| Entry |
|
|---|
| Name |
exo-alpha-sialidase;
neuraminidase;
sialidase;
alpha-neuraminidase;
acetylneuraminidase |
|---|
| Class |
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl
compounds
 |
|---|
| Sysname |
acetylneuraminyl hydrolase |
|---|
| Reaction(IUBMB) |
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic
linkages of terminal sialic acid residues in oligosaccharides,
glycoproteins, glycolipids, colominic acid and synthetic substrates |
|---|
| Reaction(KEGG) |
(other) R03491 R04018 R04634 R04650 R05115 R05117 R05996(G)
R05998(G) R05999(G) R06012(G) R06147(G) R06253(G)
 |
|---|
| Inhibitor |
2-Deoxy-2,3-dehydro-N-acetylneuraminic acid [CPD:C04580] |
|---|
| Comment |
The enzyme does not act on 4-O-acetylated sialic acids.
endo-alpha-Sialidase activity is listed as EC 3.2.1.129,
endo-alpha-sialidase. See also EC 4.2.2.15 anhydrosialidase. |
|---|
| Pathway |
ec00511 Other glycan degradation
ec00600 Sphingolipid metabolism |
|---|
| Orthology |
K01186 sialidase-1
K12357 sialidase-2/3/4 |
|---|
| Genes |
HSA: 10825(NEU3) 129807(NEU4) 4758(NEU1) 4759(NEU2)
PTR: 471968(NEU1)
MCC: 702264(NEU4) 713979(NEU2) 716740(NEU1)
MMU: 18010(Neu1) 23956(Neu2) 241159(Neu4) 50877(Neu3)
RNO: 117185(Neu3) 24591(Neu1) 29204(Neu2) 316642(Neu4)
CFA: 481717(NEU1) 485195(NEU3) 486166(NEU2) 609668(NEU4)
BTA: 281349(NEU3) 505554(NEU1) 528030(NEU4)
SSC: 100124381(NEU1)
ECB: 100057378 100059083 100064871(NEU3)
MDO: 100012303 100012630 100021389 100025319
OAA: 100082341 100092279
GGA: 430542(NEU3) 768823(NEU2)
TGU: 100220481 100224381
XLA: 444511(neu1)
XTR: 100145410(neu3)
DRE: 100000684(neu3.5) 445250(neu3.2) 553569(neu4) 555206(neu3.3)
559850(neu1) 780844(neu3.1) 793046(neu3.4)
BFO: BRAFLDRAFT_236233 BRAFLDRAFT_249134
SPU: 583431 585449 764416
NVE: NEMVE_v1g210903
PIC: PICST_3402(HYR6.2) PICST_3529(HYR6.3) PICST_61722(HYR6.4)
FGR: FG00251.1
AFM: AFUA_4G13800
MBR: MONBRDRAFT_22854
TBR: Tb927.7.6850 Tb927.7.7480
STM: STM0928(nanH)
HAP: HAPS_1616(nanH)
PMU: PM0663 PM1000
VCH: VC1784
VCO: VC0395_A1381(nanH)
ABM: ABSDF1049
PHA: PSHAb0159
BXE: Bxe_B2278
BBA: Bd2821 Bd3647
SPN: SP_1326 SP_1687
SPD: SPD_1499(nanB) SPD_1504(nanA)
SPR: spr1531(nanB) spr1536(nanA)
SPW: SPCG_0853(nanC) SPCG_1660(nanB) SPCG_1665(nanA)
SPV: SPH_1468 SPH_1797
SAG: SAG1932
SAN: gbs1919
SAK: SAK_1891
SEZ: Sez_1425(nanA)
CPE: CPE0553(nanJ) CPE0725(nanI)
CPF: CPF_0532 CPF_0721 CPF_0985
CPR: CPR_0877
CTC: CTC00453
CGL: NCgl1495(cgl1556)
CGB: cg1756(nanH)
CGT: cgR_1608
CDI: DIP0330
CKP: ckrop_1872(nanI)
SCO: SCO6557(SC4B5.07c)
SMA: SAV_1842(nanH) SAV_5934
SGR: SGR_6429
ART: Arth_0189 Arth_0543
AAU: AAur_0636 AAur_3540
PAC: PPA0684 PPA0685 PPA1560
SEN: SACE_1663 SACE_5159(nanH)
SNA: Snas_5835
BLN: Blon_2348
TDE: TDE0471
SUS: Acid_0193
BTH: BT_0455
BFR: BF1729 BF3936 BF4242
BFS: BF3709 BF4051(nanH2)
BVU: BVU_4143
PGI: PG0352
PGN: PGN_1608
PDI: BDI_2946
DFE: Dfer_3020
SLI: Slin_2629
COC: Coch_0016
SMF: Smon_0005
AMU: Amuc_0625 Amuc_1835
RBA: RB3353
PSL: Psta_4638
PLM: Plim_2856
HMA: pNG5066
 |
|---|
Reference
Authors
Title
Journal
|
1 [PMID:6762816]
Schauer R.
Chemistry, metabolism, and biological functions of sialic acids.
Adv. Carbohydr. Chem. Biochem. 40 (1982) 131-234. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:1883340]
Cabezas JA.
Some questions and suggestions on the type references of the
official nomenclature (IUB) for sialidase(s) and endosialidase.
Biochem. J. 278 ( Pt 1) (1991) 311-2.
Homo sapiens [GN:hsa] |
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| Other DBs |
ExplorEnz - The Enzyme Database: 3.2.1.18
IUBMB Enzyme Nomenclature: 3.2.1.18
ExPASy - ENZYME nomenclature database: 3.2.1.18
BRENDA, the Enzyme Database: 3.2.1.18
CAS: 9001-67-6 |
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