KEGG   ENZYME: 3.4.17.1Help
Entry
EC 3.4.17.1                 Enzyme                                 

Name
carboxypeptidase A;
carboxypolypeptidase;
pancreatic carboxypeptidase A;
tissue carboxypeptidase A
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
BRITE hierarchy
Reaction(IUBMB)
Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro
Comment
A zinc enzyme formed from procarboxypeptidase A. Isolated from cattle, pig and dogfish pancreas, and other sources including mast cells [3] and skeletal muscle [4]. Type example of peptidase family M14.
History
EC 3.4.17.1 created 1961 as EC 3.4.2.1, transferred 1972 to EC 3.4.12.2, transferred 1978 to EC 3.4.17.1
Orthology
K08779  carboxypeptidase A1
K08780  carboxypeptidase A3
K08781  carboxypeptidase A5
K08782  carboxypeptidase A6
Genes
HSA: 1357(CPA1) 1359(CPA3) 57094(CPA6) 93979(CPA5)
PTR: 100614351(CPA1) 471081(CPA3) 472786(CPA6) 742366(CPA5)
PPS: 100981388(CPA1) 100982515(CPA5) 100982967(CPA6) 100992364(CPA3)
GGO: 101129862(CPA3) 101139091(CPA6) 101153254(CPA5) 101154468(CPA1)
PON: 100431233(CPA3) 100451977(CPA6) 100459398(CPA5) 100460151(CPA1)
NLE: 100591248(CPA6) 100604190(CPA5) 100605530(CPA1) 100606371(CPA3)
MCC: 702974(CPA5) 703095(CPA1) 705117(CPA6) 712564(CPA3)
MCF: 101865458(CPA5) 102122589(CPA6) 102133770(CPA1) 102134275(CPA3)
CSAB: 103226893(CPA1) 103226894(CPA5) 103236928(CPA6) 103241514(CPA3)
RRO: 104668815(CPA6) 104671555(CPA3) 104674463(CPA5) 104674464(CPA1)
RBB: 108518295(CPA3) 108531565(CPA5) 108531568(CPA1) 108544895(CPA6)
CJC: 100389601(CPA6) 100391972(CPA1) 100393077(CPA5) 100405681(CPA3)
SBQ: 101037345(CPA3) 101037789(CPA6) 101040071(CPA5) 101040402(CPA1)
MMU: 109697(Cpa1) 12873(Cpa3) 329093(Cpa6) 74649(Cpa5)
RNO: 24269(Cpa1) 312913(Cpa6) 408212(Cpa5) 54242(Cpa3)
CGE: 100751382(Cpa3) 100757381(Cpa5) 100757667(Cpa1) 100761681(Cpa6)
NGI: 103744535(Cpa5) 103744537(Cpa1) 103745992(Cpa3) 103751382(Cpa6)
HGL: 101699386(Cpa1) 101699746(Cpa5) 101708498(Cpa6) 101715950(Cpa3)
CCAN: 109682823(Cpa3) 109699192(Cpa5) 109699196(Cpa1) 109699271(Cpa6)
OCU: 100345666(CPA6) 100349745(CPA5) 100351403(CPA1) 100355711(CPA3)
TUP: 102468722(CPA3) 102486586(CPA6) 102490256(CPA5) 102492627(CPA1)
CFA: 475192(CPA1) 482257(CPA5) 485707(CPA3) 486983(CPA6)
AML: 100471713(CPA3) 100478795(CPA5) 109488326(CPA1)
UMR: 103676661(CPA5) 103676701(CPA1) 103678079(CPA3) 103680779 103681273(CPA6)
ORO: 101370218(CPA6) 101375838(CPA1) 101376160(CPA3) 101376313(CPA5)
FCA: 101082429(CPA3) 101089089(CPA5) 101089929(CPA1) 101093080(CPA6)
PTG: 102965372(CPA1) 102966038(CPA5) 102967903(CPA3) 102972645(CPA6)
AJU: 106971274(CPA6) 106973907(CPA5) 106973908(CPA1) 106975220(CPA3)
BTA: 100337371(CPA6) 286762(CPA1) 511416(CPA5) 528454(CPA3)
BOM: 102265447(CPA3) 102266646 102270897(CPA5) 102271372(CPA1) 102277388(CPA6)
PHD: 102332437(CPA3) 102333515(CPA6) 102336067(CPA5) 102336663(CPA1)
CHX: 102173692(CPA3) 102174320(CPA6) 102182943(CPA5) 102183207(CPA1)
SSC: 100158041(CPA6) 100513961(CPA5) 100628044(CPA3) 397476(CPA1)
CFR: 102508209(CPA3) 102510282(CPA6) 102522976(CPA5) 102523392(CPA1)
