KEGG   ENZYME: 3.4.21.5Help
Entry
EC 3.4.21.5                 Enzyme                                 
Name
thrombin;
fibrinogenase;
thrombase;
thrombofort;
topical;
thrombin-C;
tropostasin;
activated blood-coagulation factor II;
blood-coagulation factor IIa;
factor IIa;
E thrombin;
beta-thrombin;
gamma-thrombin
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Selective cleavage of Arg!Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B
Comment
Formed from prothrombin. More selective than trypsin and plasmin. In peptidase family S1 (trypsin family).
Orthology
K01313  
coagulation factor II (thrombin)
Genes
HSA: 
2147(F2)
PTR: 
451158(F2)
PPS: 
GGO: 
PON: 
MCC: 
712729(F2)
MCF: 
MMU: 
14061(F2)
RNO: 
29251(F2)
CGE: 
HGL: 
101720561(F2)
CFA: 
100856539(F2)
AML: 
100472871
FCA: 
101090463(F2)
BTA: 
280685(F2)
BOM: 
102271164(F2)
PHD: 
102321823(F2)
CHX: 
102185018(F2)
SSC: 
100144442(F2)
ECB: 
100057521(F2)
MYB: 
102252492(F2)
MDO: 
100015821
SHR: 
100915186(F2)
OAA: 
100081028
GGA: 
395306(F2)
MGP: 
100549057
TGU: 
100220988(F2)
FAB: 
101811384(F2)
PHI: 
102114657(F2)
APLA: 
101792756(F2)
FPG: 
101912106(F2)
FCH: 
102047000(F2)
CLV: 
102087936(F2)
ASN: 
102370968(F2)
ACS: 
100566916(f2)
XLA: 
443652(f2) 446352(lpa)
XTR: 
548514(f2)
DRE: 
325881(f2)
TRU: 
446073(f2)
MZE: 
101463683
OLA: 
101170246
XMA: 
102217884
LCM: 
102347036(F2)
NVE: 
NEMVE_v1g164017
 » show all
Taxonomy
Reference
1
  Authors
Baughman, D.J.
  Title
Thrombin assay.
  Journal
Methods Enzymol. 19 (1970) 145-157.
Reference
2
  Authors
Magnusson, S.
  Title
Bovine prothrombin and thrombin.
  Journal
Methods Enzymol. 19 (1970) 157-184.
Reference
3
  Authors
Miller, K.D.
  Title
Horse prothrombin.
  Journal
Methods Enzymol. 19 (1970) 140-145.
Reference
4  [PMID:1011989]
  Authors
Lundblad RL, Kingdon HS, Mann KG.
  Title
Thrombin.
  Journal
Methods. Enzymol. 45 (1976) 156-76.
Reference
5  [PMID:1011988]
  Authors
Mann KG.
  Title
Prothrombin.
  Journal
Methods. Enzymol. 45 (1976) 123-56.
Reference
6  [PMID:367103]
  Authors
Davie EW, Fujikawa K, Kurachi K, Kisiel W.
  Title
The role of serine proteases in the blood coagulation cascade.
  Journal
Adv. Enzymol. Relat. Areas. Mol. Biol. 48 (1979) 277-318.
Reference
7  [PMID:6370301]
  Authors
Cho K, Tanaka T, Cook RR, Kisiel W, Fujikawa K, Kurachi K, Powers JC.
  Title
Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates.
  Journal
Biochemistry. 23 (1984) 644-50.
  Organism
Homo sapiens [GN:hsa], Bos taurus [GN:bta]
Reference
8  [PMID:6326805]
  Authors
MacGillivray RT, Davie EW.
  Title
Characterization of bovine prothrombin mRNA and its translation product.
  Journal
Biochemistry. 23 (1984) 1626-34.
  Organism
Bos taurus [GN:bta]
  Sequence
[bta:280685]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9002-04-4
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