KEGG   ENZYME: 3.2.1.24Help
Entry
EC 3.2.1.24                 Enzyme                                 
Name
alpha-mannosidase;
alpha-D-mannosidase;
p-nitrophenyl-alpha-mannosidase;
alpha-D-mannopyranosidase;
1,2-alpha-mannosidase;
1,2-alpha-D-mannosidase;
exo-alpha-mannosidase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
alpha-D-mannoside mannohydrolase
Reaction(IUBMB)
Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides
Reaction(KEGG)
(other) R08717(G) R08718(G)
Show
Comment
Also hydrolyses alpha-D-lyxosides and heptopyranosides with the same configuration at C-2, C-3 and C-4 as mannose.
Pathway
Other glycan degradation
Orthology
K01191  
alpha-mannosidase
K12311  
lysosomal alpha-mannosidase
K12312  
epididymis-specific alpha-mannosidase
Genes
HSA: 
23324(MAN2B2) 4123(MAN2C1) 4125(MAN2B1)
PTR: 
453758(MAN2C1) 455745(MAN2B1) 461102(MAN2B2)
PPS: 
100971472(MAN2C1) 100977668(MAN2B1) 100982980(MAN2B2)
GGO: 
101136007(MAN2B1) 101141976(MAN2B2) 101144805(MAN2C1)
PON: 
100171932(MAN2B2) 100174476(MAN2B1) 100174488(MAN2C1)
MCC: 
705599(MAN2C1) 710870(MAN2B2) 716173
MMU: 
17159(Man2b1) 17160(Man2b2) 73744(Man2c1)
RNO: 
246136(Man2c1) 360955(Man2b2) 361378(Man2b1)
CFA: 
100855835 484932(MAN2B1) 488779(MAN2B2) 611620(MAN2C1)
AML: 
FCA: 
101091532(MAN2B2) 101099049(MAN2C1) 493697(MAN2B1)
BTA: 
282272(MAN2B1) 523503(MAN2B2) 541086(MAN2C1)
SSC: 
100156538(MAN2C1) 100518647 396847(MAN2B2)
ECB: 
100061610(MAN2C1)
MDO: 
100010377(MAN2B1) 100019089(MAN2B2) 100030390
SHR: 
100924862(MAN2B2) 100930413(MAN2B1) 100934233(MAN2C1)
OAA: 
100081270(MAN2C1) 100092187
GGA: 
415306(MAN2C1) 422859(MAN2B2)
MGP: 
100547587(MAN2C1) 100549822(MAN2B2)
TGU: 
100228971(MAN2C1) 100229436(MAN2B2)
ACS: 
100557773
XLA: 
431951(man2c1)
XTR: 
100036651(man2c1) 100127706(man2b2) 779924(man2b1)
DRE: 
100003570(man2b2) 541519(man2b1) 569595
TRU: 
101069902 101073393 101073675
OLA: 
101167078 101168422 101173055
BFO: 
BRAFLDRAFT_131178 BRAFLDRAFT_287967
CIN: 
100176799 100181902(man2c1)
SPU: 
583500 591324 756277
DME: 
Dmel_CG4606(alpha-Man-IIb) Dmel_CG5322 Dmel_CG6206(LM408) Dmel_CG9463 Dmel_CG9465 Dmel_CG9466 Dmel_CG9468
DPO: 
Dpse_GA18295 Dpse_GA21810 Dpse_GA28078 Dpse_GA28079 Dpse_GA28080
DAN: 
Dana_GF14094 Dana_GF14351 Dana_GF14352 Dana_GF14353 Dana_GF14356 Dana_GF15795 Dana_GF18544
DER: 
Dere_GG10384 Dere_GG16955 Dere_GG23643 Dere_GG24050 Dere_GG24051 Dere_GG24052 Dere_GG24053