CDK: 105085386(CPA5) 105085388(CPA1) 105089508(CPA3) 105096937(CPA6)
BACU: 103000037(CPA3) 103007986(CPA6) 103017082(CPA5) 103017517(CPA1)
LVE: 103068506(CPA5) 103068782(CPA1) 103070002(CPA3) 103084923(CPA6)
OOR: 101272605(CPA1) 101272861(CPA5) 101287149(CPA6) 101290405(CPA3)
ECB: 100050818(CPA3) 100057174(CPA1) 100063218(CPA6) 100071982(CPA5)
EPZ: 103546320(CPA5) 103546346(CPA1) 103558754(CPA3) 103559068(CPA6)
EAI: 106829400(CPA6) 106829464(CPA3) 106839554(CPA5) 106839555(CPA1)
MYB: 102244500(CPA3) 102253809(CPA5) 102254107(CPA1) 102261578(CPA6)
MYD: 102771945(CPA3) 102774311(CPA1) 102774597(CPA5) 102775107(CPA6)
HAI: 109375860(CPA3) 109377431(CPA6) 109384611(CPA1) 109384613(CPA5)
RSS: 109444137(CPA6) 109456513(CPA3) 109457278(CPA1) 109457281(CPA5)
PALE: 102887668(CPA1) 102889901(CPA5) 102891573(CPA6) 102896116(CPA3)
LAV: 100675118(CPA3) 100675175(CPA5) 100676313(CPA6)
MDO: 100017752(CPA3) 100020573(CPA5) 100028936(CPA6) 100618537(CPA1)
GGA: 395276(CPA1) 416683(CPA5) 420171(CPA6)
APLA: 101789381 101804024(CPA6) 101805302(CPA1)
TGU: 100222078(CPA6) 100224866
PHI: 102104077(CPA6) 102108966 102109153(CPA1)
FPG: 101915285(CPA6) 101922598(CPA1) 101922771
FCH: 102054064(CPA6) 102059678 102059843(CPA1)
ASN: 102370184(CPA3) 102370973(CPA6) 102377914(CPA1)
AMJ: 102563103(CPA1) 102569985(CPA3) 102577051(CPA6) 106737473
CMY: 102929605(CPA3) 102937934(CPA6) 102942351 102942795(CPA1)
CPIC: 101930758(CPA3) 101942494(CPA1) 101947906(CPA6) 101950052
PBI: 103050484(CPA1) 103051327(CPA6) 103063807 103064043(CPA3)
XLA: 100126651 108717078 379614(cpa1.S) 379903(cpa6.L) 495367(cpa1.L)
XTR: 100144967(cpa6) 100494117(cpa3) 105947369 497006(cpa1)
DRE: 100002342(cpa6) 246092(cpa5)
IPU: 100529045(cbpa1) 108256134(cpa6) 108269091
LCO: 104921508(cpa6) 104930740
NCC: 104940976 104958691(cpa6)
NFU: 107373665 107373669(cpa1) 107382901(cpa6)
CSEM: 103377116(cpa6) 103379591(cpa1)
LCF: 108881799(cpa6) 108894026(cpa1)
HCQ: 109513694(cpa6) 109530868(cpa1)
BPEC: 110155108(cpa1) 110160851(cpa6)
LCM: 102353603(CPA1) 102358269(CPA6)
CMK: 103174486(cpa6) 103176959(cpa1)
TUT: 107359313
TSP: Tsp_08243
AQU: 100638497
 » show all
Taxonomy
Reference
1
  Authors
Petra, P.H.
  Title
Bovine procarboxypeptidase and carboxypeptidase A.
  Journal
Methods Enzymol. 19 (1970) 460-503.
Reference
2  [PMID:5140186]
  Authors
Reeck GR, Walsh KA, Neurath H.
  Title
Isolation and characterization of carboxypeptidases A and B from activated pancreatic juice.
  Journal
Biochemistry. 10 (1971) 4690-8.
Reference
3  [PMID:7371832]
  Authors
Everitt MT, Neurath H.
  Title
Rat peritoneal mast cell carboxypeptidase: localization, purification, and enzymatic properties.
  Journal
FEBS. Lett. 110 (1980) 292-6.
Reference
4  [PMID:7018567]
  Authors
Bodwell JE, Meyer WL.
  Title
Purification and characterization of carboxypeptidase A from rat skeletal muscle.
  Journal
Biochemistry. 20 (1981) 2767-77.
Other DBs
ExplorEnz - The Enzyme Database: 3.4.17.1
IUBMB Enzyme Nomenclature: 3.4.17.1
ExPASy - ENZYME nomenclature database: 3.4.17.1
BRENDA, the Enzyme Database: 3.4.17.1
CAS: 11075-17-5

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