Entry |
|
Name |
thrombin;
fibrinogenase;
thrombase;
thrombofort;
topical;
thrombin-C;
tropostasin;
activated blood-coagulation factor II;
blood-coagulation factor IIa;
factor IIa;
E thrombin;
beta-thrombin;
gamma-thrombin
|
Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
 |
Reaction(IUBMB) |
Selective cleavage of Arg!Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B
|
Comment |
Formed from prothrombin. More selective than trypsin and plasmin. In peptidase family S1 (trypsin family).
|
History |
EC 3.4.21.5 created 1961 as EC 3.4.4.13, transferred 1972 to EC 3.4.21.5
|
Orthology |
| coagulation factor II (thrombin) |
|
Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | NLE: | | MCC: | | MCF: | | CSAB: | | RRO: | | RBB: | | CJC: | | SBQ: | | MMU: | | RNO: | | CGE: | | NGI: | | HGL: | | CCAN: | | OCU: | | TUP: | | CFA: | | AML: | | UMR: | | ORO: | | FCA: | | PTG: | | AJU: | | BTA: | | BOM: | | BIU: | | PHD: | | CHX: | | OAS: | | SSC: | | CFR: | | CDK: | | BACU: | | LVE: | | OOR: | | ECB: | | EPZ: | | EAI: | | MYB: | | MYD: | | HAI: | | RSS: | | PALE: | | LAV: | | TMU: | | MDO: | | SHR: | | OAA: | | GGA: | | MGP: | | CJO: | | APLA: | | ACYG: | | TGU: | | GFR: | | FAB: | | PHI: | | PMAJ: | | CCW: | | FPG: | | FCH: | | CLV: | | EGZ: | | AAM: | | ASN: | | AMJ: | | PSS: | | CMY: | | CPIC: | | ACS: | | PVT: | | PBI: | | GJA: | | XLA: | | XTR: | | NPR: | | DRE: | | SRX: | | SANH: | | SGH: | | CCAR: | | IPU: | | AMEX: | | TRU: | | TNG: | | LCO: | | NCC: | | MZE: | | OLA: | | XMA: | | PRET: | | NFU: | | CSEM: | | LCF: | | HCQ: | | BPEC: | | SASA: | | ELS: | | SFM: | | LCM: | | CMK: | | APLC: | | SKO: | | CRG: | | OBI: | | LAK: | | NVE: | | EPA: | | ADF: | | » show all
 |
Reference |
1 |
Authors |
Baughman, D.J. |
Title |
Thrombin assay. |
Journal |
Methods Enzymol. 19 (1970) 145-157. |
Reference |
2 |
Authors |
Magnusson, S. |
Title |
Bovine prothrombin and thrombin. |
Journal |
Methods Enzymol. 19 (1970) 157-184. |
Reference |
3 |
Authors |
Miller, K.D. |
Title |
Horse prothrombin. |
Journal |
Methods Enzymol. 19 (1970) 140-145. |
Reference |
|
Authors |
Lundblad RL, Kingdon HS, Mann KG. |
Title |
Thrombin. |
Journal |
Methods. Enzymol. 45 (1976) 156-76. |
Reference |
|
Authors |
Mann KG. |
Title |
Prothrombin. |
Journal |
Methods. Enzymol. 45 (1976) 123-56. |
Reference |
|
Authors |
Davie EW, Fujikawa K, Kurachi K, Kisiel W. |
Title |
The role of serine proteases in the blood coagulation cascade. |
Journal |
Adv. Enzymol. Relat. Areas. Mol. Biol. 48 (1979) 277-318. |
Reference |
|
Authors |
Cho K, Tanaka T, Cook RR, Kisiel W, Fujikawa K, Kurachi K, Powers JC. |
Title |
Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates. |
Journal |
Biochemistry. 23 (1984) 644-50. |
Reference |
|
Authors |
MacGillivray RT, Davie EW. |
Title |
Characterization of bovine prothrombin mRNA and its translation product. |
Journal |
Biochemistry. 23 (1984) 1626-34. |
Sequence |
|
Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 9002-04-4 |