KEGG   ENZYME: 3.4.14.10Help
Entry
EC 3.4.14.10                Enzyme                                 

Name
tripeptidyl-peptidase II;
tripeptidyl aminopeptidase;
tripeptidyl peptidase;
tripeptidyl aminopeptidase II;
tripeptidyl peptidase II;
TPP
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidyl-peptidases and tripeptidyl-peptidases
BRITE hierarchy
Reaction(IUBMB)
Release of an N-terminal tripeptide from a polypeptide
Comment
A cytosolic enzyme in peptidase family S8 (subtilisin family). Active at neutral pH. Inhibited by diisopropyl fluorophosphate. Formerly included in EC 3.4.14.8
History
EC 3.4.14.10 created 1992 (part of EC 3.4.14.8 created 1989, incorporated 1992)
Orthology
K01280  tripeptidyl-peptidase II
Genes
HSA: 7174(TPP2)
PTR: 452645(TPP2)
PPS: 100979697(TPP2)
GGO: 101135379(TPP2)
PON: 100172493(TPP2)
NLE: 100581612(TPP2) 100592431 105739200
MCC: 701311(TPP2)
MCF: 101865014(TPP2)
CSAB: 103214737(TPP2)
RRO: 104654017(TPP2)
RBB: 108521644(TPP2)
CJC: 100391991(TPP2)
SBQ: 101037381(TPP2)
MMU: 22019(Tpp2)
RNO: 81815(Tpp2)
CGE: 100751018(Tpp2)
NGI: 103751647(Tpp2)
HGL: 101700345(Tpp2)
CCAN: 109693747(Tpp2)
OCU: 100359134(TPP2)
TUP: 102491918(TPP2)
CFA: 100855853(TPP2)
AML: 100472407(TPP2)
UMR: 103657636(TPP2)
ORO: 101371298(TPP2)
FCA: 101082370(TPP2)
PTG: 102969991(TPP2)
AJU: 106983027(TPP2)
BTA: 526052(TPP2)
BOM: 102273977(TPP2)
BIU: 109566938(TPP2)
PHD: 102333369(TPP2)
CHX: 102169112(TPP2)
OAS: 101113507(TPP2)
SSC: 100511152(TPP2)
CFR: 102514630(TPP2)
CDK: 105094097(TPP2)
BACU: 103006667(TPP2)
LVE: 103077108(TPP2)
OOR: 101284092(TPP2)
ECB: 100050973(TPP2)
EPZ: 103560019(TPP2)
EAI: 106830041(TPP2)
MYB: 102261518(TPP2)
MYD: 102763719(TPP2)
HAI: 109394087(TPP2)
RSS: 109439992 109447057(TPP2)
PALE: 102878730(TPP2)
LAV: 100675866(TPP2)
TMU: 101341260
MDO: 100018913(TPP2)
SHR: 100932521(TPP2)
OAA: 100082920(TPP2)
GGA: 428020(TPP2)
MGP: 100540785(TPP2)
CJO: 107307969(TPP2)
APLA: 101800618(TPP2)
ACYG: 106031919(TPP2)
TGU: 100221846(TPP2)
GFR: 102037153(TPP2)
FAB: 101820047(TPP2)
PHI: 102108612(TPP2)
PMAJ: 107207308(TPP2)
CCW: 104685991(TPP2)
FPG: 101917191(TPP2)
FCH: 102051260(TPP2)
CLV: 102092306(TPP2)
EGZ: 104131382(TPP2)
AAM: 106493913(TPP2)
ASN: 102383303(TPP2)
AMJ: 102568353(TPP2)
PSS: 102443431(TPP2)
CMY: 102932230(TPP2)
CPIC: 101932912(TPP2)
ACS: 100552517(tpp2)
PVT: 110080003(TPP2)
PBI: 103065222(TPP2)
GJA: 107115732(TPP2)
XLA: 108709744(tpp2.S) 443806(tpp2.L)
XTR: 100101674(tpp2)
NPR: 108804747(TPP2)
DRE: 100331669(tpp2)
IPU: 108258999(tpp2)
AMEX: 103046829(tpp2)
TRU: 101077190(tpp2)
LCO: 104922536(tpp2)
NCC: 104958875(tpp2)
MZE: 101481116(tpp2)
OLA: 101174009(tpp2)
XMA: 102234712(tpp2)
PRET: 103461961(tpp2)
NFU: 107381138(tpp2)
