KEGG ENZYME: 3.6.1.8

ENZYME: 3.6.1.8

Entry

EC 3.6.1.8 Enzyme

Name

ATP diphosphatase;
ATPase (ambiguous);
ATP pyrophosphatase;
adenosine triphosphate pyrophosphatase;
ATP diphosphohydrolase (ambiguous)

Class

Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides

Sysname

ATP diphosphohydrolase (diphosphate-forming)

Reaction(IUBMB)

ATP + H2O = AMP + diphosphate [RN:R00087]

Reaction(KEGG)

R00087;
(other) R00086 R00287 R00426 R00515 R00662 R00720

Substrate

ATP [CPD:C00002];
H2O [CPD:C00001]

Product

AMP [CPD:C00020];
diphosphate [CPD:C00013]

Comment

Also acts on ITP, GTP, CTP and UTP.

Pathway

ec00230	Purine metabolism
ec00240	Pyrimidine metabolism
ec01100	Metabolic pathways

Orthology

K04765

ATP diphosphatase

Genes

ECO:	b2781(mazG)
ECJ:	Y75_p2718(mazG)
ECD:	ECDH10B_2948(mazG)
EBW:	BWG_2516(mazG)
ECOK:	ECMDS42_2285(mazG)
ECE:	Z4096(mazG)
ECS:	ECs3641(mazG)
ECF:	ECH74115_4041(mazG)
ETW:	ECSP_3733(mazG)
ELX:	CDCO157_3396(mazG)
EOJ:	ECO26_3851(mazG)
EOI:	ECO111_3505(mazG)
EOH:	ECO103_3324(mazG)
ECG:	E2348C_3048(mazG)
EOK:	G2583_3433(mazG)
ELR:	ECO55CA74_16365(mazG)
ECC:	c3346(mazG)
ECP:	ECP_2762(mazG)
ECI:	UTI89_C3150(mazG)
ECV:	APECO1_3749(mazG)
ECX:	EcHS_A2925(mazG)
ECW:	EcE24377A_3085(mazG)
ECM:	EcSMS35_2919(mazG)
ECY:	ECSE_3039(mazG)
ECR:	ECIAI1_2889(mazG)
ECQ:	ECED1_3234(mazG)
ECK:	EC55989_3056(mazG)
ECT:	ECIAI39_3200(mazG)
EOC:	CE10_3205(mazG)
EUM:	ECUMN_3112(mazG)
ECZ:	ECS88_3049(mazG)
ELO:	EC042_2980(mazG)
ELN:	NRG857_13615(mazG)
ELH:	ETEC_2973
ESE:	ECSF_2574
ESO:	O3O_20045(mazG)
ESM:	O3M_05650(mazG)
ESL:	O3K_05605(mazG)
ECL:	EcolC_0931(mazG)
EBR:	ECB_02626(mazG)
EBD:	ECBD_0948(mazG)
EKO:	EKO11_0987
EKF:	KO11_09060(mazG)
EAB:	ECABU_c30520
EDH:	EcDH1_0907
EDJ:	ECDH1ME8569_2691(mazG)
EIH:	ECOK1_3155
ENA:	ECNA114_2818(mazG)
ELU:	UM146_02665(mazG)
EUN:	UMNK88_3464
ELW:	ECW_m2990(mazG)
ELL:	WFL_14600(mazG)
ELC:	i14_3071(mazG)
ELD:	i02_3071(mazG)
ELP:	P12B_c2879(mazG)
EBL:	ECD_02626(mazG)
EBE:	B21_02588(mazG)
ELF:	LF82_1282(mazG)
ECOA:	APECO78_17520(mazG)
EFE:	EFER_0283(mazG)
EBT:	EBL_c08440(mazG)
STY:	STY3083(mazG)
STT:	t2855(mazG)
SEX:	STBHUCCB_30080
STM:	STM2954(mazG)
