KEGG   ENZYME: 3.4.24.82Help
Entry
EC 3.4.24.82                Enzyme                                 

Name
ADAMTS-4 endopeptidase;
aggrecanase-1
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Glutamyl endopeptidase; bonds cleaved include -Thr-Glu-Gly-Glu373!Ala-Arg-Gly-Ser- in the interglobular domain of mammalian aggrecan
Comment
In peptidase family M12. Thought to be biologically significant for the degradation of the aggrecan component of cartilage matrix.
History
EC 3.4.24.82 created 2003
Orthology
K07764  
a disintegrin and metalloproteinase with thrombospondin motifs 4
Genes
HSA: 
9507(ADAMTS4)
PTR: 
457453(ADAMTS4)
PPS: 
100978654(ADAMTS4)
GGO: 
101151733(ADAMTS4)
PON: 
100461178(ADAMTS4)
MCC: 
719927(ADAMTS4)
MCF: 
102120792(ADAMTS4)
MMU: 
240913(Adamts4)
RNO: 
66015(Adamts4)
CGE: 
100773045(Adamts4)
HGL: 
101702362(Adamts4)
TUP: 
102502349(ADAMTS4)
CFA: 
488651(ADAMTS4)
AML: 
100482466(ADAMTS4)
FCA: 
101089488(ADAMTS4)
BTA: 
286806(ADAMTS4)
BOM: 
102273858(ADAMTS4)
PHD: 
102314989(ADAMTS4)
CHX: 
102176281(ADAMTS4)
SSC: 
100157276(ADAMTS4)
CFR: 
102524038(ADAMTS4)
ECB: 
100033914(ADAMTS4)
MYB: 
102261845(ADAMTS4)
MYD: 
102773999(ADAMTS4)
PALE: 
102897169(ADAMTS4)
MDO: 
100032755(ADAMTS4)
SHR: 
100922734(ADAMTS4)
FPG: 
101924861(ADAMTS4)
FCH: 
102058101(ADAMTS4)
ASN: 
102388568(ADAMTS4)
PSS: 
102460656(ADAMTS4)
CMY: 
102936762(ADAMTS4)
ACS: 
XTR: 
100487641(adamts4)
LCM: 
102354523(ADAMTS4)
 » show all
Taxonomy
Reference
1  [PMID:11854269]
  Authors
Westling J, Fosang AJ, Last K, Thompson VP, Tomkinson KN, Hebert T, McDonagh T, Collins-Racie LA, LaVallie ER, Morris EA, Sandy JD.
  Title
ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain.
  Journal
J. Biol. Chem. 277 (2002) 16059-66.
  Organism
Homo sapiens
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
147172-61-0

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