KEGG   ENZYME: 3.4.21.71Help
Entry
EC 3.4.21.71                Enzyme                                 
Name
pancreatic elastase II;
pancreatic elastase 2
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage: Leu!, Met! and Phe!. Hydrolyses elastin
Comment
A peptidase of family S1 (trypsin family) formed by activation of proelastase II from mammalian pancreas by trypsin. Usually, only one of the pancreatic elastases (see also EC 3.4.21.36) is expressed in a given species; human pancreatic elastase is of type II
Orthology
K01346  
pancreatic elastase II
Genes
HSA: 
51032(CELA2B) 63036(CELA2A)
PTR: 
469129(CELA2B) 747215(CELA2A)
PPS: 
100992916(CELA2A) 100993275(CELA2B)
GGO: 
101130048(CELA2A)
PON: 
MCC: 
694691(ELA2B)
MMU: 
13706(Cela2a)
RNO: 
24332(Cela2a)
BTA: 
282687(CELA2A)
SSC: 
397197(CELA2A)
ECB: 
100050670
MDO: 
100027354
SHR: 
100931746(CELA2A)
OAA: 
100092350
GGA: 
419486(CELA2A)
MGP: 
100542763
TGU: 
100224543
XLA: 
444404
XTR: 
594883(cela2a)
DRE: 
334304(ela2l)
TRU: 
101074248
OLA: 
101168781
VFI: 
VF_A0273
 » show all
Taxonomy
Reference
1  [PMID:3427074]
  Authors
Fletcher TS, Shen WF, Largman C.
  Title
Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA.
  Journal
Biochemistry. 26 (1987) 7256-61.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:2834346]
  Authors
Shirasu Y, Yoshida H, Matsuki S, Takemura K, Ikeda N, Shimada Y, Ozawa T, Mikayama T, Iijima H, Ishida A, et al.
  Title
Molecular cloning and expression in Escherichia coli of a cDNA encoding human pancreatic elastase 2.
  Journal
J. Biochem. (Tokyo). 102 (1987) 1555-63.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
75603-19-9
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