KEGG   ENZYME: 3.6.3.24Help
Entry
EC 3.6.3.24                 Enzyme                                 
Name
nickel-transporting ATPase
Class
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to catalyse transmembrane movement of substances
BRITE hierarchy
Sysname
ATP phosphohydrolase (nickel-importing)
Reaction(IUBMB)
ATP + H2O + Ni2+out = ADP + phosphate + Ni2+in [RN:R00086]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
Ni2+ [CPD:C19609]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
Ni2+ [CPD:C19609]
Comment
ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports Ni2+.
Orthology
K10824  
nickel transport system ATP-binding protein
K15587  
nickel transport system ATP-binding protein
Genes
ECO: 
b3479(nikD) b3480(nikE)
ECJ: 
Y75_p3698(nikE) Y75_p3699(nikD)
ECD: 
EBW: 
BWG_3170(nikD) BWG_3171(nikE)
ECOK: 
ECE: 
Z4871(nikD) Z4872(nikE)
ECS: 
ECs4346(nikD) ECs4347(nikE)
ECF: 
ETW: 
ECSP_4453(nikD) ECSP_4454(nikE)
ELX: 
EOJ: 
ECO26_4566(nikD) ECO26_4567(nikE)
EOI: 
ECO111_4287(nikD) ECO111_4288(nikE)
EOH: 
ECO103_4199(nikD) ECO103_4200(nikE)
ECG: 
E2348C_3720(nikD) E2348C_3721(nikE)
EOK: 
G2583_4200(nikD) G2583_4201(nikE)
ELR: 
ECO55CA74_20080(nikD) ECO55CA74_20085(nikE)
ECC: 
c4272(nikD) c4273(nikE)
ECP: 
ECP_3574(nikD) ECP_3575(nikE)
ECI: 
UTI89_C3996(nikD) UTI89_C3997(nikE)
ECV: 
APECO1_2974(nikE) APECO1_2975(nikD)
ECX: 
EcHS_A3678(nikD) EcHS_A3679(nikE)
ECW: 
EcE24377A_3963(nikD) EcE24377A_3964(nikE)
ECM: 
EcSMS35_3763(nikD) EcSMS35_3764(nikE)
ECY: 
ECSE_3747(nikD) ECSE_3748(nikE)
ECR: 
ECIAI1_3626(nikD) ECIAI1_3627(nikE)
ECQ: 
ECED1_4152(nikD) ECED1_4153(nikE)
ECK: 
EC55989_3887(nikD) EC55989_3888(nikE)
ECT: 
ECIAI39_3960(nikD) ECIAI39_3961(nikE)
EOC: 
CE10_4003(nikD) CE10_4004(nikE)
EUM: 
ECUMN_3960(nikD) ECUMN_3961(nikE)
ECZ: 
ECS88_3882(nikD) ECS88_3883(nikE)
ELO: 
EC042_3759(nikD) EC042_3760(nikE)
ELN: 
NRG857_17250(nikD) NRG857_17255(nikE)
ELH: 
ETEC_3725 ETEC_3726
ESE: 
ECSF_3298 ECSF_3299
ESO: 
O3O_23985(nikD) O3O_23990(nikE)
ESM: 
O3M_01700(nikE) O3M_01705(nikD)
ESL: 
O3K_01655(nikE) O3K_01660(nikD)
ECL: 
EcolC_0236(nikE) EcolC_0237(nikD)
EBR: 
ECB_03328(nikD) ECB_03329(nikE)
EBD: 
ECBD_0261(nikE) ECBD_0262(nikD)
EKO: 
EKO11_0261 EKO11_0262
EKF: 
