KEGG   ENZYME: 3.5.1.99Help
Entry
EC 3.5.1.99                 Enzyme                                 

Name
fatty acid amide hydrolase;
FAAH;
oleamide hydrolase;
anandamide amidohydrolase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
fatty acylamide amidohydrolase
Reaction(IUBMB)
(1) anandamide + H2O = arachidonic acid + ethanolamine [RN:R09536];
(2) oleamide + H2O = oleic acid + NH3 [RN:R09537]
Reaction(KEGG)
Substrate
anandamide [CPD:C11695];
H2O [CPD:C00001];
oleamide [CPD:C19670]
Product
arachidonic acid [CPD:C00219];
ethanolamine [CPD:C00189];
oleic acid [CPD:C00712];
NH3 [CPD:C00014]
Comment
Integral membrane protein, the enzyme is responsible for the catabolism of neuromodulatory fatty acid amides, including anandamide and oleamide, occurs in mammalia.
History
EC 3.5.1.99 created 2009
Orthology
K15528  
fatty acid amide hydrolase
Genes
HSA: 
2166(FAAH)
PTR: 
456559(FAAH)
PPS: 
GGO: 
PON: 
MCC: 
MCF: 
102134628(FAAH)
MMU: 
14073(Faah)
RNO: 
CGE: 
100771171(Faah)
HGL: 
101722224(Faah)
TUP: 
CFA: 
482510(FAAH)
AML: 
100472602(FAAH)
FCA: 
PTG: 
BTA: 
BOM: 
PHD: 
CHX: 
SSC: 
396949(FAAH)
CFR: 
102503970(FAAH)
ECB: 
MYB: 
MYD: 
102752556(FAAH)
PALE: 
102893273(FAAH)
MDO: 
SHR: 
GGA: 
MGP: 
TGU: 
FAB: 
PHI: 
APLA: 
FPG: 
FCH: 
CLV: 
ASN: 
PSS: 
102455592(FAAH)
CMY: 
ACS: 
XLA: 
100036968(faah.1)
XTR: 
100145539(faah.3) 100487591 496823(faah.2)
DRE: 
569067(faah)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
BFO: 
CIN: 
CEL: 
CELE_B0218.1(faah-1) CELE_B0218.2(faah-2)
CBR: 
LOA: 
TSP: 
SMM: 
GSL: 
EHX: 
GTT: 
GNI: 
CTM: 
 » show all
Taxonomy
Reference
1  [PMID:11128635]
  Authors
Boger DL, Fecik RA, Patterson JE, Miyauchi H, Patricelli MP, Cravatt BF
  Title
Fatty acid amide hydrolase substrate specificity.
  Journal
Bioorg. Med. Chem. Lett. 10 (2000) 2613-6.
Reference
2  [PMID:9790682]
  Authors
Patricelli MP, Lashuel HA, Giang DK, Kelly JW, Cravatt BF
  Title
Comparative characterization of a wild type and transmembrane domain-deleted fatty acid amide hydrolase: identification of the transmembrane domain as a site  for oligomerization.
  Journal
Biochemistry. 37 (1998) 15177-87.
Reference
3  [PMID:11352748]
  Authors
Patricelli MP, Cravatt BF
  Title
Characterization and manipulation of the acyl chain selectivity of fatty acid amide hydrolase.
  Journal
Biochemistry. 40 (2001) 6107-15.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system