SEO:	STM14_3559(mazG)
SEV:	STMMW_29171
SEY:	SL1344_2933
SEM:	STMDT12_C30060(mazG)
SEJ:	STMUK_2943(mazG)
SEB:	STM474_3098(mazG)
SEF:	UMN798_3211
SETU:	STU288_14940(mazG)
SPT:	SPA2811(mazG)
SEK:	SSPA2618(mazG)
SPQ:	SPAB_03667(mazG)
SEI:	SPC_3004(mazG)
SEC:	SC2888(mazG)
SEH:	SeHA_C3151(mazG)
SHB:	SU5_03435
SEE:	SNSL254_A3170(mazG)
SEW:	SeSA_A3112(mazG)
SEA:	SeAg_B3087(mazG)
SED:	SeD_A3268(mazG)
SEG:	SG2858(mazG)
SEL:	SPUL_2956
SET:	SEN2793(mazG)
SENJ:	CFSAN001992_18805(mazG)
SES:	SARI_00007(mazG)
SBG:	SBG_2570
YPE:	YPO3378(mazG)
YPK:	y0812(mazG)
YPA:	YPA_2876(mazG)
YPN:	YPN_0714(mazG)
YPM:	YP_0308(mazG)
YPP:	YPDSF_2981(mazG)
YPG:	YpAngola_A0982(mazG)
YPZ:	YPZ3_2976
YPT:	A1122_09035(mazG)
YPD:	YPD4_2962
YPX:	YPD8_2960
YPH:	YPC_3702(mazG)
YPS:	YPTB0753(mazG)
YPI:	YpsIP31758_3318(mazG)
YPY:	YPK_3448(mazG)
YPB:	YPTS_0786(mazG)
YEN:	YE0745(mazG)
YEP:	YE105_C0860
YEY:	Y11_39801
SFL:	SF2796(mazG)
SFX:	S2990(mazG)
SFV:	SFV_2674(mazG)
SFE:	SFxv_3067(mazG)
SSN:	SSON_2938(mazG)
SSJ:	SSON53_17225(mazG)
SBO:	SBO_2662(mazG)
SBC:	SbBS512_E3092(mazG)
SDY:	SDY_2998(mazG)
ECA:	ECA3568(mazG)
PCT:	PC1_3388
PCC:	PCC21_033920
PWA:	Pecwa_3547(mazG)
PEC:	W5S_3684
ETA:	ETA_27220(mazG)
EPY:	EpC_28410(mazG)
EPR:	EPYR_03075(mazG)
EAM:	EAMY_0736(mazG)
EAY:	EAM_2705(mazG)
EBI:	EbC_35460(mazG)
ERJ:	EJP617_18960(mazG)
PLU:	plu0911(mazG)
PAY:	PAU_00832(mazG)
SGL:	SG0511(mazG)
ENT:	Ent638_3235(mazG)
ENC:	ECL_04115
ENO:	ECENHK_17810(mazG)
ECLO:	ENC_30240
ESC:	Entcl_0933
EEC:	EcWSU1_03589(mazG)
ENL:	A3UG_18105(mazG)
EAS:	Entas_3482
EAE:	EAE_01960(mazG)
EAR:	ST548_p3458
ESA:	ESA_00520(mazG)
CSK:	ES15_0780(mazG)
CSZ:	CSSP291_02645(mazG)
CTU:	CTU_33420(mazG)
KPN:	KPN_03125(mazG)
KPU:	KP1_4397(mazG)
KPM:	KPHS_42020
KPP:	A79E_0972
KPE:	KPK_0997(mazG)
KPO:	KPN2242_18640(mazG)
KVA:	Kvar_0930
KOX:	KOX_01150(mazG)
CKO:	CKO_04136(mazG)
CRO:	ROD_30331(mazG)
SPE:	Spro_0793(mazG)
SRR:	SerAS9_0728
SRS:	SerAS12_0728
SRA:	SerAS13_0728
SMAF:	D781_0754
SMW:	SMWW4_v1c07790(mazG)
PMR:	PMI0218(mazG)
EIC:	NT01EI_3024
ETR:	ETAE_2713(mazG)
ETD:	ETAF_2447(mazG)
ETC:	ETAC_13120(mazG)
DDA:	Dd703_0850(mazG)
DDC:	Dd586_3327
DDD:	Dda3937_00196(mazG)
DZE:	Dd1591_0816(mazG)
