KEGG   ENZYME: 3.4.17.1Help
Entry
EC 3.4.17.1                 Enzyme                                 
Name
carboxypeptidase A;
carboxypolypeptidase;
pancreatic carboxypeptidase A;
tissue carboxypeptidase A
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
BRITE hierarchy
Reaction(IUBMB)
Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro
Comment
A zinc enzyme formed from procarboxypeptidase A. Isolated from cattle, pig and dogfish pancreas, and other sources including mast cells [3] and skeletal muscle [4]. Type example of peptidase family M14.
Orthology
K08779  
carboxypeptidase A1
K08780  
carboxypeptidase A3
K08781  
carboxypeptidase A5
K08782  
carboxypeptidase A6
Genes
HSA: 
1357(CPA1) 1359(CPA3) 57094(CPA6) 93979(CPA5)
PTR: 
100614351(CPA1) 471081(CPA3) 472786(CPA6) 742366(CPA5)
PPS: 
100981388(CPA1) 100982515(CPA5) 100982967(CPA6) 100992364(CPA3)
GGO: 
PON: 
100431233(CPA3) 100451977(CPA6) 100459398(CPA5) 100460151(CPA1)
MCC: 
702974(CPA5) 703095(CPA1) 705117(CPA6) 712564(CPA3)
MMU: 
109697(Cpa1) 12873(Cpa3) 329093(Cpa6) 74649(Cpa5)
RNO: 
24269(Cpa1) 312913(Cpa6) 408212(Cpa5) 54242(Cpa3)
CFA: 
475192(CPA1) 482257(CPA5) 485707(CPA3) 486983(CPA6)
AML: 
100471713(CPA3) 100478795(CPA5) 100479215(CPA1)
FCA: 
101082429(CPA3) 101089507(CPA5) 101089929(CPA1) 101093080(CPA6)
BTA: 
100337371 286762(CPA1) 511416(CPA5) 528454(CPA3)
SSC: 
100158041(CPA6) 100513961 397476(PCPA1)
ECB: 
100050818 100057174 100063218(CPA6) 100071982(CPA5)
MDO: 
100017752 100020573 100028936(CPA6) 100618537
SHR: 
100913477(CPA6) 100916834(CPA5) 100917098(CPA1) 100928548(CPA3)
OAA: 
100079424 100079460 100080502(CPA6)
GGA: 
395276(CPA1) 416683(CPA5) 420171(CPA6)
MGP: 
100543921(CPA6)
TGU: 
100221042 100222078(CPA6) 100224866
ACS: 
100555460 100564029 100566934(cpa6)
XLA: 
379614 379903(cpa6) 495367(cpa1)
XTR: 
100144967(cpa6) 497006(cpa1)
DRE: 
100002342 246092(cpa5)
TRU: 
100137506(cpa1) 101065753 101071569
OLA: 
101163721 101171451
 » show all
Taxonomy
Reference
1
  Authors
Petra, P.H.
  Title
Bovine procarboxypeptidase and carboxypeptidase A.
  Journal
Methods Enzymol. 19 (1970) 460-503.
Reference
2  [PMID:5140186]
  Authors
Reeck GR, Walsh KA, Neurath H.
  Title
Isolation and characterization of carboxypeptidases A and B from activated pancreatic juice.
  Journal
Biochemistry. 10 (1971) 4690-8.
  Organism
Bos taurus [GN:bta]
Reference
3  [PMID:7371832]
  Authors
Everitt MT, Neurath H.
  Title
Rat peritoneal mast cell carboxypeptidase: localization, purification, and enzymatic properties.
  Journal
FEBS. Lett. 110 (1980) 292-6.
  Organism
Rattus norvegicus [GN:rno]
Reference
4  [PMID:7018567]
  Authors
Bodwell JE, Meyer WL.
  Title
Purification and characterization of carboxypeptidase A from rat skeletal muscle.
  Journal
Biochemistry. 20 (1981) 2767-77.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
11075-17-5
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