KEGG   ENZYME: 3.2.1.184Help
Entry
EC 3.2.1.184                Enzyme                                 

Name
UDP-N,N'-diacetylbacillosamine 2-epimerase (hydrolysing);
UDP-Bac2Ac4Ac 2-epimerase;
NeuC
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
UDP-N,N'-diacetylbacillosamine hydrolase (2-epimerising)
Reaction(IUBMB)
UDP-N,N'-diacetylbacillosamine + H2O = UDP + 2,4-diacetamido-2,4,6-trideoxy-D-mannopyranose [RN:R10187]
Reaction(KEGG)
Substrate
UDP-N,N'-diacetylbacillosamine [CPD:C20357];
H2O [CPD:C00001]
Product
UDP [CPD:C00015];
2,4-diacetamido-2,4,6-trideoxy-D-mannopyranose [CPD:C20424]
Comment
Requires Mg2+. Involved in biosynthesis of legionaminic acid, a nonulosonate derivative that is incorporated by some bacteria into assorted virulence-associated cell surface glycoconjugates. The initial product formed by the enzyme from Legionella pneumophila, which incorporates legionaminic acid into the O-antigen moiety of its lipopolysaccharide, is 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose, which rapidly mutarotates to a mixture of anomers [1]. The enzyme from Campylobacter jejuni, which incorporates legionaminic acid into flagellin, prefers GDP-N,N'-diacetylbacillosamine [2].
History
EC 3.2.1.184 created 2012
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
Orthology
K18429  GDP/UDP-N,N'-diacetylbacillosamine 2-epimerase (hydrolysing)
Genes
MLQ: ASQ50_04380
LPN: lpg0753
LPH: LPV_0879(neuC)
LPO: LPO_0834(neuC)
LPU: LPE509_02458
LPM: LP6_0733(neuC)
LPF: lpl0790(neuC)
LPP: lpp0819(neuC)
LPC: LPC_2539(neuC)
LPA: lpa_01161
LPE: lp12_0763
FPH: Fphi_1168
FPI: BF30_1412(neuC)
FPX: KU46_146(neuC)
FHA: CDV26_09125(neuC)
TBN: TBH_C0741
THI: THI_0582
METR: BSY238_2010(neuC)
SULR: B649_08545
CJE: Cj1328(neuC2)
CJB: BN148_1328(neuC2)
CJI: CJSA_1264(neuC2)
CJS: CJS3_1422(neuC)
CJEJ: N564_02260
CJEU: N565_02350
CJEN: N755_02410
CJEI: N135_01416
CJER: H730_07595
CJY: QZ67_01464(legG)
CJQ: UC78_1271(legG)
CJR: CJE1517(neuC)
CCO: CCC13826_2302(legG)
CCOC: CCON33237_1631(legG)
CLA: Cla_1234(ptmD)
CCQ: N149_1291
CCF: YSQ_02210
CCY: YSS_07205
CCOI: YSU_02245
CCOF: VC76_06665(legG)
CCOO: ATE51_00908(legG)
CIS: CINS_1193(legG)
CVO: CVOL_1213(legG)
CSM: CSUB8521_1416(legG)
CSF: CSUB8523_1516(legG)
CHV: CHELV3228_1654(legG)
CLX: CLAN_1242(legG)
ABT: ABED_0621
ARC: ABLL_0810
RBM: TEF_17310
PPY: PPE_04400
TAB: CIG75_02425(neuC)
EFU: HMPREF0351_10917(neuC)
CARC: NY10_959
CBL: CLK_2100
CBB: CLD_1853
CTAE: BGI42_06560(neuC)
CTH: Cthe_2640
HSC: HVS_09995(legG)
BPB: bpr_I0429
CST: CLOST_0368(neuC)
AWO: Awo_c24830(neuC)
TIT: Thit_0480
TSH: Tsac_2669
SYW: SYNW0449(neuC)
PRC: EW14_1467
LIL: LA_1610
LIE: LIF_A1297
LIC: LIC_12172
LST: LSS_16466
GFL: GRFL_2395
FIN: KQS_03400(neuC)
MARB: CJ263_08135(neuC)
NOB: CW736_09220(neuC)
PPH: Ppha_0528
PMX: PERMA_1624(neuC)
TTK: TST_1474(wecB)
NDE: NIDE2998(wecB)
NIN: NADRNF5_2155(neuC)
NDV: NDEV_0147(neuC)
 » show all
Taxonomy
Reference
1  [PMID:18275154]
  Authors
Glaze PA, Watson DC, Young NM, Tanner ME
  Title
Biosynthesis of CMP-N,N'-diacetyllegionaminic acid from UDP-N,N'-diacetylbacillosamine in Legionella pneumophila.
  Journal
Biochemistry. 47 (2008) 3272-82.
  Sequence
[lpn:lpg0753]
Reference
2  [PMID:19282391]
  Authors
Schoenhofen IC, Vinogradov E, Whitfield DM, Brisson JR, Logan SM
  Title
The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel  GDP-linked precursors.
  Journal
Glycobiology. 19 (2009) 715-25.
  Sequence
[cje:Cj1328]
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.184
IUBMB Enzyme Nomenclature: 3.2.1.184
ExPASy - ENZYME nomenclature database: 3.2.1.184
BRENDA, the Enzyme Database: 3.2.1.184

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