KEGG   ENZYME: 3.4.21.5Help
Entry
EC 3.4.21.5                 Enzyme                                 
Name
thrombin;
fibrinogenase;
thrombase;
thrombofort;
topical;
thrombin-C;
tropostasin;
activated blood-coagulation factor II;
blood-coagulation factor IIa;
factor IIa;
E thrombin;
beta-thrombin;
gamma-thrombin
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Selective cleavage of Arg!Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B
Comment
Formed from prothrombin. More selective than trypsin and plasmin. In peptidase family S1 (trypsin family).
History
EC 3.4.21.5 created 1961 as EC 3.4.4.13, transferred 1972 to EC 3.4.21.5
Orthology
K01313  
coagulation factor II (thrombin)
Genes
HSA: 
2147(F2)
PTR: 
451158(F2)
PPS: 
GGO: 
PON: 
MCC: 
712729(F2)
MCF: 
MMU: 
14061(F2)
RNO: 
29251(F2)
CGE: 
HGL: 
101720561(F2)
TUP: 
102468231(F2)
CFA: 
100856539(F2)
AML: 
100472871
FCA: 
101090463(F2)
PTG: 
102950768(F2)
BTA: 
280685(F2)
BOM: 
102271164(F2)
PHD: 
102321823(F2)
CHX: 
102185018(F2)
SSC: 
100144442(F2)
CFR: 
102515763(F2)
BACU: 
103013731(F2)
LVE: 
103082406(F2)
ECB: 
100057521(F2)
MYB: 
102252396 102252492(F2)
MYD: 
102752205(F2)
PALE: 
102877724(F2)
MDO: 
100015821(F2)
SHR: 
100915186(F2)
OAA: 
100081028(F2)
GGA: 
395306(F2)
MGP: 
100549057
TGU: 
100220988(F2)
FAB: 
101811384(F2)
PHI: 
102114657(F2)
APLA: 
101792756(F2)
FPG: 
101912106(F2)
FCH: 
102047000(F2)
CLV: 
102087936(F2)
ASN: 
102370968(F2)
AMJ: 
102568064(F2)
PSS: 
102449827(F2)
CMY: 
102937607(F2)
ACS: 
100566916(f2)
PBI: 
103065535(F2)
XLA: 
443652(f2) 446352(lpa)
XTR: 
548514(f2)
DRE: 
325881(f2)
TRU: 
446073(f2)
MZE: 
101463683 101477799
OLA: 
101170246
XMA: 
102217884
LCM: 
102347036(F2)
CMK: 
103186030(f2)
NVE: 
NEMVE_v1g164017
 » show all
Taxonomy
Reference
1
  Authors
Baughman, D.J.
  Title
Thrombin assay.
  Journal
Methods Enzymol. 19 (1970) 145-157.
Reference
2
  Authors
Magnusson, S.
  Title
Bovine prothrombin and thrombin.
  Journal
Methods Enzymol. 19 (1970) 157-184.
Reference
3
  Authors
Miller, K.D.
  Title
Horse prothrombin.
  Journal
Methods Enzymol. 19 (1970) 140-145.
Reference
4  [PMID:1011989]
  Authors
Lundblad RL, Kingdon HS, Mann KG.
  Title
Thrombin.
  Journal
Methods. Enzymol. 45 (1976) 156-76.
Reference
5  [PMID:1011988]
  Authors
Mann KG.
  Title
Prothrombin.
  Journal
Methods. Enzymol. 45 (1976) 123-56.
Reference
6  [PMID:367103]
  Authors
Davie EW, Fujikawa K, Kurachi K, Kisiel W.
  Title
The role of serine proteases in the blood coagulation cascade.
  Journal
Adv. Enzymol. Relat. Areas. Mol. Biol. 48 (1979) 277-318.
Reference
7  [PMID:6370301]
  Authors
Cho K, Tanaka T, Cook RR, Kisiel W, Fujikawa K, Kurachi K, Powers JC.
  Title
Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates.
  Journal
Biochemistry. 23 (1984) 644-50.
  Organism
Homo sapiens, Bos taurus
Reference
8  [PMID:6326805]
  Authors
MacGillivray RT, Davie EW.
  Title
Characterization of bovine prothrombin mRNA and its translation product.
  Journal
Biochemistry. 23 (1984) 1626-34.
  Organism
Bos taurus
  Sequence
[bta:280685]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9002-04-4
DBGET integrated database retrieval system