KEGG   ENZYME: 3.6.1.9Help
Entry
EC 3.6.1.9                  Enzyme                                 

Name
nucleotide diphosphatase;
nucleotide pyrophosphatase;
nucleotide-sugar pyrophosphatase
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname
dinucleotide nucleotidohydrolase
Reaction(IUBMB)
a dinucleotide + H2O = 2 mononucleotides [RN:R00056]
Reaction(KEGG)
Substrate
dinucleotide [CPD:C01910];
H2O [CPD:C00001]
Product
mononucleotide [CPD:C02171]
Comment
Substrates include NAD+, NADP+, FAD, CoA and also ATP and ADP.
History
EC 3.6.1.9 created 1961
Pathway
Purine metabolism
Starch and sucrose metabolism
Riboflavin metabolism
Nicotinate and nicotinamide metabolism
Pantothenate and CoA biosynthesis
Metabolic pathways
Orthology
K01513  
ectonucleotide pyrophosphatase/phosphodiesterase family member 1/3
Genes
HSA: 
5167(ENPP1) 5169(ENPP3)
PTR: 
463000(ENPP3) 463002(ENPP1)
PPS: 
100973601(ENPP3) 100973949(ENPP1)
GGO: 
PON: 
100173734(ENPP3) 100434892(ENPP1)
MCC: 
710140(ENPP1) 710232(ENPP3)
MCF: 
102132755(ENPP3) 102133778(ENPP1)
MMU: 
18605(Enpp1) 209558(Enpp3)
RNO: 
54410(Enpp3) 85496(Enpp1)
CGE: 
HGL: 
101705137(Enpp3) 101706464(Enpp1)
TUP: 
102481063(ENPP3) 102481768(ENPP1)
CFA: 
100856150(ENPP1) 474820(ENPP3)
AML: 
100463837(ENPP3) 100466346(ENPP1)
FCA: 
101094103(ENPP3) 101094350(ENPP1)
PTG: 
102949274(ENPP1) 102951057(ENPP3)
BTA: 
529405(ENPP3) 615535(ENPP1)
BOM: 
102266516(ENPP1) 102266801(ENPP3)
PHD: 
102325359(ENPP3) 102325712(ENPP1)
CHX: 
102169872(ENPP3) 102190787(ENPP1)
SSC: 
CFR: 
102507770(ENPP1) 102521481(ENPP3)
ECB: 
100067583(ENPP3) 100073097(ENPP1)
MYB: 
102253850(ENPP3) 102254149(ENPP1)
MYD: 
102758074(ENPP1) 102772082(ENPP3)
PALE: 
102888142(ENPP1) 102898650(ENPP3)
MDO: 
100031034(ENPP3) 100031043(ENPP1)
SHR: 
100927611(ENPP3) 100928132(ENPP1)
OAA: 
100074336(ENPP3) 100074382(ENPP1)
GGA: 
426928(ENPP3) 426929(ENPP1)
MGP: 
TGU: 
100219928(ENPP3) 100228551(ENPP1)
FAB: 
101806551(ENPP1) 101807371(ENPP3)
PHI: 
102099744(ENPP1) 102101638(ENPP3)
APLA: 
101800212(ENPP1) 101800542(ENPP3)
FPG: 
101922223(ENPP3) 101923444(ENPP1)
FCH: 
102054192(ENPP3) 102058405(ENPP1)
CLV: 
102092189(ENPP3) 102092374(ENPP1)
ASN: 
102380437(ENPP3) 102380920(ENPP1)
PSS: 
CMY: 
102940608(ENPP3) 102942975(ENPP1)
ACS: 
XTR: 
100422807(enpp1) 100422808(enpp3)
DRE: 
562399(enpp1)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102348812(ENPP3) 102348989(ENPP1)
BFO: 
CIN: 
SPU: 
ISC: 
LOA: 
TSP: 
NVE: 
TAD: 
GMX: 
OBR: 
SMO: 
NGR: 
 » show all
Taxonomy
Reference
1  [PMID:13428775]
  Authors
JACOBSON KB, KAPLAN NO.
  Title
A reduced pyridine nucleotide pyrophosphatase.
  Journal
J. Biol. Chem. 226 (1957) 427-37.
  Organism
pigeon
Reference
2
  Authors
Kornberg, A. and Pricer, W.E.
  Title
Nucleotide pyrophosphatase.
  Journal
J. Biol. Chem. 182 (1950) 763-778.
Reference
3  [PMID:5862212]
  Authors
Kumar SA, Rao NA, Vaidyanathan CS.
  Title
Nucleotidases in plants. I. Partial purification and properties of the enzyme hydrolyzing flavine adenine dinucleotide from mung bean seedlings (Phaseolus radiatus).
  Journal
Arch. Biochem. Biophys. 111 (1965) 646-52.
  Organism
Phaseolus radiatus
Reference
4  [PMID:13549486]
  Authors
SWARTZ MN, KAPLAN NO, LAMBORG MF.
  Title
A heat-activated diphosphopyridine nucleotide pyrophosphatase from Proteus vulgaris.
  Journal
J. Biol. Chem. 232 (1958) 1051-63.
  Organism
Proteus vulgaris
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9032-64-8

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