XBO:	XBJ1_3653
XNE:	XNC1_0881
PAM:	PANA_3077(mazG)
PLF:	PANA5342_0956(mazG)
PAJ:	PAJ_2351(mazG)
PAQ:	PAGR_g0958
PVA:	Pvag_2460(mazG)
PAO:	Pat9b_3094
RAH:	Rahaq_0661
RAQ:	Rahaq2_0681
RAA:	Q7S_03035(mazG)
PSI:	S70_05025(mazG)
MMK:	MU9_1160
ROR:	RORB6_23665(mazG)
EBF:	D782_0933
HIN:	HI0460(mazG)
HIT:	NTHI0591(mazG)
HIP:	CGSHiEE_00690(mazG)
HIQ:	CGSHiGG_05540(mazG)
HIF:	HIBPF18690
HIL:	HICON_09540
HIU:	HIB_05900
HIE:	R2846_0119(mazG)
HIZ:	R2866_0113(mazG)
HDU:	HD1468(mazG)
HAP:	HAPS_0342(mazG)
HPR:	PARA_03980
HSO:	HS_1122(mazG)
HSM:	HSM_1055(mazG)
PMU:	PM1285(mazG)
PMV:	PMCN06_1950(mazG)
PUL:	NT08PM_2180
PMP:	Pmu_19460(mazG)
MSU:	MS0351(mazG)
MHT:	D648_13380 D648_13390
MHQ:	D650_11620 D650_11630
MHX:	MHH_c20030(mazG1) MHH_c20040(mazG2)
APL:	APL_0630(mazG)
APJ:	APJL_0624(mazG)
APA:	APP7_0675
ASU:	Asuc_0054(mazG)
ASI:	ASU2_03915
AAP:	NT05HA_1791(mazG)
AAT:	D11S_0657(mazG)
AAO:	ANH9381_0989
AAN:	D7S_01015
GAN:	UMN179_00925
BTO:	WQG_12780
XFA:	XF0186(mazG)
XFT:	PD0152(mazG)
XFM:	Xfasm12_0158(mazG)
XFN:	XfasM23_0139(mazG)
XFF:	XFLM_06050(mazG)
XCC:	XCC2881(mazG)
XCB:	XC_1228(mazG)
XCA:	xccb100_1272(mazG)
XCV:	XCV3199(mazG)
XCP:	XCR_3260
XAC:	XAC3065(mazG)
XAX:	XACM_2985(mazG)
XAO:	XAC29_15590(mazG)
XOO:	XOO1790(mazG)
XOM:	XOO_1693(mazG)
XOP:	PXO_01650(mazG)
XOR:	XOC_3250
XAL:	XALc_2209(mazG)
XCI:	XCAW_03351(mazG)
SML:	Smlt3663(mazG)
SMT:	Smal_3078(mazG)
BUJ:	BurJV3_3106
SMZ:	SMD_3228
PSU:	Psesu_0729
PSD:	DSC_05345(mazG)
FAU:	Fraau_2316
RHD:	R2APBS1_0874
VCH:	VC2450(mazG)
VCE:	Vch1786_I1942(mazG)
VCJ:	VCD_001904(mazG)
VCO:	VC0395_A2028(mazG)
VCR:	VC395_2565(mazG)
VCM:	VCM66_2373(mazG)
VCI:	O3Y_11745(mazG)
VCL:	VCLMA_A2154
VVU:	VV1_1577
VVY:	VV2820(mazG)
VVM:	VVMO6_00486
VPA:	VP2563(mazG)
VPB:	VPBB_2387
VHA:	VIBHAR_03527(mazG)
VSP:	VS_2610(mazG)
VEX:	VEA_002505
VEJ:	VEJY3_13225(mazG)
VFU:	vfu_A00844
VFI:	VF_2078(mazG)
VFM:	VFMJ11_2183
VSA:	VSAL_I2516
PPR:	PBPRA3081(mazG)
VAN:	VAA_03766
PAE:	PA0935
PAU:	PA14_52160(mazG)
PAP:	PSPA7_4575(mazG)
PAG:	PLES_43811(mazG)
PAF:	PAM18_4104(mazG)
PNC:	NCGM2_1718(mazG)
PDK:	PADK2_21030(mazG)
PSG:	G655_20680(mazG)
PPU:	PP_1657(mazG)
PPF:	Pput_4061(mazG)
PPG:	PputGB1_1258(mazG)
