KEGG   ENZYME: 3.4.22.68Help
Entry
EC 3.4.22.68                Enzyme                                 
Name
Ulp1 peptidase;
Smt3-protein conjugate proteinase;
Ubl-specific protease 1;
Ulp1;
Ulp1 endopeptidase;
Ulp1 protease
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly!Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein
Comment
The enzyme from Saccharomyces cerevisiae can also recognize small ubiquitin-like modifier 1 (SUMO-1) from human as a substrate in both SUMO-processing (alpha-linked peptide bonds) and SUMO-deconjugation (epsilon-linked peptide bonds) reactions [1,2,3]. Ulp1 has several functions, including an essential role in chromosomal segregation and progression of the cell cycle through the G2/M phase of the cell cycle. Belongs in peptidase family C48.
Orthology
K03345  
sentrin-specific protease 2 (axin associating molecule)
K08592  
sentrin-specific protease 1
K08593  
sentrin-specific protease 3
K08594  
sentrin-specific protease 5
K08595  
sentrin-specific protease 6
K08596  
sentrin-specific protease 7
K08597  
sentrin-specific protease 8
K16287  
ubiquitin-like-specific protease 1C/D
Genes
HSA: 
123228(SENP8) 205564(SENP5) 26054(SENP6) 26168(SENP3) 29843(SENP1) 57337(SENP7) 59343(SENP2)
PTR: 
100551502(SENP3) 451862(SENP1) 460902(SENP2) 462829(SENP6) 467720(SENP8) 471052(SENP5) 740121(SENP7)
PPS: 
100982993(SENP8) 100984249(SENP6) 100985617(SENP1) 100985684(SENP7) 100987597(SENP2) 100990075(SENP5)
GGO: 
101131081(SENP5) 101132516(SENP2) 101133509(SENP8) 101134882 101141715(SENP7) 101152279(SENP6)
PON: 
100171874(SENP2) 100190851(SENP1) 100432128(SENP6) 100437325(SENP8) 100439916(SENP7) 100441890(SENP5) 100551505(SENP3)
MCC: 
697613(SENP8) 700717(SENP2) 701453(SENP7) 710223(SENP5) 714066(SENP1) 715884(SENP3) 716554(SENP6)
MMU: 
114671(4930444G20Rik) 215351(Senp6) 223870(Senp1) 231201(Susp4) 320213(Senp5) 408191(Gm5415) 408192(Gm9839) 66315(Senp7) 71599(Senp8) 75826(Senp2) 80886(Senp3)
RNO: 
100362532 288167(Senp7) 300193(Senp1) 300860(Senp6) 303245(Senp3) 303874(Senp5) 315723(Senp8) 408216(Senp17) 408222(Senp18) 690251 78973(Senp2)
CFA: 
477629(SENP1) 478661(SENP2) 481883(SENP6) 487631(SENP8) 487955(SENP7) 488033(SENP5) 607655(SENP3)
AML: 
FCA: 
101083362(SENP2) 101088182(SENP5) 101088588(SENP1) 101094508(SENP6) 101094531(SENP7) 101096986(SENP8) 101097929(SENP3)
BTA: 
100138267(SENP3) 100298192(SENP5) 100851477 507820(SENP7) 513300(SENP8) 533853(SENP6) 538091(SENP1) 539639(SENP2)
SSC: 
100155462(SENP6) 100157986(SENP1) 100620778 100623734 100625525 100625547 100738022
ECB: 
100052291 100056855(SENP1) 100059276(SENP2) 100068828(SENP6) 100069684(SENP5) 100072208(SENP7)
MDO: 
100013705 100015849(SENP3) 100016689(SENP7) 100021128(SENP5) 100022054 100026734 100027964
SHR: 
