KEGG   ENZYME: 3.6.1.9Help
Entry
EC 3.6.1.9                  Enzyme                                 
Name
nucleotide diphosphatase;
nucleotide pyrophosphatase;
nucleotide-sugar pyrophosphatase
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname
dinucleotide nucleotidohydrolase
Reaction(IUBMB)
a dinucleotide + H2O = 2 mononucleotides [RN:R00056]
Reaction(KEGG)
Substrate
dinucleotide [CPD:C01910];
H2O [CPD:C00001]
Product
mononucleotide [CPD:C02171]
Comment
Substrates include NAD+, NADP+, FAD, CoA and also ATP and ADP.
Pathway
Purine metabolism
Starch and sucrose metabolism
Riboflavin metabolism
Nicotinate and nicotinamide metabolism
Pantothenate and CoA biosynthesis
Metabolic pathways
Orthology
K01513  
ectonucleotide pyrophosphatase/phosphodiesterase family member 1/3
Genes
HSA: 
5167(ENPP1) 5169(ENPP3)
PTR: 
463000(ENPP3) 463002(ENPP1)
PPS: 
100973601(ENPP3) 100973949(ENPP1)
GGO: 
PON: 
100173734(ENPP3) 100434892(ENPP1)
MCC: 
710140(ENPP1) 710232(ENPP3)
MMU: 
18605(Enpp1) 209558(Enpp3)
RNO: 
54410(Enpp3) 85496(Enpp1)
CFA: 
AML: 
100463837(ENPP3) 100466346(ENPP1)
FCA: 
101094103(ENPP3) 101094350(ENPP1)
BTA: 
529405(ENPP3) 615535(ENPP1)
SSC: 
100037271(ENPP1) 100621671
ECB: 
100067583(ENPP3) 100073097(ENPP1)
MDO: 
100031034(ENPP3) 100031043(ENPP1)
SHR: 
100927611(ENPP3) 100928132(ENPP1)
OAA: 
100074336(ENPP3) 100074382
GGA: 
426928(ENPP3) 426929(ENPP1)
MGP: 
100544279
TGU: 
100219928(ENPP3) 100228551(ENPP1)
ACS: 
100562470 100562666(enpp1)
XTR: 
100422807(enpp1) 100422808(enpp3)
DRE: 
562399(enpp1)
TRU: 
101064921 101078403
OLA: 
101171013
CIN: 
100175017
SPU: 
579858
ISC: 
IscW_ISCW013243
TSP: 
Tsp_08123
NVE: 
NEMVE_v1g213276
TAD: 
TRIADDRAFT_58865
NGR: 
NAEGRDRAFT_31890 NAEGRDRAFT_63323
 » show all
Taxonomy
Reference
1  [PMID:13428775]
  Authors
JACOBSON KB, KAPLAN NO.
  Title
A reduced pyridine nucleotide pyrophosphatase.
  Journal
J. Biol. Chem. 226 (1957) 427-37.
  Organism
pigeon
Reference
2
  Authors
Kornberg, A. and Pricer, W.E.
  Title
Nucleotide pyrophosphatase.
  Journal
J. Biol. Chem. 182 (1950) 763-778.
Reference
3  [PMID:5862212]
  Authors
Kumar SA, Rao NA, Vaidyanathan CS.
  Title
Nucleotidases in plants. I. Partial purification and properties of the enzyme hydrolyzing flavine adenine dinucleotide from mung bean seedlings (Phaseolus radiatus).
  Journal
Arch. Biochem. Biophys. 111 (1965) 646-52.
  Organism
Phaseolus radiatus
Reference
4  [PMID:13549486]
  Authors
SWARTZ MN, KAPLAN NO, LAMBORG MF.
  Title
A heat-activated diphosphopyridine nucleotide pyrophosphatase from Proteus vulgaris.
  Journal
J. Biol. Chem. 232 (1958) 1051-63.
  Organism
Proteus vulgaris
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9032-64-8
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