) 131-234.
Reference
2  [PMID:1883340]
  Authors
Cabezas JA.
  Title
Some questions and suggestions on the type references of the official nomenclature (IUB) for sialidase(s) and endosialidase.
  Journal
Biochem. J. 278 ( Pt 1) (1991) 311-2.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9001-67-6
DBGET integrated database retrieval system