KO11_05370(nikE) KO11_05375(nikD)
EAB: 
ECABU_c39090(nikD) ECABU_c39100(nikE)
EDH: 
EcDH1_0235 EcDH1_0236
EDJ: 
ECDH1ME8569_3356(nikD) ECDH1ME8569_3357(nikE)
EIH: 
ECOK1_3908(nikD) ECOK1_3909(nikE)
ENA: 
ECNA114_3588(nikD) ECNA114_3589(nikE)
ELU: 
UM146_17520(nikD) UM146_17525(nikE)
EUN: 
UMNK88_4249(nikD) UMNK88_4250(nikE)
ELW: 
ECW_m3741(nikD) ECW_m3742(nikE)
ELL: 
WFL_18270(nikD) WFL_18275(nikE)
ELC: 
i14_3942(nikD) i14_3943(nikE)
ELD: 
i02_3942(nikD) i02_3943(nikE)
ELP: 
P12B_c3576(nikD) P12B_c3577(nikE)
EBL: 
ECD_03328(nikD) ECD_03329(nikE)
EBE: 
B21_03281(nikD) B21_03282(nikE)
ELF: 
LF82_1491(nikD) LF82_1492(nikE)
ECOA: 
APECO78_21185 APECO78_21190(nikE)
EBT: 
EBL_c18430(nikD) EBL_c18440(nikE)
SFL: 
SF3497(nikD) SF3498(nikE)
SFX: 
S4265(nikE) S4266(nikD)
SFV: 
SFV_3482(nikD) SFV_3483(nikE)
SFE: 
SFxv_3813(nikD) SFxv_3814(nikE)
SSN: 
SSON_3717(nikD) SSON_3718(nikE)
SSJ: 
SSON53_20845(nikD) SSON53_20850(nikE)
SBO: 
SBO_3476(nikD) SBO_3477(nikE)
SBC: 
SbBS512_E3841(nikE) SbBS512_E3842(nikD)
SDY: 
SDY_3634(nikD) SDY_3635(nikE)
ENT: 
Ent638_1837(nikD) Ent638_1838(nikE)
ESC: 
Entcl_2624 Entcl_2625
EAE: 
EAE_05730(nikD) EAE_05735(nikE)
EAR: 
ST548_p4206 ST548_p4207
KPN: 
KPN_03853(nikD) KPN_03854(nikE)
KPU: 
KP1_5192(nikD) KP1_5193(nikE)
KPM: 
KPHS_50080 KPHS_50090
KPP: 
A79E_0262 A79E_0263
KPE: 
KPK_0259(nikE) KPK_0260(nikD)
KPO: 
KPN2242_22275(nikD) KPN2242_22280(nikE)
KVA: 
Kvar_0247 Kvar_0248
KOX: 
KOX_05120(nikD) KOX_05125(nikE)
CKO: 
CKO_04929(nikD) CKO_04930(nikE)
CRO: 
ROD_43171(nikE) ROD_43181(nikD)
PMR: 
PMI2943 PMI2944
ETR: 
ETAE_1375(nikE) ETAE_1376(nikD)
ETD: 
ETAF_1278(nikE) ETAF_1279(nikD)
ETC: 
ETAC_06500(nikE) ETAC_06505(nikD)
DDC: 
Dd586_1350 Dd586_1351
DDD: 
Dda3937_00758 Dda3937_00759
DZE: 
Dd1591_2757 Dd1591_2758
MMK: 
MU9_3477 MU9_3478
ROR: 
RORB6_20080(nikE) RORB6_20085(nikD)
EBF: 
D782_0696 D782_0697
MSU: 
MS0462(oppF) MS0463(dppD)
PPU: 
PP_3345(nikD) PP_3346(nikE)
PPW: 
PputW619_3008(nikD) PputW619_3009(nikE)
HHE: 
HH0414(nikE) HH0415(nikD)
HCP: 
HCN_0693(nikE)
HCB: 
HCBAA847_1296(nikE) HCBAA847_1297(nikCD)
WSU: 
WS0977(dppF) WS0978(OPP-1D) WS0987(OPP-1D) WS0988
CCV: 
CCV52592_1324
SDL: 
Sdel_0023 Sdel_0024
SBA: 
Sulba_0037 Sulba_0038 Sulba_2159
DVM: 
DvMF_2398 DvMF_2399
DDS: 
