KEGG   ENZYME: 3.4.17.1Help
Entry
EC 3.4.17.1                 Enzyme                                 

Name
carboxypeptidase A;
carboxypolypeptidase;
pancreatic carboxypeptidase A;
tissue carboxypeptidase A
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
BRITE hierarchy
Reaction(IUBMB)
Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro
Comment
A zinc enzyme formed from procarboxypeptidase A. Isolated from cattle, pig and dogfish pancreas, and other sources including mast cells [3] and skeletal muscle [4]. Type example of peptidase family M14.
History
EC 3.4.17.1 created 1961 as EC 3.4.2.1, transferred 1972 to EC 3.4.12.2, transferred 1978 to EC 3.4.17.1
Orthology
K08779  
carboxypeptidase A1
K08780  
carboxypeptidase A3
K08781  
carboxypeptidase A5
K08782  
carboxypeptidase A6
Genes
HSA: 
1357(CPA1) 1359(CPA3) 57094(CPA6) 93979(CPA5)
PTR: 
100614351(CPA1) 471081(CPA3) 472786(CPA6) 742366(CPA5)
PPS: 
100981388(CPA1) 100982515(CPA5) 100982967(CPA6) 100992364(CPA3)
GGO: 
PON: 
100431233(CPA3) 100451977(CPA6) 100459398(CPA5) 100460151(CPA1)
MCC: 
702974(CPA5) 703095(CPA1) 705117(CPA6) 712564(CPA3)
MCF: 
101865458(CPA5) 102122589(CPA6) 102133770(CPA1) 102134275(CPA3)
MMU: 
109697(Cpa1) 12873(Cpa3) 329093(Cpa6) 74649(Cpa5)
RNO: 
24269(Cpa1) 312913(Cpa6) 408212(Cpa5) 54242(Cpa3)
CGE: 
100751382(Cpa3) 100757381(Cpa5) 100757667(Cpa1) 100761681(Cpa6)
HGL: 
101699386(Cpa1) 101699746(Cpa5) 101708498(Cpa6) 101715950(Cpa3)
TUP: 
102468722(CPA3) 102486586(CPA6) 102490256(CPA5) 102492627(CPA1)
CFA: 
475192(CPA1) 482257(CPA5) 485707(CPA3) 486983(CPA6)
AML: 
100471713(CPA3) 100478795(CPA5) 100479215(CPA1)
FCA: 
101082429(CPA3) 101089507(CPA5) 101089929(CPA1) 101093080(CPA6)
PTG: 
102965372(CPA1) 102966038(CPA5) 102967903(CPA3) 102972645(CPA6)
BTA: 
100337371(CPA6) 286762(CPA1) 511416(CPA5) 528454(CPA3)
BOM: 
PHD: 
102332437(CPA3) 102333515(CPA6) 102336067(CPA5) 102336663(CPA1)
CHX: 
102173692(CPA3) 102174320(CPA6) 102182943(CPA5) 102183207(CPA1)
SSC: 
100158041(CPA6) 100513961 100628044(CPA3) 397476(PCPA1)
CFR: 
102508209(CPA3) 102510282(CPA6) 102522976(CPA5) 102523392(CPA1)
BACU: 
103000037(CPA3) 103007986(CPA6) 103017517(CPA1)
LVE: 
103068782(CPA1) 103070002(CPA3) 103084923(CPA6)
ECB: 
100050818(CPA3) 100057174(CPA1) 100063218(CPA6) 100071982(CPA5)
MYB: 
102244500(CPA3) 102253809(CPA5) 102254107(CPA1) 102261578(CPA6)
MYD: 
102771945(CPA3) 102774311(CPA1) 102774597(CPA5) 102775107(CPA6)
PALE: 
102887668(CPA1) 102889901(CPA5) 102891573(CPA6) 102896116(CPA3)
MDO: 
100017752(CPA3) 100020573(CPA5) 100028936(CPA6) 100618537(CPA1)
SHR: 
100913477(CPA6) 100916834(CPA5) 100917098(CPA1) 100928548(CPA3)
OAA: 
GGA: 
395276(CPA1) 416683(CPA5) 420171(CPA6)
MGP: 
100543921(CPA6)
TGU: 
FAB: 
PHI: 
102104077(CPA6) 102109153(CPA1)
APLA: 
101804024(CPA6) 101805302(CPA1)
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
XLA: 
379614 379903(cpa6) 495367(cpa1)
XTR: 
100144967(cpa6) 497006(cpa1)
DRE: 
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102353603(CPA1) 102358269(CPA6)
CMK: 
103174486(cpa6) 103176959(cpa1)
AQU: 
ACAN: 
EHX: 
 » show all
Taxonomy
Reference
1
  Authors
Petra, P.H.
  Title
Bovine procarboxypeptidase and carboxypeptidase A.
  Journal
Methods Enzymol. 19 (1970) 460-503.
Reference
2  [PMID:5140186]
  Authors
Reeck GR, Walsh KA, Neurath H.
  Title
Isolation and characterization of carboxypeptidases A and B from activated pancreatic juice.
  Journal
Biochemistry. 10 (1971) 4690-8.
  Organism
Bos taurus
Reference
3  [PMID:7371832]
  Authors
Everitt MT, Neurath H.
  Title
Rat peritoneal mast cell carboxypeptidase: localization, purification, and enzymatic properties.
  Journal
FEBS. Lett. 110 (1980) 292-6.
  Organism
Rattus norvegicus
Reference
4  [PMID:7018567]
  Authors
Bodwell JE, Meyer WL.
  Title
Purification and characterization of carboxypeptidase A from rat skeletal muscle.
  Journal
Biochemistry. 20 (1981) 2767-77.
  Organism
Rattus norvegicus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
11075-17-5

DBGET integrated database retrieval system