KEGG   ENZYME: 3.4.21.5Help
Entry
EC 3.4.21.5                 Enzyme                                 

Name
thrombin;
fibrinogenase;
thrombase;
thrombofort;
topical;
thrombin-C;
tropostasin;
activated blood-coagulation factor II;
blood-coagulation factor IIa;
factor IIa;
E thrombin;
beta-thrombin;
gamma-thrombin
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Selective cleavage of Arg!Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B
Comment
Formed from prothrombin. More selective than trypsin and plasmin. In peptidase family S1 (trypsin family).
History
EC 3.4.21.5 created 1961 as EC 3.4.4.13, transferred 1972 to EC 3.4.21.5
Orthology
K01313  
coagulation factor II (thrombin)
Genes
HSA: 
2147(F2)
PTR: 
451158(F2)
PPS: 
GGO: 
PON: 
NLE: 
MCC: 
712729(F2)
MCF: 
CSAB: 
RRO: 
RBB: 
108521952(F2)
CJC: 
100386446(F2)
SBQ: 
101049318(F2)
MMU: 
14061(F2)
RNO: 
29251(F2)
CGE: 
100754947(F2)
NGI: 
103742495(F2)
HGL: 
101720561(F2)
CCAN: 
109681600(F2)
OCU: 
100009146(F2)
TUP: 
102468231(F2)
CFA: 
100856539(F2)
AML: 
100472871(F2)
UMR: 
103672390(F2)
ORO: 
101381460(F2)
FCA: 
101090463(F2)
PTG: 
102950768(F2)
AJU: 
106978029(F2)
BTA: 
280685(F2)
BOM: 
102271164(F2)
BIU: 
109569554(F2)
PHD: 
102321823(F2)
CHX: 
102185018(F2)
OAS: 
100307041(F2)
SSC: 
100144442(F2)
CFR: 
102515763(F2)
CDK: 
105106867(F2)
BACU: 
103013731(F2)
LVE: 
103082406(F2)
OOR: 
101289120(F2)
ECB: 
100057521(F2)
EPZ: 
103566907(F2)
EAI: 
106844001(F2)
MYB: 
102252492(F2)
MYD: 
102752205(F2)
HAI: 
109390173(F2)
RSS: 
109453694(F2)
PALE: 
102877724(F2)
LAV: 
100666651(F2)
TMU: 
101347713
MDO: 
100015821(F2)
SHR: 
100915186(F2)
OAA: 
100081028(F2)
GGA: 
395306(F2)
MGP: 
100549057(F2)
CJO: 
107314808(F2)
APLA: 
101792756(F2)
ACYG: 
106043598(F2)
TGU: 
100220988(F2)
GFR: 
102034334(F2)
FAB: 
101811384(F2)
PHI: 
102114657(F2)
PMAJ: 
107205921(F2)
CCW: 
104697991(F2)
FPG: 
101912106(F2)
FCH: 
102047000(F2)
CLV: 
102087936(F2)
EGZ: 
104134075(F2)
AAM: 
106498225(F2)
ASN: 
102370968(F2)
AMJ: 
102568064(F2)
PSS: 
102449827(F2)
CMY: 
102937607(F2)
CPIC: 
101938037(F2)
ACS: 
100566916(f2)
PVT: 
110081895(F2)
PBI: 
103065535(F2)
GJA: 
107106779(F2)
XLA: 
443652(f2.L) 446352(f2.S)
XTR: 
548514(f2)
NPR: 
108791599(F2)
DRE: 
325881(f2)
SRX: 
107742559
SANH: 
107677184 107703282
SGH: 
107554629 107560109
CCAR: 
109055202 109081878 109081883
IPU: 
108259272(f2)
AMEX: 
103039180(f2)
TRU: 
446073(f2)
TNG: 
GSTEN00012553G001
LCO: 
104936791(f2)
NCC: 
104959957(f2)
MZE: 
101463683 101477799
OLA: 
101170246
XMA: 
102217884(f2)
PRET: 
103480906(f2)
NFU: 
107384579(f2)
CSEM: 
103389837(f2)
LCF: 
108873916 108877193
HCQ: 
109510409(f2)
BPEC: 
110172075(f2)
SASA: 
106561958 106587117
ELS: 
105017464(f2)
SFM: 
108940837(f2)
LCM: 
102347036(F2)
CMK: 
103186030(f2)
APLC: 
110974931
SKO: 
100377746
CRG: 
105327809
OBI: 
106884382
LAK: 
106168770 106175409 112042264
NVE: 
NEMVE_v1g164017
EPA: 
110232337
ADF: 
107333270
 » show all
Taxonomy
Reference
1
  Authors
Baughman, D.J.
  Title
Thrombin assay.
  Journal
Methods Enzymol. 19 (1970) 145-157.
Reference
2
  Authors
Magnusson, S.
  Title
Bovine prothrombin and thrombin.
  Journal
Methods Enzymol. 19 (1970) 157-184.
Reference
3
  Authors
Miller, K.D.
  Title
Horse prothrombin.
  Journal
Methods Enzymol. 19 (1970) 140-145.
Reference
4  [PMID:1011989]
  Authors
Lundblad RL, Kingdon HS, Mann KG.
  Title
Thrombin.
  Journal
Methods. Enzymol. 45 (1976) 156-76.
Reference
5  [PMID:1011988]
  Authors
Mann KG.
  Title
Prothrombin.
  Journal
Methods. Enzymol. 45 (1976) 123-56.
Reference
6  [PMID:367103]
  Authors
Davie EW, Fujikawa K, Kurachi K, Kisiel W.
  Title
The role of serine proteases in the blood coagulation cascade.
  Journal
Adv. Enzymol. Relat. Areas. Mol. Biol. 48 (1979) 277-318.
Reference
7  [PMID:6370301]
  Authors
Cho K, Tanaka T, Cook RR, Kisiel W, Fujikawa K, Kurachi K, Powers JC.
  Title
Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates.
  Journal
Biochemistry. 23 (1984) 644-50.
Reference
8  [PMID:6326805]
  Authors
MacGillivray RT, Davie EW.
  Title
Characterization of bovine prothrombin mRNA and its translation product.
  Journal
Biochemistry. 23 (1984) 1626-34.
  Sequence
[bta:280685]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9002-04-4
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