100914316 100915437 100918453(SENP7) 100922656(SENP6) 100922902(SENP5) 100923782(SENP3) 100926941(SENP1) 100929948(SENP8)
OAA: 
100077584(SENP6) 100079737 100081905 100084787 100089576(SENP7) 100090970
GGA: 
415322(SENP8) 421859(SENP6) 424864(SENP2) 424955(SENP5) 426185(SENP1) 769280(SENP7)
MGP: 
100541415 100544898 100545491 100547302(SENP1) 100548025
TGU: 
100217880(SENP1) 100226000(SENP5) 100229801(SENP6) 100231204 100231592(SENP7)
ACS: 
100553998(senp1) 100557880 100559910 100562838 100563272 100565068 100565738
XLA: 
100192354(senp5) 100216311(senp7) 100329216(senp1-b) 379733(senp8-a) 398517(senp1-a) 443695(senp6) 495227(senp3) 735058(senp8-b)
XTR: 
100144689(senp5) 100145737(senp8) 100485161 100486411 100495461
DRE: 
100007636(fj98g07) 503939(senp6a) 556400(im:7163520) 564950(senp3a) 565126 570299(senp5) 571373
TRU: 
101066848 101068606 101072698 101073231 101078483 101079426
OLA: 
100820721 101163035 101165680 101166203 101166989 101173111 101175292
BFO: 
BRAFLDRAFT_121370 BRAFLDRAFT_215895 BRAFLDRAFT_221105
CIN: 
100179196 100183329 100185735
SPU: 
100891399 580189 592825
DME: 
Dmel_CG10107(velo) Dmel_CG12359(Ulp1) Dmel_CG12717 Dmel_CG32110 Dmel_CG8493(Den1)
DPO: 
Dpse_GA10077 Dpse_GA21116 Dpse_GA24323 Dpse_GA25857 Dpse_GA28657
DAN: 
Dana_GF10888 Dana_GF16000 Dana_GF19818
DER: 
Dere_GG15025 Dere_GG18071 Dere_GG19540 Dere_GG20277
DPE: 
Dper_GL10824 Dper_GL13014 Dper_GL13015 Dper_GL13234
DSE: 
Dsec_GM11534 Dsec_GM11948 Dsec_GM13820 Dsec_GM21362 Dsec_GM22759 Dsec_GM22760
DSI: 
Dsim_GD10859 Dsim_GD13111 Dsim_GD15595 Dsim_GD15596 Dsim_GD20914
DWI: 
Dwil_GK10155 Dwil_GK12576 Dwil_GK22166
DYA: 
Dyak_GE12437 Dyak_GE15468 Dyak_GE16200 Dyak_GE20469
DGR: 
Dgri_GH12462 Dgri_GH16109 Dgri_GH22812 Dgri_GH22976
DMO: 
Dmoj_GI11140 Dmoj_GI12378 Dmoj_GI21188
DVI: 
Dvir_GJ12268 Dvir_GJ18697 Dvir_GJ20790
AGA: 
AgaP_AGAP005881 AgaP_AGAP011316
AAG: 
AaeL_AAEL001372 AaeL_AAEL005475 AaeL_AAEL008952
CQU: 
CpipJ_CPIJ002227 CpipJ_CPIJ012457 CpipJ_CPIJ018117
AME: 
413926 726605 726735
NVI: 
100114930(NV19129) 100121679(NV13832) 100122748(NV15691)
TCA: 
656873 659719
API: 
100162084 100163781 100165249
PHU: 
Phum_PHUM316250 Phum_PHUM376540 Phum_PHUM611490
ISC: 
IscW_ISCW003012 IscW_ISCW004690 IscW_ISCW014736
CEL: 
CELE_T10F2.3(ulp-1) CELE_Y38A8.3(ulp-2)
CBR: 
CBG21323(Cbr-ulp-1)
BMY: 
Bm1_17440 Bm1_24800 Bm1_36415
TSP: 
Tsp_07219 Tsp_07338 Tsp_10941
SMM: 
Smp_033260.2 Smp_121890 Smp_159120
NVE: 
NEMVE_v1g114023 NEMVE_v1g158777 NEMVE_v1g238848
HMG: 
100198162 100210021
TAD: 
TRIADDRAFT_23232 TRIADDRAFT_30401 TRIADDRAFT_52470
AQU: 
100634722 100638245
ATH: 
AT1G09730 AT1G10570(OTS2) AT1G60220(ULP1D) AT3G06910(ULP1A) AT4G00690(ULP1B) AT4G15880(ESD4) AT4G33620 AT5G60190
ALY: 
ARALYDRAFT_471074 ARALYDRAFT_471173 ARALYDRAFT_475298 ARALYDRAFT_493298 ARALYDRAFT_497293 ARALYDRAFT_896836 ARALYDRAFT_913052 ARALYDRAFT_919262 ARALYDRAFT_921001
