KEGG   ENZYME: 3.5.1.48Help
Entry
EC 3.5.1.48                 Enzyme                                 

Name
acetylspermidine deacetylase;
N8-monoacetylspermidine deacetylase;
N8-acetylspermidine deacetylase;
N-acetylspermidine deacetylase;
N1-acetylspermidine amidohydrolase (incorrect);
8-N-acetylspermidine amidohydrolase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
N8-acetylspermidine amidohydrolase
Reaction(IUBMB)
N8-acetylspermidine + H2O = acetate + spermidine [RN:R07300]
Reaction(KEGG)
Substrate
N8-acetylspermidine [CPD:C01029];
H2O [CPD:C00001]
Product
acetate [CPD:C00033];
spermidine [CPD:C00315]
Comment
It was initially thought that N1-acetylspermidine was the substrate for this deacetylase reaction [1] but this has since been disproved by Marchant et al. [3].
History
EC 3.5.1.48 created 1984, modified 2005
Orthology
K01454  
Genes
RET: 
RLE: 
BME: 
BMF: 
Taxonomy
Reference
1  [PMID:28089]
  Authors
Libby PR.
  Title
Properties of an acetylspermidine deacetylase from rat liver.
  Journal
Arch. Biochem. Biophys. 188 (1978) 360-3.
Reference
2  [PMID:708044]
  Authors
Blankenship J.
  Title
Deacetylation of N8-acetylspermidine by subcellular fractions of rat tissue.
  Journal
Arch. Biochem. Biophys. 189 (1978) 20-7.
Reference
3  [PMID:3955076]
  Authors
Marchant P, Manneh VA, Blankenship J.
  Title
N1-acetylspermidine is not a substrate for N-acetylspermidine deacetylase.
  Journal
Biochim. Biophys. Acta. 881 (1986) 297-9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
67339-07-5

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