KEGG   ENZYME: 3.2.1.46Help
Entry
EC 3.2.1.46                 Enzyme                                 

Name
galactosylceramidase;
cerebroside galactosidase;
galactocerebroside.beta-galactosidase;
galactosylcerebrosidase;
galactocerebrosidase;
ceramide galactosidase;
galactocerebroside galactosidase;
galactosylceramide.beta-galactosidase;
cerebroside beta-galactosidase;
galactosylceramidase I;
beta-galactosylceramidase;
galactocerebroside-beta-D-galactosidase;
lactosylceramidase I;
beta-galactocerebrosidase;
lactosylceramidase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
D-galactosyl-N-acylsphingosine galactohydrolase
Reaction(IUBMB)
a D-galactosyl-N-acylsphingosine + H2O = D-galactose + a ceramide [RN:R03617]
Reaction(KEGG)
Substrate
D-galactosyl-N-acylsphingosine [CPD:C02686];
H2O [CPD:C00001]
Product
D-galactose [CPD:C00124];
ceramide [CPD:C00195]
Comment
cf. EC 3.2.1.62 glycosylceramidase.
History
EC 3.2.1.46 created 1972
Pathway
Sphingolipid metabolism
Metabolic pathways
Orthology
K01202  
galactosylceramidase
Genes
HSA: 
2581(GALC)
PTR: 
736519(GALC)
PPS: 
100986325(GALC)
GGO: 
101137325(GALC)
PON: 
100458475(GALC)
NLE: 
100587134(GALC)
MCC: 
693322(GALC)
MCF: 
CJC: 
100412515(GALC)
MMU: 
14420(Galc)
RNO: 
314360(Galc)
CGE: 
100751905(Galc)
NGI: 
103744394(Galc)
HGL: 
101721890(Galc)
OCU: 
100351605(GALC)
TUP: 
102488515(GALC)
CFA: 
403916(GALC)
AML: 
UMR: 
103670525(GALC)
FCA: 
101084116(GALC)
PTG: 
102954621(GALC)
BTA: 
533428(GALC)
BOM: 
102281426(GALC)
PHD: 
102336792(GALC)
CHX: 
102188052(GALC)
OAS: 
101118106(GALC)
SSC: 
100156917(GALC)
CFR: 
102522511(GALC)
BACU: 
103010897(GALC)
LVE: 
103089768(GALC)
ECB: 
100034130(GALC)
MYB: 
102257416(GALC)
MYD: 
102765447(GALC)
PALE: 
102880991(GALC)
MDO: 
SHR: 
OAA: 
100081052(GALC)
GGA: 
423394(GALC)
MGP: 
APLA: 
101796301(GALC)
TGU: 
100224899(GALC)
FAB: 
101810873(GALC)
PHI: 
102113858(GALC)
FPG: 
101914337(GALC)
FCH: 
102059116(GALC)
CLV: 
102098299(GALC)
ASN: 
102374264(GALC)
AMJ: 
102575324(GALC)
PSS: 
102445851(GALC)
CMY: 
102931374(GALC)
ACS: 
100564761(galc)
PBI: 
103054662(GALC)
XTR: 
779723(galc)
DRE: 
406385(galcb) 449649(galca)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102356089(GALC)
CMK: 
103185410(galc)
BFO: 
CIN: 
100182893(galc)
SPU: 
HRO: 
LGI: 
TAD: 
AQU: 
MBR: 
SCC: 
BSA: 
 » show all
Taxonomy
Reference
1  [PMID:5320641]
  Authors
Brady RO, Gal AE, Kanfer JN, Bradley RM.
  Title
The metabolism of glucocerebrosides. 3. Purification and properties of a glucosyl- and galactosylceramide-cleaving enzyme from rat intestinal tissue.
  Journal
J. Biol. Chem. 240 (1965) 3766-70.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9027-89-8

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