GMX: 
100790302 100790705 100796777 100797013 100800268 100800444 100802161 100805645 100809894 100814225
MTR: 
MTR_2g009580 MTR_3g100390 MTR_4g061080 MTR_4g119970 MTR_5g066230 MTR_5g066240 MTR_5g066530
CSV: 
101206097 101210787 101216028
RCU: 
RCOM_0527830 RCOM_0624670 RCOM_0681230 RCOM_0886160 RCOM_1039430 RCOM_1553820 RCOM_1553830
POP: 
POPTR_551658 POPTR_559004 POPTR_562372 POPTR_570658 POPTR_587320 POPTR_778177 POPTR_821732
VVI: 
100247642 100853949
OSA: 
4326283 4332808 4333089 4338081 4341072 4349534 4351243 9270954
DOSA: 
Os01t0355900-01(Os01g0355900) Os03t0344300-01(Os03g0344300) Os05t0207900-01(Os05g0207900) Os06t0487900-01(Os06g0487900) Os11t0102700-01(Os11g0102700) Os12t0102350-01(Os12g0102350)
BDI: 
100827430 100829908 100831337 100833641 100842374 100843454
SBI: 
SORBI_01g035640(SORBIDRAFT_01g035640) SORBI_03g013930(SORBIDRAFT_03g013930) SORBI_03g034030(SORBIDRAFT_03g034030) SORBI_03g040230(SORBIDRAFT_03g040230) SORBI_04g001916(SORBIDRAFT_04g001916) SORBI_07g006230(SORBIDRAFT_07g006230) SORBI_08g020821(SORBIDRAFT_08g020821) SORBI_08g020823(SORBIDRAFT_08g020823) SORBI_08g020827(SORBIDRAFT_08g020827)
ZMA: 
100217004(cl49646_1(372)) 100275432 100280713 100283868 100284466 100382789
SMO: 
SELMODRAFT_108622 SELMODRAFT_402785 SELMODRAFT_404271 SELMODRAFT_408097 SELMODRAFT_421754 SELMODRAFT_437467 SELMODRAFT_439571 SELMODRAFT_447685 SELMODRAFT_93889
PPP: 
PHYPADRAFT_143972 PHYPADRAFT_168150 PHYPADRAFT_172040 PHYPADRAFT_60415 PHYPADRAFT_90162
CRE: 
CHLREDRAFT_123346 CHLREDRAFT_151321 CHLREDRAFT_194011
VCN: 
VOLCADRAFT_116848 VOLCADRAFT_58901 VOLCADRAFT_86350
OLU: 
OSTLU_17568 OSTLU_7192
OTA: 
Ot12g01430
SCE: 
YIL031W(ULP2) YPL020C(ULP1)
AGO: 
AGOS_ADL089C AGOS_AGL019W
ERC: 
Ecym_4350 Ecym_7307
KLA: 
KLLA0F11000g KLLA0F27665g
LTH: 
KLTH0A02618g KLTH0E04532g
PPA: 
PAS_chr1-1_0010 PAS_chr2-2_0097 PAS_chr4_0503
VPO: 
Kpol_1011p2 Kpol_1063p8 Kpol_401p13
ZRO: 
ZYRO0D15862g ZYRO0F03916g
CGR: 
CAGL0J02464g CAGL0L08646g
NCS: 
NCAS_0A13240(NCAS0A13240) NCAS_0J00620(NCAS0J00620)
NDI: 
NDAI_0A02780(NDAI0A02780) NDAI_0C06270(NDAI0C06270)
TPF: 
TPHA_0C01430(TPHA0C01430) TPHA_0C04540(TPHA0C04540) TPHA_0P00370(TPHA0P00370)
TBL: 
TBLA_0D02670(TBLA0D02670) TBLA_0D04630(TBLA0D04630)
TDL: 
TDEL_0C01000(TDEL0C01000) TDEL_0H02500(TDEL0H02500)
KAF: 
KAFR_0A02630(KAFR0A02630) KAFR_0B01650(KAFR0B01650)
DHA: 
DEHA2B13772g DEHA2C06028g DEHA2F20130g
PIC: 
PICST_29579 PICST_42365 PICST_64139
PGU: 
PGUG_00285 PGUG_01817 PGUG_05330
LEL: 
LELG_00285 LELG_02291 LELG_02679
CAL: 
CaO19.11831(ULP1) CaO19.12896(ULP2) CaO19.353(ULP3) CaO19.4353(ULP1) CaO19.5441(ULP2) CaO19.7986(ULP3)
CTP: 
CTRG_00737 CTRG_00755 CTRG_02468 CTRG_06173
CDU: 
CD36_29050 CD36_80250 CD36_83560
COT: 
CORT_0A02000 CORT_0C03780 CORT_0D07490
YLI: 
YALI0C03652g YALI0E21153g
CLU: 
CLUG_00895 CLUG_01192 CLUG_02343