DPE: 
Dper_GL19134 Dper_GL21651 Dper_GL26214 Dper_GL26217
DSE: 
Dsec_GM12683 Dsec_GM12694 Dsec_GM18459 Dsec_GM24262
DSI: 
Dsim_GD19050 Dsim_GD22254 Dsim_GD22379 Dsim_GD22383 Dsim_GD23708
DWI: 
Dwil_GK12784 Dwil_GK14881 Dwil_GK14884 Dwil_GK24522 Dwil_GK24523 Dwil_GK24524 Dwil_GK24528
DYA: 
Dyak_GE10752 Dyak_GE10763 Dyak_GE10773 Dyak_GE10784 Dyak_GE13604 Dyak_GE24341
DGR: 
Dgri_GH13617 Dgri_GH16722 Dgri_GH19293
DMO: 
Dmoj_GI13451 Dmoj_GI20521 Dmoj_GI23509
DVI: 
Dvir_GJ10261 Dvir_GJ11812 Dvir_GJ13861
AGA: 
AgaP_AGAP004032 AgaP_AGAP008584
AAG: 
AaeL_AAEL004389 AaeL_AAEL005749 AaeL_AAEL005752 AaeL_AAEL005763
CQU: 
CpipJ_CPIJ003442 CpipJ_CPIJ015654 CpipJ_CPIJ015656
AME: 
412838(alpha-Man-IIb) 552249
NVI: 
100118809(NV15396) 100120019(NV15567)
TCA: 
656534 656843 657014 659583
API: 
100158954 100159559 100159877
PHU: 
Phum_PHUM025610 Phum_PHUM407580
ISC: 
IscW_ISCW011337 IscW_ISCW012835
CEL: 
CELE_F55D10.1(aman-1)
CBR: 
CBG14532(Cbr-aman-1)
BMY: 
Bm1_30540 Bm1_32610
TSP: 
Tsp_05942
SMM: 
Smp_131580
NVE: 
NEMVE_v1g173865 NEMVE_v1g244860
HMG: 
100202780 100205567 100212242
TAD: 
TRIADDRAFT_63890
AQU: 
100639141 100639267
ATH: 
AT3G26720 AT5G66150
ALY: 
ARALYDRAFT_488225
GMX: 
100798150
CSV: 
101221354 101222242 101224849
RCU: 
RCOM_1503670
POP: 
POPTR_1095647 POPTR_816882
VVI: 
100244533
OSA: 
4348080 4350617
SMO: 
SELMODRAFT_103066
PPP: 
PHYPADRAFT_102741 PHYPADRAFT_136484
VCN: 
VOLCADRAFT_115992
SCE: 
YGL156W(AMS1)
AGO: 
AGOS_AGR385C
PPA: 
PAS_chr4_0790
VPO: 
Kpol_534p1
CGR: 
CAGL0E05148g
DHA: 
DEHA2G17798g
PIC: 
PICST_35546(MLN1) PICST_83621(AMS1)
LEL: 
LELG_05684
CAL: 
CaO19.10284(AMS1) CaO19.2768(AMS1)
YLI: 
YALI0D21890g
NCR: 
NCU07404
PAN: 
PODANSg5733
MGR: 
MGG_04464
FGR: 
FG06831.1
SSL: 
SS1G_04148
BFU: 
BC1G_10523
ANI: 
AN2936.2
AFM: 
AFUA_3G08200
AOR: 
AOR_1_2530174(AO090005001458)
ANG: 
ANI_1_1628024(An02g11720)
PCS: 
Pc20g06780
CPW: 
CPC735_043370
URE: 
UREG_07684
TML: 
GSTUM_00006536001
SPO: 
SPAC513.05(ams1)
CNE: 
CNA06750
PPL: 
POSPLDRAFT_102785
MPR: 
MPER_14666
UMA: 
UM00557.1
DDI: 
DDB_G0287577(manG) DDB_G0292206(manA)
DPP: 
DICPUDRAFT_49593
PTM: 
GSPATT00006450001 GSPATT00019586001
TBR: 
Tb10.70.5100
TCR: 
506195.120 506407.10
TVA: 
TVAG_371840
PTI: 
PHATR_52108
TPS: 
THAPS_263310
PIF: 
PITG_10031
ECR: 
ECIAI1_1941
SSN: 
SSON_1287 SSON_1289
SBO: 
SBO_1171
SBC: 
SbBS512_E0652
CKO: 
CKO_03577