PPW:	PputW619_1218(mazG)
PPT:	PPS_1309
PPB:	PPUBIRD1_3960(mazG)
PPI:	YSA_02466
PPX:	T1E_3664(mazG)
PPUH:	B479_06325(mazG)
PPUU:	PputUW4_04104(mazG)
PST:	PSPTO_1695
PSB:	Psyr_3694(mazG)
PSP:	PSPPH_3715(mazG)
PFL:	PFL_4445(mazG)
PFO:	Pfl01_4216(mazG)
PFS:	PFLU4504(mazG)
PFE:	PSF113_4424(mazG)
PFC:	PflA506_3813(mazG)
PPZ:	H045_13435(mazG)
PEN:	PSEEN1365(mazG)
PMY:	Pmen_1736(mazG)
PMK:	MDS_3125
PSA:	PST_2668(mazG)
PSZ:	PSTAB_2651(mazG)
PSR:	PSTAA_2790(mazG)
PSC:	A458_09000(mazG)
PSJ:	PSJM300_12415(mazG)
PSH:	Psest_1641
PBA:	PSEBR_a4257
PFV:	Psefu_1499
PDR:	H681_07915(mazG)
CJA:	CJA_2574
AVN:	Avin_36950(mazG)
AVL:	AvCA_36950(mazG)
AVD:	AvCA6_36950(mazG)
SON:	SO_3442
SDN:	Sden_1194(mazG)
SFR:	Sfri_1050(mazG)
SAZ:	Sama_1034(mazG)
SBL:	Sbal_3129(mazG)
SBM:	Shew185_3138(mazG)
SBN:	Sbal195_3281(mazG)
SBP:	Sbal223_1235(mazG)
SBT:	Sbal678_3288
SBS:	Sbal117_3270
SBB:	Sbal175_1223
SLO:	Shew_1203(mazG)
SPC:	Sputcn32_2759(mazG)
SHP:	Sput200_2897
SSE:	Ssed_1288(mazG)
SPL:	Spea_1183(mazG)
SHE:	Shewmr4_1113(mazG)
SHM:	Shewmr7_1184(mazG)
SHN:	Shewana3_1114(mazG)
SHW:	Sputw3181_1253(mazG)
SHL:	Shal_1220(mazG)
SWD:	Swoo_3352(mazG)
SWP:	swp_1354(mazG)
SVO:	SVI_3177
ILO:	IL0803(mazG)
CPS:	CPS_4114
PHA:	PSHAa0740(mazG)
PAT:	Patl_3706
PSM:	PSM_A2328
SDE:	Sde_2237
MAQ:	Maqu_2237
MHC:	MARHY0991(mazG)
MAD:	HP15_792
MBS:	MRBBS_2643(mazG)
AMC:	MADE_1004050
AMAC:	MASE_03250
AMB:	AMBAS45_03505
AMG:	AMEC673_03460
AMK:	AMBLS11_03425
AMAA:	amad1_03755
ALT:	ambt_14730
GAG:	Glaag_3697
GNI:	GNIT_0725(mazG)
GPS:	C427_0863
PIN:	Ping_0665
PSY:	PCNPT3_02960
TTU:	TERTU_1194
FBL:	Fbal_0843
MCA:	MCA0046
MMT:	Metme_1840
MAH:	MEALZ_2381(mazG)
MEJ:	Q7A_1889
MEC:	Q7C_57
CYQ:	Q91_1352(mazG)
ALV:	Alvin_2771
TVI:	Thivi_0804
TMB:	Thimo_0737
AEH:	Mlg_1457
HHA:	Hhal_0129
TGR:	Tgr7_2504
TKM:	TK90_1959
TNI:	TVNIR_2341(mazG_[H])
HCH:	HCH_01808
CSA:	Csal_1639
HEL:	HELO_3011(mazG)
ABO:	ABO_1622
ADI:	B5T_01547
KKO:	Kkor_0846
MMW:	Mmwyl1_1254
MME:	Marme_1123
MPC:	Mar181_2649
TOL:	TOL_0930
AHA:	AHA_0819
ASA:	ASA_3477(mazG)
AVR:	B565_0688
TAU:	Tola_2744
OCE:	GU3_04665
SAGA:	M5M_03290(mazG)
PCA:	Pcar_1432(mazG)
DVU:	DVU1186(mazG)
DVL:	Dvul_1871(mazG)
