KEGG   ENZYME: 3.4.17.2Help
Entry
EC 3.4.17.2                 Enzyme                                 

Name
carboxypeptidase B;
protaminase;
pancreatic carboxypeptidase B;
tissue carboxypeptidase B;
peptidyl-L-lysine [L-arginine]hydrolase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential release of a C-terminal lysine or arginine amino acid
Comment
A zinc enzyme formed from procarboxypeptidase B. Isolated from cattle, pig and dogfish pancreas and other sources, including skin fibroblasts [3] and adrenal medulla [4]. In peptidase family M14 (carboxypeptidase A family).
History
EC 3.4.17.2 created 1961 as EC 3.4.2.2, transferred 1972 to EC 3.4.12.3, transferred 1978 to EC 3.4.17.2
Orthology
K01291  carboxypeptidase B
Genes
HSA: 1360(CPB1)
PTR: 460763(CPB1)
PPS: 100992024(CPB1)
GGO: 101129511(CPB1)
PON: 100434248(CPB1)
NLE: 100606718(CPB1)
MCC: 712639(CPB1)
MCF: 102133877(CPB1)
CSAB: 103241512(CPB1)
RRO: 104671554(CPB1)
RBB: 108518296(CPB1)
CJC: 100406051(CPB1)
SBQ: 101037025(CPB1)
MMU: 76703(Cpb1)
RNO: 24271(Cpb1)
CGE: 100751091(Cpb1)
NGI: 103745993(Cpb1)
HGL: 101715608(Cpb1)
CCAN: 109682822(Cpb1)
OCU: 100358803(CPB1)
TUP: 102469136(CPB1)
CFA: 403512(CPB1)
AML: 100471468(CPB1)
UMR: 103678088(CPB1)
ORO: 101376449(CPB1)
FCA: 101082684(CPB1)
PTG: 102968194(CPB1)
AJU: 106975221(CPB1)
BTA: 510039(CPB1)
BOM: 102265167(CPB1)
BIU: 109564536(CPB1)
PHD: 102331849(CPB1)
CHX: 102184477(CPB1)
OAS: 101123433(CPB1)
SSC: 397341(CPB1)
CFR: 102508460(CPB1)
CDK: 105089516(CPB1)
BACU: 103002331(CPB1)
LVE: 103090379(CPB1)
OOR: 101269328(CPB1)
ECB: 100058959(CPB1)
EPZ: 103558753(CPB1)
EAI: 106829437(CPB1)
MYB: 102244805(CPB1)
MYD: 102772230(CPB1)
HAI: 109375861(CPB1)
RSS: 109456516(CPB1)
PALE: 102895857(CPB1)
LAV: 100658791(CPB1)
TMU: 101345894
MDO: 100012656(CPB1)
SHR: 100927003(CPB1)
GGA: 424888(CPB1)
MGP: 100544821(CPB1)
CJO: 107318162(CPB1)
APLA: 101797837(CPB1)
ACYG: 106036191
TGU: 100222062(CPB1)
GFR: 102034134(CPB1)
FAB: 101812580(CPB1)
PHI: 102112631(CPB1)
PMAJ: 107209058
CCW: 104693471
FPG: 101914576(CPB1)
FCH: 102052617(CPB1)
CLV: 102083429(CPB1)
EGZ: 104127123(CPB1)
AAM: 106485858(CPB1)
ASN: 102371682(CPB1)
AMJ: 102570215(CPB1)
PSS: 102455777(CPB1)
CMY: 102929825(CPB1)
CPIC: 101953934(CPB1)
ACS: 100562609(cpb1)
PVT: 110073048
PBI: 103064521(CPB1)
GJA: 107124660(CPB1)
XLA: 108716366 495368(cpb1.S) 733324
XTR: 496994(cpb1)
DRE: 322412(cpb1)
SRX: 107739144(cpb1)
SANH: 107687549
SGH: 107588040(cpb1)
IPU: 108272506(cpb1)
AMEX: 103027518(cpb1)
TRU: 101065526
LCO: 104937211(cpb1)
NCC: 104965401
MZE: 101480644(cpb1)
OLA: 101169819(cpb1)
XMA: 102232269(cpb1)
PRET: 103456548(cpb1)
NFU: 107382805(cpb1)
CSEM: 103377267(cpb1)
LCF: 108881689(cpb1)
HCQ: 109519484
BPEC: 110170041(cpb1)
SASA: 100196225(cbpb1)
ELS: 105026596
SFM: 108927668
LCM: 102347915(CPB1)
CMK: 103184479
CIN: 100181959
TCA: 656929
 » show all
Taxonomy
Reference
1
  Authors
Folk, J.E.
  Title
Carboxypeptidase B (porcine pancreas).
  Journal
Methods Enzymol. 19 (1970) 504-508.
Reference
2  [PMID:1009123]
  Authors
Brodrick JW, Geokas MC, Largman C.
  Title
Human carboxypeptidase B. II. Purification of the enzyme from pancreatic tissue and comparison with the enzymes present in pancreatic secretion.
  Journal
Biochim. Biophys. Acta. 452 (1976) 468-81.
Reference
3  [PMID:40714]
  Authors
Butterworth J, Duncan JJ.
  Title
Carboxypeptidase B activity of cultured skin fibroblasts and relationship to cystic fibrosis.
  Journal
Clin. Chim. Acta. 97 (1979) 39-43.
Reference
4  [PMID:6130442]
  Authors
Wallace EF, Evans CJ, Jurik SM, Mefford IN, Barchas JD.
  Title
Carboxypeptidase B activity from adrenal medulla--is it involved in the processing of proenkephalin?
  Journal
Life. Sci. 31 (1982) 1793-6.
Other DBs
ExplorEnz - The Enzyme Database: 3.4.17.2
IUBMB Enzyme Nomenclature: 3.4.17.2
ExPASy - ENZYME nomenclature database: 3.4.17.2
BRENDA, the Enzyme Database: 3.4.17.2
CAS: 9025-24-5

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