CSEM: 103378933(tpp2)
LCF: 108888019(tpp2)
HCQ: 109519672(tpp2)
BPEC: 110173024(tpp2)
SASA: 106575025(tpp2) 106575034
ELS: 105020121(tpp2)
SFM: 108938473(tpp2)
LCM: 102350093(TPP2)
CMK: 103177578(tpp2) 103178210
CIN: 100177474(tpp2)
SPU: 583848
APLC: 110983628
DME: Dmel_CG3991(TppII)
DSI: Dsimw501_GD25789(Dsim_GD25789)
MDE: 101889276
AAG: 5572106
AME: 412055(TppII)
BIM: 100749640
BTER: 100647107
SOC: 105200904
AEC: 105154625
ACEP: 105622872
PBAR: 105433561
HST: 105185706
CFO: 105251650
LHU: 105674024
PGC: 109854061
NVI: 100122357
TCA: 657622
DPA: 109540902
NVL: 108556611
BMOR: 101742969
PMAC: 106716063
DNX: 107165447
ZNE: 110835281
FCD: 110856131
TUT: 107366136
CEL: CELE_F21H12.6(tpp-2)
CBR: CBG02572
BMY: Bm1_25090
TSP: Tsp_09238
CRG: 105320486
MYI: 110462454
OBI: 106874742
SHX: MS3_00195
EPA: 110246127
ADF: 107332456
HMG: 100205895
ATH: AT4G20850(TPP2)
CRB: 17879953
CPAP: 110810280
CIT: 102615091
TCC: 18605576
LJA: Lj0g3v0190979.1(Lj0g3v0190979.1) Lj2g3v0391790.1(Lj2g3v0391790.1) Lj5g3v2013440.1(Lj5g3v2013440.1)
FVE: 101291383
PPER: 18787294
PMUM: 103333208
PAVI: 110767759
ZJU: 107414512
CSV: 101220162(TPP2)
CMO: 103482548
MCHA: 111025404
CMAX: 111471490
CMOS: 111430230
CPEP: 111808490
RCU: 8281007
JCU: 105648461
HBR: 110662206
VVI: 100248019(TPP2)
SLY: 101244555
SOT: 102591471
CANN: 107863279
NSY: 104243251
NTO: 104109952
INI: 109146488
SIND: 105160468
HAN: 110885815
LSV: 111900783
DCR: 108203289
BVG: 104888547
SOE: 110784171
NNU: 104596074
OSA: 4330237
DOSA: Os02t0664300-01(Os02g0664300)
OBR: 102701235
BDI: 100840642
ATS: 109732424(LOC109732424)
SBI: 8076065
ZMA: 103627523
SITA: 101765055
PDA: 103719383
EGU: 105042882
MUS: 103970347
DCT: 110099325
AOF: 109837263
ATR: 18423030
MNG: MNEG_9542
APRO: F751_2683
SPO: SPAP8A3.12c(tpp2)
MGL: MGL_0154
 » show all
Taxonomy
Reference
1  [PMID:6352701]
  Authors
Balow RM, Ragnarsson U, Zetterqvist O.
  Title
Tripeptidyl aminopeptidase in the extralysosomal fraction of rat liver.
  Journal
J. Biol. Chem. 258 (1983) 11622-8.
Reference
2  [PMID:3511062]
  Authors
Balow RM, Tomkinson B, Ragnarsson U, Zetterqvist O.
  Title
Purification, substrate specificity, and classification of tripeptidyl peptidase II.
  Journal
J. Biol. Chem. 261 (1986) 2409-17.
Reference
3  [PMID:1691635]
  Authors
Tomkinson B, Zetterqvist O.
  Title
Immunological cross-reactivity between human tripeptidyl peptidase II and fibronectin.
  Journal
Biochem. J. 267 (1990) 149-54.
  Sequence
[hsa:7174]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.14.10
IUBMB Enzyme Nomenclature: 3.4.14.10
ExPASy - ENZYME nomenclature database: 3.4.14.10
BRENDA, the Enzyme Database: 3.4.14.10
CAS: 101149-94-4

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