Ddes_1029
DMA: 
DMR_12000(nikE) DMR_12010(nikD)
DAS: 
Daes_0985 Daes_0986
AVI: 
Avi_7617(nikD) Avi_7618(nikE)
BME: 
BMEII0490(nikD) BMEII0491(nikE)
BMI: 
BMEA_B0779(nikE) BMEA_B0780(nikD)
BMZ: 
BM28_B0769(nikE) BM28_B0770(nikD)
BMG: 
BM590_B0767(nikE) BM590_B0768(nikD)
BMW: 
BMNI_II0747 BMNI_II0748
BMF: 
BAB2_0437(nikD) BAB2_0438(nikE)
BMB: 
BruAb2_0431(nikD) BruAb2_0432(nikE)
BMC: 
BAbS19_II04120(nikD) BAbS19_II04130(nikE)
BAA: 
BAA13334_II00918 BAA13334_II00919
BMS: 
BRA0800(nikE) BRA0801(nikD)
BSI: 
BS1330_II0793(nikE) BS1330_II0794(nikD)
BMT: 
BSUIS_B0792(nikE) BSUIS_B0793(nikD)
BSV: 
BSVBI22_B0792(nikE) BSVBI22_B0793(nikD)
BOV: 
BOV_A0750(nikE)
BCS: 
BCAN_B0814(nikE) BCAN_B0815(nikD)
BSK: 
BCA52141_II0063 BCA52141_II0064
BMR: 
BMI_II794(nikE) BMI_II795(nikD)
BPP: 
BPI_II856(nikE) BPI_II857(nikD)
MRD: 
Mrad2831_6072 Mrad2831_6073(nikD)
RRU: 
Rru_A2273(nikE) Rru_A2274(nikD)
RRF: 
F11_11690(nikE) F11_11695(nikD)
AZL: 
AZL_008800 AZL_008810
BLI: 
BL02421(appDB) BL02422(appFB)
BLD: 
BLi02814 BLi02815
BHA: 
BH0570 BH0571 BH2077 BH2078
BPU: 
BPUM_3066 BPUM_3067(appDB) BPUM_3092 BPUM_3093
BMQ: 
BMQ_1718(nikD) BMQ_1719(nikE)
BMD: 
BMD_1705(nikD) BMD_1706(nikE)
SAU: 
SA2251(opp-1F) SA2252(opp-1D)
SAV: 
SAV2463 SAV2464
SAW: 
SAHV_2447 SAHV_2448
SAH: 
SaurJH1_2539 SaurJH1_2540
SAJ: 
SaurJH9_2490 SaurJH9_2491
SAM: 
MW2387(opp-1F) MW2388(opp-1D)
SAS: 
SAS2354 SAS2355
SAR: 
SAR2550(opp-1F) SAR2551(opp-1D)
SAC: 
SACOL2472 SACOL2473
SAX: 
USA300HOU_2454 USA300HOU_2455
SAA: 
SAUSA300_2407 SAUSA300_2408
SAO: 
SAOUHSC_02763 SAOUHSC_02764
SAE: 
NWMN_2360(opp1F) NWMN_2361(opp1D)
SAD: 
SAAV_2529 SAAV_2530
SUU: 
M013TW_2423 M013TW_2424
SUV: 
SAVC_11185 SAVC_11190
SUH: 
SAMSHR1132_22880 SAMSHR1132_22890
SUE: 
SAOV_2513c SAOV_2514c
SUJ: 
SAA6159_02360(opp-1F) SAA6159_02361(opp-1D)
SUK: 
SAA6008_02504(opp-1F) SAA6008_02505(opp-1D)
SUC: 
ECTR2_2320 ECTR2_2321
SUT: 
SAT0131_02662(lytN) SAT0131_02663
SUQ: 
HMPREF0772_10725(opp-1D) HMPREF0772_10726(opp-1F)
SUZ: 
MS7_2476 MS7_2477
SUD: 
ST398NM01_2513 ST398NM01_2514
SUX: 
SAEMRSA15_23610(opp-1F) SAEMRSA15_23620(opp-1D)
SUW: 
SATW20_25910(opp-1F) SATW20_25920(opp-1D)
SUG: 
SAPIG2513 SAPIG2514
SUF: 
SARLGA251_22430(opp-1F) SARLGA251_22440(opp-1D)
SAB: 
SAB2346c(opp1F) SAB2347c(opp1D)
