KEGG   ENZYME: 3.4.24.15Help
Entry
EC 3.4.24.15                Enzyme                                 

Name
thimet oligopeptidase;
Pz-peptidase;
soluble metalloendopeptidase;
endo-oligopeptidase A;
tissue-endopeptidase degrading collagenase-synthetic-substrate
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage of bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5-15 residues
Comment
Thiol compounds activate at low concentrations. Type example of peptidase family M3.
History
EC 3.4.24.15 created 1984 (EC 3.4.22.19 created 1989 and EC 3.4.99.31 created 1978 both incorporated 1992)
Orthology
K01392  
thimet oligopeptidase
Genes
HSA: 
7064(THOP1)
PTR: 
750162(THOP1)
PPS: 
100985112(THOP1)
GGO: 
101143234(THOP1)
PON: 
100455971(THOP1)
MCC: 
721578(THOP1)
MCF: 
102117812(THOP1)
MMU: 
50492(Thop1)
RNO: 
64517(Thop1)
CGE: 
HGL: 
101714143(Thop1)
TUP: 
102500342(THOP1)
CFA: 
476748(THOP1)
AML: 
FCA: 
101083746(THOP1)
PTG: 
102964477(THOP1)
BTA: 
510889(THOP1)
BOM: 
102265369(THOP1)
PHD: 
CHX: 
102178165(THOP1)
SSC: 
397442(THOP1)
CFR: 
102508107(THOP1)
ECB: 
100059667(THOP1)
MYB: 
102262534(THOP1)
MYD: 
102774039(THOP1)
PALE: 
102886786(THOP1)
MDO: 
100020499(THOP1)
SHR: 
100924623(THOP1)
GGA: 
MGP: 
TGU: 
100231983(THOP1)
FAB: 
101805763(THOP1)
PHI: 
102110662(THOP1)
APLA: 
FPG: 
101913462(THOP1)
FCH: 
102053721(THOP1)
CLV: 
102095097(THOP1)
ASN: 
102383675(THOP1)
PSS: 
102457370(THOP1)
CMY: 
102940710(THOP1)
XLA: 
397806(thop1)
XTR: 
779863(thop1)
DRE: 
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102357708(THOP1)
BFO: 
CIN: 
ISC: 
SMM: 
NVE: 
HMG: 
TAD: 
ALY: 
CRB: 
CIT: 
CIC: 
TCC: 
GMX: 
MTR: 
CAM: 
FVE: 
CSV: 
RCU: 
POP: 
POPTR_0010s06460g(POPTRDRAFT_565929)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os01t0902200-01(Os01g0902200)
OBR: 
BDI: 
SBI: 
SORBI_03g042960(SORBIDRAFT_03g042960)
ZMA: 
100280152(si683006e11)
SITA: 
ATR: 
s00049p00066000(AMTR_s00049p00066000)
SMO: 
PPP: 
OLU: 
OTA: 
CME: 
MBR: 
DDI: 
DPP: 
DFA: 
ACAN: 
PIF: 
GTT: 
TBR: 
Tb927.7.190(Tb07.8P12.250)
TCR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
NGR: 
CJA: 
ABC: 
ABN: 
SDE: 
MPT: 
CFU: 
ADE: 
ACP: 
AFW: 
ANK: 
MXA: 
MFU: 
MSD: 
CCX: 
SUR: 
SCL: 
sce4462(prlC1)
SCU: 
HOH: 
DPB: 
BABL1_25(prlC)
OIH: 
NBR: 
NNO: 
MTS: 
CFI: 
CGA: 
ICA: 
NCA: 
ACA: 
GMA: 
TSA: 
SUS: 
EMI: 
FLI: 
FGI: 
 » show all
Taxonomy
Reference
1  [PMID:3244563]
  Authors
Cicilini MA, Ribeiro MJ, de Oliveira EB, Mortara RA, de Camargo AC.
  Title
Endooligopeptidase A activity in rabbit heart: generation of enkephalin from enkephalin containing peptides.
  Journal
Peptides. 9 (1988) 945-55.
  Organism
Oryctolagus cuniculus
Reference
2  [PMID:2803255]
  Authors
Orlowski M, Reznik S, Ayala J, Pierotti AR.
  Title
Endopeptidase 24.15 from rat testes. Isolation of the enzyme and its specificity toward synthetic and natural peptides, including enkephalin-containing peptides.
  Journal
Biochem. J. 261 (1989) 951-8.
  Organism
Rattus norvegicus
Reference
3  [PMID:2123097]
  Authors
Barrett AJ, Brown MA.
  Title
Chicken liver Pz-peptidase, a thiol-dependent metallo-endopeptidase.
  Journal
Biochem. J. 271 (1990) 701-6.
  Organism
Gallus gallus
Reference
4  [PMID:2261476]
  Authors
Pierotti A, Dong KW, Glucksman MJ, Orlowski M, Roberts JL.
  Title
Molecular cloning and primary structure of rat testes metalloendopeptidase EC 3.4.24.15.
  Journal
Biochemistry. 29 (1990) 10323-9.
  Organism
Rattus norvegicus
  Sequence
[rno:64517]
Reference
5  [PMID:2185743]
  Authors
Tisljar U, Barrett AJ.
  Title
Thiol-dependent metallo-endopeptidase characteristics of Pz-peptidase in rat and rabbit.
  Journal
Biochem. J. 267 (1990) 531-3.
  Organism
Rattus norvegicus, Oryctolagus cuniculus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
110639-28-6

DBGET integrated database retrieval system