KEGG   ENZYME: 3.4.24.85Help
Entry
EC 3.4.24.85                Enzyme                                 

Name
S2P endopeptidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleaves several transcription factors that are type-2 transmembrane proteins within membrane-spanning domains. Known substrates include sterol regulatory element-binding protein (SREBP) -1, SREBP-2 and forms of the transcriptional activator ATF6. SREBP-2 is cleaved at the site DRSR_ILL_483!CVLTFLCLSFNPLTSLLQWGGA, in which the membrane-spanning segment is underlined. The residues NP (bold), 11 residues distal to the site of cleavage in the membrane-spanning domain, are important for cleavage by S2P endopeptidase. Replacement of either of these residues does not prevent cleavage, but there is no cleavage if both of these residues are replaced.
Comment
Type example of peptidase family M50. The transcription factors SREBP-1 and -2 are synthesized as precursor proteins that are attached to the membranes of the endoplasmic reticulum and two cleavages are needed to release the active factor so that it can move to the nucleus. This enzyme cleaves the second of these, and is thus the "site 2 protease", S2P.
History
EC 3.4.24.85 created 2003
Orthology
K07765  S2P endopeptidase
Genes
HSA: 51360(MBTPS2)
PTR: 465532(MBTPS2)
PPS: 100988592(MBTPS2)
GGO: 101135564(MBTPS2)
PON: 100454671(MBTPS2)
MCC: 696540(MBTPS2)
MCF: 102140645(MBTPS2)
CSAB: 103231700(MBTPS2)
RRO: 104672371 104676699(MBTPS2)
RBB: 108532305(MBTPS2)
CJC: 100406330(MBTPS2)
SBQ: 101045752(MBTPS2)
MMU: 270669(Mbtps2)
RNO: 302705(Mbtps2)
CGE: 100689085(Mbtps2)
NGI: 103730145(Mbtps2)
HGL: 101726620(Mbtps2)
CCAN: 109694191(Mbtps2)
OCU: 100344858(MBTPS2)
TUP: 102496221(MBTPS2)
CFA: 491771(MBTPS2)
AML: 100465637(MBTPS2)
UMR: 103668263(MBTPS2)
ORO: 101364136(MBTPS2) 101365783
FCA: 101084262(MBTPS2)
PTG: 102954190(MBTPS2)
AJU: 106982742(MBTPS2)
BTA: 533134(MBTPS2)
BOM: 102280586(MBTPS2)
BIU: 109555212(MBTPS2)
PHD: 102340351(MBTPS2)
CHX: 102190948(MBTPS2)
OAS: 101106915(MBTPS2)
SSC: 102165056(MBTPS2)
CFR: 102512896(MBTPS2)
CDK: 105095321(MBTPS2)
BACU: 103012194
LVE: 103072780(MBTPS2)
OOR: 101272405(MBTPS2)
ECB: 100051796(MBTPS2)
EAI: 106835512(MBTPS2)
MYB: 102251140(MBTPS2)
MYD: 102759985(MBTPS2)
HAI: 109395788(MBTPS2)
RSS: 109436200(MBTPS2)
PALE: 102879833(MBTPS2) 102888641
LAV: 100656136(MBTPS2)
TMU: 101354197
MDO: 100011019(MBTPS2)
SHR: 100929394(MBTPS2)
OAA: 100083166(MBTPS2)
GGA: 427996(MBTPS2)
MGP: 100547714
CJO: 107324943(MBTPS2)
APLA: 101791896(MBTPS2)
ACYG: 106037836(MBTPS2)
TGU: 100221191(MBTPS2)
GFR: 102036374(MBTPS2)
FAB: 101809571(MBTPS2)
PHI: 102114211(MBTPS2)
PMAJ: 107208240(MBTPS2)
CCW: 104686191(MBTPS2)
FPG: 101923038(MBTPS2)
FCH: 102049253(MBTPS2)
CLV: 102083546(MBTPS2)
EGZ: 104135176(MBTPS2)
AAM: 106492099(MBTPS2)
ASN: 102387796(MBTPS2)
