KEGG   ENZYME: 3.5.3.7Help
Entry
EC 3.5.3.7                  Enzyme                                 
Name
guanidinobutyrase;
gamma-guanidobutyrase;
4-guanidinobutyrate amidinobutyrase;
gamma-guanidinobutyrate amidinohydrolase;
G-Base;
GBH;
guanidinobutyrate ureahydrolase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amidines
BRITE hierarchy
Sysname
4-guanidinobutanoate amidinohydrolase
Reaction(IUBMB)
4-guanidinobutanoate + H2O = 4-aminobutanoate + urea [RN:R01990]
Reaction(KEGG)
Substrate
4-guanidinobutanoate [CPD:C01035];
H2O [CPD:C00001]
Product
4-aminobutanoate [CPD:C00334];
urea [CPD:C00086]
Comment
Requires Mn2+. Also acts, very slowly, on 5-guanidinopentanoate and 6-guanidinohexanoate.
Pathway
Arginine and proline metabolism
Metabolic pathways
Orthology
K12255  
guanidinobutyrase
Genes
PAE: 
PA1421(gbuA)
PAU: 
PAP: 
PSPA7_3918(speB1)
PAG: 
PAF: 
PNC: 
PDK: 
PPU: 
PPF: 
PPG: 
PPW: 
PputW619_3815
PPT: 
PPS_3870
PPB: 
PPUBIRD1_1376
PPI: 
YSA_07860
PPX: 
T1E_4092(agmaT)
PPUH: 
B479_19230
PFL: 
PFL_1574(speB)
PFO: 
Pfl01_1457
PFS: 
PFLU4510
PFE: 
PSF113_1505(gbuA)
PFC: 
PflA506_3819(speB)
PPZ: 
H045_13470
PEN: 
PSEEN3933
PMY: 
Pmen_1797
PMK: 
MDS_3057
PBA: 
PSEBR_a1426
PCR: 
Pcryo_1550
ACI: 
ACIAD1299(speB)
 » show all
Taxonomy
Reference
1  [PMID:5862400]
  Authors
Mora J, Tarrab R, Martuscelli J, Soberon G.
  Title
Characteristics of arginases from ureotelic and non-ureotelic animals.
  Journal
Biochem. J. 96 (1965) 588-94.
  Organism
Gallus gallus [GN:gga]
Reference
2  [PMID:5936244]
  Authors
Nguyen Van Thoai, Thome-Beau F, Olomucki A.
  Title
[Induction and specificity of enzymes of the new catabolic arginine pathway]
  Journal
Biochim. Biophys. Acta. 115 (1966) 73-80.
  Organism
Streptomyces griseus [GN:sgr]
Reference
3
  Authors
Yorifuji, T., Kato, M., Kobayashi, T., Ozaki, S. and Ueno, S.
  Title
4-Guanidinobutyrate amidinohydrolase from Pseudomonas sp ATCC 14676: purification to homogeneity and properties.
  Journal
Agric. Biol. Chem. 44 (1980) 1127-1134.
Reference
4
  Authors
Yorifuji, T., Kobayashi, T., Tabuchi, A., Shiritani, Y. and Yonaha, K.
  Title
Distribution of amidinohydrolases among Pseudomonas and comparative studies of some purified enzymes by one-dimensional peptide mapping.
  Journal
Agric. Biol. Chem. 47 (1983) 2825-2830.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9013-69-8
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