SUY: 
SA2981_2400(opp-1F) SA2981_2401(opp-1D)
SAUB: 
C248_2513(opp-1F) C248_2514(opp-1D)
SAUM: 
BN843_25030 BN843_25040
SEP: 
SE0209 SE0210
SER: 
SERP2368 SERP2369
SLG: 
SLGD_00151 SLGD_00152
SLN: 
SLUG_01490(opp-1D) SLUG_01500(opp-1F)
SSD: 
SPSINT_0082 SPSINT_0083
SDT: 
SPSE_2394 SPSE_2395
SWA: 
A284_00440 A284_00445
LSP: 
Bsph_2973(nikE) Bsph_2974(dppD)
ESI: 
Exig_1347 Exig_1348
BBE: 
BBR47_28260 BBR47_28270
GYM: 
GYMC10_2841 GYMC10_2842
PPY: 
PPE_04750 PPE_04751
PPM: 
PPSC2_c5266 PPSC2_c5267
PMS: 
KNP414_01899 KNP414_01900 KNP414_06302 KNP414_06303
PMQ: 
PM3016_2184 PM3016_2185 PM3016_5917 PM3016_5918
PMW: 
B2K_11225 B2K_11230 B2K_30080 B2K_30085
PTA: 
HPL003_06515 HPL003_06520
SAG: 
SAG1514 SAG1515
SAN: 
gbs1573 gbs1574
SAK: 
SAK_1538(nikE) SAK_1539(nikD)
SGC: 
A964_1421(nikE) A964_1422(nikD)
SAGS: 
SaSA20_1243 SaSA20_1244(amiE)
SSA: 
SSA_0503 SSA_0504(amiF)
SEQ: 
SZO_04950 SZO_04960
SEZ: 
Sez_1452 Sez_1453
SEZO: 
SeseC_01957 SeseC_01959
SEU: 
SEQ_1644 SEQ_1645
AMT: 
Amet_1134 Amet_4718 Amet_4719
DAE: 
Dtox_0347 Dtox_0348
SGY: 
Sgly_1816 Sgly_1817
ELM: 
ELI_2578 ELI_2579
AWO: 
Awo_c00450(oppD4) Awo_c00460(oppF4)
FPR: 
FP2_28940 FP2_28950
BPRS: 
CK3_07600 CK3_07610
FNU: 
FN1500 FN1501
LBA: 
Lebu_0058 Lebu_0059
SBR: 
SY1_06390 SY1_06400
GLP: 
Glo7428_3054
DAP: 
Dacet_1570 Dacet_1571
 » show all
Taxonomy
Reference
1  [PMID:7569321]
  Authors
Kuan G, Dassa E, Saurin W, Hofnung M, Saier MH Jr.
  Title
Phylogenetic analyses of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases.
  Journal
Res. Microbiol. 146 (1995) 271-8.
  Organism
bacteria
Reference
2  [PMID:9294450]
  Authors
Hendricks JK, Mobley HL.
  Title
Helicobacter pylori ABC transporter: effect of allelic exchange mutagenesis on urease activity.
  Journal
J. Bacteriol. 179 (1997) 5892-902.
  Organism
Helicobacter pylori
Reference
3  [PMID:9889977]
  Authors
Saier MH Jr.
  Title
Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya.
  Journal
Adv. Microb. Physiol. 40 (1998) 81-136.
  Organism
bacteria
Reference
4
  Authors
Griffiths, J.K. and Sansom, C.E.
  Title
The Transporter Factsbook, Academic Press, San Diego, 1998.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
DBGET integrated database retrieval system