DDA: 
Dd703_0697
VVY: 
VVA1394
ARA: 
Arad_8466
AVI: 
Avi_5578 Avi_7334
RET: 
RHE_PF00487
REC: 
RHECIAT_PC0000709
RLE: 
pRL120348(ams1)
RLT: 
Rleg2_4785
JAN: 
Jann_2057
DSH: 
Dshi_3007(ybgG)
BHA: 
BH0789 BH0791
GKA: 
GK1902
GTN: 
GTNG_1820 GTNG_3216
LMO: 
lmo2014 lmo2015 lmo2734
LMF: 
LMOf2365_2038 LMOf2365_2040 LMOf2365_2721
LMH: 
LMHCC_0545 LMHCC_0546 LMHCC_2798
LMC: 
Lm4b_02026 Lm4b_02027 Lm4b_02708
LMN: 
LM5578_0125 LM5578_2216 LM5578_2217
LMY: 
LM5923_0125 LM5923_2167 LM5923_2168
LMT: 
LMRG_01164
LMOC: 
LMOSLCC5850_2077
LIN: 
lin2122 lin2123
LWE: 
lwe2034 lwe2035
LSG: 
lse_1996 lse_1997
PJD: 
Pjdr2_1155 Pjdr2_4199 Pjdr2_4649 Pjdr2_5576
GYM: 
GYMC10_1873 GYMC10_1876 GYMC10_2960 GYMC10_4862
LLA: 
L130682(ypdB)
SPY: 
SPy_1604
SPZ: 
M5005_Spy_1317
SPM: 
spyM18_1611
SPG: 
SpyM3_1297
SPS: 
SPs0564
SPH: 
MGAS10270_Spy1433
SPI: 
MGAS10750_Spy1426
SPJ: 
MGAS2096_Spy1338
SPK: 
MGAS9429_Spy1311
SPF: 
SpyM50538
SPA: 
M6_Spy1335
SPB: 
M28_Spy1358
SOZ: 
Spy49_1239
SPN: 
SP_2143
SPD: 
SPD_1971
SPR: 
spr1951
SPW: 
SPCG_2113
SPX: 
SPG_2083
SNE: 
SPN23F_21760
SPV: 
SPH_2336
SNM: 
SP70585_2271
SJJ: 
SPJ_2169
SPP: 
SPP_2194
SNT: 
SPT_2156
SNC: 
HMPREF0837_10145
SNB: 
SP670_2289
SNP: 
SPAP_2193
SSU: 
SSU05_1919
SSV: 
SSU98_1923
SSB: 
SSUBM407_1783
SSS: 
SSUSC84_1735
SGO: 
SGO_1768
SEQ: 
SZO_04460
SEZ: 
Sez_1510
SDS: 
SDEG_1591
SMB: 
smi_1998
SOR: 
SOR_1902
SCP: 
HMPREF0833_11628
STD: 
SPPN_11005
LPL: 
lp_3631
LPJ: 
JDM1_2901
LRH: 
LGG_02675
EFA: 
EF1707
CPE: 
CPE0856 CPE2080
CPF: 
CPF_0848 CPF_2337
CPR: 
CPR_0841 CPR_2049
CBK: 
CLL_A2125
CPY: 
Cphy_1720
ASF: 
SFBM_0790
APR: 
Apre_0149
BPB: 
bpr_III017(man38A)
TEX: 
Teth514_1096
TPD: 
Teth39_0612
TIT: 
Thit_1713
TMT: 
Tmath_1702
MAS: 
Mahau_0033 Mahau_2023
HOR: 
Hore_14420
ERH: 
ERH_0236
MMY: 
MSC_0845
MML: 
MLC_7700
MLC: 
MSB_A0898
MAB: 
MAB_4227c
MMC: 
Mmcs_0963
MKM: 
Mkms_0981
TPR: 
Tpau_2136
SCO: 
SCO0948(SCM11.03c)
SMA: 
SAV_1753(ama1) SAV_7277(ama2)
SCB: 
SCAB_15481
SVL: 
Strvi_3409 Strvi_4389 Strvi_5956
CMI: 
CMM_0347(manX) CMM_1259
CMS: 
CMS_0916 CMS_1012
MTS: 
MTES_2607 MTES_2854
ART: 
Arth_0803
AAU: 
AAur_1025
RSA: 
RSal33209_0512
BCV: 
Bcav_2999
BFA: 
Bfae_10940
SKE: 
Sked_14830
PAC: 
PPA0062 PPA1459
PAK: 
HMPREF0675_4516
MPH: 
MLP_11580
KFL: 
Kfla_0659 Kfla_0928
SRO: 
Sros_5005 Sros_5878
SEN: 
SACE_3737(ama2)
CAI: 
Caci_1595 Caci_1715 Caci_2258
SNA: 
Snas_2861
AHE: 
Arch_0034
BLO: 
