KEGG   ENZYME: 3.5.1.99Help
Entry
EC 3.5.1.99                 Enzyme                                 
Name
fatty acid amide hydrolase;
FAAH;
oleamide hydrolase;
anandamide amidohydrolase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
fatty acylamide amidohydrolase
Reaction(IUBMB)
(1) anandamide + H2O = arachidonic acid + ethanolamine [RN:R09536];
(2) oleamide + H2O = oleic acid + NH3 [RN:R09537]
Reaction(KEGG)
Substrate
anandamide [CPD:C11695];
H2O [CPD:C00001];
oleamide [CPD:C19670]
Product
arachidonic acid [CPD:C00219];
ethanolamine [CPD:C00189];
oleic acid [CPD:C00712];
NH3 [CPD:C00014]
Comment
Integral membrane protein, the enzyme is responsible for the catabolism of neuromodulatory fatty acid amides, including anandamide and oleamide, occurs in mammalia.
Orthology
K15528  
fatty acid amide hydrolase
Genes
HSA: 
2166(FAAH)
PTR: 
456559(FAAH)
PPS: 
GGO: 
PON: 
MCC: 
MMU: 
14073(Faah)
RNO: 
CFA: 
482510(FAAH)
AML: 
100472602(FAAH)
FCA: 
101095511
BTA: 
513210 540007(FAAH)
SSC: 
396949(FAAH)
ECB: 
100051756(FAAH) 100070179
MDO: 
100023917 100023944
SHR: 
100932365 100932620
GGA: 
424614(FAAH) 429098
MGP: 
100550655 100550962
TGU: 
100218384 100230788
ACS: 
100555796 100555992 100556190
XLA: 
100036968(faah.1)
XTR: 
100145539(faah.3) 100487591 496823(faah.2)
DRE: 
569067(faah)
TRU: 
101078866
OLA: 
101174015
BFO: 
BRAFLDRAFT_235900
CIN: 
100185523
CEL: 
CELE_B0218.1(faah-1)
CBR: 
CBG01557
TSP: 
Tsp_03856
SMM: 
Smp_167750
GNI: 
GNIT_3083
CTM: 
Cabther_A0860
 » show all
Taxonomy
Reference
1  [PMID:11128635]
  Authors
Boger DL, Fecik RA, Patterson JE, Miyauchi H, Patricelli MP, Cravatt BF
  Title
Fatty acid amide hydrolase substrate specificity.
  Journal
Bioorg. Med. Chem. Lett. 10 (2000) 2613-6.
Reference
2  [PMID:9790682]
  Authors
Patricelli MP, Lashuel HA, Giang DK, Kelly JW, Cravatt BF
  Title
Comparative characterization of a wild type and transmembrane domain-deleted fatty acid amide hydrolase: identification of the transmembrane domain as a site  for oligomerization.
  Journal
Biochemistry. 37 (1998) 15177-87.
Reference
3  [PMID:11352748]
  Authors
Patricelli MP, Cravatt BF
  Title
Characterization and manipulation of the acyl chain selectivity of fatty acid amide hydrolase.
  Journal
Biochemistry. 40 (2001) 6107-15.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
DBGET integrated database retrieval system