| Entry |
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| Name |
renin;
angiotensin-forming enzyme;
angiotensinogenase
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
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| Reaction(IUBMB) |
Cleavage of Leu! bond in angiotensinogen to generate angiotensin I
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| Comment |
Formed from prorenin in plasma and kidney. In peptidase family A1 (pepsin A family).
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| Orthology |
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | MCC: | | MMU: | | RNO: | | CFA: | | AML: | | FCA: | | BTA: | | SSC: | | ECB: | | MDO: | | SHR: | | OAA: | | GGA: | | ACS: | | XTR: | | DRE: | | TRU: | | OLA: | |
» show all
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| Reference |
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| Authors |
Inagami T, Murakami K. |
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| Title |
Pure Renin. Isolation from hog kidney and characterization. |
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| Journal |
J. Biol. Chem. 252 (1977) 2978-83. |
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| Organism |
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| Reference |
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| Authors |
Slater EE. |
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| Title |
Renin. |
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| Journal |
Methods. Enzymol. 80 Pt C (1981) 427-42. |
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| Reference |
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| Authors |
Inagami T |
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| Title |
Structure and function of renin. |
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| Journal |
J. Hypertens. Suppl. 7 (1989) S3-8. |
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| Reference |
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| Authors |
Sielecki AR, Hayakawa K, Fujinaga M, Murphy ME, Fraser M, Muir AK, Carilli CT, Lewicki JA, Baxter JD, James MN. |
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| Title |
Structure of recombinant human renin, a target for cardiovascular-active drugs, at 2.5 A resolution. |
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| Journal |
Science. 243 (1989) 1346-51. |
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| Organism |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 9015-94-5 |
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