KEGG   ENZYME: 3.6.1.58Help
Entry
EC 3.6.1.58                 Enzyme                                 

Name
8-oxo-dGDP phosphatase;
NUDT5;
MTH3 (gene name);
NUDT18
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname
8-oxo-dGDP phosphohydrolase
Reaction(IUBMB)
8-oxo-dGDP + H2O = 8-oxo-dGMP + phosphate [RN:R09877]
Reaction(KEGG)
Substrate
8-oxo-dGDP [CPD:C20176];
H2O [CPD:C00001]
Product
8-oxo-dGMP [CPD:C19968];
phosphate [CPD:C00009]
Comment
The enzyme catalyses the hydrolysis of both 8-oxo-dGDP and 8-oxo-GDP thereby preventing translational errors caused by oxidative damage. The preferred in vivo substrate is not known. The enzyme does not degrade 8-oxo-dGTP and 8-oxo-GTP to the monophosphates (cf. EC 3.6.1.55, 8-oxo-dGTP diphosphatase) [1,2]. Ribonucleotide diphosphates and deoxyribonucleotide diphosphates are hydrolysed with broad specificity. The bifunctional enzyme NUDT5 also hydrolyses ADP-ribose to AMP and D-ribose 5-phosphate (cf. EC 3.6.1.13, ADP-ribose diphosphatase) [4]. The human enzyme NUDT18 also hydrolyses 8-oxo-dADP and 2-hydroxy-dADP, the latter at a slower rate [6].
History
EC 3.6.1.58 created 2012
Orthology
K13987  
ADP-sugar pyrophosphatase / 8-oxo-dGDP phosphatase
K17817  
8-oxo-dGDP phosphatase
Genes
HSA: 
11164(NUDT5) 79873(NUDT18)
PTR: 
450306(NUDT5) 741929(NUDT18)
PPS: 
100977496(NUDT18) 100977876(NUDT5)
GGO: 
101132071(NUDT18) 101148720(NUDT5)
PON: 
100172071(NUDT5) 100451093(NUDT18)
NLE: 
100594282(NUDT18) 100600434(NUDT5)
MCC: 
694368(NUDT5) 707061(NUDT18)
MCF: 
102118162(NUDT5) 102138807(NUDT18)
RRO: 
104663986(NUDT18) 104664884(NUDT5)
CJC: 
100388611(NUDT18) 100414997(NUDT5)
MMU: 
213484(Nudt18) 53893(Nudt5)
RNO: 
361068(Nudt18) 361274(Nudt5)
CGE: 
100765600(Nudt18) 100772118(Nudt5)
NGI: 
103738702(Nudt5) 103747768(Nudt18)
HGL: 
101710430(Nudt18) 101722031(Nudt5)
OCU: 
100341885(NUDT5) 100357274(NUDT18)
TUP: 
102479208(NUDT18) 102481118(NUDT5)
CFA: 
478006(NUDT5) 609139(NUDT18)
AML: 
100473859(NUDT18) 100482621(NUDT5)
UMR: 
103673345(NUDT18) 103676270(NUDT5)
FCA: 
101084635(NUDT5) 101090347(NUDT18)
PTG: 
102950979(NUDT5) 102972039(NUDT18)
BTA: 
509535(NUDT18) 614149(NUDT5)
BOM: 
102283030(NUDT5) 102284141(NUDT18)
PHD: 
102331579(NUDT5) 102341737(NUDT18)
CHX: 
102174220(NUDT5) 102178907(NUDT18)
OAS: 
101117473(NUDT18) 101117779(NUDT5)
SSC: 
100156061(NUDT18) 100511529(NUDT5)
CFR: 
102506081(NUDT5) 102521795(NUDT18)
BACU: 
103014516(NUDT5) 103015615(NUDT18)
LVE: 
103088541(NUDT5) 103089589(NUDT18)
ECB: 
100056631(NUDT18) 100056812(NUDT5)
MYB: 
102243782(NUDT5) 102258993(NUDT18)
MYD: 
102755333(NUDT5) 102755914(NUDT18)
PALE: 
102895562(NUDT5) 102895707(NUDT18)
MDO: 
100013664(NUDT5) 100033092(NUDT18)
SHR: 
100913469(NUDT18) 100926504(NUDT5)
OAA: 
100084986(NUDT5) 100087230(NUDT18)
GGA: 
107050508(NUDT18) 426368(NUDT5)
MGP: 
100538350(NUDT5)
CJO: 
107317497(NUDT5) 107323725(NUDT18)
APLA: 
101792445(NUDT5)
TGU: 
100227819(NUDT5)
