| Entry |
|
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| Name |
thrombin;
fibrinogenase;
thrombase;
thrombofort;
topical;
thrombin-C;
tropostasin;
activated blood-coagulation factor II;
blood-coagulation factor IIa;
factor IIa;
E thrombin;
beta-thrombin;
gamma-thrombin
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
 |
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| Reaction(IUBMB) |
Selective cleavage of Arg!Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B
|
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| Comment |
Formed from prothrombin. More selective than trypsin and plasmin. In peptidase family S1 (trypsin family).
|
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| History |
EC 3.4.21.5 created 1961 as EC 3.4.4.13, transferred 1972 to EC 3.4.21.5
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| Orthology |
| K01313 | coagulation factor II (thrombin) |
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| Genes |
» show all
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| Reference |
1 |
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| Authors |
Baughman, D.J. |
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| Title |
Thrombin assay. |
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| Journal |
Methods Enzymol. 19 (1970) 145-157. |
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| Reference |
2 |
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| Authors |
Magnusson, S. |
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| Title |
Bovine prothrombin and thrombin. |
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| Journal |
Methods Enzymol. 19 (1970) 157-184. |
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| Reference |
3 |
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| Authors |
Miller, K.D. |
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| Title |
Horse prothrombin. |
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| Journal |
Methods Enzymol. 19 (1970) 140-145. |
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| Reference |
|
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| Authors |
Lundblad RL, Kingdon HS, Mann KG. |
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| Title |
Thrombin. |
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| Journal |
Methods. Enzymol. 45 (1976) 156-76. |
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| Reference |
|
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| Authors |
Mann KG. |
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| Title |
Prothrombin. |
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| Journal |
Methods. Enzymol. 45 (1976) 123-56. |
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| Reference |
|
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| Authors |
Davie EW, Fujikawa K, Kurachi K, Kisiel W. |
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| Title |
The role of serine proteases in the blood coagulation cascade. |
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| Journal |
Adv. Enzymol. Relat. Areas. Mol. Biol. 48 (1979) 277-318. |
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| Reference |
|
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| Authors |
Cho K, Tanaka T, Cook RR, Kisiel W, Fujikawa K, Kurachi K, Powers JC. |
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| Title |
Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates. |
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| Journal |
Biochemistry. 23 (1984) 644-50. |
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| Reference |
|
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| Authors |
MacGillivray RT, Davie EW. |
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| Title |
Characterization of bovine prothrombin mRNA and its translation product. |
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| Journal |
Biochemistry. 23 (1984) 1626-34. |
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| Sequence |
|
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.4.21.5 |
| ExPASy - ENZYME nomenclature database: | 3.4.21.5 |
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