DVM:	DvMF_3078(mazG)
DVG:	Deval_1094
DDE:	Dde_2453
DDS:	Ddes_0550(mazG)
DDN:	DND132_0109
DMA:	DMR_05590(mazG)
DSA:	Desal_1039(mazG)
DAS:	Daes_2109
DAF:	Desaf_2046
DHY:	DESAM_10130
DPI:	BN4_10619
DBA:	Dbac_0509
DRT:	Dret_2195(mazG)
DAK:	DaAHT2_1146
MXA:	MXAN_4741
MFU:	LILAB_31655
MSD:	MYSTI_05199
CCX:	COCOR_02654(mazG)
SUR:	STAUR_5591
SCL:	sce4803(mazG)
HOH:	Hoch_2302
DAO:	Desac_2617
DBR:	Deba_0953
MLO:	mll0404(mazG)
MCI:	Mesci_3714
MOP:	Mesop_4527
MAM:	Mesau_04161
MES:	Meso_1611(mazG)
SME:	SMc01051(mazG)
SMK:	Sinme_1268
SMQ:	SinmeB_1097
SMX:	SM11_chr2101(mazG)
SMI:	BN406_01198(mazG)
SMEG:	C770_GR4Chr1486
SMEL:	SM2011_c01051
SMD:	Smed_1097(mazG)
RHI:	NGR_c13030(mazG)
SFH:	SFHH103_01189(mazG)
SFD:	USDA257_c35030(mazG)
ATU:	Atu1452(mazG)
ARA:	Arad_2273(mazG)
AVI:	Avi_2144(mazG)
AGR:	AGROH133_05963(mazG)
RET:	RHE_CH01956(mazG)
REC:	RHECIAT_CH0002068(mazG)
RLE:	RL2286(mazG)
RLT:	Rleg2_1634(mazG)
RLG:	Rleg_1821(mazG)
RTR:	RTCIAT899_CH08700
BME:	BMEI0920(mazG)
BMI:	BMEA_A1108
BMZ:	BM28_A1077(mazG)
BMG:	BM590_A1064
BMW:	BMNI_I1039
BMF:	BAB1_1089(mazG)
BMB:	BruAb1_1072(mazG)
BMC:	BAbS19_I10100(mazG)
BAA:	BAA13334_I02274
BMS:	BR1067(mazG)
BSI:	BS1330_I1063(mazG)
BSV:	BSVBI22_A1063(mazG)
BOV:	BOV_1031(mazG)
BCS:	BCAN_A1082(mazG)
BSK:	BCA52141_I0027
BMR:	BMI_I1072(mazG)
BPP:	BPI_I1110(mazG)
OAN:	Oant_2150(mazG)
BJA:	bll4494(mazG)
BJU:	BJ6T_52480
BRA:	BRADO3851(mazG)
BBT:	BBta_4079(mazG)
BRS:	S23_36880
RPA:	RPA2811(mazG)
RPB:	RPB_2710(mazG)
RPC:	RPC_2752(mazG)
RPD:	RPD_2752(mazG)
RPE:	RPE_2885(mazG)
RPT:	Rpal_3151(mazG)
RPX:	Rpdx1_2693
NWI:	Nwi_1452(mazG)
NHA:	Nham_1845(mazG)
OCA:	OCAR_6102(mazG)
OCG:	OCA5_c19260(mazG)
OCO:	OCA4_c19250(mazG)
AOL:	S58_38990
BHE:	BH07410(mazG)
BQR:	RM11_0505
BTR:	Btr_1331(mazG)
BGR:	Bgr_11620(mazG)
XAU:	Xaut_4391
AZC:	AZC_1656(mazG)
SNO:	Snov_1775
MEX:	Mext_3913
MEA:	Mex_1p4291(mazG)
MDI:	METDI4902(mazG)
MCH:	Mchl_4281
MRD:	Mrad2831_1630
MET:	M446_5947
MPO:	Mpop_4386
MNO:	Mnod_6550
BID:	Bind_1527
MSL:	Msil_0537
HDN:	Hden_1692
HMC:	HYPMC_2066(mazG)
RVA:	Rvan_0875
PHL:	KKY_1402
MSC:	BN69_0228
CCR:	CC_1747(mazG)
CCS:	CCNA_01821(mazG)
CAK:	Caul_2613(mazG)
PZU:	PHZ_c1596(mazG)