AMJ: 102575368(MBTPS2)
PSS: 102444548(MBTPS2)
CMY: 102933913(MBTPS2)
CPIC: 101930956(MBTPS2)
ACS: 100560770(mbtps2)
PVT: 110076743(MBTPS2)
PBI: 103049752(MBTPS2)
GJA: 107125646(MBTPS2)
XLA: 108708013(mbtps2.L)
XTR: 549815(mbtps2)
NPR: 108791843(MBTPS2)
DRE: 334658(mbtps2)
SANH: 107671355(mbtps2)
IPU: 108256590(mbtps2)
AMEX: 103023831(mbtps2)
TRU: 101072394(mbtps2)
LCO: 104928761(mbtps2)
NCC: 104960002(mbtps2)
MZE: 101483191(mbtps2)
OLA: 101156537(mbtps2)
XMA: 102221158(mbtps2)
PRET: 103456744(mbtps2)
NFU: 107383072(mbtps2)
CSEM: 103377480(mbtps2)
LCF: 108885097(mbtps2)
HCQ: 109524711(mbtps2)
BPEC: 110161280(mbtps2)
SASA: 106590709(mbtps2)
ELS: 105007360(mbtps2)
SFM: 108939619(mbtps2)
LCM: 102359463(MBTPS2) 102362818
CMK: 103189988(mbtps2)
CIN: 100184558
SPU: 582844
APLC: 110988215
SKO: 100371404
DME: Dmel_CG8988(S2P)
DSI: Dsimw501_GD25883(Dsim_GD25883)
MDE: 101898733
AAG: 5580236
AME: 724553
BIM: 100741651
BTER: 100648700
SOC: 105199823
AEC: 105148603
ACEP: 105620494
PBAR: 105427989
HST: 105182172
CFO: 105251432
LHU: 105670511
PGC: 109852414
NVI: 100123289(S2P)
TCA: 656329
DPA: 109543687
NVL: 108561796
PMAC: 106709708
PRAP: 110993256
PXY: 105389341
API: 100162197
DNX: 107166620
ZNE: 110826742
FCD: 110851821
TUT: 107369971
CEL: CELE_Y56A3A.2(Y56A3A.2)
CBR: CBG13303
BMY: Bm1_07020
TSP: Tsp_11288
CRG: 105336925
OBI: 106881390
EPA: 110248167
ADF: 107339251
HMG: 100215228
ATH: AT4G20310
BRP: 103858089
BOE: 106306359
THJ: 104806234
CPAP: 110817438
CIT: 102620118
TCC: 18600480
GRA: 105783923
DZI: 111277328
EGR: 104445846
GMX: 100809949
VRA: 106765870
VAR: 108320667
CCAJ: 109807982
CAM: 101493040
ADU: 107476826
AIP: 107626256
LJA: Lj0g3v0230449.1(Lj0g3v0230449.1) Lj0g3v0230449.2(Lj0g3v0230449.2)
LANG: 109331887
FVE: 101307969
PPER: 18778320
PMUM: 103325623
PAVI: 110754841
MDM: 103445955
PXB: 103958088
CSV: 101207924
CMO: 103482997
MCHA: 111022467
CMAX: 111490932
CMOS: 111459160
RCU: 8279017
JCU: 105636831
HBR: 110656436
JRE: 108988814
SOT: 102605458
CANN: 107877204
NTO: 104093874
INI: 109192738
SIND: 105179585
OEU: 111374992
HAN: 110908883
BVG: 104894493
SOE: 110782937
NNU: 104599827
BDI: 100841320
ATS: 109741042(LOC109741042)
SBI: 8054963
SITA: 101770564
PDA: 103708318
EGU: 105047584
MUS: 103984723
DCT: 110105666
AOF: 109840737
ATR: 18448966
DDI: DDB_G0275939(mbtps2)
DFA: DFA_01538(mbtps2)
SPAR: SPRG_01794
 » show all
Taxonomy
Reference
1  [PMID:10693756]
  Authors
Brown MS, Ye J, Rawson RB, Goldstein JL.
  Title
Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans.
  Journal
Cell. 100 (2000) 391-8.
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.85
IUBMB Enzyme Nomenclature: 3.4.24.85
ExPASy - ENZYME nomenclature database: 3.4.24.85
BRENDA, the Enzyme Database: 3.4.24.85
CAS: 752251-31-3

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