KEGG   ENZYME: 3.6.3.43Help
Entry
EC 3.6.3.43                 Enzyme                                 

Name
peptide-transporting ATPase
Class
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to catalyse transmembrane movement of substances
BRITE hierarchy
Sysname
ATP phosphohydrolase (peptide-exporting)
Reaction(IUBMB)
ATP + H2O + peptidein = ADP + phosphate + peptideout [RN:R00086]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
peptide [CPD:C00012]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
peptide [CPD:C00012]
Comment
ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A family of enzymes that exports alpha-hemolysin, cyclolysin, colicin V and siderophores from Gram-negative bacteria, and bacteriocin, subtilin, competence factor and pediocin from Gram-positive bacteria.
History
EC 3.6.3.43 created 2000
Reference
1  [PMID:8085823]
  Authors
Klein C, Entian KD.
  Title
Genes involved in self-protection against the lantibiotic subtilin produced by Bacillus subtilis ATCC 6633.
  Journal
Appl. Environ. Microbiol. 60 (1994) 2793-801.
  Organism
Bacillus subtilis
Reference
2  [PMID:8107849]
  Authors
Momburg F, Roelse J, Howard JC, Butcher GW, Hammerling GJ, Neefjes JJ.
  Title
Selectivity of MHC-encoded peptide transporters from human, mouse and rat.
  Journal
Nature. 367 (1994) 648-51.
  Organism
Homo sapiens, Mus musculus, Rattus norvegicus
Reference
3  [PMID:9224868]
  Authors
Binet R, Letoffe S, Ghigo JM, Delepelaire P, Wandersman C.
  Title
Protein secretion by Gram-negative bacterial ABC exporters--a review.
  Journal
Gene. 192 (1997) 7-11.
  Organism
Erwinia chrysanthemi
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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