BSB:	Bresu_2370
AEX:	Astex_2903
SIL:	SPO2469(mazG)
SIT:	TM1040_0936(mazG)
RSP:	RSP_2912(mazG)
RSH:	Rsph17029_1556(mazG)
RSQ:	Rsph17025_1109(mazG)
RSK:	RSKD131_1229(mazG)
RCP:	RCAP_rcc01779
JAN:	Jann_2344(mazG)
RDE:	RD1_3133(mazG)
RLI:	RLO149_c023620(mazG)
PDE:	Pden_1418(mazG)
DSH:	Dshi_1160
KVU:	EIO_1393(mazG)
KVL:	KVU_0883(mazG)
PSF:	PSE_3266
PGA:	PGA1_c19950(mazG)
PGL:	PGA2_c18660(mazG)
OAT:	OAN307_c27300(mazG)
OAR:	OA238_c22760(mazG)
MMR:	Mmar10_1450
HNE:	HNE_2004
HBA:	Hbal_1655
ZMO:	ZMO1095
ZMN:	Za10_0223
ZMM:	Zmob_0225
ZMB:	ZZ6_0226
ZMP:	Zymop_0194
NAR:	Saro_1933
NPP:	PP1Y_AT26046
SAL:	Sala_1270
SWI:	Swit_0253
SPHM:	G432_01185
SJP:	SJA_C1-16680(mazG)
SCH:	Sphch_0709
SSY:	SLG_17920
ELI:	ELI_06250
GOX:	GOX1443
GOH:	B932_1700
GBE:	GbCGDNIH1_1126
ACR:	Acry_1759(mazG)
AMV:	ACMV_18040
GDI:	GDI_2259(mazG)
GDJ:	Gdia_0479
GXY:	GLX_24960(mazG)
APT:	APA01_03320(mazG)
APW:	APA42C_03320(mazG)
APF:	APA03_03320(mazG)
APU:	APA07_03320(mazG)
APG:	APA12_03320(mazG)
APQ:	APA22_03320(mazG)
APX:	APA26_03320(mazG)
APZ:	APA32_03320(mazG)
RRU:	Rru_A1690
RRF:	F11_08710
RCE:	RC1_0140(mazG)
RPM:	RSPPHO_01210
MAG:	amb2392(mazG)
AZL:	AZL_c01630(mazG)
ALI:	AZOLI_p10668(mazG)
ABS:	AZOBR_p110027(mazG)
TMO:	TMO_1693(mazG)
PBR:	PB2503_09659
APB:	SAR116_0223
PGV:	SL003B_2297(mazG)
MAI:	MICA_1272
MAN:	A11S_1208
APC:	HIMB59_00011810
MGM:	Mmc1_3102
SCC:	Spico_0616
SGP:	SpiGrapes_0435
ACA:	ACP_0171
GMA:	AciX8_2724
TSA:	AciPR4_1410
TRS:	Terro_1600
TAI:	Taci_1071
TID:	Thein_0776

» show all

Reference

1 [PMID:13061448]

Authors

HEPPEL LA, HILMOE RJ.

Title

Mechanism of enzymatic hydrolysis of adenosinetriphosphate.

Journal

J. Biol. Chem. 202 (1953) 217-26.

Organism

Crotalus adamanteus

Reference

2 [PMID:13058963]

Authors

JOHNSON M, KAYE MA, HEMS R, KREBS HA.

Title

Enzymic hydrolysis of adenosine phosphates by cobra venom.

Journal

Biochem. J. 54 (1953) 625-9.

Organism

Naja naja

Other DBs

ExplorEnz - The Enzyme Database:

3.6.1.8

IUBMB Enzyme Nomenclature:

3.6.1.8

ExPASy - ENZYME nomenclature database:

3.6.1.8

BRENDA, the Enzyme Database:

3.6.1.8

CAS:

37289-25-1

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