GFR: 
102042579(NUDT5)
FAB: 
101811306(NUDT5) 107604323(NUDT18)
PHI: 
102100920(NUDT5) 102114450(NUDT18)
CCW: 
104694502(NUDT5)
FPG: 
101911346(NUDT5) 101919411(NUDT18)
FCH: 
102050796(NUDT18) 102058952(NUDT5)
CLV: 
102084865(NUDT5) 102095789(NUDT18)
AAM: 
106485164(NUDT18) 106485418(NUDT5)
ASN: 
102373059(NUDT5) 102382475(NUDT18)
AMJ: 
102562108(NUDT5) 102572685(NUDT18)
PSS: 
102447968(NUDT18) 102460805(NUDT5)
CMY: 
102935770(NUDT18) 102941929(NUDT5)
ACS: 
100558579(nudt18) 100567214(nudt5)
PBI: 
103062314(NUDT18) 103064447(NUDT5)
GJA: 
107111067(NUDT5) 107120358(NUDT18)
XLA: 
432263(nudt5)
XTR: 
100488091(nudt18) 549367(nudt5)
DRE: 
415176(nudt5) 550541(nudt18)
TRU: 
101067864(nudt18)
MZE: 
101470680(nudt5) 101476216(nudt18)
OLA: 
101160293(nudt18) 101161229(nudt5)
XMA: 
102224507(nudt5) 102236783(nudt18)
LCM: 
102346525(NUDT18) 102359306(NUDT5)
CMK: 
103173152(nudt18) 103187912(nudt5)
BFO: 
SPU: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD18763(Dsim_GD18763)
DWI: 
DYA: 
Dyak_GE24179(dyak_GLEANR_7899)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
413933(GB15950)
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
BMOR: 
PXY: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG08712(Cbr-ndx-1)
LOA: 
HRO: 
LGI: 
CRG: 
OBI: 
NVE: 
TAD: 
AQU: 
CRE: 
OTA: 
PAN: 
ACAN: 
SPAR: 
GTT: 
 » show all
Taxonomy
Reference
1  [PMID:16002790]
  Authors
Ishibashi T, Hayakawa H, Ito R, Miyazawa M, Yamagata Y, Sekiguchi M
  Title
Mammalian enzymes for preventing transcriptional errors caused by oxidative damage.
  Journal
Nucleic. Acids. Res. 33 (2005) 3779-84.
  Sequence
[hsa:11164]
Reference
2  [PMID:12717453]
  Authors
Ishibashi T, Hayakawa H, Sekiguchi M
  Title
A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides.
  Journal
EMBO. Rep. 4 (2003) 479-83.
  Sequence
[hsa:11164]
Reference
3  [PMID:19699693]
  Authors
Kamiya H, Hori M, Arimori T, Sekiguchi M, Yamagata Y, Harashima H
  Title
NUDT5 hydrolyzes oxidized deoxyribonucleoside diphosphates with broad substrate specificity.
  Journal
DNA. Repair. (Amst). 8 (2009) 1250-4.
Reference
4  [PMID:21389046]
  Authors
Ito R, Sekiguchi M, Setoyama D, Nakatsu Y, Yamagata Y, Hayakawa H
  Title
Cleavage of oxidized guanine nucleotide and ADP sugar by human NUDT5 protein.
  Journal
J. Biochem. 149 (2011) 731-8.
Reference
5  [PMID:17052728]
  Authors
Zha M, Zhong C, Peng Y, Hu H, Ding J
  Title
Crystal structures of human NUDT5 reveal insights into the structural basis of the substrate specificity.
  Journal
J. Mol. Biol. 364 (2006) 1021-33.
  Sequence
[hsa:11164]
Reference
6  [PMID:22556419]
  Authors
Takagi Y, Setoyama D, Ito R, Kamiya H, Yamagata Y, Sekiguchi M
  Title
Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2.
  Journal
J. Biol. Chem. 287 (2012) 21541-9.
  Sequence
[hsa:79873]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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