KEGG   ENZYME: 3.4.17.2Help
Entry
EC 3.4.17.2                 Enzyme                                 

Name
carboxypeptidase B;
protaminase;
pancreatic carboxypeptidase B;
tissue carboxypeptidase B;
peptidyl-L-lysine [L-arginine]hydrolase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential release of a C-terminal lysine or arginine amino acid
Comment
A zinc enzyme formed from procarboxypeptidase B. Isolated from cattle, pig and dogfish pancreas and other sources, including skin fibroblasts [3] and adrenal medulla [4]. In peptidase family M14 (carboxypeptidase A family).
History
EC 3.4.17.2 created 1961 as EC 3.4.2.2, transferred 1972 to EC 3.4.12.3, transferred 1978 to EC 3.4.17.2
Orthology
K01291  
carboxypeptidase B
Genes
HSA: 
1360(CPB1)
PTR: 
460763(CPB1)
PPS: 
100992024(CPB1)
GGO: 
101129511(CPB1)
PON: 
100434248(CPB1)
NLE: 
100606718(CPB1)
MCC: 
712639(CPB1)
MCF: 
102133877(CPB1)
CJC: 
100406051(CPB1)
MMU: 
76703(Cpb1)
RNO: 
24271(Cpb1)
CGE: 
100751091(Cpb1)
NGI: 
103745993(Cpb1)
HGL: 
101715608(Cpb1)
OCU: 
100358803(CPB1)
TUP: 
102469136(CPB1)
CFA: 
403512(CPB1)
AML: 
UMR: 
103678088(CPB1)
FCA: 
101082684(CPB1)
PTG: 
102968194(CPB1)
BTA: 
510039(CPB1)
BOM: 
102265167(CPB1)
PHD: 
102331849(CPB1)
CHX: 
102184477(CPB1)
OAS: 
101123433(CPB1)
SSC: 
397341(CPB1)
CFR: 
102508460(CPB1)
BACU: 
103002331(CPB1)
LVE: 
103090379(CPB1)
ECB: 
100058959(CPB1)
MYB: 
102244805(CPB1)
MYD: 
102772230(CPB1)
PALE: 
102895857(CPB1)
MDO: 
100012656(CPB1)
SHR: 
100927003(CPB1)
GGA: 
424888(CPB1)
MGP: 
APLA: 
101797837(CPB1)
TGU: 
100222062(CPB1)
FAB: 
101812580(CPB1)
PHI: 
102112631(CPB1)
FPG: 
101914576(CPB1)
FCH: 
102052617(CPB1)
CLV: 
102083429(CPB1)
ASN: 
102371682(CPB1)
AMJ: 
102570215(CPB1)
PSS: 
102455777(CPB1)
CMY: 
102929825(CPB1)
ACS: 
100562609(cpb1)
PBI: 
103064521(CPB1)
XLA: 
495368(cpb1)
XTR: 
DRE: 
322412(cpb1)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102347915(CPB1)
CMK: 
CIN: 
 » show all
Taxonomy
Reference
1
  Authors
Folk, J.E.
  Title
Carboxypeptidase B (porcine pancreas).
  Journal
Methods Enzymol. 19 (1970) 504-508.
Reference
2  [PMID:1009123]
  Authors
Brodrick JW, Geokas MC, Largman C.
  Title
Human carboxypeptidase B. II. Purification of the enzyme from pancreatic tissue and comparison with the enzymes present in pancreatic secretion.
  Journal
Biochim. Biophys. Acta. 452 (1976) 468-81.
Reference
3  [PMID:40714]
  Authors
Butterworth J, Duncan JJ.
  Title
Carboxypeptidase B activity of cultured skin fibroblasts and relationship to cystic fibrosis.
  Journal
Clin. Chim. Acta. 97 (1979) 39-43.
Reference
4  [PMID:6130442]
  Authors
Wallace EF, Evans CJ, Jurik SM, Mefford IN, Barchas JD.
  Title
Carboxypeptidase B activity from adrenal medulla--is it involved in the processing of proenkephalin?
  Journal
Life. Sci. 31 (1982) 1793-6.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9025-24-5

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