BL1327 BL1328
BLJ: 
BLD_0188(manA1) BLD_0189(manA2) BLD_0191(manA3)
BLN: 
Blon_0868 Blon_0869
BLF: 
BLIF_1316 BLIF_1317
BLL: 
BLJ_1285 BLJ_1286 BLJ_1962
BLB: 
BBMN68_215(manA1) BBMN68_216(manA2)
BAD: 
BAD_1238
GVA: 
HMPREF0424_1049
RXY: 
Rxyl_2051
SSM: 
Spirs_1232
ABA: 
Acid345_3122
ACM: 
AciX9_3316
TSA: 
AciPR4_1642 AciPR4_1699 AciPR4_2715
BTH: 
BT_3774
BFR: 
BF0339
BFS: 
BF0287
PDI: 
BDI_0244
PRU: 
PRU_2181
SHG: 
Sph21_4307
HHY: 
Halhy_6809
FBC: 
FB2170_03905
GAU: 
GAU_2046
PSL: 
Psta_3607
PLM: 
Plim_0075
IPA: 
Isop_2888
SYN: 
slr0323(ams1)
SYW: 
SYNW0267
SYC: 
syc2388_d(ams1)
SYF: 
Synpcc7942_1703
SYD: 
Syncc9605_0261
SYE: 
Syncc9902_2083
SYG: 
sync_0308
SYR: 
SynRCC307_2336
SYX: 
SynWH7803_0311
SYP: 
SYNPCC7002_A1252(ams1)
TEL: 
tll0290
MAR: 
MAE_36540
CYT: 
cce_1203
CYP: 
PCC8801_2444
CYC: 
PCC7424_4232
CYN: 
Cyan7425_3665
CYH: 
Cyan8802_3666
CYJ: 
Cyan7822_3561
AMR: 
AM1_6392
CYU: 
UCYN_07090
GVI: 
glr0080
ANA: 
all0848
NPU: 
Npun_F4313
AVA: 
Ava_4452
NAZ: 
Aazo_1924
PMT: 
PMT1839(ams1)
PMF: 
P9303_24641
TER: 
Tery_3192
DLY: 
Dehly_0392
RRS: 
RoseRS_1434
RCA: 
Rcas_2851
CAU: 
Caur_1109
CHL: 
Chy400_1214
ATM: 
ANT_17550
DDR: 
Deide_1p00530 Deide_3p00420
TRA: 
Trad_0469
MSV: 
Mesil_2864
TMA: 
TM1231 TM1851
TPT: 
Tpet_0948 Tpet_1538
TLE: 
Tlet_0085 Tlet_0117
TRQ: 
TRQ2_0965 TRQ2_1587
TNA: 
CTN_0786 CTN_1341
TNP: 
Tnap_0606 Tnap_1561
TME: 
Tmel_1011
TAF: 
THA_1290
FNO: 
Fnod_0811
PMO: 
Pmob_0722 Pmob_1489
KOL: 
Kole_0478
DTU: 
Dtur_1758
TTR: 
Tter_1501
TVO: 
TVN0209
PTO: 
PTO0091
PHO: 
PH0835
TBA: 
TERMP_00012 TERMP_01033
SMR: 
Smar_0014 Smar_1142
SHC: 
Shell_1324
SSO: 
SSO3006
STO: 
ST1008
SIS: 
LS215_2523
SIA: 
M1425_2351
SIM: 
M1627_2429
SIY: 
YG5714_2495
SIN: 
YN1551_0409
SII: 
LD85_2653
CMA: 
Cmaq_0104 Cmaq_1289
TPE: 
Tpen_1628
 » show all
Taxonomy
Reference
1  [PMID:5905120]
  Authors
Li YT.
  Title
Presence of alpha-D-mannosidic linkage in glycoproteins. Liberation of d-mannose from various glycoproteins by alpha-mannosidase isolated from jack bean meal.
  Journal
J. Biol. Chem. 241 (1966) 1010-2.
  Organism
Canavalia ensiformis
Reference
2  [PMID:6428944]
  Authors
Winchester B.
  Title
Role of alpha-D-mannosidases in the biosynthesis and catabolism of glycoproteins.
  Journal
Biochem. Soc. Trans. 12 (1984) 522-4.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9025-42-7
DBGET integrated database retrieval system