NCR: 
NCU00734
SMP: 
SMAC_01423
PAN: 
PODANSg09883 PODANSg8721
TTT: 
THITE_2107246 THITE_2122373
MTM: 
MYCTH_2295609 MYCTH_2301060
MGR: 
MGG_05571
FGR: 
FG05026.1 FG06801.1
NHE: 
NECHADRAFT_57904 NECHADRAFT_84803
VAL: 
VDBG_04154 VDBG_05060
SSL: 
SS1G_12760
BFU: 
BC1G_05245 BC1G_08567
ANI: 
AN3754.2
NFI: 
NFIA_025570
AFM: 
AFUA_7G04610
AOR: 
AOR_1_286174(AO090005000150)
ANG: 
ANI_1_170114(An13g01190)
AFV: 
AFLA_073940
ACT: 
ACLA_006300
PCS: 
Pc21g08690
CIM: 
CIMG_07535
CPW: 
CPC735_043930
ABE: 
ARB_02420
TVE: 
TRV_04836
AJE: 
HCAG_06354
PNO: 
SNOG_03653
PTE: 
PTT_19627
ZTR: 
MYCGRDRAFT_45120
TML: 
GSTUM_00010885001 GSTUM_00011022001
SPO: 
SPAC17A5.07c(ulp2) SPBC17D11.01(nep1) SPBC19G7.09(ulp1) SPBC32H8.02c(nep2)
PPL: 
POSPLDRAFT_27430
LBC: 
LACBIDRAFT_227913 LACBIDRAFT_309247
MPR: 
MPER_12319
CCI: 
CC1G_04434
SCM: 
SCHCODRAFT_48500
MGL: 
MGL_3160
PGR: 
PGTG_02972 PGTG_05857
EHE: 
EHEL_050840
MBR: 
MONBRDRAFT_25282
NGR: 
NAEGRDRAFT_61576 NAEGRDRAFT_74065
DDI: 
DDB_G0278795(senp8) DDB_G0289557 DDB_G0292290 DDB_G0293508
DPP: 
DICPUDRAFT_155939 DICPUDRAFT_32083 DICPUDRAFT_55498 DICPUDRAFT_87334
EHI: 
EHI_067510(4.t00069)
EDI: 
EDI_071650
PCB: 
PC000686.02.0
PBE: 
PB000399.03.0
TGO: 
TGME49_014470
TET: 
TTHERM_00077170 TTHERM_00348200
TVA: 
TVAG_008810
PTI: 
PHATRDRAFT_44664
TPS: 
THAPSDRAFT_18071 THAPSDRAFT_25854
PIF: 
PITG_13913 PITG_18649
BJU: 
BJ6T_81250
 » show all
Taxonomy
Reference
1
  Authors
Lima, C.D.
  Title
Ulp1 endopeptidase.
  Journal
In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.), Handbook of Proteolytic Enzymes, 2nd ed., Elsevier, London, 2004, p. 1340-1344.
Reference
2  [PMID:10094048]
  Authors
Li SJ, Hochstrasser M.
  Title
A new protease required for cell-cycle progression in yeast.
  Journal
Nature. 398 (1999) 246-51.
Reference
3  [PMID:11884512]
  Authors
Taylor DL, Ho JC, Oliver A, Watts FZ.
  Title
Cell-cycle-dependent localisation of Ulp1, a Schizosaccharomyces pombe Pmt3 (SUMO)-specific protease.
  Journal
J. Cell. Sci. 115 (2002) 1113-22.
Reference
4  [PMID:12654900]
  Authors
Li SJ, Hochstrasser M.
  Title
The Ulp1 SUMO isopeptidase: distinct domains required for viability, nuclear envelope localization, and substrate specificity.
  Journal
J. Cell. Biol. 160 (2003) 1069-81.
Reference
5  [PMID:17428805]
  Authors
Ihara M, Koyama H, Uchimura Y, Saitoh H, Kikuchi A.
  Title
Noncovalent binding of small ubiquitin-related modifier (SUMO) protease to SUMO is necessary for enzymatic activities and cell growth.
  Journal
J. Biol. Chem. 282 (2007) 16465-75.
Reference
6  [PMID:17499995]
  Authors
Mukhopadhyay D, Dasso M.
  Title
Modification in reverse: the SUMO proteases.
  Journal
Trends. Biochem. Sci. 32 (2007) 286-95.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
DBGET integrated database retrieval system