KEGG   ENZYME: 3.4.13.18Help
Entry
EC 3.4.13.18                Enzyme                                 

Name
cytosol nonspecific dipeptidase;
N2-beta-alanylarginine dipeptidase;
glycyl-glycine dipeptidase;
glycyl-leucine dipeptidase;
iminodipeptidase;
peptidase A;
Pro-X dipeptidase;
prolinase;
prolyl dipeptidase;
prolylglycine dipeptidase;
iminodipeptidase;
prolinase;
L-prolylglycine dipeptidase;
prolylglycine dipeptidase;
diglycinase;
Gly-Leu hydrolase;
glycyl-L-leucine dipeptidase;
glycyl-L-leucine hydrolase;
glycyl-L-leucine peptidase;
L-amino-acyl-L-amino-acid hydrolase;
glycylleucine peptidase;
glycylleucine hydrolase;
glycylleucine dipeptide hydrolase;
non-specific dipeptidase;
human cytosolic non-specific dipeptidase;
glycyl-L-leucine hydrolase;
glycyl-glycine dipeptidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids
Reaction(KEGG)
(other) R01166 R01992
Show
Comment
A zinc enzyme with broad specificity, varying somewhat with source species. Activated and stabilized by dithiothreitol and Mn2+. Inhibited by bestatin and leucine.
History
EC 3.4.13.18 created 1961 as EC 3.4.3.1 and EC 3.4.3.2, transferred 1972 to EC 3.4.13.1 and EC 3.4.13.2, transferred 1978 to EC 3.4.13.11, part transferred 1992 to EC 3.4.13.18, modified 2000 (EC 3.4.13.15 created 1989, incorporated 1992)
Pathway
Arginine and proline metabolism
Histidine metabolism
beta-Alanine metabolism
Metabolic pathways
Orthology
K08660  
cytosolic nonspecific dipeptidase
Genes
HSA: 
55748(CNDP2)
PTR: 
455473(CNDP2)
GGO: 
101126755(CNDP2)
PON: 
100174694(CNDP2)
NLE: 
100583155(CNDP2)
MCC: 
695080(CNDP2)
MCF: 
CJC: 
100393355(CNDP2)
MMU: 
66054(Cndp2)
RNO: 
291394(Cndp2)
CGE: 
100760626(Cndp2)
NGI: 
103748118(Cndp2)
HGL: 
101709694(Cndp2)
OCU: 
100347984(CNDP2)
TUP: 
102489914(CNDP2)
CFA: 
476166(CNDP2)
AML: 
UMR: 
103658414(CNDP2)
FCA: 
101095774(CNDP2)
PTG: 
102964722(CNDP2)
BTA: 
512626(CNDP2)
BOM: 
102267439(CNDP2)
PHD: 
102320179(CNDP2)
CHX: 
102189261(CNDP2)
OAS: 
101111244(CNDP2)
SSC: 
100158127(CNDP2)
CFR: 
102510239(CNDP2)
BACU: 
103016660(CNDP2)
LVE: 
103085206(CNDP2)
ECB: 
100061697(CNDP2)
MYB: 
102242032(CNDP2)
MYD: 
102767302(CNDP2)
PALE: 
102880342(CNDP2)
MDO: 
100016094(CNDP2)
SHR: 
OAA: 
GGA: 
421013(CNDP2)
MGP: 
APLA: 
101791366(CNDP2)
TGU: 
100229152(CNDP2)
FAB: 
101807367(CNDP2)
PHI: 
102114713(CNDP2)
FPG: 
101914717(CNDP2)
FCH: 
102052576(CNDP2)
CLV: 
102092467(CNDP2)
ASN: 
AMJ: 
102563741(CNDP2)
PSS: 
102446043(CNDP2)
CMY: 
102938228(CNDP2)
ACS: 
PBI: 
103052866(CNDP2)
XLA: 
380001(cndp2) 446978(cndp2a)
XTR: 
394907(cndp2)
DRE: 
327288(cndp2)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102355182(CNDP2)
CMK: 
103184951(cndp2)
BFO: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
412393(GB13427)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
LOA: 
TSP: 
LGI: 
NVE: 
HMG: 
100210621(cndp2)
GSL: 
CCP: 
MBR: 
 » show all
Taxonomy
Reference
1
  Authors
Bauer, K.
  Title
Cytosol non-specific dipeptidase.
  Journal
In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.), Handbook of Proteolytic Enzymes, Academic Press, London, 1998, p. 1520-1522.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9025-31-4

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